Proteins

Genome: KpKP13

Description: Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence

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5192 / 5842 proteins Structure: AlphaFold

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Structure: AlphaFold ×
# Protein Description Gene Structure EC GO Metabolism Druggability FPocket druggability score for the preferred structure (0–1): experimental structure when available, otherwise predicted model. ≥ 0.7 highly druggable · ≥ 0.4 moderately druggable · < 0.4 low druggability. Human off-target BLASTP against the human proteome. Hit means at least one human match was detected at e-value <= 1e-5. Prefer No hit for pathogen-selective targets. Human identity (%) Best human BLAST identity percentage. Human E-value Best human BLAST E-value.
2526 KP13_05159 hypothetical protein AlphaFold + ColabFold
2.7.7.65
GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0052621Catalysis of the reaction: 2 GTP = cyclic di-3',5'-guanylate + 2 diphosphate + 2 H+. GO:0005525Binding to GTP, guanosine triphosphate. +25 total
No map 0.565 No Hit 0.0% —
2527 KP13_04227 hypothetical protein AlphaFold + ColabFold –
GO:0004519Catalysis of the cleavage of ester linkages within nucleic acids by creating internal breaks. GO:0000731Synthesis of DNA that proceeds from the broken 3' single-strand DNA end and uses the homologous intact duplex as the template. GO:0006302The repair of double-strand breaks in DNA via homologous and nonhomologous mechanisms to reform a continuous DNA helix.
No map 0.565 No Hit 0.0% —
2528 KP13_04198 30S ribosomal protein S1 rpsA AlphaFold + ColabFold –
GO:0003735The action of a molecule that contributes to the structural integrity of the ribosome. GO:0003676Binding to a nucleic acid. GO:0006412The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA or circRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA or circRNA. Translation ends with the release of a polypeptide chain from the ribosome. +47 total
No map 0.565 Hit 46.0% 7.27e-08
2529 KP13_04061 putative HTH-type transcriptional regulator AlphaFold + ColabFold –
GO:0006355Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. GO:0003700A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons. GO:0097063Binding to and responding, e.g. by conformational change, to changes in the cellular level of cadmium (Cd++). +47 total
No map 0.565 No Hit 0.0% —
2530 KP13_02820 Urease accessory protein ureG ureG AlphaFold + ColabFold –
GO:0003924Catalysis of the reaction: GTP + H2O = GDP + H+ + phosphate. GO:0006807OBSOLETE. The chemical reactions and pathways involving organic or inorganic compounds that contain nitrogen. GO:0016151Binding to a nickel (Ni) cation.
No map 0.565 No Hit 0.0% —
2531 KP13_01323 putative sn-glycerol-3-phosphate import ATP-binding protein AlphaFold + ColabFold –
GO:0016887Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient. GO:0022857Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other. GO:0008643The directed movement of carbohydrate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Carbohydrates are a group of organic compounds based of the general formula Cx(H2O)y. +47 total
No map 0.565 Hit 55.9% 2.55e-06
2532 KP13_01068 hypothetical protein AlphaFold + ColabFold – – No map 0.565 No Hit 0.0% —
2533 KP13_00670 Aerobic glycerol-3-phosphate dehydrogenase glpD AlphaFold + ColabFold
1.1.5.3
GO:0016491Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. GO:0006072The chemical reactions and pathways involving glycerol-3-phosphate, a phosphoric monoester of glycerol. GO:0004368Catalysis of the reaction: sn-glycerol 3-phosphate + a quinone = glycerone phosphate + a quinol. +36 total
No map 0.565 Hit 30.6% 9.55e-33
2534 KP13_00414 hypothetical protein AlphaFold + ColabFold – – No map 0.565 No Hit 0.0% —
2535 KP13_06748 DNA topoisomerase III AlphaFold + ColabFold
5.6.2.1
GO:0006265The process in which a transformation is induced in the topological structure of a double-stranded DNA helix, resulting in a change in linking number. GO:0003916Catalysis of the transient cleavage and passage of individual DNA strands or double helices through one another, resulting a topological transformation in double-stranded DNA. GO:0003917Catalysis of a DNA topological transformation by transiently cleaving one DNA strand at a time to allow passage of another strand; changes the linking number by +1 per catalytic cycle. +69 total
No map 0.564 Hit 22.3% 3.55e-10
2536 KP13_05245 Putative prolyl endopeptidase AlphaFold + ColabFold – – No map 0.564 No Hit 0.0% —
2537 KP13_04084 putative diguanylate cyclase AlphaFold + ColabFold
2.7.7.65
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0007165The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell. GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. +58 total
No map 0.564 No Hit 0.0% —
2538 KP13_02957 Biotin carboxylase accC AlphaFold + ColabFold
6.3.4.14
GO:0016874Catalysis of the joining of two molecules, or two groups within a single molecule, using the energy from the hydrolysis of ATP, a similar triphosphate, or a pH gradient. GO:0046872Binding to a metal ion. GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. +36 total
No map 0.564 Hit 62.5% 6.92e-08
2539 KP13_02498 4-hydroxy-2-oxo-heptane-1,7-dioate aldolase hpcH AlphaFold + ColabFold
4.1.2.52
GO:0018802OBSOLETE. Catalysis of the reaction: 2,4-dihydroxy-hept-trans-2-ene-1,7-dioate = pyruvate + succinic semialdehyde. GO:0003824Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. GO:0010124The chemical reactions and pathways resulting in the breakdown of phenylacetate. +47 total
No map 0.564 No Hit 0.0% —
2540 KP13_00961 Glycerol-3-phosphate transporter glpT AlphaFold + ColabFold –
GO:0015794The process in which glycerol-3-phosphate is transported across a membrane. Glycerol-3-phosphate is a phosphoric monoester of glycerol. GO:0022857Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other. GO:0015169Enables the transfer of glycerol-3-phosphate from one side of a membrane to the other. Glycerol-3-phosphate is a phosphoric monoester of glycerol. +58 total
No map 0.564 Hit 29.5% 1.84e-33
2541 KP13_00821 tRNA-specific adenosine deaminase tadA AlphaFold + ColabFold
3.5.4.33
GO:0008270Binding to a zinc ion (Zn). GO:0016787Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. GO:0002100The process in which an adenosine at position 34 of a tRNA is post-transcriptionally converted to inosine. The wobble nucleoside of the tRNA sequence (position 34) corresponds to the first position of the anticodon. +36 total
No map 0.564 Hit 48.4% 5.17e-12
2542 KP13_32086 conjugal transfer traI-like protein AlphaFold + ColabFold – – No map 0.563 No Hit 0.0% —
2543 KP13_20969 GtrA family protein AlphaFold + ColabFold –
GO:0000271The chemical reactions and pathways resulting in the formation of a polysaccharide, a polymer of many (typically more than 10) monosaccharide residues linked glycosidically. GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
No map 0.563 No Hit 0.0% —
2544 KP13_16560 S-ribosylhomocysteine lyase luxS AlphaFold + ColabFold
4.4.1.21
GO:0043768Catalysis of the reaction: S-(5-deoxy-D-ribos-5-yl)-L-homocysteine = (S)-4,5-dihydroxypentane-2,3-dione + L-homocysteine. GO:0005506Binding to an iron (Fe) ion. GO:0046872Binding to a metal ion. +14 total
No map 0.563 No Hit 0.0% —
2545 KP13_05062 Alkaline phosphatase synthesis transcriptional regulatory protein phoP AlphaFold + ColabFold –
GO:0006355Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. GO:0000160A conserved series of molecular signals found in prokaryotes and eukaryotes; involves autophosphorylation of a histidine kinase and the transfer of the phosphate group to an aspartate that then acts as a phospho-donor to response regulator proteins. GO:0003677Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). +47 total
No map 0.563 No Hit 0.0% —
2546 KP13_03951 S-(hydroxymethyl)glutathione dehydrogenase frmA AlphaFold + ColabFold
1.1.1.284
GO:0051903Catalysis of the reaction: S-(hydroxymethyl)glutathione + NAD(P)+ = S-formylglutathione + NAD(P)H + H+. GO:0008270Binding to a zinc ion (Zn). GO:0006069OBSOLETE. An ethanol metabolic process in which ethanol is converted to acetyl-CoA via acetaldehyde and acetate. +47 total
No map 0.563 Hit 64.6% 5.40e-28
2547 KP13_03764 hypothetical protein AlphaFold + ColabFold –
GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. GO:0004029Catalysis of the reaction: an aldehyde + H2O + NAD+ = a carboxylate + 2 H+ + NADH.
No map 0.563 No Hit 0.0% —
2548 KP13_03243 conjugative transfer protein HtdK AlphaFold + ColabFold – – No map 0.563 No Hit 0.0% —
2549 KP13_02754 GCN5-related N-acetyltransferase (GNAT) domain-containing protein AlphaFold + ColabFold –
GO:0016747Catalysis of the transfer of an acyl group, other than amino-acyl, from one compound (donor) to another (acceptor).
No map 0.563 No Hit 0.0% —
2550 KP13_02384 Signal transduction histidine-protein kinase barA barA AlphaFold + ColabFold
2.7.13.3
GO:0016310The process of introducing a phosphate group into a molecule, usually with the formation of a phosphoric ester, a phosphoric anhydride or a phosphoric amide. GO:0016772Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to another (acceptor). GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. +58 total
No map 0.563 No Hit 0.0% —
Page of 208 · 5192 total proteins