Proteins

Genome: KpKP13

Description: Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence

Search, filter, and prioritize proteins.

Export view
5842 proteins

Scoring formula None

Sorted by Druggability (descending)

Applied filters No active filters

Search query No active search

Rows per page 25

Rows
# Protein Description Gene Structure EC GO Druggability FPocket druggability score for the preferred structure (0–1): experimental structure when available, otherwise predicted model. ≥ 0.7 highly druggable · ≥ 0.4 moderately druggable · < 0.4 low druggability. Human off-target BLASTP against the human proteome. Hit means at least one human match was detected at e-value <= 1e-5. Prefer No hit for pathogen-selective targets. Human identity (%) Best human BLAST identity percentage. Human E-value Best human BLAST E-value.
2626 KP13_02950 putative acrEF/envCD operon repressor envR AlphaFold + ColabFold –
GO:0003677Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). GO:0003700A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons. GO:0045892Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription. +14 total
0.595 No Hit 0.0% —
2627 KP13_00890 hypothetical protein ColabFold – – 0.595 No Hit 0.0% —
2628 KP13_02628 hypothetical protein AlphaFold + ColabFold – – 0.594 No Hit 0.0% —
2629 KP13_01730 DNA recombination protein rmuC rmuC AlphaFold + ColabFold –
GO:0006310Any process in which a new genotype is formed by reassortment of genes resulting in gene combinations different from those that were present in the parents. In eukaryotes genetic recombination can occur by chromosome assortment, intrachromosomal recombination, or nonreciprocal interchromosomal recombination. Interchromosomal recombination occurs by crossing over. In bacteria it may occur by genetic transformation, conjugation, transduction, or F-duction.
0.594 No Hit 0.0% —
2630 KP13_00243 Inner membrane protein AlphaFold + ColabFold –
GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0006974Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating damage to its DNA from environmental insults or errors during metabolism.
0.594 No Hit 0.0% —
2631 KP13_02611 Glutamate--cysteine ligase gshA AlphaFold + ColabFold
6.3.2.2
GO:0006750The chemical reactions and pathways resulting in the formation of glutathione, the tripeptide glutamylcysteinylglycine, which acts as a coenzyme for some enzymes and as an antioxidant in the protection of sulfhydryl groups in enzymes and other proteins. GO:0003824Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. GO:0004357Catalysis of the reaction: L-cysteine + L-glutamate + ATP = L-gamma-glutamyl-L-cysteine + ADP + 2 H+ + phosphate. +36 total
0.593 No Hit 0.0% —
2632 KP13_01552 SpoVR family protein AlphaFold + ColabFold – – 0.593 No Hit 0.0% —
2633 KP13_00441 hypothetical protein AlphaFold + ColabFold – – 0.593 No Hit 0.0% —
2634 KP13_00060 D-galactonate transporter dgoT AlphaFold + ColabFold –
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0022857Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other. GO:0055085The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other.
0.593 Hit 35.3% 6.59e-06
2635 KP13_31499 Cytidylate kinase cmk AlphaFold + ColabFold
2.7.4.25
GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. GO:0004127OBSOLETE. Catalysis of the reaction: ATP + (d)CMP = ADP + (d)CDP. GO:0006139Any cellular metabolic process involving nucleobases, nucleosides, nucleotides and nucleic acids. +58 total
0.592 No Hit 0.0% —
2636 KP13_05588 D-lactate dehydrogenase ldhA AlphaFold + ColabFold –
GO:0051287Binding to nicotinamide adenine dinucleotide, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NAD+, or the reduced form, NADH. GO:0016616Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group acts as a hydrogen or electron donor and reduces NAD+ or NADP. GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. +14 total
0.592 Hit 41.0% 7.84e-23
2637 KP13_05484 Sulfite exporter TauE family protein AlphaFold + ColabFold –
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
0.592 No Hit 0.0% —
2638 KP13_05314 Glyoxalase/bleomycin resistance protein/dioxygenase domain-containing protein AlphaFold + ColabFold – – 0.592 No Hit 0.0% —
2639 KP13_03979 putative lipoprotein AlphaFold + ColabFold – – 0.592 No Hit 0.0% —
2640 KP13_02537 putative DNA helicase AlphaFold + ColabFold –
GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. GO:0004386Catalysis of the reaction: ATP + H2O = ADP + phosphate, to drive the unwinding of a DNA or RNA helix. GO:0006468The process of introducing a phosphate group on to a protein. +36 total
0.592 Hit 37.8% 1.33e-09
2641 KP13_01679 hypothetical protein AlphaFold + ColabFold – – 0.592 No Hit 0.0% —
2642 KP13_01008 putative disulfide bond reductase AlphaFold + ColabFold –
GO:0015036Catalysis of the reaction: substrate with reduced sulfide groups = substrate with oxidized disulfide bonds.
0.592 No Hit 0.0% —
2643 KP13_00988 NADH-quinone oxidoreductase subunit G nuoG AlphaFold + ColabFold
7.1.1.-
GO:0008137Catalysis of the reaction: NADH + ubiquinone + 5 H+(in) = NAD+ + ubiquinol + 4 H+(out). GO:0016491Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. +811 total
0.592 Hit 24.9% 4.23e-46
2644 KP13_00554 Argininosuccinate lyase argH AlphaFold + ColabFold
4.3.2.1
GO:0004056Catalysis of the reaction: N-(L-arginino)succinate = fumarate + L-arginine. GO:0003824Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. GO:0042450OBSOLETE. The chemical reactions and pathways resulting in the formation of arginine (2-amino-5-guanidinopentanoic acid) via the intermediate compound ornithine. +14 total
0.592 Hit 70.0% 9.84e-18
2645 KP13_31781 hypothetical protein ColabFold – – 0.591 No Hit 0.0% —
2646 KP13_05026 hypothetical protein AlphaFold + ColabFold – – 0.591 No Hit 0.0% —
2647 KP13_04224 Cold shock-like protein cspD cspD AlphaFold + ColabFold –
GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. GO:0003676Binding to a nucleic acid. GO:0006355Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. +25 total
0.591 Hit 40.3% 4.45e-07
2648 KP13_03304 hypothetical protein AlphaFold + ColabFold –
GO:0006355Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.
0.591 No Hit 0.0% —
2649 KP13_00122 hypothetical protein AlphaFold + ColabFold – – 0.591 No Hit 0.0% —
2650 KP13_31500 Glutamate racemase murI AlphaFold + ColabFold
5.1.1.3
GO:0016855Catalysis of a reaction that alters the configuration of one or more chiral centers in an amino acid. GO:0036361OBSOLETE. Catalysis of the interconversion of the two enantiomers of a chiral amino acid or amino acid derivative. GO:0008881Catalysis of the reaction: L-glutamate = D-glutamate. +47 total
0.59 No Hit 0.0% —
Page of 234 · 5842 total proteins