Proteins

Genome: KpKP13

Description: Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence

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5842 proteins

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# Protein Description Gene Structure EC GO Druggability FPocket druggability score for the preferred structure (0–1): experimental structure when available, otherwise predicted model. ≥ 0.7 highly druggable · ≥ 0.4 moderately druggable · < 0.4 low druggability. Human off-target BLASTP against the human proteome. Hit means at least one human match was detected at e-value <= 1e-5. Prefer No hit for pathogen-selective targets. Human identity (%) Best human BLAST identity percentage. Human E-value Best human BLAST E-value.
2576 KP13_01938 Thiamine import ATP-binding protein thiQ thiQ AlphaFold + ColabFold –
GO:0016887Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient. GO:0042626Primary active transporter of a solute across a membrane, via the reaction: ATP + H2O = ADP + phosphate, to directly drive the transport of a substance across a membrane. The transport protein may be transiently phosphorylated (P-type transporters), or not (ABC-type transporters and other families of transporters). Primary active transport occurs up the solute's concentration gradient and is driven by a primary energy source. GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. +25 total
0.602 Hit 34.9% 1.24e-20
2577 KP13_00283 Protein BcsE bcsE AlphaFold + ColabFold –
GO:0035438Binding to cyclic-di-GMP, cyclic dimeric guanosine monophosphate.
0.602 No Hit 0.0% —
2578 KP13_32138 hypothetical protein ColabFold – – 0.601 No Hit 0.0% —
2579 KP13_06281 hypothetical protein ColabFold – – 0.601 No Hit 0.0% —
2580 KP13_05194 Glyoxalase/bleomycin resistance protein/dioxygenase family protein AlphaFold + ColabFold –
GO:0004462Catalysis of the reaction: (R)-S-lactoylglutathione = glutathione + methylglyoxal. GO:0046872Binding to a metal ion.
0.601 No Hit 0.0% —
2581 KP13_04888 Triosephosphate isomerase 2 tpiA2 AlphaFold + ColabFold
5.3.1.1
GO:0004807Catalysis of the reaction: D-glyceraldehyde 3-phosphate = dihydroxyacetone phosphate. GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. GO:0006094The formation of glucose from noncarbohydrate precursors, such as pyruvate, amino acids and glycerol. +36 total
0.601 Hit 42.6% 3.15e-18
2582 KP13_04377 Aromatic amino acid transport protein aroP AlphaFold + ColabFold –
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0055085The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other. GO:0006865The directed movement of amino acids, organic acids containing one or more amino substituents, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. +14 total
0.601 Hit 25.2% 5.73e-08
2583 KP13_03811 Phosphoribosylglycinamide formyltransferase purN AlphaFold + ColabFold
2.1.2.2
GO:0009058A cellular process consisting of the biochemical pathways by which a living organism synthesizes chemical substances. This typically represents the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones. GO:0006189The chemical reactions and pathways resulting in the formation of IMP, inosine monophosphate, by the stepwise assembly of a purine ring on ribose 5-phosphate. GO:0004644Catalysis of the reaction: 10-formyltetrahydrofolate + N1-(5-phospho-D-ribosyl)glycinamide = tetrahydrofolate + N2-formyl-N1-(5-phospho-D-ribosyl)glycinamide. +14 total
0.601 Hit 44.0% 1.92e-35
2584 KP13_02674 hypothetical protein ColabFold – – 0.601 No Hit 0.0% —
2585 KP13_02131 putative HTH-type transcriptional regulator matA matA AlphaFold + ColabFold –
GO:0006355Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. GO:0003677Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
0.601 No Hit 0.0% —
2586 KP13_01633 hypothetical protein AlphaFold + ColabFold –
GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
0.601 No Hit 0.0% —
2587 KP13_32178 hypothetical protein ColabFold – – 0.6 No Hit 0.0% —
2588 KP13_32050 hypothetical protein ColabFold – – 0.6 Hit 22.4% 8.12e-08
2589 KP13_32014 hypothetical protein ColabFold – – 0.6 No Hit 0.0% —
2590 KP13_06694 conjugal transfer TraG-like protein AlphaFold + ColabFold – – 0.6 No Hit 0.0% —
2591 KP13_05326 Multidrug resistance protein mdtM AlphaFold + ColabFold –
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0022857Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other. GO:0055085The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other. +36 total
0.6 No Hit 0.0% —
2592 KP13_04620 putative 4-hydroxyphenylpyruvate dioxygenase AlphaFold + ColabFold
4.2.1.118
GO:0046279The chemical reactions and pathways resulting in the formation of 3,4-dihydroxybenzoate. GO:0046565Catalysis of the reaction: 3-dehydroshikimate = 3,4-dihydroxybenzoate + H2O. 3,4-dihydroxybenzoate is also known as protocatechuate. GO:0051213Catalysis of the incorporation of both atoms of molecular oxygen (O2) into the substrate. +14 total
0.6 Hit 26.4% 2.08e-07
2593 KP13_03087 F-type conjugal transfer protein TraL AlphaFold + ColabFold –
GO:0019867The external membrane of Gram-negative bacteria or certain organelles such as mitochondria and chloroplasts; freely permeable to most ions and metabolites.
0.6 No Hit 0.0% —
2594 KP13_02739 Nucleoside-triphosphatase rdgB rdgB AlphaFold + ColabFold
3.6.1.66
GO:0009143The chemical reactions and pathways resulting in the breakdown of a nucleoside triphosphate, a compound consisting of a nucleobase linked to a deoxyribose or ribose sugar esterified with triphosphate on the sugar. GO:0017111Catalysis of the reaction: a ribonucleoside triphosphate + H2O = a ribonucleoside diphosphate + H+ + phosphate. GO:0047429Catalysis of the reaction: a nucleoside triphosphate + H2O = a nucleotide + H+ + diphosphate. +811 total
0.6 Hit 31.6% 2.82e-13
2595 KP13_02650 hypothetical protein AlphaFold + ColabFold – – 0.6 No Hit 0.0% —
2596 KP13_02067 Isochorismatase domain-containing protein AlphaFold + ColabFold –
GO:0016787Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc.
0.6 No Hit 0.0% —
2597 KP13_00874 hypothetical protein AlphaFold + ColabFold – – 0.6 No Hit 0.0% —
2598 KP13_00775 hypothetical protein AlphaFold + ColabFold – – 0.6 No Hit 0.0% —
2599 KP13_04412 Sugar efflux transporter B setB AlphaFold + ColabFold –
GO:0005351Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: carbohydrate(out) + H+(out) = carbohydrate(in) + H+(in). GO:0022857Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other. GO:0008643The directed movement of carbohydrate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Carbohydrates are a group of organic compounds based of the general formula Cx(H2O)y. +69 total
0.599 No Hit 0.0% —
2600 KP13_03416 putative transposase ColabFold – – 0.599 No Hit 0.0% —
Page of 234 · 5842 total proteins