Proteins

Genome: KpKP13

Description: Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence

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5842 proteins

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# Protein Description Gene Structure EC GO Druggability FPocket druggability score for the preferred structure (0–1): experimental structure when available, otherwise predicted model. ≥ 0.7 highly druggable · ≥ 0.4 moderately druggable · < 0.4 low druggability. Human off-target BLASTP against the human proteome. Hit means at least one human match was detected at e-value <= 1e-5. Prefer No hit for pathogen-selective targets. Human identity (%) Best human BLAST identity percentage. Human E-value Best human BLAST E-value.
2601 KP13_00895 hypothetical protein AlphaFold + ColabFold – – 0.599 No Hit 0.0% —
2602 KP13_00271 Dipeptide transport ATP-binding protein dppD dppD AlphaFold + ColabFold
7.4.2.9
GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. GO:0016887Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient. GO:0015833The directed movement of peptides, compounds of two or more amino acids where the alpha carboxyl group of one is bound to the alpha amino group of another, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. +36 total
0.599 Hit 33.0% 8.95e-06
2603 KP13_05525 hypothetical protein AlphaFold + ColabFold –
GO:0016491Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced.
0.598 No Hit 0.0% —
2604 KP13_04862 Ribosomal large subunit pseudouridine synthase E rluE AlphaFold + ColabFold
5.4.99.-
GO:0009451The covalent alteration of one or more nucleotides within an RNA molecule to produce an RNA molecule with a sequence that differs from that coded genetically. GO:0009982Catalysis of the reaction: a uridine in RNA = a pseudouridine in RNA. Conversion of uridine in an RNA molecule to pseudouridine by rotation of the C1'-N-1 glycosidic bond of uridine in RNA to a C1'-C5. GO:0001522The intramolecular conversion of uridine to pseudouridine within an RNA molecule. +47 total
0.598 No Hit 0.0% —
2605 KP13_03456 Secretion protein HlyD family AlphaFold + ColabFold –
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0022857Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other. GO:0055085The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other.
0.598 No Hit 0.0% —
2606 KP13_03196 hypothetical protein ColabFold – – 0.598 No Hit 0.0% —
2607 KP13_02345 putative sufE-like protein AlphaFold + ColabFold – – 0.598 No Hit 0.0% —
2608 KP13_02011 Protein smp smp AlphaFold + ColabFold –
GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
0.598 No Hit 0.0% —
2609 KP13_01795 DNA polymerase III subunit alpha dnaE AlphaFold + ColabFold
2.7.7.7
GO:0003676Binding to a nucleic acid. GO:0006260The cellular metabolic process in which a cell duplicates one or more molecules of DNA. DNA replication begins when specific sequences, known as origins of replication, are recognized and bound by the origin recognition complex, and ends when the original DNA molecule has been completely duplicated and the copies topologically separated. The unit of replication usually corresponds to the genome of the cell, an organelle, or a virus. The template for replication can either be an existing DNA molecule or RNA. GO:0003824Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. +36 total
0.598 No Hit 0.0% —
2610 KP13_00785 Putative ribosome maturation factor rimN rimN AlphaFold + ColabFold
2.7.7.87
GO:0002949The attachment of a carbonyl group and a threonine to the amino group of the adenine residue immediately 3' of the anticodon, in tRNAs that decode ANN codons (where N is any base). GO:0003725Binding to double-stranded RNA. GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. +47 total
0.598 Hit 27.6% 6.36e-07
2611 KP13_00032 Phosphate transport system permease protein pstA pstA AlphaFold + ColabFold –
GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0005315Enables the transfer of phosphate ions from one side of a membrane to the other, up its concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction and is driven by a chemiosmotic source of energy. Secondary active transporters include symporters and antiporters. GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. +25 total
0.598 No Hit 0.0% —
2612 KP13_03417 Deoxyribonucleoside regulator deoR AlphaFold + ColabFold –
GO:0030246Binding to a carbohydrate, which includes monosaccharides, oligosaccharides and polysaccharides as well as substances derived from monosaccharides by reduction of the carbonyl group (alditols), by oxidation of one or more hydroxy groups to afford the corresponding aldehydes, ketones, or carboxylic acids, or by replacement of one or more hydroxy group(s) by a hydrogen atom. Cyclitols are generally not regarded as carbohydrates. GO:0006355Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. GO:0003700A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons. +14 total
0.597 No Hit 0.0% —
2613 KP13_02715 putative Glucose/ribitol dehydrogenase AlphaFold + ColabFold –
GO:0016491Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced.
0.597 Hit 34.9% 2.81e-06
2614 KP13_01781 D-methionine-binding lipoprotein metQ metQ AlphaFold + ColabFold –
GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0015821The directed movement of methionine, 2-amino-4-(methylthio)butanoic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
0.597 No Hit 0.0% —
2615 KP13_31984 Cytotoxic necrotizing domain-containing protein AlphaFold + ColabFold – – 0.596 Hit 29.4% 8.66e-09
2616 KP13_04691 putative potassium channel protein AlphaFold + ColabFold –
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0005216Enables the facilitated diffusion of a monoatomic ion (by an energy-independent process) by passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism. May be either selective (it enables passage of a specific ion only) or non-selective (it enables passage of two or more ions of same charge but different size). GO:0006811The directed movement of a monoatomic ion into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Monatomic ions (also called simple ions) are ions consisting of exactly one atom. +47 total
0.596 Hit 37.2% 2.30e-28
2617 KP13_04351 hypothetical protein AlphaFold + ColabFold – – 0.596 No Hit 0.0% —
2618 KP13_04057 hypothetical protein AlphaFold + ColabFold – – 0.596 No Hit 0.0% —
2619 KP13_01828 Ferrichrome-iron receptor fhuA AlphaFold + ColabFold –
GO:0009279A lipid bilayer that forms the outermost membrane of the cell envelope; enriched in polysaccharide and protein; the outer leaflet of the membrane contains specific lipopolysaccharide structures. GO:0015891The directed movement of siderophores, low molecular weight Fe(III)-chelating substances, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. GO:0015343Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: siderophore-iron(out) + H+(out) = siderophore-iron(in) + H+(in). +25 total
0.596 No Hit 0.0% —
2620 KP13_01560 putative septum site-determining protein minC minC AlphaFold + ColabFold –
GO:0051302Any process that modulates the frequency, rate or extent of the physical partitioning and separation of a cell into daughter cells. GO:0051726Any process that modulates the rate or extent of progression through the cell cycle. GO:0000902The developmental process in which the size or shape of a cell is generated and organized. +25 total
0.596 No Hit 0.0% —
2621 KP13_00646 Death on curing protein of phage P1 doc AlphaFold + ColabFold –
GO:0016301Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule.
0.596 No Hit 0.0% —
2622 KP13_00360 Lysine-sensitive aspartokinase 3 lysC AlphaFold + ColabFold
2.7.2.4
GO:0009089OBSOLETE. The chemical reactions and pathways resulting in the formation of lysine, via the intermediate diaminopimelate. GO:0004072Catalysis of the reaction: L-aspartate + ATP = 4-phospho-L-aspartate + ADP + H+. GO:0008652The chemical reactions and pathways resulting in the formation of amino acids, organic acids containing one or more amino substituents. +47 total
0.596 No Hit 0.0% —
2623 KP13_05195 putative acyl-CoA synthase AlphaFold + ColabFold –
GO:0031956Catalysis of the reaction: a medium-chain fatty acid + ATP + CoA = a medium-chain fatty acyl-CoA + AMP + diphosphate. A medium-chain fatty acid has an aliphatic tail containing 6 to 12 carbons. GO:0006631The chemical reactions and pathways involving fatty acids, aliphatic monocarboxylic acids liberated from naturally occurring fats and oils by hydrolysis.
0.595 Hit 43.5% 9.09e-06
2624 KP13_04673 phenylalanyl-tRNA synthetase alpha subunit pheS AlphaFold + ColabFold
6.1.1.20
GO:0004812Catalysis of the formation of aminoacyl-tRNA from ATP, amino acid, and tRNA with the release of diphosphate and AMP. GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. GO:0004826Catalysis of the reaction: ATP + L-phenylalanine + tRNA(Phe) = AMP + diphosphate + L-phenylalanyl-tRNA(Phe). +69 total
0.595 Hit 33.3% 3.03e-10
2625 KP13_03220 hypothetical protein AlphaFold + ColabFold –
GO:0003824Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. GO:0051536Binding to an iron-sulfur cluster, a combination of iron and sulfur atoms. GO:0051539Binding to a 4 iron, 4 sulfur (4Fe-4S) cluster; this cluster consists of four iron atoms, with the inorganic sulfur atoms found between the irons and acting as bridging ligands. +14 total
0.595 Hit 24.0% 3.38e-11
Page of 234 · 5842 total proteins