Proteins

Genome: KpKP13

Description: Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence

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5842 proteins

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# Protein Description Gene Structure EC GO Druggability FPocket druggability score for the preferred structure (0–1): experimental structure when available, otherwise predicted model. ≥ 0.7 highly druggable · ≥ 0.4 moderately druggable · < 0.4 low druggability. Human off-target BLASTP against the human proteome. Hit means at least one human match was detected at e-value <= 1e-5. Prefer No hit for pathogen-selective targets. Human identity (%) Best human BLAST identity percentage. Human E-value Best human BLAST E-value.
2701 KP13_03279 Succinate dehydrogenase flavoprotein subunit sdhA AlphaFold + ColabFold
1.3.5.1
GO:0022900A process in which a series of electron carriers operate together to transfer electrons from donors to any of several different terminal electron acceptors. GO:0016491Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. GO:0016627Catalysis of an oxidation-reduction (redox) reaction in which a CH-CH group acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor. +69 total
0.582 Hit 63.5% 1.69e-120
2702 KP13_03136 UTP--glucose-1-phosphate uridylyltransferase in cps region galF AlphaFold + ColabFold
2.7.7.9
GO:0030234A molecular function regulator that modulates a catalytic activity. GO:0009058A cellular process consisting of the biochemical pathways by which a living organism synthesizes chemical substances. This typically represents the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones. GO:0003983Catalysis of the reaction: alpha-D-glucose 1-phosphate + UTP = diphosphate + UDP-D-glucose. +36 total
0.582 Hit 25.9% 4.26e-07
2703 KP13_05187 putative DeoR family transcriptional regulator AlphaFold + ColabFold –
GO:0006355Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. GO:0003700A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons. GO:0003677Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
0.581 No Hit 0.0% —
2704 KP13_02291 Exodeoxyribonuclease V gamma chain recC AlphaFold + ColabFold –
GO:0009338An enzyme complex that catalyzes exonucleolytic cleavage (in the presence of ATP) in either 5' to 3' or 3' to 5' direction to yield 5'-phosphooligonucleotides. Exodeoxyribonuclease V shows a preference for double-stranded DNA and possesses DNA-dependent ATPase activity. It acts endonucleolytically on single-stranded circular DNA. GO:0008854Catalysis of the exonucleolytic cleavage (in the presence of ATP) in either 5' to 3' or 3' to 5' direction to yield 5'-phosphooligonucleotides. GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. +36 total
0.581 No Hit 0.0% —
2705 KP13_02249 hypothetical protein AlphaFold + ColabFold –
GO:0006355Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. GO:0003700A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons. GO:0000976Binding to a specific sequence of DNA that is part of a regulatory region that controls transcription of that section of the DNA. The transcribed region might be described as a gene, cistron, or operon.
0.581 No Hit 0.0% —
2706 KP13_01823 H(+)/Cl(-) exchange transporter ClcA clcA AlphaFold + ColabFold –
GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0005247Enables the transmembrane transfer of a chloride ion by a voltage-gated channel. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded. GO:0015108Enables the transfer of chloride ions from one side of a membrane to the other. +47 total
0.581 Hit 32.7% 6.76e-10
2707 KP13_01373 Regulator of sigma D rsd AlphaFold + ColabFold –
GO:0006355Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.
0.581 No Hit 0.0% —
2708 KP13_05463 hypothetical protein ColabFold – – 0.58 No Hit 0.0% —
2709 KP13_02919 putative transmembrane protein AlphaFold + ColabFold – – 0.58 No Hit 0.0% —
2710 KP13_01225 30S ribosomal protein S18 rpsR AlphaFold + ColabFold –
GO:0003735The action of a molecule that contributes to the structural integrity of the ribosome. GO:0005840An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins. GO:0006412The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA or circRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA or circRNA. Translation ends with the release of a polypeptide chain from the ribosome. +25 total
0.58 No Hit 0.0% —
2711 KP13_00318 Nickel import ATP-binding protein NikD nikD AlphaFold + ColabFold
7.4.2.9
GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. GO:0016887Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient. GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
0.58 Hit 32.4% 3.63e-07
2712 KP13_31962 hypothetical protein ColabFold – – 0.579 No Hit 0.0% —
2713 KP13_04908 fibronectin-binding protein AlphaFold + ColabFold –
GO:0031241The leaflet of a outer cell membrane that faces the periplasm, including any protein embedded in, attached to, or peripherally associated with it. GO:0030234A molecular function regulator that modulates a catalytic activity. GO:0009252The chemical reactions and pathways resulting in the formation of peptidoglycans, any of a class of glycoconjugates found in bacterial cell walls and consisting of long glycan strands of alternating residues of beta-(1,4) linked N-acetylglucosamine and N-acetylmuramic acid, cross-linked by short peptides. +14 total
0.579 No Hit 0.0% —
2714 KP13_04367 TetR-like transcription regulator AlphaFold + ColabFold –
GO:0003677Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). GO:0003700A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons. GO:0000976Binding to a specific sequence of DNA that is part of a regulatory region that controls transcription of that section of the DNA. The transcribed region might be described as a gene, cistron, or operon.
0.579 No Hit 0.0% —
2715 KP13_03008 putative HTH-type transcriptional regulator AlphaFold + ColabFold –
GO:0006355Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. GO:0003677Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
0.579 No Hit 0.0% —
2716 KP13_02898 Acetoin:2,6-dichlorophenolindophenol oxidoreductase, alpha subunit acoA AlphaFold + ColabFold –
GO:0016624Catalysis of an oxidation-reduction (redox) reaction in which an aldehyde or ketone (oxo) group acts as a hydrogen or electron donor and reduces a disulfide. GO:0004739Catalysis of the reaction: N(6)-[(R)-lipoyl]-L-lysyl-[protein] + pyruvate + H+ = N(6)-[(R)-S(8)-acetyldihydrolipoyl]-L-lysyl-[protein] + CO2. GO:0006086The chemical reactions and pathways resulting in the formation of acetyl-CoA from pyruvate. In most organisms, this pathway links glycolysis to the TCA cycle, by a series of three reactions carried out by a multisubunit complex called the 'pyruvate dehydrogenase complex', even though pyruvate dehydrogenase activity describes only one of those reactions. The combination of the three reactions can be summarized as: pyruvate + coenzyme A + NAD+ -> acetyl-CoA + CO2 + NADH.
0.579 Hit 36.8% 5.18e-62
2717 KP13_02429 Protein grpE grpE AlphaFold + ColabFold –
GO:0000774Binds to and stimulates the hydrolysis and exchange of adenyl nucleotides by other proteins. GO:0051087Binding to a chaperone protein, a class of proteins that bind to nascent or unfolded polypeptides and ensure correct folding or transport. GO:0042803Binding to an identical protein to form a homodimer. +36 total
0.579 Hit 35.8% 4.16e-16
2718 KP13_01875 hypothetical protein AlphaFold + ColabFold – – 0.579 No Hit 0.0% —
2719 KP13_01236 Bifunctional 2',3'-cyclic-nucleotide 2'-phosphodiesterase/3'-nucleotidase cpdB Experimental + ColabFold –
GO:0009166The chemical reactions and pathways resulting in the breakdown of nucleotides, any nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the glycose moiety; may be mono-, di- or triphosphate; this definition includes cyclic-nucleotides (nucleoside cyclic phosphates). GO:0009117The chemical reactions and pathways involving a nucleotide, a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the glycose moiety; may be mono-, di- or triphosphate; this definition includes cyclic nucleotides (nucleoside cyclic phosphates). GO:0016787Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. +47 total
0.579 Hit 26.8% 3.01e-08
2720 KP13_00710 Siroheme synthase 2 cysG2 AlphaFold + ColabFold –
GO:0004851Catalysis of the reaction: uroporphyrinogen III + 2 S-adenosyl-L-methionine = precorrin-2 + 2 S-adenosyl-L-homocysteine + H+. GO:0051266Catalysis of the reaction: siroheme + 2 H+ = Fe(2+) + sirohydrochlorin. GO:0008168Catalysis of the transfer of a methyl group to an acceptor molecule. +58 total
0.579 No Hit 0.0% —
2721 KP13_00604 AzlC family protein AlphaFold + ColabFold –
GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:1903785The directed movement of L-valine across a membrane.
0.579 No Hit 0.0% —
2722 KP13_00365 Endoribonuclease L-PSP/chorismate mutase-like domain-containing protein AlphaFold + ColabFold –
GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. GO:0019239Catalysis of the removal of an amino group from a substrate, producing a substituted or nonsubstituted ammonia (NH4+/NH2R).
0.579 Hit 43.2% 1.75e-14
2723 KP13_06734 conjugal transfer TrbF-like protein trbF AlphaFold + ColabFold –
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it.
0.578 No Hit 0.0% —
2724 KP13_05467 Diaminobutyrate--2-oxoglutarate aminotransferase dat AlphaFold + ColabFold –
GO:0030170Binding to pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6. GO:0008483Catalysis of the transfer of an amino group to an acceptor, usually a 2-oxo acid. GO:0003824Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. +14 total
0.578 Hit 29.7% 1.38e-39
2725 KP13_03085 F-type conjugal transfer protein TraK AlphaFold + ColabFold – – 0.578 No Hit 0.0% —
Page of 234 · 5842 total proteins