Proteins

Genome: KpKP13

Description: Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence

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5842 proteins

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Rows
# Protein Description Gene Structure EC GO Druggability FPocket druggability score for the preferred structure (0–1): experimental structure when available, otherwise predicted model. ≥ 0.7 highly druggable · ≥ 0.4 moderately druggable · < 0.4 low druggability. Human off-target BLASTP against the human proteome. Hit means at least one human match was detected at e-value <= 1e-5. Prefer No hit for pathogen-selective targets. Human identity (%) Best human BLAST identity percentage. Human E-value Best human BLAST E-value.
2726 KP13_02204 hypothetical protein AlphaFold + ColabFold –
GO:0051920Catalysis of the reaction: [protein]-dithol + ROOH = [protein]-disulfide + H2O + ROH.
0.578 No Hit 0.0% —
2727 KP13_01739 3-octaprenyl-4-hydroxybenzoate carboxy-lyase ubiD AlphaFold + ColabFold
4.1.1.98
GO:0016831Catalysis of the nonhydrolytic addition or removal of a carboxyl group to or from a compound. GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0008694Catalysis of the reaction: a 4-hydroxy-3-(all-trans-polyprenyl)benzoate + H+ = a 2-(all-trans-polyprenyl)phenol + CO2. +36 total
0.578 No Hit 0.0% —
2728 KP13_00777 Large-conductance mechanosensitive channel mscL AlphaFold + ColabFold –
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0034220A process in which a monoatomic ion is transported across a membrane. Monatomic ions (also called simple ions) are ions consisting of exactly one atom. GO:0008381Enables the transmembrane transfer of an monoatomic ion by a channel that opens in response to a mechanical stress. +14 total
0.578 No Hit 0.0% —
2729 KP13_00553 morphology and auto-aggregation control protein oxyR AlphaFold + ColabFold –
GO:0006355Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. GO:0003700A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons. GO:0032993A macromolecular complex containing both protein and DNA molecules. +14 total
0.578 No Hit 0.0% —
2730 KP13_03045 hypothetical protein AlphaFold + ColabFold – – 0.577 No Hit 0.0% —
2731 KP13_02481 2-dehydro-3-deoxy-6-phosphogalactonate aldolase AlphaFold + ColabFold –
GO:0016829Catalysis of the cleavage of C-C, C-O, C-N and other bonds by other means than by hydrolysis or oxidation, or conversely adding a group to a double bond. They differ from other enzymes in that two substrates are involved in one reaction direction, but only one in the other direction. When acting on the single substrate, a molecule is eliminated and this generates either a new double bond or a new ring.
0.577 No Hit 0.0% —
2732 KP13_00883 Helix-turn-helix type 3 protein AlphaFold + ColabFold –
GO:0003677Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
0.577 No Hit 0.0% —
2733 KP13_32154 ATP-dependent Clp protease proteolytic subunit ClpP clpP AlphaFold + ColabFold
3.4.21.92
GO:0006508The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds. GO:0004176Catalysis of the hydrolysis of peptide bonds, driven by ATP hydrolysis. GO:0004252Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine). +47 total
0.576 Hit 56.0% 3.74e-64
2734 KP13_05642 hypothetical protein AlphaFold + ColabFold – – 0.576 No Hit 0.0% —
2735 KP13_05238 Oxidoreductase, 2OG-Fe(II) oxygenase family protein AlphaFold + ColabFold
1.13.12.19 1.14.20.7
GO:0102276Catalysis of the reaction: 2-oxoglutarate(2-) + O2 + 2 H+ = ethene + 3 carbon dioxide + H2O. GO:0046872Binding to a metal ion. GO:0009693The chemical reactions and pathways resulting in the formation of ethylene (C2-H4, ethene), a simple hydrocarbon gas that can function in plants as a growth regulator.
0.576 No Hit 0.0% —
2736 KP13_04547 hypothetical protein ColabFold – – 0.576 No Hit 0.0% —
2737 KP13_04154 putative protein psiA psiA AlphaFold + ColabFold – – 0.576 No Hit 0.0% —
2738 KP13_01642 L-arabinose-binding periplasmic protein araF AlphaFold + ColabFold –
GO:0042882The process in which L-arabinose, the L-enantiomer of arabinose, is transported across a lipid bilayer, from one side of a membrane to the other. GO:0030288The region between the inner (cytoplasmic or plasma) membrane and outer membrane of organisms with two membranes such as Gram negative bacteria. These periplasmic spaces are relatively thick and contain a thin peptidoglycan layer (PGL), also referred to as a thin cell wall. GO:0030246Binding to a carbohydrate, which includes monosaccharides, oligosaccharides and polysaccharides as well as substances derived from monosaccharides by reduction of the carbonyl group (alditols), by oxidation of one or more hydroxy groups to afford the corresponding aldehydes, ketones, or carboxylic acids, or by replacement of one or more hydroxy group(s) by a hydrogen atom. Cyclitols are generally not regarded as carbohydrates.
0.576 No Hit 0.0% —
2739 KP13_04161 DNA-binding protein H-NS hns AlphaFold + ColabFold –
GO:0030527The action of a molecule that contributes to the structural integrity of chromatin. GO:0006355Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. GO:0003677Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). +811 total
0.575 No Hit 0.0% —
2740 KP13_03716 hypothetical protein AlphaFold + ColabFold – – 0.575 No Hit 0.0% —
2741 KP13_03137 hypothetical protein ColabFold – – 0.575 No Hit 0.0% —
2742 KP13_01705 Uroporphyrinogen-III synthase hemD AlphaFold + ColabFold
4.2.1.75
GO:0006780The chemical reactions and pathways resulting in the formation of uroporphyrinogen III. GO:0033014The chemical reactions and pathways leading to the formation of tetrapyrroles, natural pigments containing four pyrrole rings joined by one-carbon units linking position 2 of one pyrrole ring to position 5 of the next. GO:0004852Catalysis of the reaction: hydroxymethylbilane = H2O + uroporphyrinogen III. +14 total
0.575 No Hit 0.0% —
2743 KP13_01540 putative transglutaminase AlphaFold + ColabFold – – 0.575 No Hit 0.0% —
2744 KP13_01300 hypothetical protein AlphaFold + ColabFold – – 0.575 No Hit 0.0% —
2745 KP13_01284 Trehalose-6-phosphate hydrolase treC AlphaFold + ColabFold
3.2.1.93
GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. GO:0005975The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. GO:0005993The chemical reactions and pathways resulting in the breakdown of trehalose, a disaccharide that consists of two molecules of glucose and is isomeric with sucrose. +25 total
0.575 Hit 40.3% 3.65e-11
2746 KP13_31508 putative cystathionine-beta-synthase AlphaFold + ColabFold –
GO:0006535OBSOLETE. The chemical reactions and pathways resulting in the formation of cysteine from L- serine.
0.574 Hit 54.3% 7.60e-25
2747 KP13_06641 DNA-binding protein HU-beta AlphaFold + ColabFold –
GO:0030527The action of a molecule that contributes to the structural integrity of chromatin. GO:0003677Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. +69 total
0.574 No Hit 0.0% —
2748 KP13_03824 Dihydrodipicolinate synthase Experimental + ColabFold
4.3.3.7
GO:0009089OBSOLETE. The chemical reactions and pathways resulting in the formation of lysine, via the intermediate diaminopimelate. GO:0016829Catalysis of the cleavage of C-C, C-O, C-N and other bonds by other means than by hydrolysis or oxidation, or conversely adding a group to a double bond. They differ from other enzymes in that two substrates are involved in one reaction direction, but only one in the other direction. When acting on the single substrate, a molecule is eliminated and this generates either a new double bond or a new ring. GO:0008840Catalysis of the reaction: L-aspartate 4-semialdehyde + pyruvate = (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinate + H2O + H+. +25 total
0.574 Hit 29.2% 4.76e-22
2749 KP13_02670 hypothetical protein AlphaFold + ColabFold – – 0.574 No Hit 0.0% —
2750 KP13_02640 hypothetical protein AlphaFold + ColabFold – – 0.574 No Hit 0.0% —
Page of 234 · 5842 total proteins