Proteins

Genome: KpKP13

Description: Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence

Search, filter, and prioritize proteins.

Export view
5192 / 5842 proteins Structure: AlphaFold

Scoring formula None

Sorted by Druggability (descending)

Applied filters Structure: AlphaFold

Search query No active search

Rows per page 25

Rows
Active criteria 1
Structure: AlphaFold DB model ×
# Protein Description Gene Structure EC GO Metabolism Druggability FPocket druggability score for the preferred structure (0–1): experimental structure when available, otherwise predicted model. ≥ 0.7 highly druggable · ≥ 0.4 moderately druggable · < 0.4 low druggability. Human off-target BLASTP against the human proteome. Hit means at least one human match was detected at e-value <= 1e-5. Prefer No hit for pathogen-selective targets. Human identity (%) Best human BLAST identity percentage. Human E-value Best human BLAST E-value.
2826 KP13_31925 Glutamine-binding periplasmic protein glnH AlphaFold DB model + ColabFold model –
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0015276Enables the transmembrane transfer of an ion by a channel that opens when a specific ligand has been bound by the channel complex or one of its constituent parts. GO:0030288The region between the inner (cytoplasmic or plasma) membrane and outer membrane of organisms with two membranes such as Gram negative bacteria. These periplasmic spaces are relatively thick and contain a thin peptidoglycan layer (PGL), also referred to as a thin cell wall.
No map 0.516 Hit 35.6% 4.48e-07
2827 KP13_06675 hypothetical protein AlphaFold DB model + ColabFold model – – No map 0.516 No Hit 0.0% —
2828 KP13_04853 DNA-binding protein AlphaFold DB model + ColabFold model –
GO:0003677Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
No map 0.516 No Hit 0.0% —
2829 KP13_04655 hypothetical protein AlphaFold DB model + ColabFold model – – No map 0.516 No Hit 0.0% —
2830 KP13_03771 Imidazole glycerol phosphate synthase subunit hisH hisH AlphaFold DB model + ColabFold model
4.3.2.10 3.5.1.2
GO:0000105The chemical reactions and pathways resulting in the formation of L-histidine, 2-amino-3-(1H-imidazol-4-yl)propanoic acid. GO:0016763Catalysis of the transfer of a pentosyl group from one compound (donor) to another (acceptor). GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. +36 total
No map 0.516 No Hit 0.0% —
2831 KP13_02938 Hydroxyacylglutathione hydrolase gloB AlphaFold DB model + ColabFold model
3.1.2.6
GO:0019243OBSOLETE. The chemical reactions and pathways resulting in the breakdown of methylglyoxal, CH3-CO-CHO, into pyruvate via the intermediate (R)-S-lactoyl-glutathione. Glutathione is used in the first step of the pathway and then regenerated in the second step. GO:0004416Catalysis of the reaction: an S-(2-hydroxyacyl)glutathione + H2O = a 2-hydroxy carboxylate + glutathione + H+. GO:0046872Binding to a metal ion.
No map 0.516 Hit 36.1% 6.45e-21
2832 KP13_02786 hypothetical protein AlphaFold DB model + ColabFold model – – No map 0.516 No Hit 0.0% —
2833 KP13_01542 hypothetical protein AlphaFold DB model + ColabFold model – – No map 0.516 No Hit 0.0% —
2834 KP13_01162 Voltage-gated ClC-type chloride channel clcB clcB AlphaFold DB model + ColabFold model –
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0005247Enables the transmembrane transfer of a chloride ion by a voltage-gated channel. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded. GO:0006821The directed movement of chloride into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. +47 total
No map 0.516 No Hit 0.0% —
2835 KP13_31532 hypothetical protein AlphaFold DB model + ColabFold model – – No map 0.515 No Hit 0.0% —
2836 KP13_06722 hypothetical protein AlphaFold DB model + ColabFold model – – No map 0.515 No Hit 0.0% —
2837 KP13_05613 hypothetical protein AlphaFold DB model + ColabFold model – – No map 0.515 No Hit 0.0% —
2838 KP13_03688 hypothetical protein AlphaFold DB model + ColabFold model – – No map 0.515 No Hit 0.0% —
2839 KP13_03391 plasmid stabilization system, cytotoxic translational repressor protein AlphaFold DB model + ColabFold model – – No map 0.515 No Hit 0.0% —
2840 KP13_01871 S-adenosylmethionine decarboxylase proenzyme speD AlphaFold DB model + ColabFold model
4.1.1.50
GO:0008295The chemical reactions and pathways resulting in the formation of spermidine, N-(3-aminopropyl)-1,4-diaminobutane. GO:0004014Catalysis of the reaction: S-adenosyl-L-methionine + H+ = S-adenosylmethioninamine + CO2. GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
No map 0.515 No Hit 0.0% —
2841 KP13_01621 Holliday junction ATP-dependent DNA helicase ruvA ruvA AlphaFold DB model + ColabFold model –
GO:0003678Unwinding of a DNA helix, driven by ATP hydrolysis. GO:0006310Any process in which a new genotype is formed by reassortment of genes resulting in gene combinations different from those that were present in the parents. In eukaryotes genetic recombination can occur by chromosome assortment, intrachromosomal recombination, or nonreciprocal interchromosomal recombination. Interchromosomal recombination occurs by crossing over. In bacteria it may occur by genetic transformation, conjugation, transduction, or F-duction. GO:0009379A DNA helicase complex found at Holliday junctions where the helicase activity is involved in the migration of the junction branch point. The best-characterized example is the E. coli RuvAB complex, in which a hexamer of RuvB subunits possesses helicase activity that is modulated by association with RuvA. +811 total
No map 0.515 No Hit 0.0% —
2842 KP13_01464 Glutamyl-tRNA reductase hemA AlphaFold DB model + ColabFold model
1.2.1.70
GO:0008883Catalysis of the reaction: (S)-4-amino-5-oxopentanoate + NADP+ + tRNA(Glu) = L-glutamyl-tRNA(Glu) + H+ + NADPH. GO:0050661Binding to nicotinamide-adenine dinucleotide phosphate, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NADP+, or the reduced form, NADPH. GO:0033014The chemical reactions and pathways leading to the formation of tetrapyrroles, natural pigments containing four pyrrole rings joined by one-carbon units linking position 2 of one pyrrole ring to position 5 of the next. +14 total
No map 0.515 No Hit 0.0% —
2843 KP13_01218 L-ribulose-5-phosphate 3-epimerase ulaE ulaE AlphaFold DB model + ColabFold model –
GO:0005975The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. GO:0016861Catalysis of an oxidation-reduction (redox) reaction in which the hydrogen donor and acceptor, which is an aldose or a ketose, are the same molecule, and no oxidized product appears. GO:0034015Catalysis of the reaction: L-ribulose 5-phosphate = L-xylulose 5-phosphate. +14 total
No map 0.515 No Hit 0.0% —
2844 KP13_00432 Inner membrane protein AlphaFold DB model + ColabFold model –
GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
No map 0.515 No Hit 0.0% —
2845 KP13_32187 Proline porter II AlphaFold DB model + ColabFold model –
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0022857Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other. GO:0055085The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other. +25 total
No map 0.514 No Hit 0.0% —
2846 KP13_04804 Type IV secretion system protein virB10 virB10 AlphaFold DB model + ColabFold model –
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it.
No map 0.514 No Hit 0.0% —
2847 KP13_04516 Pca regulon regulatory protein pcaR AlphaFold DB model + ColabFold model –
GO:0006355Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. GO:0003677Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). GO:0003700A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons. +14 total
No map 0.514 No Hit 0.0% —
2848 KP13_01562 Cell division topological specificity factor minE AlphaFold DB model + ColabFold model –
GO:0051301The process resulting in division and partitioning of components of a cell to form more cells; may or may not be accompanied by the physical separation of a cell into distinct, individually membrane-bounded daughter cells. GO:0032955Any process that modulates the frequency, rate or extent of division septum formation. Division septum formation is the assembly and arrangement of a septum that spans the plasma membrane interface between progeny cells following cytokinesis. GO:0042802Binding to an identical protein or proteins.
No map 0.514 No Hit 0.0% —
2849 KP13_05507 hypothetical protein AlphaFold DB model + ColabFold model – – No map 0.513 No Hit 0.0% —
2850 KP13_04759 tellurite resistance YeaR-type protein AlphaFold DB model + ColabFold model – – No map 0.513 No Hit 0.0% —
Page of 208 · 5192 total proteins