Proteins

Genome: KpKP13

Description: Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence

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5842 / 5842 proteins

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# Protein Description Gene Structure EC GO Metabolism Druggability FPocket druggability score for the preferred structure (0–1): experimental structure when available, otherwise predicted model. ≥ 0.7 highly druggable · ≥ 0.4 moderately druggable · < 0.4 low druggability. Human off-target BLASTP against the human proteome. Hit means at least one human match was detected at e-value <= 1e-5. Prefer No hit for pathogen-selective targets. Human identity (%) Best human BLAST identity percentage. Human E-value Best human BLAST E-value.
2876 KP13_02372 LOG family protein AlphaFold DB model + ColabFold model
3.2.2.10 3.2.2.4
GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. GO:0008714Catalysis of the reaction: AMP + H2O = D-ribose 5-phosphate + adenine. GO:0047405Catalysis of the reaction: H2O + a pyrimidine 5'-nucleotide = ribose-5-phosphate + a pyrimidine.
No map 0.896 No Hit 0.0% —
2877 KP13_02373 NADPH-dependent 7-cyano-7-deazaguanine reductase queF AlphaFold DB model + ColabFold model
1.7.1.13
GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. GO:0046857Catalysis of an oxidation-reduction (redox) reaction in which a nitrogenous group, excluding NH and NH2 groups, acts as a hydrogen or electron donor and reduces NAD or NADP. GO:0033739Catalysis of the reaction: 7-aminomethyl-7-carbaguanine + 2 NADP+ = 7-cyano-7-deazaguanine + 2 NADPH + 3 H+. +14 total
No map 0.692 No Hit 0.0% —
2878 KP13_02374 Protein syd syd AlphaFold DB model + ColabFold model –
GO:0009898The leaflet of the plasma membrane that faces the cytoplasm, including any protein embedded in, attached to, or peripherally associated with it.
No map 0.432 No Hit 0.0% —
2879 KP13_02375 hypothetical protein AlphaFold DB model + ColabFold model – – No map 0.756 No Hit 0.0% —
2880 KP13_02376 hypothetical protein AlphaFold DB model + ColabFold model –
GO:0044010A process in which planktonically growing microorganisms of the same species grow at a liquid-air interface or on a solid substrate under the flow of a liquid and produce extracellular polymers that facilitate matrix formation, resulting in a change in the organisms' growth rate and gene transcription.
No map 0.46 No Hit 0.0% —
2881 KP13_02379 hypothetical protein ColabFold model – – No map 0.571 No Hit 0.0% —
2882 KP13_02381 Glucarate dehydratase-related protein gudX AlphaFold DB model + ColabFold model –
GO:0009063The chemical reactions and pathways resulting in the breakdown of amino acids, organic acids containing one or more amino substituents. GO:0016829Catalysis of the cleavage of C-C, C-O, C-N and other bonds by other means than by hydrolysis or oxidation, or conversely adding a group to a double bond. They differ from other enzymes in that two substrates are involved in one reaction direction, but only one in the other direction. When acting on the single substrate, a molecule is eliminated and this generates either a new double bond or a new ring. GO:0046872Binding to a metal ion.
No map 0.944 No Hit 0.0% —
2883 KP13_02382 Glucarate dehydratase gudD AlphaFold DB model + ColabFold model
4.2.1.40
GO:0019394OBSOLETE. The chemical reactions and pathways resulting in the breakdown of glucarate, the anion of glucaric acid. GO:0000287Binding to a magnesium (Mg) ion. GO:0008872Catalysis of the reaction: D-glucarate = 5-dehydro-4-deoxy-D-glucarate + H2O. +14 total
No map 0.758 No Hit 0.0% —
2884 KP13_02383 Glycerate kinase 2 AlphaFold DB model + ColabFold model –
GO:0008887Catalysis of the reaction: D-glycerate + ATP = 3-phospho-D-glycerate + ADP + 2 H+. GO:0031388The process of introducing one or more phosphate groups into an organic acid.
No map 0.969 No Hit 0.0% —
2885 KP13_02384 Signal transduction histidine-protein kinase barA barA AlphaFold DB model + ColabFold model
2.7.13.3
GO:0016310The process of introducing a phosphate group into a molecule, usually with the formation of a phosphoric ester, a phosphoric anhydride or a phosphoric amide. GO:0016772Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to another (acceptor). GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. +58 total
No map 0.563 No Hit 0.0% —
2886 KP13_02386 GTP pyrophosphokinase relA AlphaFold DB model + ColabFold model
2.7.6.5
GO:0015969The chemical reactions and pathways involving guanine tetraphosphate (5'-ppGpp-3'), a derivative of guanine riboside with four phosphates. GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. +69 total
No map 0.911 No Hit 0.0% —
2887 KP13_02387 Nucleoside triphosphate pyrophosphohydrolase mazG AlphaFold DB model + ColabFold model
3.6.1.8
GO:0047693Catalysis of the reaction: ATP + H2O = AMP + H+ + diphosphate. GO:0046061The chemical reactions and pathways resulting in the breakdown of dATP, deoxyadenosine triphosphate (2'-deoxyadenosine 5'-triphosphate). GO:0006203The chemical reactions and pathways resulting in the breakdown of dGTP, guanosine triphosphate. +58 total
No map 0.925 No Hit 0.0% —
2888 KP13_02388 hypothetical protein ColabFold model – – No map 0.694 No Hit 0.0% —
2889 KP13_02392 7-carboxy-7-deazaguanine synthase-like protein AlphaFold DB model + ColabFold model
4.3.99.3
GO:0003824Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. GO:0051536Binding to an iron-sulfur cluster, a combination of iron and sulfur atoms. GO:0051539Binding to a 4 iron, 4 sulfur (4Fe-4S) cluster; this cluster consists of four iron atoms, with the inorganic sulfur atoms found between the irons and acting as bridging ligands. +47 total
No map 0.201 No Hit 0.0% —
2890 KP13_02394 hypothetical protein AlphaFold DB model + ColabFold model – – No map 0.416 No Hit 0.0% —
2891 KP13_02395 hypothetical protein ColabFold model – – No map No pocket No Hit 0.0% —
2892 KP13_02397 Sulfite reductase [NADPH] hemoprotein beta-component cysL AlphaFold DB model + ColabFold model
1.8.1.2
GO:0004783Catalysis of the reaction: hydrogen sulfide + 3 NADP+ + 3 H2O = sulfite + 3 NADPH + 3 H+. GO:0051539Binding to a 4 iron, 4 sulfur (4Fe-4S) cluster; this cluster consists of four iron atoms, with the inorganic sulfur atoms found between the irons and acting as bridging ligands. GO:0009337A multisubunit iron flavoprotein, which in yeast is composed of 2 alpha and 2 beta subunits. Catalyzes the reduction of sulfite to sulfide. +1013 total
No map 0.921 No Hit 0.0% —
2893 KP13_02398 Phosphoadenosine phosphosulfate reductase cysH AlphaFold DB model + ColabFold model
1.8.4.8
GO:0004604Catalysis of the reaction: adenosine 3',5'-diphosphate + H+ + sulfite + thioredoxin disulfide = 3'-phospho-5'-adenylyl sulfate + thioredoxin. Thioredoxin disulfide is the oxidized form of thioredoxin; 3'-phosphoadenosine 5'-phosphosulfate is also known as PAPS. GO:0003824Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. GO:0019379The pathway by which inorganic sulfate is processed and incorporated into sulfated compounds, where the phosphoadenylyl sulfate reduction step is catalyzed by the enzyme phosphoadenylyl-sulfate reductase (thioredoxin) (EC:1.8.4.8). +25 total
No map 0.797 No Hit 0.0% —
2894 KP13_02399 Alkaline phosphatase isozyme conversion protein iap AlphaFold DB model + ColabFold model –
GO:0006508The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds. GO:0008235Catalysis of the hydrolysis of a peptide bond not more than three residues from the N- or C-terminus of a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions. GO:0004177Catalysis of the hydrolysis of a single N-terminal amino acid residue from a polypeptide chain. +14 total
No map 0.369 No Hit 0.0% —
2895 KP13_02400 Siroheme synthase 1 cysG1 AlphaFold DB model + ColabFold model –
GO:0004851Catalysis of the reaction: uroporphyrinogen III + 2 S-adenosyl-L-methionine = precorrin-2 + 2 S-adenosyl-L-homocysteine + H+. GO:0051266Catalysis of the reaction: siroheme + 2 H+ = Fe(2+) + sirohydrochlorin. GO:0008168Catalysis of the transfer of a methyl group to an acceptor molecule. +69 total
No map 0.752 No Hit 0.0% —
2896 KP13_02401 Sulfate adenylyltransferase subunit 2 cysD AlphaFold DB model + ColabFold model
2.7.7.4
GO:0019419OBSOLETE. The chemical reactions and pathways resulting in the reduction of sulfate to another sulfur-containing ion or compound such as hydrogen sulfide, adenosine-phosphosulfate (APS) or thiosulfate. GO:0003824Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. GO:0004781Catalysis of the reaction: ATP + H+ + sulfate = adenosine 5'-phosphosulfate + diphosphate. +36 total
No map 0.627 No Hit 0.0% —
2897 KP13_02404 hypothetical protein ColabFold model – – No map 0.443 No Hit 0.0% —
2898 KP13_02411 putative lipoprotein AlphaFold DB model + ColabFold model –
GO:0005515Binding to a protein. GO:1990063Protein complex which is involved in assembly and insertion of beta-barrel proteins into the outer membrane. In E. coli it is composed of BamABCDE, of the outer membrane protein BamA, and four lipoproteins BamB, BamC, BamD and BamE. BamA interacts directly with BamB and the BamCDE subcomplex. GO:0043165The assembly of an outer membrane of the type formed in Gram-negative bacteria. This membrane is enriched in polysaccharide and protein, and the outer leaflet of the membrane contains specific lipopolysaccharide structures. +14 total
No map 0.367 No Hit 0.0% —
2899 KP13_02412 Ribosome-associated inhibitor A raiA AlphaFold DB model + ColabFold model –
GO:0044238The chemical reactions and pathways involving those compounds which are formed as a part of the normal anabolic and catabolic processes. These processes take place in most, if not all, cells of the organism. GO:0022627The small subunit of a ribosome located in the cytosol. GO:0043024Binding to a small ribosomal subunit. +14 total
No map 0.356 No Hit 0.0% —
2900 KP13_02413 Bifunctional P-protein pheA AlphaFold DB model + ColabFold model
4.2.1.51 5.4.99.5
GO:0009094The chemical reactions and pathways resulting in the formation of L-phenylalanine, the L-enantiomer of 2-amino-3-phenylpropanoic acid, i.e. (2S)-2-amino-3-phenylpropanoic acid. GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. GO:0046417The chemical reactions and pathways involving chorismate, the anion of (3R-trans)-3-((1-carboxyethenyl)oxy)-4-hydroxy-1,5-cyclohexadiene-1-carboxylic acid. +25 total
No map 0.694 No Hit 0.0% —
Page of 234 · 5842 total proteins