Proteins

Genome: KpKP13

Description: Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence

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5192 / 5842 proteins Structure: AlphaFold

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# Protein Description Gene Structure EC GO Metabolism Druggability FPocket druggability score for the preferred structure (0–1): experimental structure when available, otherwise predicted model. ≥ 0.7 highly druggable · ≥ 0.4 moderately druggable · < 0.4 low druggability. Human off-target BLASTP against the human proteome. Hit means at least one human match was detected at e-value <= 1e-5. Prefer No hit for pathogen-selective targets. Human identity (%) Best human BLAST identity percentage. Human E-value Best human BLAST E-value.
2926 KP13_02007 putative ABC transporter ATP-binding protein AlphaFold DB model + ColabFold model
3.6.1.-
GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. GO:0045900Any process that stops, prevents, or reduces the frequency, rate or extent of translational elongation. GO:0016887Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient. +58 total
No map 0.5 Hit 35.0% 1.64e-13
2927 KP13_01955 Chaperone surA surA AlphaFold DB model + ColabFold model
5.2.1.8
GO:0043165The assembly of an outer membrane of the type formed in Gram-negative bacteria. This membrane is enriched in polysaccharide and protein, and the outer leaflet of the membrane contains specific lipopolysaccharide structures. GO:0030288The region between the inner (cytoplasmic or plasma) membrane and outer membrane of organisms with two membranes such as Gram negative bacteria. These periplasmic spaces are relatively thick and contain a thin peptidoglycan layer (PGL), also referred to as a thin cell wall. GO:0003755Catalysis of the reaction: peptidyl-proline (omega=180) = peptidyl-proline (omega=0). +47 total
No map 0.5 No Hit 0.0% —
2928 KP13_01758 HlyD family secretion protein AlphaFold DB model + ColabFold model – – No map 0.5 No Hit 0.0% —
2929 KP13_01203 transposase insH for insertion sequence element IS5H insH6 AlphaFold DB model + ColabFold model –
GO:0004803Catalysis of the transposition of transposable elements or transposons. Transposases are involved in recombination required for transposition and are site-specific for the transposon/transposable element. GO:0006313A type of transposition in which a transposable element (transposon) is moved to another part of a genome, either by a cut-and-paste mechanism or a replicative mechanism. GO:0003677Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
No map 0.5 No Hit 0.0% —
2930 KP13_00635 Molybdopterin-guanine dinucleotide biosynthesis protein A mobA AlphaFold DB model + ColabFold model –
GO:0003824Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. GO:0006777The chemical reactions and pathways resulting in the formation of the Mo-molybdopterin cofactor, essential for the catalytic activity of some enzymes. The cofactor consists of a mononuclear molybdenum (Mo) ion coordinated by one or two molybdopterin ligands.
No map 0.5 No Hit 0.0% —
2931 KP13_00387 Phage shock protein G AlphaFold DB model + ColabFold model – – No map 0.5 No Hit 0.0% —
2932 KP13_07851 Ribonuclease PH rph AlphaFold DB model + ColabFold model
2.7.7.56
GO:0000049Binding to a transfer RNA. GO:0009022Catalysis of the reaction: tRNA(n+1) + phosphate = tRNA(n) + a nucleoside diphosphate. GO:0008033The process in which a pre-tRNA molecule is converted to a mature tRNA, ready for addition of an aminoacyl group. +36 total
No map 0.499 Hit 38.0% 6.71e-06
2933 KP13_06779 entry exclusion protein 1 (Exc1) excl AlphaFold DB model + ColabFold model –
GO:0003677Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
No map 0.499 No Hit 0.0% —
2934 KP13_06674 hypothetical protein AlphaFold DB model + ColabFold model – – No map 0.499 No Hit 0.0% —
2935 KP13_04326 HTH-type transcriptional regulator perR perR AlphaFold DB model + ColabFold model –
GO:0006355Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. GO:0003700A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons. GO:0043565Binding to DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. +14 total
No map 0.499 No Hit 0.0% —
2936 KP13_04279 Ribosomal protein S12 methylthiotransferase RimO rimO AlphaFold DB model + ColabFold model –
GO:0051539Binding to a 4 iron, 4 sulfur (4Fe-4S) cluster; this cluster consists of four iron atoms, with the inorganic sulfur atoms found between the irons and acting as bridging ligands. GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. GO:0035596Catalysis of the addition of a methylthioether group (-SCH3) to a nucleic acid or protein acceptor. +58 total
No map 0.499 Hit 31.7% 2.28e-11
2937 KP13_03963 hypothetical protein AlphaFold DB model + ColabFold model – – No map 0.499 No Hit 0.0% —
2938 KP13_03741 hypothetical protein AlphaFold DB model + ColabFold model – – No map 0.499 No Hit 0.0% —
2939 KP13_02293 Exodeoxyribonuclease V beta chain recB AlphaFold DB model + ColabFold model
3.1.11.5 5.6.2.4
GO:0016787Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. GO:0003678Unwinding of a DNA helix, driven by ATP hydrolysis. GO:0008854Catalysis of the exonucleolytic cleavage (in the presence of ATP) in either 5' to 3' or 3' to 5' direction to yield 5'-phosphooligonucleotides. +912 total
No map 0.499 No Hit 0.0% —
2940 KP13_01575 PTS system mannose-specific EIIAB component manX AlphaFold DB model + ColabFold model
2.7.1.191
GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. GO:0016773Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to an alcohol group (acceptor). GO:0008643The directed movement of carbohydrate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Carbohydrates are a group of organic compounds based of the general formula Cx(H2O)y. +58 total
No map 0.499 No Hit 0.0% —
2941 KP13_00292 Peptidase M16 domain-containing protein AlphaFold DB model + ColabFold model –
GO:0046872Binding to a metal ion. GO:0008237Catalysis of the hydrolysis of peptide bonds by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions. GO:0006508The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds.
No map 0.499 No Hit 0.0% —
2942 KP13_00026 ATP synthase epsilon chain atpC AlphaFold DB model + ColabFold model –
GO:0045261OBSOLETE. The sector of a hydrogen-transporting ATP synthase complex in which the catalytic activity resides; it comprises the catalytic core and central stalk, and is peripherally associated with a membrane, such as the plasma membrane or the mitochondrial inner membrane, when the entire ATP synthase is assembled. GO:0015986The chemical reactions and pathways resulting in the formation of ATP driven by transport of protons across a membrane to generate an electrochemical gradient (proton-motive force). GO:0046933Enables the synthesis of ATP from ADP and phosphate by the transfer of protons from one side of a membrane to the other by a rotational mechanism driven by a gradient according to the reaction: ADP + phosphate + 5 H+(out) => ATP + H2O + 4 H+(in). +36 total
No map 0.499 No Hit 0.0% —
2943 KP13_05604 Virulence protein msgA msgA AlphaFold DB model + ColabFold model – – No map 0.498 No Hit 0.0% —
2944 KP13_05110 hypothetical protein AlphaFold DB model + ColabFold model –
GO:0046872Binding to a metal ion.
No map 0.498 No Hit 0.0% —
2945 KP13_05045 4-carboxymuconolactone decarboxylase pcaC AlphaFold DB model + ColabFold model
4.1.1.44
GO:0051920Catalysis of the reaction: [protein]-dithol + ROOH = [protein]-disulfide + H2O + ROH. GO:0047575Catalysis of the reaction: (R)-2-(carboxymethyl)-5-oxo-2,5-dihydro-2-furoate + H+ = 5-oxo-4,5-dihydro-2-furylacetate + CO2.
No map 0.498 No Hit 0.0% —
2946 KP13_03581 two-component regulatory system response regulator AlphaFold DB model + ColabFold model –
GO:0006355Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. GO:0003677Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
No map 0.498 No Hit 0.0% —
2947 KP13_02448 Cystine-binding periplasmic protein AlphaFold DB model + ColabFold model – – No map 0.498 No Hit 0.0% —
2948 KP13_05383 Cell division activator cedA cedA AlphaFold DB model + ColabFold model –
GO:0051301The process resulting in division and partitioning of components of a cell to form more cells; may or may not be accompanied by the physical separation of a cell into distinct, individually membrane-bounded daughter cells. GO:0003677Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
No map 0.497 No Hit 0.0% —
2949 KP13_05343 hypothetical protein AlphaFold DB model + ColabFold model – – No map 0.497 No Hit 0.0% —
2950 KP13_05260 hypothetical protein AlphaFold DB model + ColabFold model – – No map 0.497 No Hit 0.0% —
Page of 208 · 5192 total proteins