Proteins

Genome: KpKP13

Description: Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence

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5842 proteins

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Rows
# Protein Description Gene Structure EC GO Druggability FPocket druggability score for the preferred structure (0–1): experimental structure when available, otherwise predicted model. ≥ 0.7 highly druggable · ≥ 0.4 moderately druggable · < 0.4 low druggability. Human off-target BLASTP against the human proteome. Hit means at least one human match was detected at e-value <= 1e-5. Prefer No hit for pathogen-selective targets. Human identity (%) Best human BLAST identity percentage. Human E-value Best human BLAST E-value.
2976 KP13_04824 thiazolinyl-S-HMWP1 reductase AlphaFold + ColabFold –
GO:0000166Binding to a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose.
0.542 No Hit 0.0% —
2977 KP13_04533 Glyoxalase/fosfomycin resistance/dioxygenase domain-containing protein AlphaFold + ColabFold – – 0.542 No Hit 0.0% —
2978 KP13_03161 Mandelate racemase/muconate lactonizing enzyme family protein AlphaFold + ColabFold –
GO:0016836Catalysis of the cleavage of a carbon-oxygen bond by elimination of water. GO:0000287Binding to a magnesium (Mg) ion. GO:0016052The chemical reactions and pathways resulting in the breakdown of carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y.
0.542 Hit 25.4% 1.75e-06
2979 KP13_01651 hypothetical protein AlphaFold + ColabFold – – 0.542 No Hit 0.0% —
2980 KP13_01492 hypothetical protein AlphaFold + ColabFold – – 0.542 No Hit 0.0% —
2981 KP13_01311 Methylmalonate semialdehyde dehydrogenase acylating iolA AlphaFold + ColabFold –
GO:0016491Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. GO:0016620Catalysis of an oxidation-reduction (redox) reaction in which an aldehyde or ketone (oxo) group acts as a hydrogen or electron donor and reduces NAD or NADP. GO:0004491Catalysis of the reaction: 2-methyl-3-oxopropanoate + CoA + NAD+ = propanoyl-CoA + hydrogencarbonate + NADH + H+. Can also use malonate (3-oxopropanoate) as a substrate. The reaction occurs in two steps with the decarboxylation process preceding CoA-binding. Bicarbonate rather than CO2 is released as a final product.
0.542 Hit 44.1% 1.30e-71
2982 KP13_00523 hypothetical protein AlphaFold + ColabFold – – 0.542 No Hit 0.0% —
2983 KP13_05605 Lipopolysaccharide 1,2-N-acetylglucosaminetransferase waaU AlphaFold + ColabFold –
GO:0016757Catalysis of the transfer of a glycosyl group from one compound (donor) to another (acceptor). GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. GO:0008713Catalysis of the reaction: heptosyl-KDO2-lipid A + ADP-L-glycero-beta-D-manno-heptose = heptosyl2-KDO2-lipid A + ADP + H+. +14 total
0.541 No Hit 0.0% —
2984 KP13_05443 hypothetical protein ColabFold – – 0.541 No Hit 0.0% —
2985 KP13_04925 Ribosomal large subunit pseudouridine synthase C rluC AlphaFold + ColabFold
5.4.99.-
GO:0003723Binding to an RNA molecule or a portion thereof. GO:0001522The intramolecular conversion of uridine to pseudouridine within an RNA molecule. GO:0009451The covalent alteration of one or more nucleotides within an RNA molecule to produce an RNA molecule with a sequence that differs from that coded genetically. +36 total
0.541 Hit 39.0% 1.27e-07
2986 KP13_04592 Transcriptional regulatory protein ompR AlphaFold + ColabFold –
GO:0006355Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. GO:0000160A conserved series of molecular signals found in prokaryotes and eukaryotes; involves autophosphorylation of a histidine kinase and the transfer of the phosphate group to an aspartate that then acts as a phospho-donor to response regulator proteins. GO:0003677Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). +47 total
0.541 No Hit 0.0% —
2987 KP13_04499 Tautomerase pptA pptA AlphaFold + ColabFold
5.3.2.-
GO:0016853Catalysis of the geometric or structural changes within one molecule. Isomerase is the systematic name for any enzyme of EC class 5. GO:0016862Catalysis of an oxidation-reduction (redox) reaction in which the hydrogen donor and acceptor, which is a keto- or an enol-group, are the same molecule, and no oxidized product appears. GO:0006725OBSOLETE. The chemical reactions and pathways involving aromatic compounds, any organic compound characterized by one or more planar rings, each of which contains conjugated double bonds and delocalized pi electrons, as carried out by individual cells. +14 total
0.541 No Hit 0.0% —
2988 KP13_04491 putative hydrolase AlphaFold + ColabFold –
GO:0016787Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. GO:0046872Binding to a metal ion. GO:0050118Catalysis of the reaction: H2O + N-acetyl-(2S,6S)-2,6-diaminoheptanedioate = (2S,6S)-2,6-diaminoheptanedioate + acetate. +14 total
0.541 No Hit 0.0% —
2989 KP13_03146 LuxR family transcriptional regulator AlphaFold + ColabFold –
GO:0006355Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. GO:0003677Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
0.541 No Hit 0.0% —
2990 KP13_32097 hypothetical protein AlphaFold + ColabFold – – 0.54 No Hit 0.0% —
2991 KP13_05637 hypothetical protein ColabFold – – 0.54 No Hit 0.0% —
2992 KP13_04300 HTH-type transcriptional regulator gmuR gmuR AlphaFold + ColabFold –
GO:0006355Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. GO:0003677Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). GO:0003700A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons. +14 total
0.54 No Hit 0.0% —
2993 KP13_02549 hypothetical protein AlphaFold + ColabFold – – 0.54 No Hit 0.0% —
2994 KP13_20435 7-cyano-7-deazaguanine synthase queC AlphaFold + ColabFold
6.3.4.20
GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. GO:0016879Catalysis of the joining of two molecules, or two groups within a single molecule, via a carbon-nitrogen bond, with the concomitant hydrolysis of the diphosphate bond in ATP or a similar triphosphate. GO:0008270Binding to a zinc ion (Zn). +14 total
0.539 No Hit 0.0% —
2995 KP13_06058 hypothetical protein ColabFold – – 0.539 No Hit 0.0% —
2996 KP13_04757 hypothetical protein AlphaFold + ColabFold – – 0.539 No Hit 0.0% —
2997 KP13_04172 N-carbamoyl-L-amino acid hydrolase amaB AlphaFold + ColabFold –
GO:0016813Catalysis of the hydrolysis of any non-peptide carbon-nitrogen bond in a linear amidine, a compound of the form R-C(=NH)-NH2. GO:0016787Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. GO:0046872Binding to a metal ion.
0.539 No Hit 0.0% —
2998 KP13_03986 hypothetical protein AlphaFold + ColabFold – – 0.539 No Hit 0.0% —
2999 KP13_03355 Universal stress protein G AlphaFold + ColabFold – – 0.539 No Hit 0.0% —
3000 KP13_02539 Fic domain-containing protein AlphaFold + ColabFold
2.7.7.-
GO:0016779Catalysis of the transfer of a nucleotidyl group from one compound (donor) to another (acceptor).
0.539 Hit 26.0% 1.67e-09
Page of 234 · 5842 total proteins