Proteins

Genome: KpKP13

Description: Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence

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5192 / 5842 proteins Structure: AlphaFold

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Structure: AlphaFold DB model ×
# Protein Description Gene Structure EC GO Metabolism Druggability FPocket druggability score for the preferred structure (0–1): experimental structure when available, otherwise predicted model. ≥ 0.7 highly druggable · ≥ 0.4 moderately druggable · < 0.4 low druggability. Human off-target BLASTP against the human proteome. Hit means at least one human match was detected at e-value <= 1e-5. Prefer No hit for pathogen-selective targets. Human identity (%) Best human BLAST identity percentage. Human E-value Best human BLAST E-value.
3051 KP13_31809 Dephospho-CoA kinase coaE AlphaFold DB model + ColabFold model
2.7.1.24
GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. GO:0004140Catalysis of the reaction: 3'-dephospho-CoA + ATP = ADP + CoA + 2 H+. GO:0015937The chemical reactions and pathways resulting in the formation of coenzyme A, 3'-phosphoadenosine-(5')diphospho(4')pantatheine, an acyl carrier in many acylation and acyl-transfer reactions in which the intermediate is a thiol ester. +14 total
No map 0.48 Hit 45.9% 7.74e-25
3052 KP13_05372 putative ferredoxin-like protein AlphaFold DB model + ColabFold model – – No map 0.48 No Hit 0.0% —
3053 KP13_04563 hypothetical protein AlphaFold DB model + ColabFold model –
GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
No map 0.48 No Hit 0.0% —
3054 KP13_02354 L-fucose isomerase fucI AlphaFold DB model + ColabFold model
5.3.1.25
GO:0030145Binding to a manganese ion (Mn). GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. GO:0008736Catalysis of the reaction: L-fucose = L-fuculose. +710 total
No map 0.48 No Hit 0.0% —
3055 KP13_02161 Fructose-bisphosphate aldolase class 2 fbaA AlphaFold DB model + ColabFold model
4.1.2.13
GO:0008270Binding to a zinc ion (Zn). GO:0005975The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. GO:0016832Catalysis of the cleavage of a C-C bond in a molecule containing a hydroxyl group and a carbonyl group to form two smaller molecules, each being an aldehyde or a ketone. +47 total
No map 0.48 No Hit 0.0% —
3056 KP13_01649 hypothetical protein AlphaFold DB model + ColabFold model – – No map 0.48 No Hit 0.0% —
3057 KP13_00024 ATP synthase gamma chain atpG AlphaFold DB model + ColabFold model –
GO:0045261OBSOLETE. The sector of a hydrogen-transporting ATP synthase complex in which the catalytic activity resides; it comprises the catalytic core and central stalk, and is peripherally associated with a membrane, such as the plasma membrane or the mitochondrial inner membrane, when the entire ATP synthase is assembled. GO:0015986The chemical reactions and pathways resulting in the formation of ATP driven by transport of protons across a membrane to generate an electrochemical gradient (proton-motive force). GO:0046933Enables the synthesis of ATP from ADP and phosphate by the transfer of protons from one side of a membrane to the other by a rotational mechanism driven by a gradient according to the reaction: ADP + phosphate + 5 H+(out) => ATP + H2O + 4 H+(in). +47 total
No map 0.48 Hit 30.2% 1.60e-27
3058 KP13_03180 hypothetical protein Experimental + AlphaFold DB model + ColabFold model – – No map 0.479 No Hit 0.0% —
3059 KP13_01241 Glycosyl hydrolase 42 family protein AlphaFold DB model + ColabFold model
3.2.1.23
GO:0004565Catalysis of the hydrolysis of terminal, non-reducing beta-D-galactose residues in beta-D-galactosides. GO:0005975The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. GO:0009341A protein complex that possesses beta-galactosidase activity, i.e. catalyzes the hydrolysis of terminal non-reducing beta-D-galactose residues in beta-D-galactosides. In E. coli, the complex is a homotetramer; dimeric and hexameric beta-galactosidase complexes have been observed in other species. +14 total
No map 0.479 No Hit 0.0% —
3060 KP13_32405 hypothetical protein AlphaFold DB model + ColabFold model – – No map 0.478 No Hit 0.0% —
3061 KP13_31744 Formate dehydrogenase-O iron-sulfur subunit fdoH AlphaFold DB model + ColabFold model –
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0015944The chemical reactions and pathways by which formate is converted to CO2. GO:0045333The enzymatic release of energy from inorganic and organic compounds (especially carbohydrates and fats) which either requires oxygen (aerobic respiration) or does not (anaerobic respiration). +69 total
No map 0.478 No Hit 0.0% —
3062 KP13_01751 putative membrane protein AlphaFold DB model + ColabFold model –
GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
No map 0.478 No Hit 0.0% —
3063 KP13_01711 hypothetical protein AlphaFold DB model + ColabFold model – – No map 0.478 No Hit 0.0% —
3064 KP13_00894 hypothetical protein AlphaFold DB model + ColabFold model – – No map 0.478 No Hit 0.0% —
3065 KP13_00301 GCN5-related N-acetyltransferase AlphaFold DB model + ColabFold model –
GO:0016747Catalysis of the transfer of an acyl group, other than amino-acyl, from one compound (donor) to another (acceptor).
No map 0.478 No Hit 0.0% —
3066 KP13_00199 lipopolysaccharide core biosynthesis protein RfaZ rfaZ AlphaFold DB model + ColabFold model – – No map 0.478 No Hit 0.0% —
3067 KP13_12908 hypothetical protein AlphaFold DB model + ColabFold model – – No map 0.477 No Hit 0.0% —
3068 KP13_05360 putative hydroxypyruvate reductase ttuD AlphaFold DB model + ColabFold model –
GO:0008887Catalysis of the reaction: D-glycerate + ATP = 3-phospho-D-glycerate + ADP + 2 H+. GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
No map 0.477 Hit 44.1% 1.01e-38
3069 KP13_04675 50S ribosomal protein L35 rpmI AlphaFold DB model + ColabFold model –
GO:0003735The action of a molecule that contributes to the structural integrity of the ribosome. GO:0005840An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins. GO:0006412The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA or circRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA or circRNA. Translation ends with the release of a polypeptide chain from the ribosome. +14 total
No map 0.477 No Hit 0.0% —
3070 KP13_02744 A/G-specific adenine glycosylase mutY AlphaFold DB model + ColabFold model
3.2.2.31
GO:0051539Binding to a 4 iron, 4 sulfur (4Fe-4S) cluster; this cluster consists of four iron atoms, with the inorganic sulfur atoms found between the irons and acting as bridging ligands. GO:0016798Catalysis of the hydrolysis of any glycosyl bond. GO:0006284In base excision repair, an altered base is removed by a DNA glycosylase enzyme, followed by excision of the resulting sugar phosphate. The small gap left in the DNA helix is filled in by the sequential action of DNA polymerase and DNA ligase. +1013 total
No map 0.477 Hit 44.9% 2.75e-56
3071 KP13_01617 High-affinity zinc uptake system protein znuA znuA AlphaFold DB model + ColabFold model –
GO:0030001The directed movement of metal ions, any metal ion with an electric charge, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. GO:0046872Binding to a metal ion. GO:0006829The directed movement of zinc (Zn II) ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. +14 total
No map 0.477 No Hit 0.0% —
3072 KP13_01595 Ribosomal RNA small subunit methyltransferase F rsmF AlphaFold DB model + ColabFold model
2.1.1.178
GO:0001510Posttranscriptional addition of a methyl group to either a nucleotide or 2'-O ribose in a polyribonucleotide. Usually uses S-adenosylmethionine as a cofactor. GO:0008168Catalysis of the transfer of a methyl group to an acceptor molecule. GO:0008649Catalysis of the transfer of a methyl group from S-adenosyl-L-methionine to a nucleoside residue in an rRNA molecule. The methyl group can be transfered to the nucleobase or to the ribose group of the nucleoside. +69 total
No map 0.477 Hit 39.2% 7.47e-26
3073 KP13_04617 hypothetical protein AlphaFold DB model + ColabFold model –
GO:0030973Binding to a molybdate ion (MoO4 2-). GO:0015689The directed movement of molybdate (MoO4 2-) ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Molybdate is the bivalent anion derived from molybdic acid.
No map 0.476 No Hit 0.0% —
3074 KP13_04012 putative lysozyme from lambdoid prophage DLP12 arrD AlphaFold DB model + ColabFold model –
GO:0009253The chemical reactions and pathways resulting in the breakdown of peptidoglycans, any of a class of glycoconjugates found in bacterial cell walls and consisting of long glycan strands of alternating residues of beta-(1,4) linked N-acetylglucosamine and N-acetylmuramic acid, cross-linked by short peptides. GO:0003796Catalysis of the hydrolysis of the beta-(1->4) linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues in a peptidoglycan. GO:0016998The chemical reactions and pathways resulting in the breakdown of macromolecules that form part of a cell wall.
No map 0.476 No Hit 0.0% —
3075 KP13_02970 Ribonuclease G rng AlphaFold DB model + ColabFold model –
GO:0003676Binding to a nucleic acid. GO:0004540Catalysis of the cleavage of phosphodiester bonds in chains of RNA. GO:0006396Any process involved in the conversion of one or more primary RNA transcripts into one or more mature RNA molecules. +14 total
No map 0.476 No Hit 0.0% —
Page of 208 · 5192 total proteins