Proteins

Genome: KpKP13

Description: Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence

Search, filter, and prioritize proteins.

Export view
5192 / 5842 proteins Structure: AlphaFold

Scoring formula None

Sorted by Druggability (descending)

Applied filters Structure: AlphaFold

Search query No active search

Rows per page 25

Rows
Active criteria 1
Structure: AlphaFold ×
# Protein Description Gene Structure EC GO Druggability FPocket druggability score for the preferred structure (0–1): experimental structure when available, otherwise predicted model. ≥ 0.7 highly druggable · ≥ 0.4 moderately druggable · < 0.4 low druggability. Human off-target BLASTP against the human proteome. Hit means at least one human match was detected at e-value <= 1e-5. Prefer No hit for pathogen-selective targets. Human identity (%) Best human BLAST identity percentage. Human E-value Best human BLAST E-value.
3426 KP13_04383 Glycerol-3-phosphate regulon repressor AlphaFold + ColabFold –
GO:0006355Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. GO:0003700A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons. GO:0003677Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
0.415 No Hit 0.0% —
3427 KP13_02352 L-fucose mutarotase fucU AlphaFold + ColabFold
5.1.3.29
GO:0016853Catalysis of the geometric or structural changes within one molecule. Isomerase is the systematic name for any enzyme of EC class 5. GO:0042354The chemical reactions and pathways involving L-fucose, 6-deoxy-L-galactose, a sugar that occurs in fucans, a class of polysaccharides in seaweeds, especially Fucus species, and in the cell wall matrix of higher plants. GO:0016854Catalysis of a reaction that alters the configuration of one or more chiral centers in a molecule. +69 total
0.415 Hit 47.2% 2.05e-36
3428 KP13_00398 hypothetical protein AlphaFold + ColabFold – – 0.415 No Hit 0.0% —
3429 KP13_31853 hypothetical protein AlphaFold + ColabFold – – 0.414 No Hit 0.0% —
3430 KP13_31802 hypothetical protein AlphaFold + ColabFold –
GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
0.414 No Hit 0.0% —
3431 KP13_02873 Uronate isomerase uxaC AlphaFold + ColabFold
5.3.1.12
GO:0006064The chemical reactions and pathways resulting in the breakdown of glucuronate, any salt or ester of glucuronic acid. GO:0008880Catalysis of the reaction: D-glucuronate = D-fructuronate. Also converts D-galacturonate to D-tagaturonate. GO:0019698The chemical reactions and pathways resulting in the breakdown of D-galacturonate, the D-enantiomer of galacturonate, the anion of galacturonic acid. +14 total
0.414 No Hit 0.0% —
3432 KP13_02808 Multifunctional CCA protein cca AlphaFold + ColabFold –
GO:0001680Post-transcriptional addition of the terminal 3' CCA sequence to a tRNA which does not encode this sequence within the primary transcript. CCA addition proceeds by the sequential addition of CTP, CTP, and then ATP to the 3' end of the tRNA, yielding a diphosphate with each nucleotide addition. GO:0016779Catalysis of the transfer of a nucleotidyl group from one compound (donor) to another (acceptor). GO:0004810Catalysis of the reaction: a tRNA precursor + ATP + 2 CTP = a tRNA with a 3' CCA end + 3 diphosphate. +912 total
0.414 Hit 31.4% 1.31e-08
3433 KP13_01618 Zinc import ATP-binding protein znuC znuC AlphaFold + ColabFold –
GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. GO:0016887Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient. GO:0010043Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a zinc ion stimulus. +14 total
0.414 Hit 41.5% 1.32e-07
3434 KP13_01334 hypothetical protein AlphaFold + ColabFold – – 0.414 No Hit 0.0% —
3435 KP13_01293 hypothetical protein AlphaFold + ColabFold – – 0.414 No Hit 0.0% —
3436 KP13_01282 6-phospho-beta-glucosidase licH AlphaFold + ColabFold –
GO:0005975The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. GO:0004553Catalysis of the hydrolysis of any O-glycosyl bond. GO:0003824Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. +25 total
0.414 No Hit 0.0% —
3437 KP13_00726 hypothetical protein AlphaFold + ColabFold – – 0.414 No Hit 0.0% —
3438 KP13_05053 putative transporter protein AlphaFold + ColabFold – – 0.413 No Hit 0.0% —
3439 KP13_03844 Ethanolamine utilization cobalamin adenosyltransferase eutT AlphaFold + ColabFold –
GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. GO:0006580The chemical reactions and pathways involving ethanolamine (2-aminoethanol), an important water-soluble base of phospholipid (phosphatidylethanolamine). GO:0009236The chemical reactions and pathways resulting in the formation of cobalamin (vitamin B12), a water-soluble vitamin characterized by possession of a corrin nucleus containing a cobalt atom. +14 total
0.413 No Hit 0.0% —
3440 KP13_03742 HTH-type transcriptional regulator cynR cynR AlphaFold + ColabFold –
GO:0006355Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. GO:0003700A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons. GO:0032993A macromolecular complex containing both protein and DNA molecules. +14 total
0.413 No Hit 0.0% —
3441 KP13_03019 Formimidoylglutamase hutG AlphaFold + ColabFold
3.5.3.8
GO:0019556OBSOLETE. The chemical reactions and pathways resulting in the breakdown of L-histidine into other compounds, including glutamate and formamide. GO:0016813Catalysis of the hydrolysis of any non-peptide carbon-nitrogen bond in a linear amidine, a compound of the form R-C(=NH)-NH2. GO:0046872Binding to a metal ion. +58 total
0.413 Hit 23.1% 2.45e-08
3442 KP13_02107 Taurine import ATP-binding protein TauB tauB AlphaFold + ColabFold –
GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. GO:0016887Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient. GO:0042918The directed movement of an alkanesulfonate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Alkanesulfonates are organic esters or salts of sulfonic acid containing an aliphatic hydrocarbon radical.
0.413 Hit 51.3% 4.78e-06
3443 KP13_12391 hypothetical protein AlphaFold + ColabFold – – 0.412 No Hit 0.0% —
3444 KP13_05481 Transcriptional regulator, GntR family AlphaFold + ColabFold –
GO:0006355Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. GO:0003700A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons. GO:0003677Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
0.412 No Hit 0.0% —
3445 KP13_05127 hypothetical protein AlphaFold + ColabFold – – 0.412 No Hit 0.0% —
3446 KP13_05015 Fumarate hydratase class I, aerobic fumA AlphaFold + ColabFold
4.2.1.2
GO:0006091The chemical reactions and pathways resulting in the formation of precursor metabolites, substances from which energy is derived, and any process involved in the liberation of energy from these substances. GO:0016836Catalysis of the cleavage of a carbon-oxygen bond by elimination of water. GO:0004333Catalysis of the reaction: (S)-malate = fumarate + H2O. +58 total
0.412 No Hit 0.0% —
3447 KP13_04689 Cardiolipin synthase cls AlphaFold + ColabFold
2.7.8.-
GO:0008808Catalysis of the reaction: phosphatidylglycerol + phosphatidylglycerol = diphosphatidylglycerol (cardiolipin) + glycerol. GO:0032049The chemical reactions and pathways resulting in the formation of cardiolipin, 1,3-bis(3-phosphatidyl)glycerol. GO:0016780Catalysis of the transfer of a substituted phosphate group, other than diphosphate or nucleotidyl residues, from one compound (donor) to a another (acceptor). +25 total
0.412 No Hit 0.0% —
3448 KP13_04538 Glutathione import ATP-binding protein GsiA AlphaFold + ColabFold –
GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. GO:0016887Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient. GO:0015833The directed movement of peptides, compounds of two or more amino acids where the alpha carboxyl group of one is bound to the alpha amino group of another, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. +25 total
0.412 Hit 59.0% 2.22e-07
3449 KP13_04290 Putative pyruvate formate-lyase 3-activating enzyme AlphaFold + ColabFold –
GO:0016491Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. GO:0003824Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. GO:0051539Binding to a 4 iron, 4 sulfur (4Fe-4S) cluster; this cluster consists of four iron atoms, with the inorganic sulfur atoms found between the irons and acting as bridging ligands. +36 total
0.412 No Hit 0.0% —
3450 KP13_03256 putative Iron-dependent fumarate hydratase AlphaFold + ColabFold –
GO:0016836Catalysis of the cleavage of a carbon-oxygen bond by elimination of water.
0.412 No Hit 0.0% —
Page of 208 · 5192 total proteins