Proteins

Genome: KpKP13

Description: Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence

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5842 / 5842 proteins

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# Protein Description Gene Structure EC GO Metabolism Druggability FPocket druggability score for the preferred structure (0–1): experimental structure when available, otherwise predicted model. ≥ 0.7 highly druggable · ≥ 0.4 moderately druggable · < 0.4 low druggability. Human off-target BLASTP against the human proteome. Hit means at least one human match was detected at e-value <= 1e-5. Prefer No hit for pathogen-selective targets. Human identity (%) Best human BLAST identity percentage. Human E-value Best human BLAST E-value.
3651 KP13_03558 hypothetical protein AlphaFold DB model + ColabFold model – – No map 0.588 No Hit 0.0% —
3652 KP13_03560 putative HTH-type transcriptional regulator AlphaFold DB model + ColabFold model –
GO:0006355Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. GO:0003700A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons. GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. +14 total
No map 0.629 No Hit 0.0% —
3653 KP13_03563 putative DNA-binding domain-containing protein AlphaFold DB model + ColabFold model – – No map 0.615 No Hit 0.0% —
3654 KP13_03565 Rhizopine catabolism protein mocC mocC AlphaFold DB model + ColabFold model – – No map 0.923 No Hit 0.0% —
3655 KP13_03566 hypothetical protein ColabFold model – – No map 0.334 No Hit 0.0% —
3656 KP13_03570 Lysine decarboxylase, inducible cadA AlphaFold DB model + ColabFold model –
GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. GO:0006520The chemical reactions and pathways involving amino acids, carboxylic acids containing one or more amino groups. GO:0016831Catalysis of the nonhydrolytic addition or removal of a carboxyl group to or from a compound. +14 total
No map 0.74 No Hit 0.0% —
3657 KP13_03572 Transcriptional activator cadC cadC AlphaFold DB model + ColabFold model –
GO:0005515Binding to a protein. GO:0006355Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. GO:0000160A conserved series of molecular signals found in prokaryotes and eukaryotes; involves autophosphorylation of a histidine kinase and the transfer of the phosphate group to an aspartate that then acts as a phospho-donor to response regulator proteins. +14 total
No map 0.803 No Hit 0.0% —
3658 KP13_03573 hypothetical protein ColabFold model – – No map 0.463 No Hit 0.0% —
3659 KP13_03574 hypothetical protein AlphaFold DB model + ColabFold model – – No map 0.108 No Hit 0.0% —
3660 KP13_03575 Lipid A biosynthesis lauroyl acyltransferase htrB AlphaFold DB model + ColabFold model
2.3.1.241
GO:0016740Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2. GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0009245The chemical reactions and pathways resulting in the formation of lipid A, the glycolipid group of bacterial lipopolysaccharides, consisting of four to six fatty acyl chains linked to two glucosamine residues. Further modifications of the backbone are common. +47 total
No map 0.316 No Hit 0.0% —
3661 KP13_03576 hypothetical protein AlphaFold DB model + ColabFold model –
GO:0016747Catalysis of the transfer of an acyl group, other than amino-acyl, from one compound (donor) to another (acceptor).
No map 0.495 No Hit 0.0% —
3662 KP13_03577 Fimbrial biogenesis outer membrane protein AlphaFold DB model + ColabFold model –
GO:0007155The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules. GO:0009289A proteinaceous hair-like appendage on the surface of bacteria ranging from 2-8 nm in diameter. GO:0043709The attachment of a cell to a solid substrate, via cell adhesion molecules, during the formation of a biofilm composed of microorganisms of the same species.
No map 0.187 No Hit 0.0% —
3663 KP13_03578 Outer membrane usher protein AlphaFold DB model + ColabFold model –
GO:0005515Binding to a protein. GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0015473A porin that acts in the assembly of fimbria together with fimbrial chaperone. +25 total
No map 0.473 No Hit 0.0% —
3664 KP13_03579 putative pilin chaperone AlphaFold DB model + ColabFold model –
GO:0061077OBSOLETE. The process of inhibiting aggregation and assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure that is dependent on interaction with a chaperone. GO:0043711A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a pilus, a short filamentous structure on a bacterial cell, flagella-like in structure and generally present in many copies. GO:0030288The region between the inner (cytoplasmic or plasma) membrane and outer membrane of organisms with two membranes such as Gram negative bacteria. These periplasmic spaces are relatively thick and contain a thin peptidoglycan layer (PGL), also referred to as a thin cell wall. +14 total
No map 0.344 No Hit 0.0% —
3665 KP13_03580 Putative fimbrial protein AlphaFold DB model + ColabFold model –
GO:0007155The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules. GO:0009289A proteinaceous hair-like appendage on the surface of bacteria ranging from 2-8 nm in diameter. GO:0043709The attachment of a cell to a solid substrate, via cell adhesion molecules, during the formation of a biofilm composed of microorganisms of the same species.
No map 0.142 No Hit 0.0% —
3666 KP13_03581 two-component regulatory system response regulator AlphaFold DB model + ColabFold model –
GO:0006355Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. GO:0003677Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
No map 0.498 No Hit 0.0% —
3667 KP13_03582 hypothetical protein AlphaFold DB model + ColabFold model – – No map 0.74 No Hit 0.0% —
3668 KP13_03585 hypothetical protein AlphaFold DB model + ColabFold model – – No map 0.633 No Hit 0.0% —
3669 KP13_03588 hypothetical protein AlphaFold DB model + ColabFold model –
GO:0003723Binding to an RNA molecule or a portion thereof.
No map 0.12 No Hit 0.0% —
3670 KP13_03591 UDP-2,3-diacylglucosamine hydrolase lpxH Experimental + ColabFold model –
GO:0016462Catalysis of the hydrolysis of a pyrophosphate bond (diphosphate bond) between two phosphate groups. GO:0009245The chemical reactions and pathways resulting in the formation of lipid A, the glycolipid group of bacterial lipopolysaccharides, consisting of four to six fatty acyl chains linked to two glucosamine residues. Further modifications of the backbone are common. GO:0016787Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. +14 total
No map 0.994 No Hit 0.0% —
3671 KP13_03594 Phosphoribosylaminoimidazole carboxylase ATPase subunit purK AlphaFold DB model + ColabFold model
6.3.4.18
GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. GO:0006189The chemical reactions and pathways resulting in the formation of IMP, inosine monophosphate, by the stepwise assembly of a purine ring on ribose 5-phosphate. GO:0046872Binding to a metal ion. +36 total
No map 0.56 No Hit 0.0% —
3672 KP13_03595 tRNA 2-selenouridine synthase selU AlphaFold DB model + ColabFold model
2.9.1.3
GO:0002098The process in which a uridine at position 34 of a tRNA is post-transcriptionally modified. The wobble nucleoside of the tRNA sequence (position 34) corresponds to the first position of the anticodon. GO:0043828Catalysis of the reaction: 5-methylaminomethyl-2-thiouridine + selenophosphate = 5-methylaminomethyl-2-selenouridine + phosphate (at the wobble position in tRNA). GO:0016765Catalysis of the transfer of an alkyl or aryl (but not methyl) group from one compound (donor) to another (acceptor).
No map 0.346 No Hit 0.0% —
3673 KP13_03596 Outer membrane protein C AlphaFold DB model + ColabFold model – – No map 0.159 No Hit 0.0% —
3674 KP13_03597 putative ABC transporter permease AlphaFold DB model + ColabFold model –
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
No map 0.984 No Hit 0.0% —
3675 KP13_03602 putative inner membrane protein AlphaFold DB model + ColabFold model –
GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
No map 0.358 No Hit 0.0% —
Page of 234 · 5842 total proteins