Proteins

Genome: KpKP13

Description: Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence

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5192 / 5842 proteins Structure: AlphaFold

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Structure: AlphaFold ×
# Protein Description Gene Structure EC GO Druggability FPocket druggability score for the preferred structure (0–1): experimental structure when available, otherwise predicted model. ≥ 0.7 highly druggable · ≥ 0.4 moderately druggable · < 0.4 low druggability. Human off-target BLASTP against the human proteome. Hit means at least one human match was detected at e-value <= 1e-5. Prefer No hit for pathogen-selective targets. Human identity (%) Best human BLAST identity percentage. Human E-value Best human BLAST E-value.
3676 KP13_00095 putative 2-aminoethylphosphonate-binding periplasmic protein phnS AlphaFold + ColabFold –
GO:0030288The region between the inner (cytoplasmic or plasma) membrane and outer membrane of organisms with two membranes such as Gram negative bacteria. These periplasmic spaces are relatively thick and contain a thin peptidoglycan layer (PGL), also referred to as a thin cell wall. GO:0030975Binding to thiamine (vitamin B1), a water soluble vitamin present in fresh vegetables and meats, especially liver. GO:0030976Binding to thiamine pyrophosphate, the diphosphoric ester of thiamine. Acts as a coenzyme of several (de)carboxylases, transketolases, and alpha-oxoacid dehydrogenases. +14 total
0.374 No Hit 0.0% —
3677 KP13_04690 hypothetical protein AlphaFold + ColabFold – – 0.373 No Hit 0.0% —
3678 KP13_04660 hypothetical protein AlphaFold + ColabFold – – 0.373 No Hit 0.0% —
3679 KP13_02804 Bifunctional protein hldE hldE AlphaFold + ColabFold –
GO:0016773Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to an alcohol group (acceptor). GO:0009058A cellular process consisting of the biochemical pathways by which a living organism synthesizes chemical substances. This typically represents the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones. GO:0016301Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule. +912 total
0.373 Hit 39.7% 1.44e-06
3680 KP13_01361 DNA-directed RNA polymerase subunit beta' rpoC AlphaFold + ColabFold
2.7.7.6
GO:0003899Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1). Utilizes a DNA template, i.e. the catalysis of DNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time. Can initiate a chain 'de novo'. GO:0003677Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). GO:0006351The synthesis of an RNA transcript from a DNA template. +47 total
0.373 Hit 44.7% 9.73e-20
3681 KP13_03881 Ribosomal RNA large subunit methyltransferase I rlmI AlphaFold + ColabFold
2.1.1.191
GO:0003723Binding to an RNA molecule or a portion thereof. GO:0008649Catalysis of the transfer of a methyl group from S-adenosyl-L-methionine to a nucleoside residue in an rRNA molecule. The methyl group can be transfered to the nucleobase or to the ribose group of the nucleoside. GO:0008168Catalysis of the transfer of a methyl group to an acceptor molecule. +25 total
0.372 No Hit 0.0% —
3682 KP13_01907 UDP-N-acetylmuramoylalanine--D-glutamate ligase murD AlphaFold + ColabFold
6.3.2.9
GO:0008764Catalysis of the reaction: D-glutamate + ATP + UDP-N-acetylmuramoyl-L-alanine = ADP + 2 H+ + phosphate + UDP-N-acetylmuramoyl-L-alanyl-D-glutamate. GO:0008360Any process that modulates the surface configuration of a cell. GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. +69 total
0.372 No Hit 0.0% —
3683 KP13_01841 General secretion pathway protein H pulH AlphaFold + ColabFold –
GO:0015627A large protein complex, containing 12-15 subunits, that spans the cell envelope of Gram-negative bacteria and mediates the movement of proteins into the extracellular environment. The complex includes a component in the cytoplasm, an inner membrane subcomplex that reaches into the periplasmic compartment and a secretion pore in the outer membrane. Proteins using the Type II pathway are transported across the cytoplasmic membrane by the Sec or Tat complex. GO:0015628The process in which proteins are secreted across the outer membrane of Gram-negative bacteria by the type II secretion system. Proteins using this pathway are first translocated across the cytoplasmic membrane via the Sec or Tat pathways. GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
0.372 No Hit 0.0% —
3684 KP13_01113 Transcription elongation factor greA greA AlphaFold + ColabFold –
GO:0032784Any process that modulates the frequency, rate or extent of transcription elongation, the extension of an RNA molecule after transcription initiation and promoter clearance by the addition of ribonucleotides catalyzed by a DNA-dependent RNA polymerase. GO:0070063Binding to an RNA polymerase molecule or complex. GO:0003677Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). +25 total
0.372 No Hit 0.0% —
3685 KP13_00986 NADH-quinone oxidoreductase subunit I nuoI AlphaFold + ColabFold
7.1.1.-
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0051539Binding to a 4 iron, 4 sulfur (4Fe-4S) cluster; this cluster consists of four iron atoms, with the inorganic sulfur atoms found between the irons and acting as bridging ligands. GO:0016651Catalysis of an oxidation-reduction (redox) reaction in which NADH or NADPH acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor. +58 total
0.372 Hit 47.9% 7.04e-07
3686 KP13_05199 Putative tartrate transporter AlphaFold + ColabFold –
GO:0022857Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other. GO:0055085The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other. GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
0.371 No Hit 0.0% —
3687 KP13_03543 Sulfate transport system permease protein cysW cysW AlphaFold + ColabFold –
GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0015419Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + sulfate(out) = ADP + phosphate + sulfate(in). GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. +25 total
0.371 No Hit 0.0% —
3688 KP13_03501 Protein moaF moaF AlphaFold + ColabFold – – 0.371 No Hit 0.0% —
3689 KP13_03152 Signal transduction histidine-protein kinase baeS baeS AlphaFold + ColabFold
2.7.13.3
GO:0016310The process of introducing a phosphate group into a molecule, usually with the formation of a phosphoric ester, a phosphoric anhydride or a phosphoric amide. GO:0016772Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to another (acceptor). GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. +36 total
0.371 No Hit 0.0% —
3690 KP13_02212 Arsenical resistance operon repressor arsR AlphaFold + ColabFold –
GO:0006355Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. GO:0003700A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons. GO:0003677Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). +14 total
0.371 No Hit 0.0% —
3691 KP13_00132 Cytoplasmic membrane lipoprotein-28 nlpA AlphaFold + ColabFold –
GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0015821The directed movement of methionine, 2-amino-4-(methylthio)butanoic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
0.371 No Hit 0.0% —
3692 KP13_05698 hypothetical protein AlphaFold + ColabFold – – 0.37 No Hit 0.0% —
3693 KP13_04800 hypothetical protein AlphaFold + ColabFold – – 0.37 No Hit 0.0% —
3694 KP13_03631 hypothetical protein AlphaFold + ColabFold – – 0.37 No Hit 0.0% —
3695 KP13_02043 Thiamine-monophosphate kinase thiL AlphaFold + ColabFold
2.7.4.16
GO:0009228The chemical reactions and pathways resulting in the formation of thiamine (vitamin B1), a water soluble vitamin present in fresh vegetables and meats, especially liver. GO:0009030Catalysis of the reaction: ATP + thiamine phosphate = ADP + H+ + thiamine diphosphate. GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. +25 total
0.37 No Hit 0.0% —
3696 KP13_00080 hypothetical protein AlphaFold + ColabFold – – 0.37 No Hit 0.0% —
3697 KP13_05968 hypothetical protein AlphaFold + ColabFold – – 0.369 No Hit 0.0% —
3698 KP13_05234 AraC family transcriptional regulator AlphaFold + ColabFold –
GO:0043565Binding to DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. GO:0006355Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. GO:0003700A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons.
0.369 No Hit 0.0% —
3699 KP13_04857 Exodeoxyribonuclease 8 recE AlphaFold + ColabFold –
GO:0003676Binding to a nucleic acid. GO:0051908Catalysis of the sequential cleavage of mononucleotides from a free 5' terminus of a double-stranded DNA molecule. GO:0090305OBSOLETE. The nucleic acid metabolic process in which the phosphodiester bonds between nucleotides are cleaved by hydrolysis.
0.369 No Hit 0.0% —
3700 KP13_04765 hypothetical protein AlphaFold + ColabFold – – 0.369 No Hit 0.0% —
Page of 208 · 5192 total proteins