Proteins

Genome: KpKP13

Description: Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence

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5842 / 5842 proteins

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# Protein Description Gene Structure EC GO Metabolism Druggability FPocket druggability score for the preferred structure (0–1): experimental structure when available, otherwise predicted model. ≥ 0.7 highly druggable · ≥ 0.4 moderately druggable · < 0.4 low druggability. Human off-target BLASTP against the human proteome. Hit means at least one human match was detected at e-value <= 1e-5. Prefer No hit for pathogen-selective targets. Human identity (%) Best human BLAST identity percentage. Human E-value Best human BLAST E-value.
351 KP13_31775 Acriflavine resistance protein E acrE AlphaFold DB model + ColabFold model –
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0055085The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other. GO:0022857Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other.
No map 0.913 No Hit 0.0% —
352 KP13_31770 intracellular growth attenuator protein IgaA igaA Experimental + AlphaFold DB model + ColabFold model –
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
No map 0.876 No Hit 0.0% —
353 KP13_31769 chloride channel protein AlphaFold DB model + ColabFold model – – No map 0.313 No Hit 0.0% —
354 KP13_31768 hypothetical protein ColabFold model – – No map 0.424 No Hit 0.0% —
355 KP13_31767 hypothetical protein ColabFold model – – No map 0.147 No Hit 0.0% —
356 KP13_31764 hypothetical protein AlphaFold DB model + ColabFold model – – No map 0.311 No Hit 0.0% —
357 KP13_31763 Insertion element IS1 protein insA AlphaFold DB model + ColabFold model –
GO:0006313A type of transposition in which a transposable element (transposon) is moved to another part of a genome, either by a cut-and-paste mechanism or a replicative mechanism.
No map 0.438 No Hit 0.0% —
358 KP13_31761 biotin sulfoxide reductase bisC AlphaFold DB model + ColabFold model –
GO:0016491Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. GO:0043546Binding to a molybdopterin cofactor (Moco), essential for the catalytic activity of some enzymes, e.g. sulfite oxidase, xanthine dehydrogenase, and aldehyde oxidase. The cofactor consists of a mononuclear molybdenum (Mo-molybdopterin) or tungsten ion (W-molybdopterin) coordinated by one or two molybdopterin ligands. GO:0030288The region between the inner (cytoplasmic or plasma) membrane and outer membrane of organisms with two membranes such as Gram negative bacteria. These periplasmic spaces are relatively thick and contain a thin peptidoglycan layer (PGL), also referred to as a thin cell wall. +36 total
No map 0.958 No Hit 0.0% —
359 KP13_31760 putative lipoprotein AlphaFold DB model + ColabFold model – – No map 0.333 No Hit 0.0% —
360 KP13_31758 hypothetical protein ColabFold model – – No map 0.55 No Hit 0.0% —
361 KP13_31757 hypothetical protein ColabFold model – – No map 0.258 No Hit 0.0% —
362 KP13_31756 sodium/glutamate symporter gltS AlphaFold DB model + ColabFold model –
GO:0015501Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: glutamate(out) + Na+(out) = glutamate(in) + Na+(in). GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0015813The directed movement of L-glutamate across a membrane by means of some agent such as a transporter or a pore. +14 total
No map 0.803 No Hit 0.0% —
363 KP13_31753 hypothetical protein ColabFold model – – No map 0.248 No Hit 0.0% —
364 KP13_31752 hypothetical protein ColabFold model – – No map 0.315 No Hit 0.0% —
365 KP13_31751 hypothetical protein ColabFold model – – No map 0.356 No Hit 0.0% —
366 KP13_31750 RelE family toxin-antitoxin system protein ColabFold model – – No map 0.899 No Hit 0.0% —
367 KP13_31748 Ferrous iron transport protein A feoA Experimental + ColabFold model –
GO:0046914Binding to a transition metal ions; a transition metal is an element whose atom has an incomplete d-subshell of extranuclear electrons, or which gives rise to a cation or cations with an incomplete d-subshell. Transition metals often have more than one valency state. Biologically relevant transition metals include vanadium, manganese, iron, copper, cobalt, nickel, molybdenum and silver.
No map 0.318 No Hit 0.0% —
368 KP13_31745 Nitrogen assimilation regulatory protein ntrC AlphaFold DB model + ColabFold model –
GO:0016887Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient. GO:0006355Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. GO:0006808Any process that modulates the frequency, rate or extent of nitrogen utilization. +710 total
No map 0.916 No Hit 0.0% —
369 KP13_31744 Formate dehydrogenase-O iron-sulfur subunit fdoH AlphaFold DB model + ColabFold model –
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0015944The chemical reactions and pathways by which formate is converted to CO2. GO:0045333The enzymatic release of energy from inorganic and organic compounds (especially carbohydrates and fats) which either requires oxygen (aerobic respiration) or does not (anaerobic respiration). +69 total
No map 0.478 No Hit 0.0% —
370 KP13_31743 putative serine protease AlphaFold DB model + ColabFold model
3.4.21.-
GO:0006508The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds. GO:0008236Catalysis of the hydrolysis of peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine). GO:0004252Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine).
No map 0.212 No Hit 0.0% —
371 KP13_31742 Homoserine O-succinyltransferase metA AlphaFold DB model + ColabFold model
2.3.1.46
GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. GO:0019281OBSOLETE. The chemical reactions and pathways resulting in the formation of L-methionine from other compounds, including homoserine, via the intermediates O-succinyl-L-homoserine and cystathionine. GO:0008899Catalysis of the reaction: L-homoserine + succinyl-CoA = O-succinyl-L-homoserine + CoA. +14 total
No map 0.408 No Hit 0.0% —
372 KP13_31741 hypothetical protein ColabFold model – – No map 0.161 No Hit 0.0% —
373 KP13_31740 putative antitoxin in type II toxin-antitoxin system ColabFold model – – No map 0.177 No Hit 0.0% —
374 KP13_31738 LexA-regulated protein tisB tisB AlphaFold DB model + ColabFold model –
GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0005253Enables the energy-independent facilitated diffusion of a monoatomic anion through a transmembrane aqueous pore or channel. GO:0009432An error-prone process for repairing damaged microbial DNA. +14 total
No map 0.26 No Hit 0.0% —
375 KP13_31737 HTH-type transcriptional regulator dsdC AlphaFold DB model + ColabFold model –
GO:0006355Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. GO:0003700A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons. GO:0043565Binding to DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. +14 total
No map 0.4 No Hit 0.0% —
Page of 234 · 5842 total proteins