Proteins

Genome: KpKP13

Description: Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence

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5842 / 5842 proteins

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# Protein Description Gene Structure EC GO Metabolism Druggability FPocket druggability score for the preferred structure (0–1): experimental structure when available, otherwise predicted model. ≥ 0.7 highly druggable · ≥ 0.4 moderately druggable · < 0.4 low druggability. Human off-target BLASTP against the human proteome. Hit means at least one human match was detected at e-value <= 1e-5. Prefer No hit for pathogen-selective targets. Human identity (%) Best human BLAST identity percentage. Human E-value Best human BLAST E-value.
3801 KP13_03809 Capsule assembly 55.8 kDa protein in cps region wzi AlphaFold DB model + ColabFold model – – No map 0.955 No Hit 0.0% —
3802 KP13_03810 hypothetical protein ColabFold model – – No map 0.845 No Hit 0.0% —
3803 KP13_03817 DNA replication initiation factor hda AlphaFold DB model + ColabFold model –
GO:0032297Any process that stops, prevents, or reduces the frequency, rate or extent of initiation of DNA-dependent DNA replication.
No map 0.487 No Hit 0.0% —
3804 KP13_03818 putative transposase AlphaFold DB model + ColabFold model –
GO:1990238Catalysis of the hydrolysis of ester linkages within a double-stranded DNA molecule by creating internal breaks. GO:0006310Any process in which a new genotype is formed by reassortment of genes resulting in gene combinations different from those that were present in the parents. In eukaryotes genetic recombination can occur by chromosome assortment, intrachromosomal recombination, or nonreciprocal interchromosomal recombination. Interchromosomal recombination occurs by crossing over. In bacteria it may occur by genetic transformation, conjugation, transduction, or F-duction.
No map 0.306 No Hit 0.0% —
3805 KP13_03819 putative arsenate reductase AlphaFold DB model + ColabFold model
1.20.4.1
GO:0008794Catalysis of the reaction: arsenate + reduced glutaredoxin = arsenite + oxidized glutaredoxin. Glutaredoxin functions as the electron donor for arsenate reduction. The electron flow therefore is ( NADPH -> glutathione reductase (EC:1.6.4.2) -> ) glutathione -> glutaredoxin -> arsenate reductase, i.e. glutathione is reduced by glutathione reductase and glutaredoxin is reduced by glutathione.
No map 0.159 No Hit 0.0% —
3806 KP13_03820 TPR repeat-containing protein AlphaFold DB model + ColabFold model
3.4.-.-
GO:0004222Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions. GO:0006508The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds. GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. +69 total
No map 0.818 No Hit 0.0% —
3807 KP13_03821 Putative permease perM perM AlphaFold DB model + ColabFold model – – No map 0.983 No Hit 0.0% —
3808 KP13_03823 Glycine cleavage system transcriptional repressor gcvR AlphaFold DB model + ColabFold model –
GO:0006355Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
No map 0.473 No Hit 0.0% —
3809 KP13_03825 Lipoprotein 34 nlpB AlphaFold DB model + ColabFold model –
GO:0009279A lipid bilayer that forms the outermost membrane of the cell envelope; enriched in polysaccharide and protein; the outer leaflet of the membrane contains specific lipopolysaccharide structures. GO:0043165The assembly of an outer membrane of the type formed in Gram-negative bacteria. This membrane is enriched in polysaccharide and protein, and the outer leaflet of the membrane contains specific lipopolysaccharide structures. GO:0051205The process that results in the incorporation of a protein into a biological membrane. Incorporation in this context means having some part or covalently attached group that is inserted into the the hydrophobic region of one or both bilayers.
No map 0.558 No Hit 0.0% —
3810 KP13_03827 hypothetical protein AlphaFold DB model + ColabFold model –
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it.
No map 0.948 No Hit 0.0% —
3811 KP13_03829 Esterase AlphaFold DB model + ColabFold model –
GO:0016787Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc.
No map 0.089 No Hit 0.0% —
3812 KP13_03830 hypothetical protein AlphaFold DB model + ColabFold model –
GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
No map 0.365 No Hit 0.0% —
3813 KP13_03832 thioredoxin domain-containing protein AlphaFold DB model + ColabFold model – – No map 0.295 No Hit 0.0% —
3814 KP13_03833 putative aminoglycoside efflux pump acrD AlphaFold DB model + ColabFold model –
GO:0022857Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other. GO:0015562Enables the transfer of a specific substance or related group of substances from the inside of the cell to the outside of the cell across a membrane. GO:0042908The directed movement of a xenobiotic into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. A xenobiotic is a compound foreign to the organism exposed to it. It may be synthesized by another organism (like ampicilin) or it can be a synthetic chemical. +58 total
No map 0.674 No Hit 0.0% —
3815 KP13_03834 hypothetical protein AlphaFold DB model + ColabFold model – – No map 0.445 No Hit 0.0% —
3816 KP13_03837 hypothetical protein AlphaFold DB model + ColabFold model – – No map 0.798 No Hit 0.0% —
3817 KP13_03841 Ethanolamine utilization protein eutS eutS AlphaFold DB model + ColabFold model –
GO:0031469An organelle found in bacteria consisting of a proteinaceous coat containing metabolic enzymes whose purpose is the sequestration or concentration of metabolites and which has the appearance of a polygonal granule by electron microscopy.
No map No pocket No Hit 0.0% —
3818 KP13_03842 Ethanolamine utilization protein eutP eutP AlphaFold DB model + ColabFold model –
GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. GO:0006576The chemical reactions and pathways occurring at the level of individual cells involving any of a group of naturally occurring, biologically active amines, such as norepinephrine, histamine, and serotonin, many of which act as neurotransmitters.
No map 0.226 No Hit 0.0% —
3819 KP13_03843 Ethanolamine utilization protein eutQ eutQ AlphaFold DB model + ColabFold model – – No map 0.447 No Hit 0.0% —
3820 KP13_03844 Ethanolamine utilization cobalamin adenosyltransferase eutT AlphaFold DB model + ColabFold model –
GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. GO:0006580The chemical reactions and pathways involving ethanolamine (2-aminoethanol), an important water-soluble base of phospholipid (phosphatidylethanolamine). GO:0009236The chemical reactions and pathways resulting in the formation of cobalamin (vitamin B12), a water-soluble vitamin characterized by possession of a corrin nucleus containing a cobalt atom. +14 total
No map 0.413 No Hit 0.0% —
3821 KP13_03845 Ethanolamine utilization protein eutD eutD AlphaFold DB model + ColabFold model
2.3.1.8
GO:0016407Catalysis of the transfer of an acetyl group to an acceptor molecule. GO:0016746Catalysis of the transfer of an acyl group from one compound (donor) to another (acceptor). GO:0008959Catalysis of the reaction: acetyl-CoA + phosphate = CoA + acetyl phosphate.
No map 0.356 No Hit 0.0% —
3822 KP13_03846 Ethanolamine utilization protein eutM eutM AlphaFold DB model + ColabFold model –
GO:0031469An organelle found in bacteria consisting of a proteinaceous coat containing metabolic enzymes whose purpose is the sequestration or concentration of metabolites and which has the appearance of a polygonal granule by electron microscopy.
No map 0.767 No Hit 0.0% —
3823 KP13_03847 Ethanolamine utilization protein eutN eutN AlphaFold DB model + ColabFold model –
GO:0031469An organelle found in bacteria consisting of a proteinaceous coat containing metabolic enzymes whose purpose is the sequestration or concentration of metabolites and which has the appearance of a polygonal granule by electron microscopy.
No map 0.404 No Hit 0.0% —
3824 KP13_03849 Ethanolamine utilization protein eutJ eutJ AlphaFold DB model + ColabFold model – – No map 0.966 No Hit 0.0% —
3825 KP13_03851 Ethanolamine utilization protein eutH eutH AlphaFold DB model + ColabFold model –
GO:0034228Enables the transfer of ethanolamine from one side of a membrane to the other. Ethanolamine (2-aminoethanol, monoethanolamine) is an amino alcohol that occurs widely in living organisms as a constituent of certain types of phospholipids, such as phosphatidylethanolamine. GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0034229The directed movement of ethanolamine into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Ethanolamine (2-aminoethanol, monoethanolamine) is an amino alcohol that occurs widely in living organisms as a constituent of certain types of phospholipids, such as phosphatidylethanolamine. +14 total
No map 0.783 No Hit 0.0% —
Page of 234 · 5842 total proteins