Proteins

Genome: KpKP13

Description: Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence

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5192 / 5842 proteins Structure: AlphaFold

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Structure: AlphaFold ×
# Protein Description Gene Structure EC GO Druggability FPocket druggability score for the preferred structure (0–1): experimental structure when available, otherwise predicted model. ≥ 0.7 highly druggable · ≥ 0.4 moderately druggable · < 0.4 low druggability. Human off-target BLASTP against the human proteome. Hit means at least one human match was detected at e-value <= 1e-5. Prefer No hit for pathogen-selective targets. Human identity (%) Best human BLAST identity percentage. Human E-value Best human BLAST E-value.
3826 KP13_00770 30S ribosomal protein S13 rpsM AlphaFold + ColabFold –
GO:0003735The action of a molecule that contributes to the structural integrity of the ribosome. GO:0003676Binding to a nucleic acid. GO:0006412The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA or circRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA or circRNA. Translation ends with the release of a polypeptide chain from the ribosome. +69 total
0.348 Hit 27.3% 4.49e-06
3827 KP13_00682 hypothetical protein AlphaFold + ColabFold – – 0.348 No Hit 0.0% —
3828 KP13_03947 GCN5-related N-acetyltransferase (GNAT) AlphaFold + ColabFold –
GO:0016747Catalysis of the transfer of an acyl group, other than amino-acyl, from one compound (donor) to another (acceptor). GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. GO:1990189Catalysis of the reaction: acetyl-CoA + N-terminal L-seryl-[protein] = CoA + H+ + N-terminal Nalpha-acetyl-L-seryl-[protein]. +14 total
0.347 No Hit 0.0% —
3829 KP13_03498 Anaerobic sulfatase-maturating enzyme atsB AlphaFold + ColabFold –
GO:0016491Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. GO:0003824Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. GO:0051539Binding to a 4 iron, 4 sulfur (4Fe-4S) cluster; this cluster consists of four iron atoms, with the inorganic sulfur atoms found between the irons and acting as bridging ligands. +25 total
0.347 No Hit 0.0% —
3830 KP13_03062 putative metal-dependent phosphohydrolase AlphaFold + ColabFold – – 0.347 Hit 52.2% 5.35e-12
3831 KP13_00805 L-aspartate oxidase nadB AlphaFold + ColabFold
1.4.3.16
GO:0016491Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. GO:0008734Catalysis of the reaction: L-aspartate + O2 = iminosuccinate + H2O2. Can also use fumatate as electron acceptor under anaerobic conditions, yielding succinate. GO:0009435The chemical reactions and pathways resulting in the formation of nicotinamide adenine dinucleotide (NAD+), a coenzyme that interconverts with its reduced form, NADH, in many redox and catabolic reactions. NAD+ is derived from various sources including vitamin B3. +36 total
0.347 Hit 33.5% 1.22e-23
3832 KP13_00535 hypothetical protein AlphaFold + ColabFold – – 0.347 No Hit 0.0% —
3833 KP13_31865 Arabinose 5-phosphate isomerase GutQ gutQ AlphaFold + ColabFold
5.3.1.13
GO:0016853Catalysis of the geometric or structural changes within one molecule. Isomerase is the systematic name for any enzyme of EC class 5. GO:0005975The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. GO:1901135The chemical reactions and pathways involving carbohydrate derivative. +58 total
0.346 No Hit 0.0% —
3834 KP13_03595 tRNA 2-selenouridine synthase selU AlphaFold + ColabFold
2.9.1.3
GO:0002098The process in which a uridine at position 34 of a tRNA is post-transcriptionally modified. The wobble nucleoside of the tRNA sequence (position 34) corresponds to the first position of the anticodon. GO:0043828Catalysis of the reaction: 5-methylaminomethyl-2-thiouridine + selenophosphate = 5-methylaminomethyl-2-selenouridine + phosphate (at the wobble position in tRNA). GO:0016765Catalysis of the transfer of an alkyl or aryl (but not methyl) group from one compound (donor) to another (acceptor).
0.346 No Hit 0.0% —
3835 KP13_02655 putative transmembrane protein AlphaFold + ColabFold – – 0.346 No Hit 0.0% —
3836 KP13_02609 Phosphatase AlphaFold + ColabFold –
GO:0046872Binding to a metal ion. GO:0050308Catalysis of the reaction: sugar phosphate + H2O = sugar + phosphate.
0.346 Hit 35.6% 2.55e-20
3837 KP13_01817 Periplasmic serine endoprotease DegP degP AlphaFold + ColabFold
3.4.21.107
GO:0006508The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds. GO:0005515Binding to a protein. GO:0004252Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine).
0.346 Hit 47.0% 6.61e-22
3838 KP13_01161 Twin-arginine leader-binding protein dmsD dmsD AlphaFold + ColabFold –
GO:0005048Binding to a signal sequence, a specific peptide sequence found on protein precursors or mature proteins that dictates where the mature protein is localized.
0.346 No Hit 0.0% —
3839 KP13_00488 Aspartate ammonia-lyase aspA AlphaFold + ColabFold –
GO:0003824Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. GO:0006531The chemical reactions and pathways involving aspartate, the anion derived from aspartic acid, 2-aminobutanedioic acid. GO:0006099A nearly universal metabolic pathway in which the acetyl group of acetyl coenzyme A is effectively oxidized to two CO2 and four pairs of electrons are transferred to coenzymes. The acetyl group combines with oxaloacetate to form citrate, which undergoes successive transformations to isocitrate, 2-oxoglutarate, succinyl-CoA, succinate, fumarate, malate, and oxaloacetate again, thus completing the cycle. In eukaryotes the tricarboxylic acid is confined to the mitochondria. See also glyoxylate cycle. +25 total
0.346 Hit 42.9% 2.13e-27
3840 KP13_04106 hypothetical protein AlphaFold + ColabFold –
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0034639Enables the transfer of an L-amino acid from the inside of the cell to the outside of the cell across a membrane. GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. +14 total
0.345 No Hit 0.0% —
3841 KP13_04103 hypothetical protein AlphaFold + ColabFold – – 0.345 No Hit 0.0% —
3842 KP13_02231 Type 1 fimbriae regulatory protein fimE fimE AlphaFold + ColabFold –
GO:0006310Any process in which a new genotype is formed by reassortment of genes resulting in gene combinations different from those that were present in the parents. In eukaryotes genetic recombination can occur by chromosome assortment, intrachromosomal recombination, or nonreciprocal interchromosomal recombination. Interchromosomal recombination occurs by crossing over. In bacteria it may occur by genetic transformation, conjugation, transduction, or F-duction. GO:0003677Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). GO:0015074The process in which a DNA segment is incorporated into another, usually larger, DNA molecule such as a chromosome.
0.345 No Hit 0.0% —
3843 KP13_01051 hypothetical protein AlphaFold + ColabFold – – 0.345 No Hit 0.0% —
3844 KP13_31840 hypothetical protein AlphaFold + ColabFold – – 0.344 No Hit 0.0% —
3845 KP13_05415 Non-specific acid phosphatase phoN AlphaFold + ColabFold
3.1.3.2
GO:0003993Catalysis of the reaction: an orthophosphoric monoester + H2O = an alcohol + phosphate, with an acid pH optimum. GO:0030288The region between the inner (cytoplasmic or plasma) membrane and outer membrane of organisms with two membranes such as Gram negative bacteria. These periplasmic spaces are relatively thick and contain a thin peptidoglycan layer (PGL), also referred to as a thin cell wall.
0.344 No Hit 0.0% —
3846 KP13_04954 hypothetical protein AlphaFold + ColabFold –
GO:0008270Binding to a zinc ion (Zn). GO:0003824Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. +25 total
0.344 No Hit 0.0% —
3847 KP13_04323 putative transketolase family protein AlphaFold + ColabFold – – 0.344 Hit 37.5% 3.09e-15
3848 KP13_04286 Isoaspartyl peptidase iaaA AlphaFold + ColabFold –
GO:0016787Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc.
0.344 Hit 42.0% 1.96e-22
3849 KP13_04086 L-asparaginase ansB AlphaFold + ColabFold –
GO:0006520The chemical reactions and pathways involving amino acids, carboxylic acids containing one or more amino groups. GO:0004067Catalysis of the reaction: L-asparagine + H2O = L-aspartate + NH4+. GO:0006528The chemical reactions and pathways involving asparagine, 2-amino-3-carbamoylpropanoic acid.
0.344 No Hit 0.0% —
3850 KP13_03579 putative pilin chaperone AlphaFold + ColabFold –
GO:0061077OBSOLETE. The process of inhibiting aggregation and assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure that is dependent on interaction with a chaperone. GO:0043711A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a pilus, a short filamentous structure on a bacterial cell, flagella-like in structure and generally present in many copies. GO:0030288The region between the inner (cytoplasmic or plasma) membrane and outer membrane of organisms with two membranes such as Gram negative bacteria. These periplasmic spaces are relatively thick and contain a thin peptidoglycan layer (PGL), also referred to as a thin cell wall. +14 total
0.344 No Hit 0.0% —
Page of 208 · 5192 total proteins