Proteins

Genome: KpKP13

Description: Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence

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5842 proteins

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Rows
# Protein Description Gene Structure EC GO Druggability FPocket druggability score for the preferred structure (0–1): experimental structure when available, otherwise predicted model. ≥ 0.7 highly druggable · ≥ 0.4 moderately druggable · < 0.4 low druggability. Human off-target BLASTP against the human proteome. Hit means at least one human match was detected at e-value <= 1e-5. Prefer No hit for pathogen-selective targets. Human identity (%) Best human BLAST identity percentage. Human E-value Best human BLAST E-value.
4301 KP13_04323 putative transketolase family protein AlphaFold + ColabFold – – 0.344 Hit 37.5% 3.09e-15
4302 KP13_04286 Isoaspartyl peptidase iaaA AlphaFold + ColabFold –
GO:0016787Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc.
0.344 Hit 42.0% 1.96e-22
4303 KP13_04086 L-asparaginase ansB AlphaFold + ColabFold –
GO:0006520The chemical reactions and pathways involving amino acids, carboxylic acids containing one or more amino groups. GO:0004067Catalysis of the reaction: L-asparagine + H2O = L-aspartate + NH4+. GO:0006528The chemical reactions and pathways involving asparagine, 2-amino-3-carbamoylpropanoic acid.
0.344 No Hit 0.0% —
4304 KP13_03579 putative pilin chaperone AlphaFold + ColabFold –
GO:0061077OBSOLETE. The process of inhibiting aggregation and assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure that is dependent on interaction with a chaperone. GO:0043711A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a pilus, a short filamentous structure on a bacterial cell, flagella-like in structure and generally present in many copies. GO:0030288The region between the inner (cytoplasmic or plasma) membrane and outer membrane of organisms with two membranes such as Gram negative bacteria. These periplasmic spaces are relatively thick and contain a thin peptidoglycan layer (PGL), also referred to as a thin cell wall. +14 total
0.344 No Hit 0.0% —
4305 KP13_02030 hypothetical protein ColabFold – – 0.344 No Hit 0.0% —
4306 KP13_01713 putative HAD-superfamily hydrolase AlphaFold + ColabFold –
GO:0016787Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. GO:0046872Binding to a metal ion. GO:0009231The chemical reactions and pathways resulting in the formation of riboflavin (vitamin B2), the precursor for the coenzymes flavin mononucleotide (FMN) and flavin adenine dinucleotide (FAD).
0.344 Hit 24.7% 2.06e-11
4307 KP13_00776 HTH-type transcriptional regulator zntR zntR AlphaFold + ColabFold –
GO:0008270Binding to a zinc ion (Zn). GO:0006355Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. GO:0003700A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons. +25 total
0.344 No Hit 0.0% —
4308 KP13_31507 Threonine dehydratase biosynthetic ilvA AlphaFold + ColabFold
4.3.1.19
GO:0030170Binding to pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6. GO:0006520The chemical reactions and pathways involving amino acids, carboxylic acids containing one or more amino groups. GO:0004794Catalysis of the reaction: L-threonine = 2-oxobutanoate + NH4. +47 total
0.343 Hit 51.6% 2.26e-14
4309 KP13_04230 hypothetical protein AlphaFold + ColabFold –
GO:1903401The directed movement of L-lysine across a membrane. GO:0015661Enables the transfer of L-lysine from the inside of the cell to the outside of the cell across a membrane.
0.343 No Hit 0.0% —
4310 KP13_01586 hypothetical protein AlphaFold + ColabFold – – 0.343 No Hit 0.0% —
4311 KP13_01418 hypothetical protein AlphaFold + ColabFold – – 0.343 No Hit 0.0% —
4312 KP13_01012 GCN5-related N-acetyltransferase AlphaFold + ColabFold –
GO:0016747Catalysis of the transfer of an acyl group, other than amino-acyl, from one compound (donor) to another (acceptor).
0.343 No Hit 0.0% —
4313 KP13_00436 TPR-like domain-containing protein Experimental + ColabFold –
GO:0005515Binding to a protein.
0.343 No Hit 0.0% —
4314 KP13_32061 hypothetical protein AlphaFold + ColabFold – – 0.342 No Hit 0.0% —
4315 KP13_12999 hypothetical protein ColabFold – – 0.342 No Hit 0.0% —
4316 KP13_04296 putative alpha-xylosidase AlphaFold + ColabFold –
GO:0030246Binding to a carbohydrate, which includes monosaccharides, oligosaccharides and polysaccharides as well as substances derived from monosaccharides by reduction of the carbonyl group (alditols), by oxidation of one or more hydroxy groups to afford the corresponding aldehydes, ketones, or carboxylic acids, or by replacement of one or more hydroxy group(s) by a hydrogen atom. Cyclitols are generally not regarded as carbohydrates. GO:0005975The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. GO:0004553Catalysis of the hydrolysis of any O-glycosyl bond. +14 total
0.342 Hit 30.1% 9.44e-80
4317 KP13_03036 CofD family protein AlphaFold + ColabFold –
GO:0043743Catalysis of the reaction: 7,8-didemethyl-8-hydroxy-5-deazariboflavin + lactyl-2-diphospho-5'-guanosine = coenzyme F420-0 + GMP. GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. GO:0008360Any process that modulates the surface configuration of a cell.
0.342 No Hit 0.0% —
4318 KP13_05667 KfrA protein AlphaFold + ColabFold –
GO:0008134Binding to a transcription factor, a protein required to initiate or regulate transcription. GO:0070840Binding to a dynein complex, a protein complex that contains two or three dynein heavy chains and several light chains, and has microtubule motor activity. GO:0042803Binding to an identical protein to form a homodimer.
0.341 Hit 24.8% 5.36e-07
4319 KP13_05285 putative high-affinity branched-chain amino acid transporter periplasmic binding component AlphaFold + ColabFold –
GO:0006865The directed movement of amino acids, organic acids containing one or more amino substituents, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
0.341 No Hit 0.0% —
4320 KP13_04598 taurine ABC superfamily ATP binding cassette transporter, binding protein AlphaFold + ColabFold – – 0.341 No Hit 0.0% —
4321 KP13_04339 DotU family type VI secretion system protein AlphaFold + ColabFold – – 0.341 No Hit 0.0% —
4322 KP13_03738 hypothetical protein ColabFold – – 0.341 No Hit 0.0% —
4323 KP13_02032 Ferric iron reductase protein fhuF fhuF AlphaFold + ColabFold –
GO:0051537Binding to a 2 iron, 2 sulfur (2Fe-2S) cluster; this cluster consists of two iron atoms, with two inorganic sulfur atoms found between the irons and acting as bridging ligands. GO:0003824Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic.
0.341 No Hit 0.0% —
4324 KP13_04277 Biofilm regulator bssR bssR AlphaFold + ColabFold – – 0.34 No Hit 0.0% —
4325 KP13_03601 thioredoxin domain-containing protein AlphaFold + ColabFold –
GO:0005515Binding to a protein. GO:0045454Any process that maintains the redox environment of a cell or compartment within a cell. GO:0006950Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a disturbance in organismal or cellular homeostasis, usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation).
0.34 Hit 36.5% 6.85e-07
Page of 234 · 5842 total proteins