Proteins

Genome: KpKP13

Description: Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence

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# Protein Description Gene Structure EC GO Metabolism Druggability (P2Rank) P2RANK ligandability score for the best pocket in the experimental structure (0–1). Higher values indicate higher predicted ligandability. Available only for genomes analyzed with the curated pipeline. Druggability (FPocket) FPocket druggability score for the preferred structure (0–1): experimental structure when available, otherwise predicted model. ≥ 0.7 highly druggable · ≥ 0.4 moderately druggable · < 0.4 low druggability. Human off-target BLASTP against the human proteome. Hit means at least one human match was detected at e-value <= 1e-5. Prefer No hit for pathogen-selective targets. Human identity (%) Best human BLAST identity percentage. Human E-value Best human BLAST E-value.
4301 KP13_00661 hypothetical protein AlphaFold DB model + ColabFold model – – No map 0.215 0.848 No Hit 0.0% —
4302 KP13_06632 hypothetical protein AlphaFold DB model + ColabFold model – – No map 0.214 0.975 No Hit 0.0% —
4303 KP13_04948 hypothetical protein AlphaFold DB model + ColabFold model – – No map N/A 0.214 No Hit 0.0% —
4304 KP13_02216 MSF superfamily transporter AlphaFold DB model + ColabFold model – – No map N/A 0.214 No Hit 0.0% —
4305 KP13_01566 M22 peptidase-like protein AlphaFold DB model + ColabFold model –
GO:0002949The attachment of a carbonyl group and a threonine to the amino group of the adenine residue immediately 3' of the anticodon, in tRNAs that decode ANN codons (where N is any base). GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
No map 0.214 0.605 No Hit 0.0% —
4306 KP13_01344 transposase for insertion sequence element IS1222 ColabFold model –
GO:0003676Binding to a nucleic acid. GO:0015074The process in which a DNA segment is incorporated into another, usually larger, DNA molecule such as a chromosome.
No map 0.214 0.239 No Hit 0.0% —
4307 KP13_00543 hypothetical protein ColabFold model – – No map N/A 0.214 No Hit 0.0% —
4308 KP13_05336 putative siderophore transport system ATP-binding protein AlphaFold DB model + ColabFold model –
GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. GO:0016887Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient. GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. +14 total
No map 0.213 0.201 Hit 34.2% 9.55e-07
4309 KP13_04697 hypothetical protein AlphaFold DB model + ColabFold model –
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
No map 0.213 0.923 No Hit 0.0% —
4310 KP13_04248 putative transcriptional regulator AlphaFold DB model + ColabFold model –
GO:0006355Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. GO:0000160A conserved series of molecular signals found in prokaryotes and eukaryotes; involves autophosphorylation of a histidine kinase and the transfer of the phosphate group to an aspartate that then acts as a phospho-donor to response regulator proteins. GO:0003677Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). +47 total
No map 0.213 0.251 No Hit 0.0% —
4311 KP13_04029 Gp10 phage protein AlphaFold DB model + ColabFold model – – No map N/A 0.213 No Hit 0.0% —
4312 KP13_02660 hypothetical protein ColabFold model – – No map 0.213 0.852 No Hit 0.0% —
4313 KP13_00358 hypothetical protein AlphaFold DB model + ColabFold model – – No map N/A 0.213 No Hit 0.0% —
4314 KP13_18751 putative phospholipid import ATP-binding protein mlaF mlaF AlphaFold DB model + ColabFold model –
GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. GO:0016887Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient. GO:0006869The directed movement of lipids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Lipids are compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent.
No map 0.212 0.7 Hit 33.3% 5.19e-09
4315 KP13_05432 putative oxidoreductase AlphaFold DB model + ColabFold model – – No map 0.212 0.737 No Hit 0.0% —
4316 KP13_04633 Protein sufA sufA AlphaFold DB model + ColabFold model –
GO:0016226The incorporation of iron and exogenous sulfur into a metallo-sulfur cluster. GO:0051536Binding to an iron-sulfur cluster, a combination of iron and sulfur atoms. GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. +14 total
No map N/A 0.212 Hit 37.7% 9.44e-25
4317 KP13_02718 Rieske [2Fe-2S] iron-sulfur domain-containing protein AlphaFold DB model + ColabFold model –
GO:0051537Binding to a 2 iron, 2 sulfur (2Fe-2S) cluster; this cluster consists of two iron atoms, with two inorganic sulfur atoms found between the irons and acting as bridging ligands. GO:0046872Binding to a metal ion.
No map N/A 0.212 Hit 34.3% 5.67e-09
4318 KP13_02282 hypothetical protein AlphaFold DB model + ColabFold model – – No map N/A 0.212 No Hit 0.0% —
4319 KP13_02217 Multidrug resistance outer membrane protein mdtP mdtP AlphaFold DB model + ColabFold model –
GO:0015562Enables the transfer of a specific substance or related group of substances from the inside of the cell to the outside of the cell across a membrane. GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0055085The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other. +25 total
No map 0.212 0.695 No Hit 0.0% —
4320 KP13_01253 Inner membrane ABC transporter permease protein AlphaFold DB model + ColabFold model –
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0022857Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other. GO:0055085The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other. +14 total
No map 0.212 0.443 No Hit 0.0% —
4321 KP13_01148 putative HTH-type transcriptional regulator AlphaFold DB model + ColabFold model –
GO:0006355Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. GO:0003700A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons. GO:0003677Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
No map 0.212 0.684 No Hit 0.0% —
4322 KP13_01019 3-octaprenyl-4-hydroxybenzoate carboxy-lyase ubiX AlphaFold DB model + ColabFold model
2.5.1.129
GO:0003824Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. GO:0016831Catalysis of the nonhydrolytic addition or removal of a carboxyl group to or from a compound. GO:0106141Catalysis of the reaction: dimethylallyl phosphate + FMNH2 = phosphate + prenyl-FMNH2.
No map 0.212 0.558 No Hit 0.0% —
4323 KP13_00444 Ribose transport system permease protein rbsC AlphaFold DB model + ColabFold model –
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0022857Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other. GO:0055085The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other. +14 total
No map 0.212 0.731 No Hit 0.0% —
4324 KP13_00129 50S ribosomal protein L21 AlphaFold DB model + ColabFold model –
GO:0005840An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins.
No map 0.212 0.66 No Hit 0.0% —
4325 KP13_05697 hypothetical protein AlphaFold DB model + ColabFold model – – No map N/A 0.211 No Hit 0.0% —
Page of 234 · 5842 total proteins