Proteins

Genome: KpKP13

Description: Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence

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# Protein Description Gene Structure EC GO Metabolism Druggability (P2Rank) P2RANK ligandability score for the best pocket in the experimental structure (0–1). Higher values indicate higher predicted ligandability. Available only for genomes analyzed with the curated pipeline. Druggability (FPocket) FPocket druggability score for the preferred structure (0–1): experimental structure when available, otherwise predicted model. ≥ 0.7 highly druggable · ≥ 0.4 moderately druggable · < 0.4 low druggability. Human off-target BLASTP against the human proteome. Hit means at least one human match was detected at e-value <= 1e-5. Prefer No hit for pathogen-selective targets. Human identity (%) Best human BLAST identity percentage. Human E-value Best human BLAST E-value.
4326 KP13_05430 hypothetical protein AlphaFold DB model + ColabFold model – – No map 0.211 0.708 No Hit 0.0% —
4327 KP13_05064 hypothetical protein ColabFold model –
GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0055085The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other. +14 total
No map 0.211 0.745 No Hit 0.0% —
4328 KP13_04154 putative protein psiA psiA AlphaFold DB model + ColabFold model – – No map 0.211 0.576 No Hit 0.0% —
4329 KP13_03957 hypothetical protein AlphaFold DB model + ColabFold model – – No map 0.211 0.177 No Hit 0.0% —
4330 KP13_03829 Esterase AlphaFold DB model + ColabFold model –
GO:0016787Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc.
No map 0.211 0.089 No Hit 0.0% —
4331 KP13_03537 Acetyltransferase AlphaFold DB model + ColabFold model
2.3.1.-
GO:0016747Catalysis of the transfer of an acyl group, other than amino-acyl, from one compound (donor) to another (acceptor).
No map 0.211 0.055 Hit 35.5% 1.57e-07
4332 KP13_32003 hypothetical protein AlphaFold DB model + ColabFold model – – No map N/A 0.21 No Hit 0.0% —
4333 KP13_04931 hypothetical protein AlphaFold DB model + ColabFold model – – No map 0.210 0.338 No Hit 0.0% —
4334 KP13_01609 KHG/KDPG aldolase eda AlphaFold DB model + ColabFold model
4.1.2.14
GO:0016829Catalysis of the cleavage of C-C, C-O, C-N and other bonds by other means than by hydrolysis or oxidation, or conversely adding a group to a double bond. They differ from other enzymes in that two substrates are involved in one reaction direction, but only one in the other direction. When acting on the single substrate, a molecule is eliminated and this generates either a new double bond or a new ring. GO:0008675Catalysis of the reaction: 2-dehydro-3-deoxy-D-gluconate 6-phosphate = pyruvate + D-glyceraldehyde 3-phosphate.
No map 0.210 0.94 No Hit 0.0% —
4335 KP13_00953 Capsular synthesis regulator component B rcsB AlphaFold DB model + ColabFold model –
GO:0006355Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. GO:0000160A conserved series of molecular signals found in prokaryotes and eukaryotes; involves autophosphorylation of a histidine kinase and the transfer of the phosphate group to an aspartate that then acts as a phospho-donor to response regulator proteins. GO:0003677Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
No map 0.210 0.409 No Hit 0.0% —
4336 KP13_04894 Lipoprotein-releasing system ATP-binding protein LolD lolD AlphaFold DB model + ColabFold model –
GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0016887Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient. +14 total
No map 0.209 0.55 Hit 54.1% 5.74e-06
4337 KP13_02767 hypothetical protein AlphaFold DB model + ColabFold model – – No map 0.209 0.834 No Hit 0.0% —
4338 KP13_02684 hypothetical protein AlphaFold DB model + ColabFold model – – No map N/A 0.209 No Hit 0.0% —
4339 KP13_04068 hypothetical protein ColabFold model – – No map N/A 0.208 No Hit 0.0% —
4340 KP13_03276 Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex sucB AlphaFold DB model + ColabFold model
2.3.1.61
GO:0045252A multi-enzyme complex that catalyzes the oxidative decarboxylation of alpha-ketoglutarate (also known as 2-oxoglutarate) to form succinyl-CoA. The complex comprises multiple copies of three enzymes referred to as E1, E2 and E3: oxoglutarate dehydrogenase (lipoamide) (E1), dihydrolipoamide S-succinyltransferase (E2) and dihydrolipoamide dehydrogenase (E3). Additional proteins may also be present. GO:0006099A nearly universal metabolic pathway in which the acetyl group of acetyl coenzyme A is effectively oxidized to two CO2 and four pairs of electrons are transferred to coenzymes. The acetyl group combines with oxaloacetate to form citrate, which undergoes successive transformations to isocitrate, 2-oxoglutarate, succinyl-CoA, succinate, fumarate, malate, and oxaloacetate again, thus completing the cycle. In eukaryotes the tricarboxylic acid is confined to the mitochondria. See also glyoxylate cycle. GO:0016746Catalysis of the transfer of an acyl group from one compound (donor) to another (acceptor). +36 total
No map 0.208 0.683 Hit 58.2% 7.31e-98
4341 KP13_02736 alanine racemase domain-containing protein AlphaFold DB model + ColabFold model –
GO:0030170Binding to pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6.
No map 0.208 0.873 Hit 66.7% 9.32e-06
4342 KP13_01642 L-arabinose-binding periplasmic protein araF AlphaFold DB model + ColabFold model –
GO:0042882The process in which L-arabinose, the L-enantiomer of arabinose, is transported across a lipid bilayer, from one side of a membrane to the other. GO:0030288The region between the inner (cytoplasmic or plasma) membrane and outer membrane of organisms with two membranes such as Gram negative bacteria. These periplasmic spaces are relatively thick and contain a thin peptidoglycan layer (PGL), also referred to as a thin cell wall. GO:0030246Binding to a carbohydrate, which includes monosaccharides, oligosaccharides and polysaccharides as well as substances derived from monosaccharides by reduction of the carbonyl group (alditols), by oxidation of one or more hydroxy groups to afford the corresponding aldehydes, ketones, or carboxylic acids, or by replacement of one or more hydroxy group(s) by a hydrogen atom. Cyclitols are generally not regarded as carbohydrates.
No map 0.208 0.576 No Hit 0.0% —
4343 KP13_00294 hypothetical protein AlphaFold DB model + ColabFold model – – No map N/A 0.208 No Hit 0.0% —
4344 KP13_00072 hypothetical protein AlphaFold DB model + ColabFold model
1.1.99.-
GO:0016491Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced.
No map 0.208 0.704 No Hit 0.0% —
4345 KP13_32394 putative HTH-type transcriptional regulator AlphaFold DB model + ColabFold model –
GO:0043565Binding to DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. GO:0006355Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. GO:0003700A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons.
No map 0.207 0.317 No Hit 0.0% —
4346 KP13_03818 putative transposase AlphaFold DB model + ColabFold model –
GO:1990238Catalysis of the hydrolysis of ester linkages within a double-stranded DNA molecule by creating internal breaks. GO:0006310Any process in which a new genotype is formed by reassortment of genes resulting in gene combinations different from those that were present in the parents. In eukaryotes genetic recombination can occur by chromosome assortment, intrachromosomal recombination, or nonreciprocal interchromosomal recombination. Interchromosomal recombination occurs by crossing over. In bacteria it may occur by genetic transformation, conjugation, transduction, or F-duction.
No map 0.207 0.306 No Hit 0.0% —
4347 KP13_02800 Zinc transporter zupT zupT AlphaFold DB model + ColabFold model –
GO:0030001The directed movement of metal ions, any metal ion with an electric charge, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. GO:0055085The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other. GO:0046873Enables the transfer of metal ions from one side of a membrane to the other. +25 total
No map 0.207 0.766 Hit 39.8% 1.53e-08
4348 KP13_01994 hypothetical protein ColabFold model – – No map 0.207 0.741 No Hit 0.0% —
4349 KP13_01477 Type VI secretion system domain-containing protein AlphaFold DB model + ColabFold model – – No map N/A 0.207 No Hit 0.0% —
4350 KP13_00916 hypothetical protein ColabFold model – – No map N/A 0.207 No Hit 0.0% —
Page of 234 · 5842 total proteins