Proteins

Genome: KpKP13

Description: Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence

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# Protein Description Gene Structure EC GO Metabolism Druggability (P2Rank) P2RANK ligandability score for the best pocket in the experimental structure (0–1). Higher values indicate higher predicted ligandability. Available only for genomes analyzed with the curated pipeline. Druggability (FPocket) FPocket druggability score for the preferred structure (0–1): experimental structure when available, otherwise predicted model. ≥ 0.7 highly druggable · ≥ 0.4 moderately druggable · < 0.4 low druggability. Human off-target BLASTP against the human proteome. Hit means at least one human match was detected at e-value <= 1e-5. Prefer No hit for pathogen-selective targets. Human identity (%) Best human BLAST identity percentage. Human E-value Best human BLAST E-value.
4251 KP13_01513 AIG2 family protein AlphaFold DB model + ColabFold model – – No map 0.223 0.442 No Hit 0.0% —
4252 KP13_03812 Phosphoribosylformylglycinamidine cyclo-ligase purM AlphaFold DB model + ColabFold model –
GO:0004641Catalysis of the reaction: 2-(formamido)-N(1)-(5-phospho-D-ribosyl)acetamidine + ATP = 5-amino-1-(5-phospho-D-ribosyl)imidazole + ADP + 2 H+ + phosphate. GO:0006189The chemical reactions and pathways resulting in the formation of IMP, inosine monophosphate, by the stepwise assembly of a purine ring on ribose 5-phosphate.
No map 0.222 0.456 Hit 49.4% 1.41e-106
4253 KP13_02772 Biopolymer transport protein exbD exbD AlphaFold DB model + ColabFold model –
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0055085The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other. GO:0022857Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other. +36 total
No map N/A 0.222 No Hit 0.0% —
4254 KP13_01681 putative inner membrane protein AlphaFold DB model + ColabFold model – – No map 0.222 0.842 No Hit 0.0% —
4255 KP13_32182 Protein hfq hfq AlphaFold DB model + ColabFold model –
GO:0006355Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. GO:0003723Binding to an RNA molecule or a portion thereof. GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. +25 total
No map N/A 0.221 No Hit 0.0% —
4256 KP13_05506 Glutamyl-tRNA(Gln) amidotransferase subunit A gatA AlphaFold DB model + ColabFold model
6.3.5.-
GO:0003824Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. GO:0016787Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. GO:0016874Catalysis of the joining of two molecules, or two groups within a single molecule, using the energy from the hydrolysis of ATP, a similar triphosphate, or a pH gradient.
No map 0.221 0.8 Hit 38.7% 3.29e-13
4257 KP13_03880 Heat shock protein hspQ hspQ AlphaFold DB model + ColabFold model –
GO:0009408Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a heat stimulus, a temperature stimulus above the optimal temperature for that organism. GO:0003677Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
No map N/A 0.221 No Hit 0.0% —
4258 KP13_03713 Cation efflux system protein cusF cusF AlphaFold DB model + ColabFold model – – No map N/A 0.221 No Hit 0.0% —
4259 KP13_03413 putative lipoprotein AlphaFold DB model + ColabFold model – – No map N/A 0.221 No Hit 0.0% —
4260 KP13_02668 hypothetical protein AlphaFold DB model + ColabFold model –
GO:0008168Catalysis of the transfer of a methyl group to an acceptor molecule. GO:0032259The process in which a methyl group is covalently attached to a molecule.
No map 0.221 0.278 No Hit 0.0% —
4261 KP13_01433 replication initiation protein RepC repC AlphaFold DB model + ColabFold model – – No map N/A 0.221 No Hit 0.0% —
4262 KP13_00981 NADH-quinone oxidoreductase subunit N nuoN AlphaFold DB model + ColabFold model
7.1.1.-
GO:0042773The transfer of electrons through a series of electron donors and acceptors, generating energy that is ultimately used for synthesis of ATP. GO:0008137Catalysis of the reaction: NADH + ubiquinone + 5 H+(in) = NAD+ + ubiquinol + 4 H+(out). GO:0012505A collection of membranous structures involved in transport within the cell. The main components of the endomembrane system are endoplasmic reticulum, Golgi bodies, vesicles, cell membrane and nuclear envelope. Members of the endomembrane system pass materials through each other or though the use of vesicles. +36 total
No map 0.221 0.953 Hit 21.9% 7.77e-12
4263 KP13_04616 putative ABC transporter ATP-binding protein AlphaFold DB model + ColabFold model –
GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. GO:0016887Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient.
No map 0.220 0.407 Hit 32.9% 3.65e-09
4264 KP13_03671 competence protein ComEA-related protein AlphaFold DB model + ColabFold model –
GO:0006281The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway. GO:0003677Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). GO:0015627A large protein complex, containing 12-15 subunits, that spans the cell envelope of Gram-negative bacteria and mediates the movement of proteins into the extracellular environment. The complex includes a component in the cytoplasm, an inner membrane subcomplex that reaches into the periplasmic compartment and a secretion pore in the outer membrane. Proteins using the Type II pathway are transported across the cytoplasmic membrane by the Sec or Tat complex. +14 total
No map N/A 0.22 Hit 37.5% 4.21e-06
4265 KP13_02641 hypothetical protein AlphaFold DB model + ColabFold model – – No map N/A 0.22 No Hit 0.0% —
4266 KP13_02315 Propanediol dehydratase small subunit pduE AlphaFold DB model + ColabFold model – – No map 0.220 0.604 No Hit 0.0% —
4267 KP13_01786 Lipoprotein NlpE nlpE AlphaFold DB model + ColabFold model – – No map 0.220 0.436 No Hit 0.0% —
4268 KP13_31857 hypothetical protein ColabFold model – – No map N/A 0.219 No Hit 0.0% —
4269 KP13_03663 Multidrug resistance-like ATP-binding protein MdlB mdlB AlphaFold DB model + ColabFold model
7.6.2.2
GO:0016887Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient. GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. +58 total
No map 0.219 0.71 Hit 54.3% 6.06e-22
4270 KP13_03406 Ferric enterobactin transport ATP-binding protein fepC fepC AlphaFold DB model + ColabFold model –
GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. GO:0016887Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient. GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. +14 total
No map 0.219 0.178 Hit 32.0% 3.42e-15
4271 KP13_03333 LPS-assembly lipoprotein lptE lptE AlphaFold DB model + ColabFold model –
GO:0043165The assembly of an outer membrane of the type formed in Gram-negative bacteria. This membrane is enriched in polysaccharide and protein, and the outer leaflet of the membrane contains specific lipopolysaccharide structures. GO:0019867The external membrane of Gram-negative bacteria or certain organelles such as mitochondria and chloroplasts; freely permeable to most ions and metabolites. GO:0009279A lipid bilayer that forms the outermost membrane of the cell envelope; enriched in polysaccharide and protein; the outer leaflet of the membrane contains specific lipopolysaccharide structures. +36 total
No map N/A 0.219 No Hit 0.0% —
4272 KP13_03198 Inner membrane protein AlphaFold DB model + ColabFold model –
GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
No map 0.219 0.409 No Hit 0.0% —
4273 KP13_01536 hypothetical protein AlphaFold DB model + ColabFold model –
GO:0004497Catalysis of the incorporation of one atom of molecular oxygen (O2) into the substrate and the reduction of the other atom of O2 to water.
No map N/A 0.219 No Hit 0.0% —
4274 KP13_00317 Nickel import ATP-binding protein NikE nikE AlphaFold DB model + ColabFold model
7.2.2.11
GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0016887Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient. GO:0016151Binding to a nickel (Ni) cation. +36 total
No map 0.219 0.459 Hit 38.5% 3.03e-06
4275 KP13_05314 Glyoxalase/bleomycin resistance protein/dioxygenase domain-containing protein AlphaFold DB model + ColabFold model – – No map 0.218 0.592 No Hit 0.0% —
Page of 234 · 5842 total proteins