Proteins

Genome: KpKP13

Description: Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence

Search, filter, and prioritize proteins.

Export view
5842 proteins

Scoring formula None

Sorted by Druggability (descending)

Applied filters No active filters

Search query No active search

Rows per page 25

Rows
# Protein Description Gene Structure EC GO Druggability FPocket druggability score for the preferred structure (0–1): experimental structure when available, otherwise predicted model. ≥ 0.7 highly druggable · ≥ 0.4 moderately druggable · < 0.4 low druggability. Human off-target BLASTP against the human proteome. Hit means at least one human match was detected at e-value <= 1e-5. Prefer No hit for pathogen-selective targets. Human identity (%) Best human BLAST identity percentage. Human E-value Best human BLAST E-value.
4251 KP13_00843 tRNA (cytidine/uridine-2'-O-)-methyltransferase TrmJ trmJ AlphaFold + ColabFold
2.1.1.200
GO:0008173Catalysis of the transfer of a methyl group from a donor to a nucleoside residue in an RNA molecule. GO:0006396Any process involved in the conversion of one or more primary RNA transcripts into one or more mature RNA molecules. GO:0003723Binding to an RNA molecule or a portion thereof. +47 total
0.352 No Hit 0.0% —
4252 KP13_00668 hypothetical protein AlphaFold + ColabFold – – 0.352 No Hit 0.0% —
4253 KP13_04676 Translation initiation factor IF-3 infC AlphaFold + ColabFold –
GO:0003743Functions in the initiation of ribosome-mediated translation of mRNA into a polypeptide. GO:0006413The process preceding formation of the peptide bond between the first two amino acids of a protein. This includes the formation of a complex of the ribosome, mRNA or circRNA, and an initiation complex that contains the first aminoacyl-tRNA. GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. +36 total
0.351 No Hit 0.0% —
4254 KP13_03766 hypothetical protein AlphaFold + ColabFold – – 0.351 No Hit 0.0% —
4255 KP13_02733 putative Holliday junction resolvase AlphaFold + ColabFold –
GO:0006364Any process involved in the conversion of a primary ribosomal RNA (rRNA) transcript into one or more mature rRNA molecules. GO:0006139Any cellular metabolic process involving nucleobases, nucleosides, nucleotides and nucleic acids.
0.351 No Hit 0.0% —
4256 KP13_00495 hypothetical protein AlphaFold + ColabFold – – 0.351 No Hit 0.0% —
4257 KP13_05739 hypothetical protein AlphaFold + ColabFold – – 0.35 No Hit 0.0% —
4258 KP13_01377 hypothetical protein AlphaFold + ColabFold – – 0.35 No Hit 0.0% —
4259 KP13_00206 hypothetical protein AlphaFold + ColabFold –
GO:0005975The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y.
0.35 No Hit 0.0% —
4260 KP13_06648 hypothetical protein ColabFold – – 0.349 No Hit 0.0% —
4261 KP13_04715 Nitrate/nitrite response regulator protein narL narL AlphaFold + ColabFold –
GO:0006355Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. GO:0000160A conserved series of molecular signals found in prokaryotes and eukaryotes; involves autophosphorylation of a histidine kinase and the transfer of the phosphate group to an aspartate that then acts as a phospho-donor to response regulator proteins. GO:0003677Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). +25 total
0.349 No Hit 0.0% —
4262 KP13_02700 Ketol-acid reductoisomerase ilvC AlphaFold + ColabFold
1.1.1.86
GO:0016491Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. GO:0004455Catalysis of the reaction: (R)-2,3-dihydroxy-3-methylbutanoate + NADP+ = (S)-2-hydroxy-2-methyl-3-oxobutanoate + NADPH + H+. GO:0009082The chemical reactions and pathways resulting in the formation of amino acids containing a branched carbon skeleton, comprising isoleucine, leucine and valine. +47 total
0.349 No Hit 0.0% —
4263 KP13_02227 Outer membrane usher protein fimD fimD AlphaFold + ColabFold –
GO:0005515Binding to a protein. GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0015473A porin that acts in the assembly of fimbria together with fimbrial chaperone. +25 total
0.349 No Hit 0.0% —
4264 KP13_02058 Acyl carrier protein phosphodiesterase acpH ColabFold –
GO:0006633The chemical reactions and pathways resulting in the formation of a fatty acid, any of the aliphatic monocarboxylic acids that can be liberated by hydrolysis from naturally occurring fats and oils. Fatty acids are predominantly straight-chain acids of 4 to 24 carbon atoms, which may be saturated or unsaturated; branched fatty acids and hydroxy fatty acids also occur, and very long chain acids of over 30 carbons are found in waxes. GO:0008770Catalysis of the reaction: [acyl-carrier protein] + H2O = 4'-phosphopantetheine + apoprotein.
0.349 No Hit 0.0% —
4265 KP13_01607 YebG family protein AlphaFold + ColabFold – – 0.349 No Hit 0.0% —
4266 KP13_01563 Ribonuclease D rnd AlphaFold + ColabFold
3.1.13.5
GO:0044237OBSOLETE. The chemical reactions and pathways by which individual cells transform chemical substances. GO:0003676Binding to a nucleic acid. GO:0033890Catalysis of the exonucleolytic cleavage that removes extra residues from the 3'-terminus of tRNA to produce 5'-mononucleotides. +69 total
0.349 Hit 25.5% 6.64e-10
4267 KP13_00833 NAGC-like transcriptional regulator AlphaFold + ColabFold –
GO:0003677Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). GO:0006351The synthesis of an RNA transcript from a DNA template.
0.349 Hit 26.5% 5.01e-14
4268 KP13_00282 Cellulose biosynthesis protein BcsF bcsF AlphaFold + ColabFold – – 0.349 No Hit 0.0% —
4269 KP13_31936 aspartyl-tRNA synthetase aspS AlphaFold + ColabFold
6.1.1.12
GO:0004812Catalysis of the formation of aminoacyl-tRNA from ATP, amino acid, and tRNA with the release of diphosphate and AMP. GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. GO:0003676Binding to a nucleic acid. +69 total
0.348 Hit 63.0% 1.23e-06
4270 KP13_05837 hypothetical protein ColabFold – – 0.348 No Hit 0.0% —
4271 KP13_05510 regulation of transcription, DNA-dependent sugar isomerase domain-containing protein AlphaFold + ColabFold –
GO:1901135The chemical reactions and pathways involving carbohydrate derivative. GO:0006355Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. GO:0003700A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons. +36 total
0.348 No Hit 0.0% —
4272 KP13_03625 hypothetical protein AlphaFold + ColabFold – – 0.348 No Hit 0.0% —
4273 KP13_03412 putative periplasmic binding protein/LacI transcriptional regulator AlphaFold + ColabFold –
GO:0030313An envelope that surrounds a bacterial cell and includes the cytoplasmic membrane and everything external, encompassing the periplasmic space, cell wall, and outer membrane if present. GO:0030246Binding to a carbohydrate, which includes monosaccharides, oligosaccharides and polysaccharides as well as substances derived from monosaccharides by reduction of the carbonyl group (alditols), by oxidation of one or more hydroxy groups to afford the corresponding aldehydes, ketones, or carboxylic acids, or by replacement of one or more hydroxy group(s) by a hydrogen atom. Cyclitols are generally not regarded as carbohydrates. GO:0055085The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other.
0.348 No Hit 0.0% —
4274 KP13_01529 ABC-type high-affinity branched-chain amino acid transport system livJ AlphaFold + ColabFold –
GO:0006865The directed movement of amino acids, organic acids containing one or more amino substituents, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
0.348 No Hit 0.0% —
4275 KP13_00770 30S ribosomal protein S13 rpsM AlphaFold + ColabFold –
GO:0003735The action of a molecule that contributes to the structural integrity of the ribosome. GO:0003676Binding to a nucleic acid. GO:0006412The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA or circRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA or circRNA. Translation ends with the release of a polypeptide chain from the ribosome. +69 total
0.348 Hit 27.3% 4.49e-06
Page of 234 · 5842 total proteins