Proteins

Genome: KpKP13

Description: Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence

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5192 proteins Structure: AlphaFold

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Structure: AlphaFold ×
# Protein Description Gene Structure EC GO Druggability FPocket druggability score for the preferred structure (0–1): experimental structure when available, otherwise predicted model. ≥ 0.7 highly druggable · ≥ 0.4 moderately druggable · < 0.4 low druggability. Human off-target BLASTP against the human proteome. Hit means at least one human match was detected at e-value <= 1e-5. Prefer No hit for pathogen-selective targets. Human identity (%) Best human BLAST identity percentage. Human E-value Best human BLAST E-value.
4326 KP13_01850 2'-5'-RNA ligase ligT AlphaFold + ColabFold
3.1.4.58
GO:0008664Catalysis the reaction: a 3'-end 2',3'-cyclophospho-ribonucleotide-RNA + H2O = a 3'-end 2'-phospho-ribonucleotide-RNA + H+. GO:0004113Catalysis of the reaction: nucleoside 2',3'-cyclic phosphate + H2O = nucleoside 2'-phosphate. GO:0016874Catalysis of the joining of two molecules, or two groups within a single molecule, using the energy from the hydrolysis of ATP, a similar triphosphate, or a pH gradient.
0.258 No Hit 0.0% —
4327 KP13_00363 LpxA-like domain-containing transferase AlphaFold + ColabFold – – 0.258 No Hit 0.0% —
4328 KP13_04338 putative type VI secretion system protein AlphaFold + ColabFold – – 0.257 No Hit 0.0% —
4329 KP13_02913 Xanthine phosphoribosyltransferase gpt AlphaFold + ColabFold
2.4.2.22
GO:0000310Catalysis of the reaction: diphosphate + XMP = 5-phospho-alpha-D-ribose 1-diphosphate + xanthine. GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. +710 total
0.257 No Hit 0.0% —
4330 KP13_02402 Sulfate adenylyltransferase subunit 1 cysN AlphaFold + ColabFold
2.7.7.4
GO:0003924Catalysis of the reaction: GTP + H2O = GDP + H+ + phosphate. GO:0005525Binding to GTP, guanosine triphosphate. GO:0006790The chemical reactions and pathways involving the nonmetallic element sulfur or compounds that contain sulfur, such as the amino acids methionine and cysteine or the tripeptide glutathione. +47 total
0.257 Hit 37.1% 2.19e-28
4331 KP13_31601 HTH-type transcriptional regulator hdfR hdfR AlphaFold + ColabFold –
GO:0006355Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. GO:0045892Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription. GO:0003677Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). +14 total
0.256 No Hit 0.0% —
4332 KP13_04750 Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase AlphaFold + ColabFold
2.4.2.21
GO:0008939Catalysis of the reaction: 5,6-dimethylbenzimidazole + nicotinate D-ribonucleotide = alpha-ribazole 5'-phosphate + H+ + nicotinate. GO:0009236The chemical reactions and pathways resulting in the formation of cobalamin (vitamin B12), a water-soluble vitamin characterized by possession of a corrin nucleus containing a cobalt atom.
0.256 No Hit 0.0% —
4333 KP13_03748 putative response regulatory protein AlphaFold + ColabFold –
GO:0000160A conserved series of molecular signals found in prokaryotes and eukaryotes; involves autophosphorylation of a histidine kinase and the transfer of the phosphate group to an aspartate that then acts as a phospho-donor to response regulator proteins. GO:0003677Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). GO:0000156Responds to a phosphorelay sensor to initiate a change in cell state or activity. The activity of the response regulator is regulated by transfer of a phosphate from a histidine residue in the sensor, to an aspartate residue in the response regulator. Many but not all response regulators act as transcriptional regulators to elicit a response. +14 total
0.256 No Hit 0.0% —
4334 KP13_01504 pyocin domain-containing protein AlphaFold + ColabFold – – 0.256 No Hit 0.0% —
4335 KP13_02895 Tetratricopeptide repeat-containing protein AlphaFold + ColabFold –
GO:0005515Binding to a protein.
0.255 No Hit 0.0% —
4336 KP13_02446 Xylose isomerase domain-containing protein AlphaFold + ColabFold – – 0.255 No Hit 0.0% —
4337 KP13_31979 hypothetical protein AlphaFold + ColabFold – – 0.254 No Hit 0.0% —
4338 KP13_03932 isochorismatase-like hydrolase AlphaFold + ColabFold –
GO:0016787Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc.
0.254 Hit 27.4% 5.70e-06
4339 KP13_03411 putative enterobactin synthetase, component D AlphaFold + ColabFold –
GO:0016780Catalysis of the transfer of a substituted phosphate group, other than diphosphate or nucleotidyl residues, from one compound (donor) to a another (acceptor). GO:0008897Catalysis of the reaction: CoA + substrate-serine = adenosine 3',5'-bisphosphate + substrate-serine-4'-phosphopantetheine. The transfer of the 4'-phosphopantetheine (Ppant) co-factor from coenzyme A to the hydroxyl side chain of the serine residue of acyl- or peptidyl-carrier protein (ACP or PCP) to convert them from the apo to the holo form. GO:0000287Binding to a magnesium (Mg) ion. +36 total
0.254 No Hit 0.0% —
4340 KP13_00613 PilT domain-containing protein AlphaFold + ColabFold –
GO:0004540Catalysis of the cleavage of phosphodiester bonds in chains of RNA.
0.254 No Hit 0.0% —
4341 KP13_02727 Galactose-proton symporter galP AlphaFold + ColabFold –
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0022857Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other. GO:0055085The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other. +36 total
0.253 Hit 37.6% 1.09e-12
4342 KP13_02191 tRNA-modifying protein AlphaFold + ColabFold –
GO:0009451The covalent alteration of one or more nucleotides within an RNA molecule to produce an RNA molecule with a sequence that differs from that coded genetically. GO:0005542Binding to folic acid, pteroylglutamic acid. Folic acid is widely distributed as a member of the vitamin B complex and is essential for the synthesis of purine and pyrimidines. GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. +25 total
0.253 No Hit 0.0% —
4343 KP13_02830 Positive transcription regulator evgA evgA AlphaFold + ColabFold –
GO:0006355Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. GO:0000160A conserved series of molecular signals found in prokaryotes and eukaryotes; involves autophosphorylation of a histidine kinase and the transfer of the phosphate group to an aspartate that then acts as a phospho-donor to response regulator proteins. GO:0003677Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
0.252 No Hit 0.0% —
4344 KP13_02581 hypothetical protein AlphaFold + ColabFold –
GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. GO:0016788Catalysis of the hydrolysis of any ester bond. GO:0016070The cellular chemical reactions and pathways involving RNA, ribonucleic acid, one of the two main type of nucleic acid, consisting of a long, unbranched macromolecule formed from ribonucleotides joined in 3',5'-phosphodiester linkage. +14 total
0.252 No Hit 0.0% —
4345 KP13_02436 hypothetical protein AlphaFold + ColabFold –
GO:0016740Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2.
0.252 No Hit 0.0% —
4346 KP13_05591 hypothetical protein AlphaFold + ColabFold – – 0.251 No Hit 0.0% —
4347 KP13_05223 putative lipoprotein AlphaFold + ColabFold – – 0.251 No Hit 0.0% —
4348 KP13_04394 Ribosomal small subunit pseudouridine synthase A rsuA AlphaFold + ColabFold
5.4.99.-
GO:0009451The covalent alteration of one or more nucleotides within an RNA molecule to produce an RNA molecule with a sequence that differs from that coded genetically. GO:0009982Catalysis of the reaction: a uridine in RNA = a pseudouridine in RNA. Conversion of uridine in an RNA molecule to pseudouridine by rotation of the C1'-N-1 glycosidic bond of uridine in RNA to a C1'-C5. GO:0001522The intramolecular conversion of uridine to pseudouridine within an RNA molecule. +58 total
0.251 No Hit 0.0% —
4349 KP13_04248 putative transcriptional regulator AlphaFold + ColabFold –
GO:0006355Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. GO:0000160A conserved series of molecular signals found in prokaryotes and eukaryotes; involves autophosphorylation of a histidine kinase and the transfer of the phosphate group to an aspartate that then acts as a phospho-donor to response regulator proteins. GO:0003677Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). +47 total
0.251 No Hit 0.0% —
4350 KP13_01201 Inner membrane ABC transporter permease protein AlphaFold + ColabFold –
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0055085The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other. GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
0.251 No Hit 0.0% —
Page of 208 · 5192 total proteins