Proteins

Genome: KpKP13

Description: Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence

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# Protein Description Gene Structure EC GO Metabolism Druggability (P2Rank) P2RANK ligandability score for the best pocket in the experimental structure (0–1). Higher values indicate higher predicted ligandability. Available only for genomes analyzed with the curated pipeline. Druggability (FPocket) FPocket druggability score for the preferred structure (0–1): experimental structure when available, otherwise predicted model. ≥ 0.7 highly druggable · ≥ 0.4 moderately druggable · < 0.4 low druggability. Human off-target BLASTP against the human proteome. Hit means at least one human match was detected at e-value <= 1e-5. Prefer No hit for pathogen-selective targets. Human identity (%) Best human BLAST identity percentage. Human E-value Best human BLAST E-value.
4451 KP13_01261 transposase for insertion sequence element ISKpn1 AlphaFold DB model + ColabFold model –
GO:0043565Binding to DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding.
No map 0.186 0.623 No Hit 0.0% —
4452 KP13_32096 hypothetical protein AlphaFold DB model + ColabFold model – – No map N/A 0.185 No Hit 0.0% —
4453 KP13_04973 putative enoyl-CoA hydratase paaG paaG AlphaFold DB model + ColabFold model –
GO:0010124The chemical reactions and pathways resulting in the breakdown of phenylacetate. GO:0003824Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic.
No map 0.185 0.828 Hit 37.1% 7.35e-07
4454 KP13_03331 hypothetical protein AlphaFold DB model + ColabFold model – – No map 0.185 0.548 No Hit 0.0% —
4455 KP13_02363 Methionine import ATP-binding protein AlphaFold DB model + ColabFold model –
GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. GO:0016887Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient. GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. +14 total
No map 0.185 0.587 Hit 37.8% 1.16e-28
4456 KP13_02341 Bifunctional adenosylcobalamin biosynthesis protein cobU cobU Experimental + ColabFold model
2.7.1.156 2.7.7.62
GO:0000166Binding to a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose. GO:0043752Catalysis of the reaction: RTP + adenosylcobinamide = adenosylcobinamide phosphate + RDP (where RTP is either ATP or GTP). GO:0009236The chemical reactions and pathways resulting in the formation of cobalamin (vitamin B12), a water-soluble vitamin characterized by possession of a corrin nucleus containing a cobalt atom. +36 total
No map 0.185 0.345 No Hit 0.0% —
4457 KP13_01777 hypothetical protein ColabFold model – – No map N/A 0.185 No Hit 0.0% —
4458 KP13_32164 transposase insH for insertion sequence element IS5H AlphaFold DB model + ColabFold model –
GO:0004803Catalysis of the transposition of transposable elements or transposons. Transposases are involved in recombination required for transposition and are site-specific for the transposon/transposable element. GO:0006313A type of transposition in which a transposable element (transposon) is moved to another part of a genome, either by a cut-and-paste mechanism or a replicative mechanism. GO:0003677Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
No map 0.184 0.5 No Hit 0.0% —
4459 KP13_32073 hypothetical protein ColabFold model – – No map N/A 0.184 No Hit 0.0% —
4460 KP13_32067 hypothetical protein ColabFold model – – No map N/A 0.184 No Hit 0.0% —
4461 KP13_32057 transposase insH for insertion sequence element IS5 AlphaFold DB model + ColabFold model –
GO:0004803Catalysis of the transposition of transposable elements or transposons. Transposases are involved in recombination required for transposition and are site-specific for the transposon/transposable element. GO:0006313A type of transposition in which a transposable element (transposon) is moved to another part of a genome, either by a cut-and-paste mechanism or a replicative mechanism. GO:0003677Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
No map 0.184 0.5 No Hit 0.0% —
4462 KP13_05292 hypothetical protein AlphaFold DB model + ColabFold model – – No map N/A 0.184 No Hit 0.0% —
4463 KP13_04270 Putative undecaprenyl-diphosphatase AlphaFold DB model + ColabFold model
3.6.1.27
GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0050380Catalysis of the reaction: di-trans,octa-cis-undecaprenyl diphosphate + H2O = di-trans,octa-cis-undecaprenyl phosphate + H+ + phosphate.
No map 0.184 0.975 No Hit 0.0% —
4464 KP13_03836 GDP-mannose pyrophosphatase nudK AlphaFold DB model + ColabFold model –
GO:0016818Catalysis of the hydrolysis of any acid anhydride which contains phosphorus. GO:0046872Binding to a metal ion. GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. +25 total
No map 0.184 0.323 Hit 32.4% 1.07e-08
4465 KP13_03073 transposase insH for insertion sequence element IS5 insH3 AlphaFold DB model + ColabFold model –
GO:0004803Catalysis of the transposition of transposable elements or transposons. Transposases are involved in recombination required for transposition and are site-specific for the transposon/transposable element. GO:0006313A type of transposition in which a transposable element (transposon) is moved to another part of a genome, either by a cut-and-paste mechanism or a replicative mechanism. GO:0003677Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
No map 0.184 0.5 No Hit 0.0% —
4466 KP13_01203 transposase insH for insertion sequence element IS5H insH6 AlphaFold DB model + ColabFold model –
GO:0004803Catalysis of the transposition of transposable elements or transposons. Transposases are involved in recombination required for transposition and are site-specific for the transposon/transposable element. GO:0006313A type of transposition in which a transposable element (transposon) is moved to another part of a genome, either by a cut-and-paste mechanism or a replicative mechanism. GO:0003677Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
No map 0.184 0.5 No Hit 0.0% —
4467 KP13_12496 hypothetical protein AlphaFold DB model + ColabFold model – – No map N/A 0.183 No Hit 0.0% —
4468 KP13_05309 Heme exporter protein B ccmB AlphaFold DB model + ColabFold model –
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0015232Enables the transfer of heme from one side of a membrane to the other. GO:0015886The directed movement of heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. +36 total
No map 0.183 0.69 No Hit 0.0% —
4469 KP13_03995 hypothetical protein ColabFold model – – No map N/A 0.183 No Hit 0.0% —
4470 KP13_03076 hypothetical protein AlphaFold DB model + ColabFold model – – No map 0.183 0.527 No Hit 0.0% —
4471 KP13_02749 hypothetical protein AlphaFold DB model + ColabFold model – – No map 0.183 0.771 No Hit 0.0% —
4472 KP13_01618 Zinc import ATP-binding protein znuC znuC AlphaFold DB model + ColabFold model –
GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. GO:0016887Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient. GO:0010043Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a zinc ion stimulus. +14 total
No map 0.183 0.414 Hit 41.5% 1.32e-07
4473 KP13_00613 PilT domain-containing protein AlphaFold DB model + ColabFold model –
GO:0004540Catalysis of the cleavage of phosphodiester bonds in chains of RNA.
No map 0.183 0.254 No Hit 0.0% —
4474 KP13_00024 ATP synthase gamma chain atpG AlphaFold DB model + ColabFold model –
GO:0045261OBSOLETE. The sector of a hydrogen-transporting ATP synthase complex in which the catalytic activity resides; it comprises the catalytic core and central stalk, and is peripherally associated with a membrane, such as the plasma membrane or the mitochondrial inner membrane, when the entire ATP synthase is assembled. GO:0015986The chemical reactions and pathways resulting in the formation of ATP driven by transport of protons across a membrane to generate an electrochemical gradient (proton-motive force). GO:0046933Enables the synthesis of ATP from ADP and phosphate by the transfer of protons from one side of a membrane to the other by a rotational mechanism driven by a gradient according to the reaction: ADP + phosphate + 5 H+(out) => ATP + H2O + 4 H+(in). +47 total
No map 0.183 0.48 Hit 30.2% 1.60e-27
4475 KP13_05613 hypothetical protein AlphaFold DB model + ColabFold model – – No map 0.182 0.515 No Hit 0.0% —
Page of 234 · 5842 total proteins