Proteins

Genome: KpKP13

Description: Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence

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# Protein Description Gene Structure EC GO Metabolism Druggability (P2Rank) P2RANK ligandability score for the best pocket in the experimental structure (0–1). Higher values indicate higher predicted ligandability. Available only for genomes analyzed with the curated pipeline. Druggability (FPocket) FPocket druggability score for the preferred structure (0–1): experimental structure when available, otherwise predicted model. ≥ 0.7 highly druggable · ≥ 0.4 moderately druggable · < 0.4 low druggability. Human off-target BLASTP against the human proteome. Hit means at least one human match was detected at e-value <= 1e-5. Prefer No hit for pathogen-selective targets. Human identity (%) Best human BLAST identity percentage. Human E-value Best human BLAST E-value.
4426 KP13_06737 conjugal transfer TrbB-like protein trbB AlphaFold DB model + ColabFold model –
GO:0044097The controlled release of proteins or DNA by a cell, via the type IV secretion system. GO:0043684A complex of proteins related to those involved in bacterial DNA conjugative transfer, that permits the transfer of DNA or proteins into the extracellular milieu or directly into host cells. In general the type IV complex forms a multisubunit cell-envelope-spanning structure composed of a secretion channel and often a pilus or other surface filament or protein(s). GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. +14 total
No map 0.189 0.653 No Hit 0.0% —
4427 KP13_04726 putative aromatic amino acid transporter AlphaFold DB model + ColabFold model –
GO:0003333The process in which an amino acid is transported across a membrane. GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
No map 0.189 0.602 No Hit 0.0% —
4428 KP13_03882 phosphatidylethanolamine-binding protein AlphaFold DB model + ColabFold model – – No map 0.189 0.482 No Hit 0.0% —
4429 KP13_01830 hypothetical protein AlphaFold DB model + ColabFold model – – No map N/A 0.189 No Hit 0.0% —
4430 KP13_01358 50S ribosomal protein L10 rplJ AlphaFold DB model + ColabFold model –
GO:0003735The action of a molecule that contributes to the structural integrity of the ribosome. GO:0015934The larger of the two subunits of a ribosome. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). GO:0006412The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA or circRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA or circRNA. Translation ends with the release of a polypeptide chain from the ribosome. +14 total
No map 0.189 0.559 No Hit 0.0% —
4431 KP13_31586 hypothetical protein ColabFold model – – No map N/A 0.188 No Hit 0.0% —
4432 KP13_31551 LysR family transcriptional regulator AlphaFold DB model + ColabFold model –
GO:0006355Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. GO:0003700A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons. GO:0043565Binding to DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. +14 total
No map 0.188 0.712 No Hit 0.0% —
4433 KP13_06881 hypothetical protein AlphaFold DB model + ColabFold model – – No map N/A 0.188 No Hit 0.0% —
4434 KP13_05558 hypothetical protein AlphaFold DB model + ColabFold model – – No map 0.188 0.956 No Hit 0.0% —
4435 KP13_03946 hypothetical protein AlphaFold DB model + ColabFold model – – No map N/A 0.188 No Hit 0.0% —
4436 KP13_03904 hypothetical protein AlphaFold DB model + ColabFold model – – No map N/A 0.188 No Hit 0.0% —
4437 KP13_03771 Imidazole glycerol phosphate synthase subunit hisH hisH AlphaFold DB model + ColabFold model
4.3.2.10 3.5.1.2
GO:0000105The chemical reactions and pathways resulting in the formation of L-histidine, 2-amino-3-(1H-imidazol-4-yl)propanoic acid. GO:0016763Catalysis of the transfer of a pentosyl group from one compound (donor) to another (acceptor). GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. +36 total
No map 0.188 0.516 No Hit 0.0% —
4438 KP13_02371 Serine transporter sdaC AlphaFold DB model + ColabFold model –
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0006865The directed movement of amino acids, organic acids containing one or more amino substituents, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. GO:0003333The process in which an amino acid is transported across a membrane. +36 total
No map 0.188 0.285 No Hit 0.0% —
4439 KP13_02301 Propanediol utilization protein pduV pduV AlphaFold DB model + ColabFold model –
GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. GO:0006576The chemical reactions and pathways occurring at the level of individual cells involving any of a group of naturally occurring, biologically active amines, such as norepinephrine, histamine, and serotonin, many of which act as neurotransmitters.
No map 0.188 0.636 No Hit 0.0% —
4440 KP13_01814 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase dapD AlphaFold DB model + ColabFold model
2.3.1.117
GO:0009089OBSOLETE. The chemical reactions and pathways resulting in the formation of lysine, via the intermediate diaminopimelate. GO:0016740Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2. GO:0008666Catalysis of the reaction: (S)-2,3,4,5-tetrahydrodipicolinate + H2O + succinyl-CoA = L-2-succinylamino-6-oxopimelate + CoA. +36 total
No map 0.188 0.532 No Hit 0.0% —
4441 KP13_01591 ProP effector proQ AlphaFold DB model + ColabFold model –
GO:0034057Facilitates the displacement of one strand of an RNA-RNA duplex and its replacement with a different strand of higher complementarity. GO:0010608Any process that modulates the frequency, rate or extent of gene expression after the production of an RNA transcript. GO:0033592An activity that facilitates the formation of a complementary double-stranded RNA molecule. +25 total
No map 0.188 0.378 No Hit 0.0% —
4442 KP13_00322 LysR family transcriptional regulator AlphaFold DB model + ColabFold model –
GO:0006355Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. GO:0003700A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons. GO:0000976Binding to a specific sequence of DNA that is part of a regulatory region that controls transcription of that section of the DNA. The transcribed region might be described as a gene, cistron, or operon.
No map 0.188 0.753 No Hit 0.0% —
4443 KP13_05281 High-affinity branched-chain amino acid transport ATP-binding protein AlphaFold DB model + ColabFold model –
GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. GO:0016887Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient. GO:0015658Enables the transfer of branched-chain amino acids from one side of a membrane to the other. Branched-chain amino acids are amino acids with a branched carbon skeleton without rings. +14 total
No map 0.187 0.306 Hit 34.5% 7.61e-23
4444 KP13_03377 Cytosine deaminase AlphaFold DB model + ColabFold model –
GO:0016810Catalysis of the hydrolysis of any carbon-nitrogen bond, C-N, with the exception of peptide bonds. GO:0004131Catalysis of the reaction: cytosine + H2O = uracil + NH4+. GO:0035888Catalysis of the reaction: H+ + H2O + isoguanine = NH4+ + xanthine. +25 total
No map 0.187 0.21 No Hit 0.0% —
4445 KP13_02473 PTS system protein, mannose/fructose/sorbose family, IID component AlphaFold DB model + ColabFold model –
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0009401The uptake and phosphorylation of specific carbohydrates from the extracellular environment; uptake and phosphorylation are coupled, making the PTS a link between the uptake and metabolism of sugars; phosphoenolpyruvate is the original phosphate donor; phosphoenolpyruvate passes the phosphate via a signal transduction pathway, to enzyme 1 (E1), which in turn passes it on to the histidine protein, HPr; the next step in the system involves sugar-specific membrane-bound complex, enzyme 2 (EII), which transports the sugar into the cell; it includes the sugar permease, which catalyzes the transport reactions; EII is usually divided into three different domains, EIIA, EIIB, and EIIC. GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
No map 0.187 0.943 No Hit 0.0% —
4446 KP13_32030 hypothetical protein ColabFold model – – No map 0.186 0.848 No Hit 0.0% —
4447 KP13_06830 transposase for insertion sequence element ISKpn1 AlphaFold DB model + ColabFold model –
GO:0043565Binding to DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding.
No map 0.186 0.623 No Hit 0.0% —
4448 KP13_03527 transposase for insertion sequence element ISKpn1 AlphaFold DB model + ColabFold model –
GO:0043565Binding to DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding.
No map 0.186 0.623 No Hit 0.0% —
4449 KP13_02671 hypothetical protein AlphaFold DB model + ColabFold model – – No map N/A 0.186 No Hit 0.0% —
4450 KP13_02182 transposase for insertion sequence element ISKpn1 AlphaFold DB model + ColabFold model –
GO:0043565Binding to DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding.
No map 0.186 0.623 No Hit 0.0% —
Page of 234 · 5842 total proteins