Proteins

Genome: KpKP13

Description: Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence

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5192 proteins Structure: AlphaFold

Scoring formula None

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Structure: AlphaFold ×
# Protein Description Gene Structure EC GO Druggability FPocket druggability score for the preferred structure (0–1): experimental structure when available, otherwise predicted model. ≥ 0.7 highly druggable · ≥ 0.4 moderately druggable · < 0.4 low druggability. Human off-target BLASTP against the human proteome. Hit means at least one human match was detected at e-value <= 1e-5. Prefer No hit for pathogen-selective targets. Human identity (%) Best human BLAST identity percentage. Human E-value Best human BLAST E-value.
4451 KP13_01324 Metallo-dependent phosphatase AlphaFold + ColabFold –
GO:0004112Catalysis of the reaction: a nucleoside cyclic phosphate + H2O = a nucleoside phosphate. GO:0016787Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. GO:0046872Binding to a metal ion.
0.229 No Hit 0.0% —
4452 KP13_31838 putative transposase AlphaFold + ColabFold –
GO:0003676Binding to a nucleic acid. GO:0015074The process in which a DNA segment is incorporated into another, usually larger, DNA molecule such as a chromosome.
0.228 No Hit 0.0% —
4453 KP13_06811 putative transposase AlphaFold + ColabFold –
GO:0003676Binding to a nucleic acid. GO:0015074The process in which a DNA segment is incorporated into another, usually larger, DNA molecule such as a chromosome.
0.228 No Hit 0.0% —
4454 KP13_05969 hypothetical protein AlphaFold + ColabFold – – 0.228 No Hit 0.0% —
4455 KP13_04426 hypothetical protein AlphaFold + ColabFold – – 0.228 No Hit 0.0% —
4456 KP13_04143 hypothetical protein AlphaFold + ColabFold – – 0.228 No Hit 0.0% —
4457 KP13_04007 hypothetical protein AlphaFold + ColabFold – – 0.228 No Hit 0.0% —
4458 KP13_00293 2-dehydro-3-deoxygluconokinase AlphaFold + ColabFold
2.7.1.45
GO:0016301Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule. GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. GO:0008673Catalysis of the reaction: 2-dehydro-3-deoxy-D-gluconate + ATP = 2-dehydro-3-deoxy-6-phospho-D-gluconate + ADP + 2 H+. +47 total
0.228 No Hit 0.0% —
4459 KP13_32181 HTH-type transcriptional repressor NsrR nsrR AlphaFold + ColabFold –
GO:0045892Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription. GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. GO:0051537Binding to a 2 iron, 2 sulfur (2Fe-2S) cluster; this cluster consists of two iron atoms, with two inorganic sulfur atoms found between the irons and acting as bridging ligands. +36 total
0.227 No Hit 0.0% —
4460 KP13_05658 HNH endonuclease domain-containing protein AlphaFold + ColabFold –
GO:0003676Binding to a nucleic acid. GO:0008270Binding to a zinc ion (Zn). GO:0004519Catalysis of the cleavage of ester linkages within nucleic acids by creating internal breaks.
0.227 No Hit 0.0% —
4461 KP13_04631 putative ATP-dependent transporter sufC sufC AlphaFold + ColabFold –
GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. GO:0016887Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient. GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
0.227 Hit 31.0% 2.68e-10
4462 KP13_01255 Fructose-1,6-bisphosphatase class 1 fbp AlphaFold + ColabFold
3.1.3.11
GO:0005975The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. GO:0042578Catalysis of the reaction: RPO-R' + H2O = RPOOH + R'H. This reaction is the hydrolysis of any phosphoric ester bond, any ester formed from orthophosphoric acid, O=P(OH)3. GO:0016791Catalysis of the hydrolysis of a phosphoric monoester, releasing a phosphate. +811 total
0.227 Hit 48.9% 1.20e-31
4463 KP13_32064 RepFIB replication protein A AlphaFold + ColabFold –
GO:0003887Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1); DNA-template-directed extension of the 3'-end of a DNA strand by one nucleotide at a time. GO:0006270The process in which DNA-dependent DNA replication is started; it begins when specific sequences, known as origins of replication, are recognized and bound by the origin recognition complex, followed by DNA unwinding.
0.226 No Hit 0.0% —
4464 KP13_05218 hypothetical protein AlphaFold + ColabFold – – 0.226 No Hit 0.0% —
4465 KP13_05014 Mannose-6-phosphate isomerase manA AlphaFold + ColabFold
5.3.1.8
GO:0004476Catalysis of the reaction: D-mannose 6-phosphate = D-fructose 6-phosphate. GO:0008270Binding to a zinc ion (Zn). GO:0005975The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. +25 total
0.226 Hit 39.8% 1.59e-29
4466 KP13_04988 LysR family transcriptional regulator AlphaFold + ColabFold –
GO:0006355Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. GO:0003700A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons. GO:0043565Binding to DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. +14 total
0.226 No Hit 0.0% —
4467 KP13_03842 Ethanolamine utilization protein eutP eutP AlphaFold + ColabFold –
GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. GO:0006576The chemical reactions and pathways occurring at the level of individual cells involving any of a group of naturally occurring, biologically active amines, such as norepinephrine, histamine, and serotonin, many of which act as neurotransmitters.
0.226 No Hit 0.0% —
4468 KP13_03050 hypothetical protein AlphaFold + ColabFold – – 0.226 No Hit 0.0% —
4469 KP13_01303 Valyl-tRNA synthetase valS AlphaFold + ColabFold
6.1.1.9
GO:0002161The hydrolysis of an incorrectly aminoacylated tRNA. GO:0006438The process of coupling valine to valyl-tRNA, catalyzed by valyl-tRNA synthetase. The valyl-tRNA synthetase is a class-I synthetase. The activated amino acid is transferred to the 2'-OH group of a valine-accetping tRNA. The 2'-O-aminoacyl-tRNA will ultimately migrate to the 3' position via transesterification. GO:0004812Catalysis of the formation of aminoacyl-tRNA from ATP, amino acid, and tRNA with the release of diphosphate and AMP. +69 total
0.226 Hit 50.0% 4.33e-63
4470 KP13_00135 beta-lactamase domain-containing protein AlphaFold + ColabFold –
GO:0016787Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc.
0.226 No Hit 0.0% —
4471 KP13_31831 Type 3 fimbrial subunit MrkB mrkB AlphaFold + ColabFold –
GO:0061077OBSOLETE. The process of inhibiting aggregation and assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure that is dependent on interaction with a chaperone. GO:0043711A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a pilus, a short filamentous structure on a bacterial cell, flagella-like in structure and generally present in many copies. GO:0030288The region between the inner (cytoplasmic or plasma) membrane and outer membrane of organisms with two membranes such as Gram negative bacteria. These periplasmic spaces are relatively thick and contain a thin peptidoglycan layer (PGL), also referred to as a thin cell wall. +14 total
0.225 No Hit 0.0% —
4472 KP13_03453 Carboxylate-amine ligase AlphaFold + ColabFold –
GO:0016879Catalysis of the joining of two molecules, or two groups within a single molecule, via a carbon-nitrogen bond, with the concomitant hydrolysis of the diphosphate bond in ATP or a similar triphosphate. GO:0003824Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. GO:0042398The chemical reactions and pathways resulting in the formation of compounds derived from amino acids, organic acids containing one or more amino substituents. +14 total
0.225 No Hit 0.0% —
4473 KP13_02782 Protein sufI sufI AlphaFold + ColabFold –
GO:0016491Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. GO:0005507Binding to a copper (Cu) ion. GO:0043093A cytokinesis process that involves a set of conserved proteins including FtsZ, and results in the formation of two similarly sized and shaped cells. +25 total
0.225 No Hit 0.0% —
4474 KP13_01833 General secretion pathway protein B AlphaFold + ColabFold –
GO:0015627A large protein complex, containing 12-15 subunits, that spans the cell envelope of Gram-negative bacteria and mediates the movement of proteins into the extracellular environment. The complex includes a component in the cytoplasm, an inner membrane subcomplex that reaches into the periplasmic compartment and a secretion pore in the outer membrane. Proteins using the Type II pathway are transported across the cytoplasmic membrane by the Sec or Tat complex.
0.225 No Hit 0.0% —
4475 KP13_00193 putative glycosyltransferase in waa region AlphaFold + ColabFold –
GO:0016757Catalysis of the transfer of a glycosyl group from one compound (donor) to another (acceptor). GO:1901135The chemical reactions and pathways involving carbohydrate derivative.
0.225 No Hit 0.0% —
Page of 208 · 5192 total proteins