Proteins

Genome: KpKP13

Description: Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence

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5192 proteins Structure: AlphaFold

Scoring formula None

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Structure: AlphaFold ×
# Protein Description Gene Structure EC GO Druggability FPocket druggability score for the preferred structure (0–1): experimental structure when available, otherwise predicted model. ≥ 0.7 highly druggable · ≥ 0.4 moderately druggable · < 0.4 low druggability. Human off-target BLASTP against the human proteome. Hit means at least one human match was detected at e-value <= 1e-5. Prefer No hit for pathogen-selective targets. Human identity (%) Best human BLAST identity percentage. Human E-value Best human BLAST E-value.
4651 KP13_04662 putative lipoprotein nlpC AlphaFold + ColabFold –
GO:0008234Catalysis of the hydrolysis of peptide bonds in a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile. GO:0006508The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds.
0.186 No Hit 0.0% —
4652 KP13_02671 hypothetical protein AlphaFold + ColabFold – – 0.186 No Hit 0.0% —
4653 KP13_32096 hypothetical protein AlphaFold + ColabFold – – 0.185 No Hit 0.0% —
4654 KP13_05434 hypothetical protein AlphaFold + ColabFold – – 0.184 No Hit 0.0% —
4655 KP13_05292 hypothetical protein AlphaFold + ColabFold – – 0.184 No Hit 0.0% —
4656 KP13_02738 hypothetical protein AlphaFold + ColabFold –
GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
0.184 Hit 34.2% 7.22e-11
4657 KP13_16520 Alanyl-tRNA synthetase alaS AlphaFold + ColabFold
6.1.1.7
GO:0006419The process of coupling alanine to alanyl-tRNA, catalyzed by alanyl-tRNA synthetase. The alanyl-tRNA synthetase is a class-II synthetases. The activated amino acid is transferred to the 3'-OH group of an alanine accetping tRNA. GO:0004812Catalysis of the formation of aminoacyl-tRNA from ATP, amino acid, and tRNA with the release of diphosphate and AMP. GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. +1013 total
0.183 Hit 58.1% 1.88e-10
4658 KP13_12496 hypothetical protein AlphaFold + ColabFold – – 0.183 No Hit 0.0% —
4659 KP13_04081 cyclic diguanylate phosphodiesterase domain-containing protein AlphaFold + ColabFold – – 0.183 No Hit 0.0% —
4660 KP13_03583 Citrate synthase AlphaFold + ColabFold –
GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. GO:0006099A nearly universal metabolic pathway in which the acetyl group of acetyl coenzyme A is effectively oxidized to two CO2 and four pairs of electrons are transferred to coenzymes. The acetyl group combines with oxaloacetate to form citrate, which undergoes successive transformations to isocitrate, 2-oxoglutarate, succinyl-CoA, succinate, fumarate, malate, and oxaloacetate again, thus completing the cycle. In eukaryotes the tricarboxylic acid is confined to the mitochondria. See also glyoxylate cycle. GO:0046912Catalysis of the transfer of an acyl group from one compound (donor) to another (acceptor), with the acyl group being converted into alkyl on transfer. +25 total
0.183 Hit 22.2% 6.07e-11
4661 KP13_02423 tRNA (guanine-N(1)-)-methyltransferase trmD AlphaFold + ColabFold
2.1.1.228
GO:0052906Catalysis of the reaction: S-adenosyl-L-methionine + guanine(37) in tRNA = N(1)-methylguanine(37) in tRNA + S-adenosyl-L-homocysteine. GO:0008033The process in which a pre-tRNA molecule is converted to a mature tRNA, ready for addition of an aminoacyl group. GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. +14 total
0.183 No Hit 0.0% —
4662 KP13_05387 HTH-type transcriptional regulator chbR chbR AlphaFold + ColabFold –
GO:0043565Binding to DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. GO:0006355Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. GO:0003700A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons.
0.181 No Hit 0.0% —
4663 KP13_02991 2,3-bisphosphoglycerate-dependent phosphoglycerate mutase gpmA AlphaFold + ColabFold
5.4.2.11
GO:0016868Catalysis of the transfer of a phosphate group from one position to another within a single molecule. GO:0003824Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. GO:0006096The chemical reactions and pathways resulting in the breakdown of a carbohydrate into pyruvate, with the concomitant production of a small amount of ATP and the reduction of NAD(P) to NAD(P)H. Glycolysis begins with the metabolism of a carbohydrate to generate products that can enter the pathway and ends with the production of pyruvate. Pyruvate may be converted to acetyl-coenzyme A, ethanol, lactate, or other small molecules. +25 total
0.181 Hit 58.1% 3.47e-101
4664 KP13_00846 NifU-like protein nifU AlphaFold + ColabFold –
GO:0016226The incorporation of iron and exogenous sulfur into a metallo-sulfur cluster. GO:0005506Binding to an iron (Fe) ion. GO:0051536Binding to an iron-sulfur cluster, a combination of iron and sulfur atoms.
0.181 Hit 75.4% 2.18e-69
4665 KP13_00803 ATP-dependent RNA helicase srmB srmB AlphaFold + ColabFold
3.6.4.13
GO:0000027The aggregation, arrangement and bonding together of constituent RNAs and proteins to form the large ribosomal subunit. GO:0003676Binding to a nucleic acid. GO:0003724Unwinding of an RNA helix, driven by ATP hydrolysis. +36 total
0.181 Hit 56.5% 2.92e-14
4666 KP13_05440 Peptide transport periplasmic protein sapA sapA AlphaFold + ColabFold –
GO:0043190A complex for the transport of metabolites into and out of the cell, typically comprised of four domains; two membrane-associated domains and two ATP-binding domains at the intracellular face of the membrane, that form a central pore through the plasma membrane. Each of the four core domains may be encoded as a separate polypeptide or the domains can be fused in any one of a number of ways into multidomain polypeptides. In Bacteria and Archaebacteria, ABC transporters also include substrate binding proteins to bind substrate external to the cytoplasm and deliver it to the transporter. GO:0055085The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other. GO:0030288The region between the inner (cytoplasmic or plasma) membrane and outer membrane of organisms with two membranes such as Gram negative bacteria. These periplasmic spaces are relatively thick and contain a thin peptidoglycan layer (PGL), also referred to as a thin cell wall. +25 total
0.18 No Hit 0.0% —
4667 KP13_05213 putative oxidoreductase, Fe-S subunit AlphaFold + ColabFold –
GO:0016788Catalysis of the hydrolysis of any ester bond.
0.18 No Hit 0.0% —
4668 KP13_13105 Thioredoxin-1 trxA AlphaFold + ColabFold –
GO:0015035Catalysis of the reaction: a protein with reduced sulfide groups = a protein with oxidized disulfide bonds. GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. GO:0045454Any process that maintains the redox environment of a cell or compartment within a cell.
0.179 Hit 41.9% 9.27e-18
4669 KP13_31930 transposase insD for insertion element IS2I AlphaFold + ColabFold –
GO:0003676Binding to a nucleic acid. GO:0015074The process in which a DNA segment is incorporated into another, usually larger, DNA molecule such as a chromosome.
0.178 No Hit 0.0% —
4670 KP13_31637 DNAase like-I protein AlphaFold + ColabFold –
GO:0003824Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. GO:0004519Catalysis of the cleavage of ester linkages within nucleic acids by creating internal breaks.
0.178 No Hit 0.0% —
4671 KP13_25163 3-oxoadipate CoA-transferase subunit A pcal AlphaFold + ColabFold –
GO:0008410Catalysis of the transfer of a coenzyme A (CoA) group from one compound (donor) to another (acceptor).
0.178 Hit 48.2% 4.02e-21
4672 KP13_05661 L-asparaginase 1 ansA AlphaFold + ColabFold
3.5.1.1
GO:0006520The chemical reactions and pathways involving amino acids, carboxylic acids containing one or more amino groups. GO:0004067Catalysis of the reaction: L-asparagine + H2O = L-aspartate + NH4+. GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. +14 total
0.178 Hit 58.6% 6.13e-34
4673 KP13_05515 Aminotransferase, class V domain-containing protein AlphaFold + ColabFold –
GO:0003824Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. GO:0008453Catalysis of the reaction: L-alanine + glyoxylate = pyruvate + glycine. GO:0004760Catalysis of the reaction: L-serine + pyruvate = 3-hydroxypyruvate + L-alanine. +14 total
0.178 Hit 33.0% 1.63e-64
4674 KP13_04107 hypothetical protein AlphaFold + ColabFold – – 0.178 No Hit 0.0% —
4675 KP13_03657 hypothetical protein AlphaFold + ColabFold – – 0.178 No Hit 0.0% —
Page of 208 · 5192 total proteins