Proteins

Genome: KpKP13

Description: Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence

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5842 / 5842 proteins

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# Protein Description Gene Structure EC GO Druggability FPocket druggability score for the preferred structure (0–1): experimental structure when available, otherwise predicted model. ≥ 0.7 highly druggable · ≥ 0.4 moderately druggable · < 0.4 low druggability. Human off-target BLASTP against the human proteome. Hit means at least one human match was detected at e-value <= 1e-5. Prefer No hit for pathogen-selective targets. Human identity (%) Best human BLAST identity percentage. Human E-value Best human BLAST E-value.
4676 KP13_05018 Sensor protein rstB rstB AlphaFold + ColabFold
2.7.13.3
GO:0016310The process of introducing a phosphate group into a molecule, usually with the formation of a phosphoric ester, a phosphoric anhydride or a phosphoric amide. GO:0016772Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to another (acceptor). GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. +47 total
0.956 No Hit 0.0% —
4677 KP13_05019 hypothetical protein AlphaFold + ColabFold – – 0.611 No Hit 0.0% —
4678 KP13_05020 Transcriptional regulatory protein rstA rstA Experimental + ColabFold –
GO:0006355Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. GO:0000160A conserved series of molecular signals found in prokaryotes and eukaryotes; involves autophosphorylation of a histidine kinase and the transfer of the phosphate group to an aspartate that then acts as a phospho-donor to response regulator proteins. GO:0003677Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
0.347 No Hit 0.0% —
4679 KP13_05021 Inner membrane protein AlphaFold + ColabFold – – 0.849 No Hit 0.0% —
4680 KP13_05023 Putative arginine/ornithine antiporter AlphaFold + ColabFold –
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0006865The directed movement of amino acids, organic acids containing one or more amino substituents, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. GO:0055085The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other. +36 total
0.85 No Hit 0.0% —
4681 KP13_05024 hypothetical protein AlphaFold + ColabFold – – 0.317 No Hit 0.0% —
4682 KP13_05025 hypothetical protein AlphaFold + ColabFold – – 0.04 No Hit 0.0% —
4683 KP13_05026 hypothetical protein AlphaFold + ColabFold – – 0.591 No Hit 0.0% —
4684 KP13_05029 hypothetical protein AlphaFold + ColabFold – – 0.606 No Hit 0.0% —
4685 KP13_05030 Universal stress protein E uspE AlphaFold + ColabFold –
GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
0.311 No Hit 0.0% —
4686 KP13_05031 Fumarate nitrate reduction regulatory protein fnr AlphaFold + ColabFold –
GO:0006355Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. GO:0003677Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). GO:0003700A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons. +58 total
0.511 No Hit 0.0% —
4687 KP13_05033 hypothetical protein AlphaFold + ColabFold – – 0.654 No Hit 0.0% —
4688 KP13_05034 Aminobenzoyl-glutamate transport protein abgT AlphaFold + ColabFold –
GO:0015558Enables the transfer of p-aminobenzoyl-glutamate from one side of a membrane to the other, up its concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction and is driven by a chemiosmotic source of energy. Secondary active transporters include symporters and antiporters. p-aminobenzoyl-glutamate is the anion of p-aminobenzoyl-glutamic acid. GO:1902604The directed movement of N-(4-aminobenzoyl)-L-glutamate across a membrane.
0.88 No Hit 0.0% —
4689 KP13_05036 Indole-3-acetyl-aspartic acid hydrolase iaaH Experimental + ColabFold –
GO:0016787Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. GO:0016810Catalysis of the hydrolysis of any carbon-nitrogen bond, C-N, with the exception of peptide bonds.
0.378 No Hit 0.0% —
4690 KP13_05037 HTH-type transcriptional regulator abgR abgR AlphaFold + ColabFold –
GO:0006355Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. GO:0003700A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons. GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. +14 total
0.377 No Hit 0.0% —
4691 KP13_05038 hypothetical protein AlphaFold + ColabFold –
GO:0004520Catalysis of the cleavage of ester linkages within deoxyribonucleic acid by creating internal breaks.
0.378 No Hit 0.0% —
4692 KP13_05039 Pca regulon regulatory protein AlphaFold + ColabFold –
GO:0045893Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription. GO:0006355Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. GO:0046278The chemical reactions and pathways involving protocatechuate, the anion of protocatechuic acid (3,4-dihydroxybenzoic acid). +14 total
0.875 No Hit 0.0% —
4693 KP13_05045 4-carboxymuconolactone decarboxylase pcaC AlphaFold + ColabFold
4.1.1.44
GO:0051920Catalysis of the reaction: [protein]-dithol + ROOH = [protein]-disulfide + H2O + ROH. GO:0047575Catalysis of the reaction: (R)-2-(carboxymethyl)-5-oxo-2,5-dihydro-2-furoate + H+ = 5-oxo-4,5-dihydro-2-furylacetate + CO2.
0.498 No Hit 0.0% —
4694 KP13_05046 MscS mechanosensitive ion channel AlphaFold + ColabFold –
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0055085The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other. GO:0008381Enables the transmembrane transfer of an monoatomic ion by a channel that opens in response to a mechanical stress. +14 total
0.469 No Hit 0.0% —
4695 KP13_05047 Fumarate hydratase class I, anaerobic fumB AlphaFold + ColabFold
4.2.1.2
GO:0016836Catalysis of the cleavage of a carbon-oxygen bond by elimination of water. GO:0016829Catalysis of the cleavage of C-C, C-O, C-N and other bonds by other means than by hydrolysis or oxidation, or conversely adding a group to a double bond. They differ from other enzymes in that two substrates are involved in one reaction direction, but only one in the other direction. When acting on the single substrate, a molecule is eliminated and this generates either a new double bond or a new ring. GO:0004333Catalysis of the reaction: (S)-malate = fumarate + H2O. +58 total
0.481 No Hit 0.0% —
4696 KP13_05050 hypothetical protein ColabFold – – 0.755 No Hit 0.0% —
4697 KP13_05051 insertion element IS1 protein InsB ColabFold –
GO:0004803Catalysis of the transposition of transposable elements or transposons. Transposases are involved in recombination required for transposition and are site-specific for the transposon/transposable element. GO:0006313A type of transposition in which a transposable element (transposon) is moved to another part of a genome, either by a cut-and-paste mechanism or a replicative mechanism. GO:0003677Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
0.254 No Hit 0.0% —
4698 KP13_05052 insertion element IS1 protein insA AlphaFold + ColabFold –
GO:0006313A type of transposition in which a transposable element (transposon) is moved to another part of a genome, either by a cut-and-paste mechanism or a replicative mechanism.
0.438 No Hit 0.0% —
4699 KP13_05053 putative transporter protein AlphaFold + ColabFold – – 0.413 No Hit 0.0% —
4700 KP13_05056 Colicin I receptor cirA AlphaFold + ColabFold –
GO:0009279A lipid bilayer that forms the outermost membrane of the cell envelope; enriched in polysaccharide and protein; the outer leaflet of the membrane contains specific lipopolysaccharide structures. GO:0015344Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: siderophore-iron(ferrioxamine)(out) + H+(out) = siderophore-iron(ferrioxamine)(in) + H+(in). GO:0044718The directed movement of siderophores, low molecular weight Fe(III)-chelating substances, from one side of a membrane to the other, by means of some agent such as a transporter or pore.
0.943 No Hit 0.0% —
Page of 234 · 5842 total proteins