Proteins

Genome: KpKP13

Description: Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence

Search, filter, and prioritize proteins.

Export view
5842 proteins

Scoring formula None

Sorted by Human identity (%) (ascending)

Applied filters No active filters

Search query No active search

Rows per page 25

Rows
# Protein Description Gene Structure EC GO Druggability FPocket druggability score for the preferred structure (0–1): experimental structure when available, otherwise predicted model. ≥ 0.7 highly druggable · ≥ 0.4 moderately druggable · < 0.4 low druggability. Human off-target BLASTP against the human proteome. Hit means at least one human match was detected at e-value <= 1e-5. Prefer No hit for pathogen-selective targets. Human identity (%) Best human BLAST identity percentage. Human E-value Best human BLAST E-value.
26 KP13_00041 hypothetical protein AlphaFold + ColabFold –
GO:0008897Catalysis of the reaction: CoA + substrate-serine = adenosine 3',5'-bisphosphate + substrate-serine-4'-phosphopantetheine. The transfer of the 4'-phosphopantetheine (Ppant) co-factor from coenzyme A to the hydroxyl side chain of the serine residue of acyl- or peptidyl-carrier protein (ACP or PCP) to convert them from the apo to the holo form. GO:0000287Binding to a magnesium (Mg) ion.
0.209 No Hit 0.0% —
27 KP13_00044 GCN5-like N-acetyltransferase AlphaFold + ColabFold –
GO:0016747Catalysis of the transfer of an acyl group, other than amino-acyl, from one compound (donor) to another (acceptor). GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. GO:0008080Catalysis of the transfer of an acetyl group to a nitrogen atom on the acceptor molecule.
0.205 No Hit 0.0% —
28 KP13_00047 hypothetical protein AlphaFold + ColabFold – – 0.36 No Hit 0.0% —
29 KP13_00049 DNA polymerase III subunit beta dnaN AlphaFold + ColabFold –
GO:0009360The DNA polymerase III holoenzyme is a complex that contains 10 different types of subunits. These subunits are organized into 3 functionally essential sub-assemblies: the pol III core, the beta sliding clamp processivity factor and the clamp-loading complex. The pol III core carries out the polymerase and the 3'-5' exonuclease proofreading activities. The polymerase is tethered to the template via the sliding clamp processivity factor. The clamp-loading complex assembles the beta processivity factor onto the primer template and plays a central role in the organization and communication at the replication fork. GO:0006260The cellular metabolic process in which a cell duplicates one or more molecules of DNA. DNA replication begins when specific sequences, known as origins of replication, are recognized and bound by the origin recognition complex, and ends when the original DNA molecule has been completely duplicated and the copies topologically separated. The unit of replication usually corresponds to the genome of the cell, an organelle, or a virus. The template for replication can either be an existing DNA molecule or RNA. GO:0003887Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1); DNA-template-directed extension of the 3'-end of a DNA strand by one nucleotide at a time. +58 total
0.232 No Hit 0.0% —
30 KP13_00050 DNA replication and repair protein recF recF AlphaFold + ColabFold –
GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. GO:0006281The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway. GO:0003697Binding to single-stranded DNA. +58 total
0.812 No Hit 0.0% —
31 KP13_00052 Phosphatase AlphaFold + ColabFold
3.1.3.23
GO:0016787Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. GO:0000287Binding to a magnesium (Mg) ion. +14 total
0.202 No Hit 0.0% —
32 KP13_00054 Bacterial surface antigen (D15)- containing protein AlphaFold + ColabFold –
GO:0019867The external membrane of Gram-negative bacteria or certain organelles such as mitochondria and chloroplasts; freely permeable to most ions and metabolites.
0.861 No Hit 0.0% —
33 KP13_00055 Galactonate operon transcriptional repressor dgoR AlphaFold + ColabFold –
GO:0006355Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. GO:0003700A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons. GO:0003677Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
0.588 No Hit 0.0% —
34 KP13_00056 2-oxo-3-deoxygalactonate kinase dgoK Experimental + ColabFold –
GO:0008671Catalysis of the reaction: 2-dehydro-3-deoxy-D-galactonate + ATP = 6-phospho-2-dehydro-3-deoxy-D-galactonate + ADP + 2 H+. GO:0034194The chemical reactions and pathways resulting in the breakdown of D-galactonate, the anion of D-galactonic acid.
0.709 No Hit 0.0% —
35 KP13_00057 2-dehydro-3-deoxy-6-phosphogalactonate aldolase dgoA AlphaFold + ColabFold –
GO:0016829Catalysis of the cleavage of C-C, C-O, C-N and other bonds by other means than by hydrolysis or oxidation, or conversely adding a group to a double bond. They differ from other enzymes in that two substrates are involved in one reaction direction, but only one in the other direction. When acting on the single substrate, a molecule is eliminated and this generates either a new double bond or a new ring.
0.411 No Hit 0.0% —
36 KP13_00059 hypothetical protein ColabFold – – 0.735 No Hit 0.0% —
37 KP13_00061 hypothetical protein AlphaFold + ColabFold – – 0.634 No Hit 0.0% —
38 KP13_00062 hypothetical protein AlphaFold + ColabFold – – 0.286 No Hit 0.0% —
39 KP13_00063 Small heat shock protein ibpA ibpA AlphaFold + ColabFold –
GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. GO:0050821Any process involved in maintaining the structure and integrity of a protein and preventing it from degradation or aggregation.
0.401 No Hit 0.0% —
40 KP13_00064 Small heat shock protein ibpB ibpB AlphaFold + ColabFold –
GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. GO:0050821Any process involved in maintaining the structure and integrity of a protein and preventing it from degradation or aggregation.
0.409 No Hit 0.0% —
41 KP13_00065 DNA-damage-inducible protein D dinD AlphaFold + ColabFold – – 0.905 No Hit 0.0% —
42 KP13_00067 putative HTH transcriptional regulator, GntR AlphaFold + ColabFold –
GO:0006355Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. GO:0003677Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). GO:0003700A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons. +14 total
0.448 No Hit 0.0% —
43 KP13_00068 PTS system alpha-glucoside-specific EIICB component aglA AlphaFold + ColabFold –
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0009401The uptake and phosphorylation of specific carbohydrates from the extracellular environment; uptake and phosphorylation are coupled, making the PTS a link between the uptake and metabolism of sugars; phosphoenolpyruvate is the original phosphate donor; phosphoenolpyruvate passes the phosphate via a signal transduction pathway, to enzyme 1 (E1), which in turn passes it on to the histidine protein, HPr; the next step in the system involves sugar-specific membrane-bound complex, enzyme 2 (EII), which transports the sugar into the cell; it includes the sugar permease, which catalyzes the transport reactions; EII is usually divided into three different domains, EIIA, EIIB, and EIIC. GO:0008982Catalysis of the PEP-dependent, phosphoryl transfer-driven transport of substances across a membrane. The transport happens by catalysis of the reaction: protein N-phosphohistidine + sugar(out) = protein histidine + sugar phosphate(in). This differs from primary and secondary active transport in that the solute is modified during transport. +36 total
0.742 No Hit 0.0% —
44 KP13_00069 6-phospho-alpha-glucosidase aglB Experimental + ColabFold
3.2.1.122
GO:0005975The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. GO:0004553Catalysis of the hydrolysis of any O-glycosyl bond. GO:0003824Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. +47 total
0.681 No Hit 0.0% —
45 KP13_00070 putative inner membrane protein AlphaFold + ColabFold –
GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
0.714 No Hit 0.0% —
46 KP13_00071 putative inner membrane protein AlphaFold + ColabFold –
GO:0012505A collection of membranous structures involved in transport within the cell. The main components of the endomembrane system are endoplasmic reticulum, Golgi bodies, vesicles, cell membrane and nuclear envelope. Members of the endomembrane system pass materials through each other or though the use of vesicles.
0.852 No Hit 0.0% —
47 KP13_00072 hypothetical protein AlphaFold + ColabFold
1.1.99.-
GO:0016491Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced.
0.704 No Hit 0.0% —
48 KP13_00073 D-serine dehydratase dsdA AlphaFold + ColabFold
4.3.1.18
GO:0030170Binding to pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6. GO:0006520The chemical reactions and pathways involving amino acids, carboxylic acids containing one or more amino groups. GO:0046416The chemical reactions and pathways involving D-amino acids, the D-enantiomers of amino acids. +47 total
0.608 No Hit 0.0% —
49 KP13_00077 putative transmembrane protein AlphaFold + ColabFold –
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0022857Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other. +25 total
0.824 No Hit 0.0% —
50 KP13_00078 GCN5-related N-acetyltransferase AlphaFold + ColabFold –
GO:0016747Catalysis of the transfer of an acyl group, other than amino-acyl, from one compound (donor) to another (acceptor).
0.244 No Hit 0.0% —
Page of 234 · 5842 total proteins