Proteins

Genome: KpKP13

Description: Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence

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5842 proteins

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# Protein Description Gene Structure EC GO Druggability FPocket druggability score for the preferred structure (0–1): experimental structure when available, otherwise predicted model. ≥ 0.7 highly druggable · ≥ 0.4 moderately druggable · < 0.4 low druggability. Human off-target BLASTP against the human proteome. Hit means at least one human match was detected at e-value <= 1e-5. Prefer No hit for pathogen-selective targets. Human identity (%) Best human BLAST identity percentage. Human E-value Best human BLAST E-value.
26 KP13_00143 Alpha-xylosidase AlphaFold + ColabFold
3.2.1.177
GO:0030246Binding to a carbohydrate, which includes monosaccharides, oligosaccharides and polysaccharides as well as substances derived from monosaccharides by reduction of the carbonyl group (alditols), by oxidation of one or more hydroxy groups to afford the corresponding aldehydes, ketones, or carboxylic acids, or by replacement of one or more hydroxy group(s) by a hydrogen atom. Cyclitols are generally not regarded as carbohydrates. GO:0005975The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. GO:0004553Catalysis of the hydrolysis of any O-glycosyl bond. +25 total
0.212 Hit 29.5% 4.82e-41
27 KP13_00148 putative purine permease AlphaFold + ColabFold –
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0022857Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other. GO:0055085The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other. +25 total
0.863 Hit 27.8% 9.48e-08
28 KP13_00150 Glycerol kinase glpK AlphaFold + ColabFold
2.7.1.30
GO:0016773Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to an alcohol group (acceptor). GO:0005975The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. GO:0016301Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule. +69 total
0.891 Hit 49.0% 2.45e-07
29 KP13_00157 Triosephosphate isomerase tpiA AlphaFold + ColabFold
5.3.1.1
GO:0004807Catalysis of the reaction: D-glyceraldehyde 3-phosphate = dihydroxyacetone phosphate. GO:0006096The chemical reactions and pathways resulting in the breakdown of a carbohydrate into pyruvate, with the concomitant production of a small amount of ATP and the reduction of NAD(P) to NAD(P)H. Glycolysis begins with the metabolism of a carbohydrate to generate products that can enter the pathway and ends with the production of pyruvate. Pyruvate may be converted to acetyl-coenzyme A, ethanol, lactate, or other small molecules. GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. +36 total
0.766 Hit 57.6% 1.74e-06
30 KP13_00162 ATP-dependent DNA helicase recG recG AlphaFold + ColabFold
5.6.2.4
GO:0003676Binding to a nucleic acid. GO:0003678Unwinding of a DNA helix, driven by ATP hydrolysis. GO:0006310Any process in which a new genotype is formed by reassortment of genes resulting in gene combinations different from those that were present in the parents. In eukaryotes genetic recombination can occur by chromosome assortment, intrachromosomal recombination, or nonreciprocal interchromosomal recombination. Interchromosomal recombination occurs by crossing over. In bacteria it may occur by genetic transformation, conjugation, transduction, or F-duction. +58 total
0.673 Hit 38.0% 4.92e-06
31 KP13_00163 tRNA guanosine-2'-O-methyltransferase trmH AlphaFold + ColabFold
2.1.1.34
GO:0008173Catalysis of the transfer of a methyl group from a donor to a nucleoside residue in an RNA molecule. GO:0030488The posttranscriptional addition of methyl groups to specific residues in a tRNA molecule. GO:0008168Catalysis of the transfer of a methyl group to an acceptor molecule. +69 total
0.155 Hit 25.3% 1.63e-08
32 KP13_00164 Bifunctional (p)ppGpp synthase/hydrolase SpoT spoT AlphaFold + ColabFold
3.1.7.2
GO:0015969The chemical reactions and pathways involving guanine tetraphosphate (5'-ppGpp-3'), a derivative of guanine riboside with four phosphates. GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0008728Catalysis of the reaction: ATP + GTP = AMP + guanosine 3'-diphosphate 5'-triphosphate. +47 total
0.313 Hit 37.8% 6.03e-12
33 KP13_00166 Guanylate kinase gmk AlphaFold + ColabFold
2.7.4.8
GO:0004385Catalysis of the reaction: ATP + GMP = ADP + GDP. GO:0006163The chemical reactions and pathways involving a purine nucleotide, a compound consisting of nucleoside (a purine base linked to a deoxyribose or ribose sugar) esterified with a phosphate group at either the 3' or 5'-hydroxyl group of the sugar. GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. +14 total
0.156 Hit 52.2% 1.84e-06
34 KP13_00170 methylated-DNA/protein-cysteine methyltransferase AlphaFold + ColabFold
2.1.1.63
GO:0008270Binding to a zinc ion (Zn). GO:0006355Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. GO:0008168Catalysis of the transfer of a methyl group to an acceptor molecule. +710 total
0.843 Hit 31.3% 2.39e-16
35 KP13_00184 Coenzyme A biosynthesis bifunctional protein coaBC coaBC AlphaFold + ColabFold –
GO:0015941The chemical reactions and pathways resulting in the breakdown of pantothenate, the anion of pantothenic acid. It is a B complex vitamin that is a constituent of coenzyme A and is distributed ubiquitously in foods. GO:0010181Binding to flavin mono nucleotide. Flavin mono nucleotide (FMN) is the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes. GO:0004633Catalysis of the reaction: N-[(R)-4-phosphonatopantothenoyl]-L-cysteinate + H+ = CO2 + pantetheine 4'-phosphate. +58 total
0.698 Hit 32.6% 1.22e-17
36 KP13_00187 50S ribosomal protein L33 rpmG AlphaFold + ColabFold –
GO:0003735The action of a molecule that contributes to the structural integrity of the ribosome. GO:0005840An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins. GO:0006412The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA or circRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA or circRNA. Translation ends with the release of a polypeptide chain from the ribosome. +14 total
0.28 Hit 44.4% 3.45e-07
37 KP13_00188 Formamidopyrimidine-DNA glycosylase bifunctional protein mutM AlphaFold + ColabFold
3.2.2.23 4.2.99.18
GO:0008270Binding to a zinc ion (Zn). GO:0003684Binding to damaged DNA. GO:0003906Catalysis of the cleavage of the C-O-P bond in the AP site created when DNA glycosylase removes a damaged base, involved in the DNA base excision repair pathway (BER). +912 total
0.296 Hit 28.9% 2.44e-06
38 KP13_00192 putative glycosyltransferase in waa region AlphaFold + ColabFold –
GO:0016758Catalysis of the transfer of a hexosyl group from one compound (donor) to another (acceptor).
0.611 Hit 33.0% 2.85e-09
39 KP13_00202 ADP-L-glycero-D-manno-heptose-6-epimerase hldD AlphaFold + ColabFold
5.1.3.20
GO:0008712Catalysis of the reaction: ADP-D-glycero-D-manno-heptose = ADP-L-glycero-D-manno-heptose. GO:0050661Binding to nicotinamide-adenine dinucleotide phosphate, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NADP+, or the reduced form, NADPH. GO:0005975The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. +25 total
0.416 Hit 25.4% 4.21e-06
40 KP13_00203 putative 8-amino-7-oxononanoate synthase/2-amino-3-ketobutyrate coenzyme A ligase AlphaFold + ColabFold
2.3.1.29
GO:0030170Binding to pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6. GO:0009058A cellular process consisting of the biochemical pathways by which a living organism synthesizes chemical substances. This typically represents the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones. GO:0016740Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2. +69 total
0.193 Hit 55.4% 1.78e-149
41 KP13_00204 L-threonine 3-dehydrogenase tdh AlphaFold + ColabFold
1.1.1.103
GO:0016491Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. GO:0008270Binding to a zinc ion (Zn). GO:0006567The chemical reactions and pathways resulting in the breakdown of L-threonine. +36 total
0.45 Hit 32.4% 1.06e-08
42 KP13_00211 Glutaredoxin-3 grxC AlphaFold + ColabFold –
GO:0045454Any process that maintains the redox environment of a cell or compartment within a cell. GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. GO:0015038Catalysis of the reaction: 2 glutathione + electron acceptor = glutathione disulfide + electron donor. +25 total
0.195 Hit 34.1% 3.47e-10
43 KP13_00213 Glycerol-3-phosphate dehydrogenase [NAD(P)+] gpsA AlphaFold + ColabFold
1.1.1.94
GO:0016616Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group acts as a hydrogen or electron donor and reduces NAD+ or NADP. GO:0047952Catalysis of the reaction: sn-glycerol 3-phosphate + NAD(P)+ = glycerone phosphate + NAD(P)H + H+. GO:0046168The chemical reactions and pathways resulting in the breakdown of glycerol-3-phosphate, a phosphoric monoester of glycerol. +1013 total
0.971 Hit 33.0% 1.60e-06
44 KP13_00216 L-lactate dehydrogenase lldD AlphaFold + ColabFold
1.1.-.-
GO:0016491Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. GO:0006089The chemical reactions and pathways involving lactate, the anion of lactic acid. GO:0010181Binding to flavin mono nucleotide. Flavin mono nucleotide (FMN) is the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes. +47 total
0.793 Hit 35.0% 8.23e-63
45 KP13_00226 glutathione S-transferase gst AlphaFold + ColabFold –
GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
0.673 Hit 30.3% 1.76e-08
46 KP13_00228 Selenocysteine-specific elongation factor selB AlphaFold + ColabFold –
GO:0003746Functions in chain elongation during polypeptide synthesis at the ribosome. GO:0003924Catalysis of the reaction: GTP + H2O = GDP + H+ + phosphate. GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. +710 total
0.28 Hit 31.6% 4.80e-10
47 KP13_00231 Valine--pyruvate aminotransferase avtA AlphaFold + ColabFold –
GO:0030170Binding to pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6. GO:0009058A cellular process consisting of the biochemical pathways by which a living organism synthesizes chemical substances. This typically represents the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones. GO:0003824Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. +36 total
0.525 Hit 26.0% 1.46e-08
48 KP13_00232 Alpha-amylase malS Experimental + ColabFold
3.2.1.98
GO:0030980The chemical reactions and pathways resulting in the breakdown of alpha-glucans. GO:0009313The chemical reactions and pathways resulting in the breakdown of oligosaccharides, molecules with between two and (about) 20 monosaccharide residues connected by glycosidic linkages. GO:0042597The region between the inner (cytoplasmic) and outer membrane (Gram-negative Bacteria) or cytoplasmic membrane and cell wall (Fungi and Gram-positive Bacteria). +47 total
0.846 Hit 28.0% 8.80e-06
49 KP13_00237 Xylose import ATP-binding protein xylG xylG AlphaFold + ColabFold –
GO:0016887Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient. GO:0015614Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + D-xylose(out) = ADP + phosphate + D-xylose(in). GO:0015753The process in which D-xylose is transported across a lipid bilayer, from one side of a membrane to the other. D-xylose (the naturally occurring enantiomer is always D-) is a constituent of plant polysaccharides. +36 total
0.726 Hit 33.7% 4.20e-09
50 KP13_00241 Xylulose kinase xylB AlphaFold + ColabFold
2.7.1.17
GO:0016773Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to an alcohol group (acceptor). GO:0005975The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. GO:0016301Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule. +58 total
0.549 Hit 31.4% 5.41e-07
Page of 234 · 5842 total proteins