Proteins

Genome: KpKP13

Description: Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence

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5842 proteins

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# Protein Description Gene Structure EC GO Druggability FPocket druggability score for the preferred structure (0–1): experimental structure when available, otherwise predicted model. ≥ 0.7 highly druggable · ≥ 0.4 moderately druggable · < 0.4 low druggability. Human off-target BLASTP against the human proteome. Hit means at least one human match was detected at e-value <= 1e-5. Prefer No hit for pathogen-selective targets. Human identity (%) Best human BLAST identity percentage. Human E-value Best human BLAST E-value.
526 KP13_00468 Curved DNA-binding protein cbpA Experimental + ColabFold –
GO:0051082Binding to an unfolded protein. GO:0006457The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure.
0.437 Hit 54.7% 8.75e-15
527 KP13_01533 Threonine dehydratase catabolic tdcB AlphaFold + ColabFold
4.3.1.17
GO:0030170Binding to pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6. GO:0006520The chemical reactions and pathways involving amino acids, carboxylic acids containing one or more amino groups. GO:0003941Catalysis of the reaction: L-serine = pyruvate + NH4+. +47 total
0.264 Hit 47.5% 9.61e-15
528 KP13_01181 Malonyl CoA-acyl carrier protein transacylase AlphaFold + ColabFold –
GO:0016740Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2.
0.806 Hit 26.1% 9.76e-15
529 KP13_31749 putative esterase AlphaFold + ColabFold –
GO:0047372Catalysis of the reaction: a monoacylglycerol + H2O = a fatty acid + glycerol + H+. GO:0034338Catalysis of the reaction: a carboxylic ester + H2O = an alcohol + a carboxylic anion, where the carboxylic chain has 8 or fewer carbon atoms.
0.984 Hit 32.4% 9.98e-15
530 KP13_03863 ABC transporter ATP-binding protein uup uup AlphaFold + ColabFold
3.6.1.-
GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. GO:0016887Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient. GO:0006281The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway. +36 total
0.056 Hit 36.5% 1.00e-14
531 KP13_03483 Phenylalanine-specific permease pheP AlphaFold + ColabFold –
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0055085The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other. GO:0006865The directed movement of amino acids, organic acids containing one or more amino substituents, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. +14 total
0.826 Hit 26.9% 1.03e-14
532 KP13_04878 Medium-chain-fatty-acid--CoA ligase alkK AlphaFold + ColabFold
6.2.1.25
GO:0018858Catalysis of the reaction: ATP + benzoate + CoA = AMP + benzoyl-CoA + diphosphate. GO:0006631The chemical reactions and pathways involving fatty acids, aliphatic monocarboxylic acids liberated from naturally occurring fats and oils by hydrolysis.
0.396 Hit 28.6% 1.05e-14
533 KP13_00651 Glycerophosphoryl diester phosphodiesterase ugpQ AlphaFold + ColabFold –
GO:0008081Catalysis of the hydrolysis of a phosphodiester to give a phosphomonoester and a free hydroxyl group. GO:0006629The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids.
0.451 Hit 41.2% 1.20e-14
534 KP13_04683 kinase-like domain-containing protein AlphaFold + ColabFold – – 0.96 Hit 43.4% 1.29e-14
535 KP13_02377 tRNA pseudouridine synthase C truC AlphaFold + ColabFold
5.4.99.26
GO:0003723Binding to an RNA molecule or a portion thereof. GO:0001522The intramolecular conversion of uridine to pseudouridine within an RNA molecule. GO:0009451The covalent alteration of one or more nucleotides within an RNA molecule to produce an RNA molecule with a sequence that differs from that coded genetically. +47 total
0.088 Hit 29.9% 1.35e-14
536 KP13_02574 Formate hydrogenlyase subunit 3 hycC AlphaFold + ColabFold –
GO:0042773The transfer of electrons through a series of electron donors and acceptors, generating energy that is ultimately used for synthesis of ATP. GO:0008137Catalysis of the reaction: NADH + ubiquinone + 5 H+(in) = NAD+ + ubiquinol + 4 H+(out). GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. +14 total
0.971 Hit 27.0% 1.43e-14
537 KP13_00365 Endoribonuclease L-PSP/chorismate mutase-like domain-containing protein AlphaFold + ColabFold –
GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. GO:0019239Catalysis of the removal of an amino group from a substrate, producing a substituted or nonsubstituted ammonia (NH4+/NH2R).
0.579 Hit 43.2% 1.75e-14
538 KP13_02582 6-phospho-beta-glucosidase ascB ascB AlphaFold + ColabFold –
GO:0005975The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. GO:0004553Catalysis of the hydrolysis of any O-glycosyl bond. GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. +25 total
0.984 Hit 39.6% 1.80e-14
539 KP13_03301 Phosphoglucomutase pgm AlphaFold + ColabFold
5.4.2.2
GO:0004614Catalysis of the reaction: alpha-D-glucose 1-phosphate = alpha-D-glucose 6-phosphate. GO:0005975The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. GO:0071704OBSOLETE. The chemical reactions and pathways involving an organic substance, any molecular entity containing carbon. +36 total
0.855 Hit 25.8% 1.88e-14
540 KP13_03760 Elongation factor G 1 fusA1 AlphaFold + ColabFold –
GO:0003924Catalysis of the reaction: GTP + H2O = GDP + H+ + phosphate. GO:0003746Functions in chain elongation during polypeptide synthesis at the ribosome. GO:0005525Binding to GTP, guanosine triphosphate. +47 total
0.557 Hit 60.0% 1.92e-14
541 KP13_01007 GST-like protein Experimental + ColabFold – – 0.534 Hit 36.6% 2.26e-14
542 KP13_31507 Threonine dehydratase biosynthetic ilvA AlphaFold + ColabFold
4.3.1.19
GO:0030170Binding to pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6. GO:0006520The chemical reactions and pathways involving amino acids, carboxylic acids containing one or more amino groups. GO:0004794Catalysis of the reaction: L-threonine = 2-oxobutanoate + NH4. +47 total
0.343 Hit 51.6% 2.26e-14
543 KP13_00615 Acetyl esterase aes AlphaFold + ColabFold –
GO:0016787Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc.
0.523 Hit 37.6% 2.33e-14
544 KP13_02484 Endoribonuclease L-PSP family protein AlphaFold + ColabFold –
GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. GO:0019239Catalysis of the removal of an amino group from a substrate, producing a substituted or nonsubstituted ammonia (NH4+/NH2R).
0.729 Hit 30.3% 2.63e-14
545 KP13_00803 ATP-dependent RNA helicase srmB srmB AlphaFold + ColabFold
3.6.4.13
GO:0000027The aggregation, arrangement and bonding together of constituent RNAs and proteins to form the large ribosomal subunit. GO:0003676Binding to a nucleic acid. GO:0003724Unwinding of an RNA helix, driven by ATP hydrolysis. +36 total
0.181 Hit 56.5% 2.92e-14
546 KP13_02003 phosphoglycerate mutase gpmB AlphaFold + ColabFold
5.4.2.-
GO:0004619Catalysis of the reaction: (2R)-2-phosphoglycerate = (2R)-3-phosphoglycerate. GO:0003824Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. GO:0006096The chemical reactions and pathways resulting in the breakdown of a carbohydrate into pyruvate, with the concomitant production of a small amount of ATP and the reduction of NAD(P) to NAD(P)H. Glycolysis begins with the metabolism of a carbohydrate to generate products that can enter the pathway and ends with the production of pyruvate. Pyruvate may be converted to acetyl-coenzyme A, ethanol, lactate, or other small molecules. +25 total
0.86 Hit 35.9% 2.96e-14
547 KP13_01039 putative adenine-specific methylase AlphaFold + ColabFold
2.1.1.298
GO:0009007Catalysis of the reaction: S-adenosyl-L-methionine + DNA adenine = S-adenosyl-L-homocysteine + DNA 6-methylaminopurine. GO:0008168Catalysis of the transfer of a methyl group to an acceptor molecule. GO:0003676Binding to a nucleic acid. +710 total
0.957 Hit 29.0% 3.21e-14
548 KP13_02822 putative O-sialoglycoprotein endopeptidase gcp AlphaFold + ColabFold
2.3.1.234
GO:0002949The attachment of a carbonyl group and a threonine to the amino group of the adenine residue immediately 3' of the anticodon, in tRNAs that decode ANN codons (where N is any base). GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. GO:0005506Binding to an iron (Fe) ion. +14 total
0.606 Hit 42.4% 3.35e-14
549 KP13_01737 Deoxyribonuclease tatD tatD AlphaFold + ColabFold
3.1.11.- 3.1.13.-
GO:0016788Catalysis of the hydrolysis of any ester bond. GO:0008408Catalysis of the hydrolysis of ester linkages within nucleic acids by removing nucleotide residues from the 3' end. GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. +36 total
0.007 Hit 36.4% 3.42e-14
550 KP13_00750 50S ribosomal protein L4 rplD AlphaFold + ColabFold –
GO:0003735The action of a molecule that contributes to the structural integrity of the ribosome. GO:0005840An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins. GO:0006412The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA or circRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA or circRNA. Translation ends with the release of a polypeptide chain from the ribosome. +25 total
0.261 Hit 56.1% 3.53e-14
Page of 234 · 5842 total proteins