Proteins

Genome: KpKP13

Description: Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence

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# Protein Description Gene Structure EC GO Metabolism Druggability FPocket druggability score for the preferred structure (0–1): experimental structure when available, otherwise predicted model. ≥ 0.7 highly druggable · ≥ 0.4 moderately druggable · < 0.4 low druggability. Human off-target BLASTP against the human proteome. Hit means at least one human match was detected at e-value <= 1e-5. Prefer No hit for pathogen-selective targets. Human identity (%) Best human BLAST identity percentage. Human E-value Best human BLAST E-value.
776 KP13_03687 Protoheme IX farnesyltransferase cyoE AlphaFold DB model + ColabFold model
2.5.1.141
GO:0016765Catalysis of the transfer of an alkyl or aryl (but not methyl) group from one compound (donor) to another (acceptor). GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0008495Catalysis of the reaction: protoheme IX + (2E,6E)-farnesyl diphosphate + H2O = heme O + diphosphate. +36 total
No map 0.857 Hit 37.5% 3.73e-27
777 KP13_03693 hypothetical protein AlphaFold DB model + ColabFold model – – No map 0.451 Hit 34.6% 1.17e-08
778 KP13_03696 4-hydroxybenzoate transporter AlphaFold DB model + ColabFold model –
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0022857Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other. GO:0055085The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other. +25 total
No map 0.417 Hit 33.3% 5.89e-09
779 KP13_03697 putative oxidoreductase AlphaFold DB model + ColabFold model –
GO:0000166Binding to a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose.
No map 0.422 Hit 26.5% 2.69e-07
780 KP13_03701 Protein thiJ thiJ ColabFold model – – No map 0.694 Hit 34.4% 2.72e-18
781 KP13_03717 Outer membrane lipoprotein blc AlphaFold DB model + ColabFold model –
GO:0009279A lipid bilayer that forms the outermost membrane of the cell envelope; enriched in polysaccharide and protein; the outer leaflet of the membrane contains specific lipopolysaccharide structures. GO:0008289Binding to a lipid. GO:0006950Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a disturbance in organismal or cellular homeostasis, usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation).
No map 0.81 Hit 32.1% 4.77e-07
782 KP13_03720 putative oxidoreductase AlphaFold DB model + ColabFold model –
GO:0016491Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it.
No map 0.97 Hit 34.5% 6.05e-06
783 KP13_03743 Guanine deaminase guaD AlphaFold DB model + ColabFold model –
GO:0008270Binding to a zinc ion (Zn). GO:0003824Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. GO:0016787Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. +25 total
No map 0.731 Hit 26.2% 1.59e-09
784 KP13_03745 putative aminotransferase AlphaFold DB model + ColabFold model –
GO:0030170Binding to pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6. GO:0009058A cellular process consisting of the biochemical pathways by which a living organism synthesizes chemical substances. This typically represents the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones. GO:0003824Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. +14 total
No map 0.967 Hit 28.6% 1.10e-16
785 KP13_03752 putative oxidoreductase AlphaFold DB model + ColabFold model –
GO:0016491Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. GO:0051596The chemical reactions and pathways resulting in the breakdown of methylglyoxal, CH3-CO-CHO, the aldehyde of pyruvic acid.
No map 0.389 Hit 40.7% 1.54e-06
786 KP13_03754 putative manganese transport protein mntH mntH AlphaFold DB model + ColabFold model –
GO:0030001The directed movement of metal ions, any metal ion with an electric charge, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. GO:0046873Enables the transfer of metal ions from one side of a membrane to the other. GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. +69 total
No map 0.985 Hit 46.4% 4.91e-17
787 KP13_03756 Nucleoside permease nupC nupC AlphaFold DB model + ColabFold model –
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0005337Enables the transfer of a nucleoside, a nucleobase linked to either beta-D-ribofuranose (ribonucleoside) or 2-deoxy-beta-D-ribofuranose, (a deoxyribonucleotide) from one side of a membrane to the other. GO:1901642The directed movement of nucleoside across a membrane. +47 total
No map 0.975 Hit 26.5% 2.20e-28
788 KP13_03760 Elongation factor G 1 fusA1 AlphaFold DB model + ColabFold model –
GO:0003924Catalysis of the reaction: GTP + H2O = GDP + H+ + phosphate. GO:0003746Functions in chain elongation during polypeptide synthesis at the ribosome. GO:0005525Binding to GTP, guanosine triphosphate. +47 total
No map 0.557 Hit 60.0% 1.92e-14
789 KP13_03762 Inner membrane transport protein AlphaFold DB model + ColabFold model –
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0055085The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other. GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. +25 total
No map 0.566 Hit 26.9% 1.26e-09
790 KP13_03769 Histidinol-phosphate aminotransferase hisC Experimental + ColabFold model –
GO:0030170Binding to pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6. GO:0004400Catalysis of the reaction: L-histidinol-phosphate + 2-oxoglutarate = 3-(imidazol-4-yl)-2-oxopropyl phosphate + L-glutamate. GO:0000105The chemical reactions and pathways resulting in the formation of L-histidine, 2-amino-3-(1H-imidazol-4-yl)propanoic acid. +36 total
No map 0.775 Hit 30.7% 1.30e-08
791 KP13_03778 putative glycosyltransferase family 2 AlphaFold DB model + ColabFold model
2.4.1.212
GO:0050501Catalysis of the reaction: UDP-D-glucuronate + UDP-N-acetyl-D-glucosamine = [beta-N-acetyl-D-glucosaminyl-(1->4)-beta-D-glucuronosyl-(1->3)](n) + 2n UDP.
No map 0.783 Hit 38.3% 7.60e-06
792 KP13_03782 Glycosyltransferase family 8 wbbM Experimental + ColabFold model –
GO:0016757Catalysis of the transfer of a glycosyl group from one compound (donor) to another (acceptor). GO:0046872Binding to a metal ion.
No map 0.358 Hit 23.0% 1.50e-07
793 KP13_03783 O-antigen export system ATP-binding protein rfbB rfbB AlphaFold DB model + ColabFold model –
GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0016887Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient. +14 total
No map 0.881 Hit 33.5% 5.68e-26
794 KP13_03786 Uridine diphosphate galacturonate 4-epimerase uge-2 AlphaFold DB model + ColabFold model – – No map 0.74 Hit 32.9% 1.43e-18
795 KP13_03793 Uridine diphosphate galacturonate 4-epimerase in cps region uge-1 AlphaFold DB model + ColabFold model – – No map 0.381 Hit 36.2% 4.24e-19
796 KP13_03794 UDP-glucose 6-dehydrogenase in cps region ugd Experimental + ColabFold model
1.1.1.22
GO:0016616Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group acts as a hydrogen or electron donor and reduces NAD+ or NADP. GO:0000271The chemical reactions and pathways resulting in the formation of a polysaccharide, a polymer of many (typically more than 10) monosaccharide residues linked glycosidically. GO:0016491Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. +36 total
No map 0.951 Hit 31.7% 4.92e-06
797 KP13_03796 dTDP-4-dehydrorhamnose reductase in cps region rmlD Experimental + ColabFold model
1.1.1.133
GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. GO:0008831Catalysis of the reaction: dTDP-6-deoxy-L-mannose + NADP+ = dTDP-4-dehydro-6-deoxy-L-mannose + H+ + NADPH. GO:0000166Binding to a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose. +25 total
No map 0.895 Hit 34.2% 7.45e-15
798 KP13_03797 Glucose-1-phosphate thymidylyltransferase in cps region rmlA AlphaFold DB model + ColabFold model
2.7.7.24
GO:0045226OBSOLETE. The chemical reactions and pathways resulting in the formation of polysaccharides used in extracellular structures. GO:0009058A cellular process consisting of the biochemical pathways by which a living organism synthesizes chemical substances. This typically represents the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones. GO:0008879Catalysis of the reaction: alpha-D-glucose 1-phosphate + dTTP = diphosphate + dTDP-glucose. +14 total
No map 0.309 Hit 34.5% 3.05e-07
799 KP13_03807 Protein-tyrosine-phosphatase in cps region wzb AlphaFold DB model + ColabFold model
3.1.3.48
GO:0004725Catalysis of the reaction: protein tyrosine phosphate + H2O = protein tyrosine + phosphate. GO:0006470The process of removing one or more phosphoric residues from a protein.
No map 0.381 Hit 39.4% 1.46e-06
800 KP13_03811 Phosphoribosylglycinamide formyltransferase purN AlphaFold DB model + ColabFold model
2.1.2.2
GO:0009058A cellular process consisting of the biochemical pathways by which a living organism synthesizes chemical substances. This typically represents the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones. GO:0006189The chemical reactions and pathways resulting in the formation of IMP, inosine monophosphate, by the stepwise assembly of a purine ring on ribose 5-phosphate. GO:0004644Catalysis of the reaction: 10-formyltetrahydrofolate + N1-(5-phospho-D-ribosyl)glycinamide = tetrahydrofolate + N2-formyl-N1-(5-phospho-D-ribosyl)glycinamide. +14 total
No map 0.601 Hit 44.0% 1.92e-35
Page of 234 · 5842 total proteins