Proteins

Genome: KpKP13

Description: Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence

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5842 proteins

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# Protein Description Gene Structure EC GO Druggability FPocket druggability score for the preferred structure (0–1): experimental structure when available, otherwise predicted model. ≥ 0.7 highly druggable · ≥ 0.4 moderately druggable · < 0.4 low druggability. Human off-target BLASTP against the human proteome. Hit means at least one human match was detected at e-value <= 1e-5. Prefer No hit for pathogen-selective targets. Human identity (%) Best human BLAST identity percentage. Human E-value Best human BLAST E-value.
1076 KP13_03601 thioredoxin domain-containing protein AlphaFold + ColabFold –
GO:0005515Binding to a protein. GO:0045454Any process that maintains the redox environment of a cell or compartment within a cell. GO:0006950Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a disturbance in organismal or cellular homeostasis, usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation).
0.34 Hit 36.5% 6.85e-07
1077 KP13_04645 Fe(3+) dicitrate transport ATP-binding protein fecE fecE AlphaFold + ColabFold –
GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. GO:0016887Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient.
0.294 Hit 36.2% 6.90e-07
1078 KP13_00986 NADH-quinone oxidoreductase subunit I nuoI AlphaFold + ColabFold
7.1.1.-
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0051539Binding to a 4 iron, 4 sulfur (4Fe-4S) cluster; this cluster consists of four iron atoms, with the inorganic sulfur atoms found between the irons and acting as bridging ligands. GO:0016651Catalysis of an oxidation-reduction (redox) reaction in which NADH or NADPH acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor. +58 total
0.372 Hit 47.9% 7.04e-07
1079 KP13_04871 Clavaminate synthase-like superfamily protein AlphaFold + ColabFold –
GO:0016706Catalysis of the reaction: A + 2-oxoglutarate + O2 = B + succinate + CO2. This is an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from 2-oxoglutarate and one other donor, and one atom of oxygen is incorporated into each donor. GO:0046872Binding to a metal ion.
0.862 Hit 37.5% 7.29e-07
1080 KP13_04312 Glutamine transport ATP-binding protein glnQ glnQ AlphaFold + ColabFold –
GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. GO:0016887Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient. GO:0003333The process in which an amino acid is transported across a membrane. +14 total
0.223 Hit 61.1% 7.30e-07
1081 KP13_04973 putative enoyl-CoA hydratase paaG paaG AlphaFold + ColabFold –
GO:0010124The chemical reactions and pathways resulting in the breakdown of phenylacetate. GO:0003824Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic.
0.828 Hit 37.1% 7.35e-07
1082 KP13_02170 5-formyltetrahydrofolate cyclo-ligase family protein AlphaFold + ColabFold – – 0.99 Hit 27.2% 7.39e-07
1083 KP13_04826 High-molecular-weight protein 2 irp2 AlphaFold + ColabFold –
GO:0031177Binding to phosphopantetheine, the vitamin pantetheine 4'-(dihydrogen phosphate). GO:0003824Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. +36 total
0.976 Hit 35.4% 7.39e-07
1084 KP13_02380 putative glucarate transporter gudP AlphaFold + ColabFold –
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0022857Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other. GO:0055085The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other. +36 total
0.908 Hit 31.5% 7.54e-07
1085 KP13_32212 Iron-binding protein iscA iscA AlphaFold + ColabFold –
GO:0016226The incorporation of iron and exogenous sulfur into a metallo-sulfur cluster. GO:0051536Binding to an iron-sulfur cluster, a combination of iron and sulfur atoms. GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. +25 total
0.014 Hit 54.8% 7.79e-07
1086 KP13_00533 Protein hflC hflC AlphaFold + ColabFold –
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0052547Any process that modulates the frequency, rate or extent of peptidase activity, the hydrolysis of peptide bonds within proteins. GO:0008233Catalysis of the hydrolysis of a peptide bond. A peptide bond is a covalent bond formed when the carbon atom from the carboxyl group of one amino acid shares electrons with the nitrogen atom from the amino group of a second amino acid. +14 total
0.367 Hit 28.1% 7.97e-07
1087 KP13_25192 3-oxoadipate enol-lactonase 2 AlphaFold + ColabFold –
GO:0047570Catalysis of the reaction: 3-oxoadipate enol-lactone + H2O = 3-oxoadipate. GO:0042952A pathway of aromatic compound degradation by ortho-cleavage; one branch converts protocatechuate, derived from phenolic compounds, to beta-ketoadipate, and the other branch converts catechol, generated from various aromatic hydrocarbons, amino aromatics, and lignin monomers, also to beta-ketoadipate. Two additional steps accomplish the conversion of beta-ketoadipate to tricarboxylic acid cycle intermediates.
0.536 Hit 29.4% 8.02e-07
1088 KP13_04606 Putative 3-hydroxyphenylpropionic acid transporter mhpT AlphaFold + ColabFold –
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0022857Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other. GO:0055085The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other. +25 total
0.896 Hit 36.6% 8.24e-07
1089 KP13_04584 putative Glutamine amidotransferase AlphaFold + ColabFold –
GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
0.787 Hit 31.9% 8.29e-07
1090 KP13_01430 Tryptophanyl-tRNA synthetase AlphaFold + ColabFold – – 0.271 Hit 26.2% 8.32e-07
1091 KP13_00686 hypothetical protein AlphaFold + ColabFold –
GO:0003676Binding to a nucleic acid. GO:0006139Any cellular metabolic process involving nucleobases, nucleosides, nucleotides and nucleic acids. GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. +36 total
0.251 Hit 37.9% 8.37e-07
1092 KP13_02449 Amino acid ABC transporter, permease protein/ATP-binding protein AlphaFold + ColabFold –
GO:0016887Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient. GO:0022857Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other. GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. +58 total
0.811 Hit 62.9% 8.68e-07
1093 KP13_03155 putative lipid kinase AlphaFold + ColabFold
2.7.1.-
GO:0016310The process of introducing a phosphate group into a molecule, usually with the formation of a phosphoric ester, a phosphoric anhydride or a phosphoric amide. GO:0016301Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule. GO:0001727Catalysis of the phosphorylation of a simple or complex lipid. +69 total
0.221 Hit 28.2% 8.76e-07
1094 KP13_00814 GTP-binding protein Era era AlphaFold + ColabFold –
GO:0005525Binding to GTP, guanosine triphosphate. GO:0003723Binding to an RNA molecule or a portion thereof.
0.147 Hit 46.4% 9.03e-07
1095 KP13_04229 Aquaporin Z aqpZ AlphaFold + ColabFold –
GO:0015267Enables the energy-independent facilitated diffusion of a solute through a transmembrane aqueous pore or channel. Stereospecificity is not exhibited but this transport may be specific for a particular molecular species or class of molecules. GO:0006833The directed movement of water (H2O) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. +36 total
0.945 Hit 41.9% 9.32e-07
1096 KP13_00813 Ribonuclease 3 rnc AlphaFold + ColabFold
3.1.26.3
GO:0004525Catalysis of the endonucleolytic cleavage of RNA with 5'-phosphomonoesters and 3'-OH termini; makes two staggered cuts in both strands of dsRNA, leaving a 3' overhang of 2 nt. GO:0006364Any process involved in the conversion of a primary ribosomal RNA (rRNA) transcript into one or more mature rRNA molecules. GO:0006396Any process involved in the conversion of one or more primary RNA transcripts into one or more mature RNA molecules. +912 total
0.374 Hit 35.1% 9.48e-07
1097 KP13_02277 Protein tas tas AlphaFold + ColabFold –
GO:0016491Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced.
0.998 Hit 48.1% 9.50e-07
1098 KP13_04479 Putative NADP-dependent oxidoreductase AlphaFold + ColabFold –
GO:0016491Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. GO:0016628Catalysis of an oxidation-reduction (redox) reaction in which a CH-CH group acts as a hydrogen or electron donor and reduces NAD or NADP.
0.989 Hit 40.8% 9.54e-07
1099 KP13_05336 putative siderophore transport system ATP-binding protein AlphaFold + ColabFold –
GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. GO:0016887Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient. GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. +14 total
0.201 Hit 34.2% 9.55e-07
1100 KP13_00753 30S ribosomal protein S19 rpsS AlphaFold + ColabFold –
GO:0015935The smaller of the two subunits of a ribosome. GO:0003735The action of a molecule that contributes to the structural integrity of the ribosome. GO:0006412The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA or circRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA or circRNA. Translation ends with the release of a polypeptide chain from the ribosome. +58 total
0.404 Hit 38.8% 1.01e-06
Page of 234 · 5842 total proteins