Proteins

Genome: KpKP13

Description: Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence

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5842 proteins

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# Protein Description Gene Structure EC GO Druggability FPocket druggability score for the preferred structure (0–1): experimental structure when available, otherwise predicted model. ≥ 0.7 highly druggable · ≥ 0.4 moderately druggable · < 0.4 low druggability. Human off-target BLASTP against the human proteome. Hit means at least one human match was detected at e-value <= 1e-5. Prefer No hit for pathogen-selective targets. Human identity (%) Best human BLAST identity percentage. Human E-value Best human BLAST E-value.
101 KP13_05217 Methionine aminopeptidase AlphaFold + ColabFold
3.4.11.18
GO:0006508The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds. GO:0070006Catalysis of the hydrolysis of a single N-terminal amino acid residue from a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions. GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. +25 total
0.315 Hit 44.3% 1.35e-59
102 KP13_04976 Beta-ketoadipyl-CoA thiolase paaJ AlphaFold + ColabFold
2.3.1.174
GO:0019619The chemical reactions and pathways resulting in the breakdown of 3,4-dihydroxybenzoate. GO:0016746Catalysis of the transfer of an acyl group from one compound (donor) to another (acceptor). GO:0016747Catalysis of the transfer of an acyl group, other than amino-acyl, from one compound (donor) to another (acceptor). +14 total
0.801 Hit 47.1% 2.95e-59
103 KP13_01043 3-ketoacyl-CoA thiolase fadI AlphaFold + ColabFold
2.3.1.16
GO:0016746Catalysis of the transfer of an acyl group from one compound (donor) to another (acceptor). GO:0016042The chemical reactions and pathways resulting in the breakdown of lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. +58 total
0.76 Hit 47.8% 7.17e-59
104 KP13_00254 Glyoxylate/hydroxypyruvate reductase B ghrB AlphaFold + ColabFold
1.1.1.79 1.1.1.81
GO:0016618Catalysis of the reaction: (R)-glycerate + NAD(P)+ = 3-hydroxypyruvate + NAD(P)H + H+. GO:0051287Binding to nicotinamide adenine dinucleotide, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NAD+, or the reduced form, NADH. GO:0030267Catalysis of the reaction: glycolate + NADP+ = glyoxylate + NADPH + H+. +58 total
0.427 Hit 40.2% 3.45e-58
105 KP13_02744 A/G-specific adenine glycosylase mutY AlphaFold + ColabFold
3.2.2.31
GO:0051539Binding to a 4 iron, 4 sulfur (4Fe-4S) cluster; this cluster consists of four iron atoms, with the inorganic sulfur atoms found between the irons and acting as bridging ligands. GO:0016798Catalysis of the hydrolysis of any glycosyl bond. GO:0006284In base excision repair, an altered base is removed by a DNA glycosylase enzyme, followed by excision of the resulting sugar phosphate. The small gap left in the DNA helix is filled in by the sequential action of DNA polymerase and DNA ligase. +1013 total
0.477 Hit 44.9% 2.75e-56
106 KP13_01299 Ornithine carbamoyltransferase argI Experimental + ColabFold
2.1.3.3
GO:0016597Binding to an amino acid, organic acids containing one or more amino substituents. GO:0006520The chemical reactions and pathways involving amino acids, carboxylic acids containing one or more amino groups. GO:0004585Catalysis of the reaction: carbamoyl phosphate + L-ornithine = phosphate + L-citrulline. +58 total
0.453 Hit 36.9% 2.95e-56
107 KP13_02059 putative peroxiredoxin AlphaFold + ColabFold –
GO:0016491Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. GO:0051920Catalysis of the reaction: [protein]-dithol + ROOH = [protein]-disulfide + H2O + ROH. GO:0016209Inhibition of the reactions brought about by dioxygen (O2) or peroxides. Usually the antioxidant is effective because it can itself be more easily oxidized than the substance protected. The term is often applied to components that can trap free radicals, thereby breaking the chain reaction that normally leads to extensive biological damage. +69 total
0.711 Hit 50.0% 1.54e-55
108 KP13_04095 Aldehyde dehydrogenase aldA AlphaFold + ColabFold
1.2.1.- 1.2.1.48
GO:0016491Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. GO:0016620Catalysis of an oxidation-reduction (redox) reaction in which an aldehyde or ketone (oxo) group acts as a hydrogen or electron donor and reduces NAD or NADP. GO:0050061Catalysis of the reaction: a long-chain fatty aldehyde + H2O + NAD+ = a long-chain fatty acid + 2 H+ + NADH.
0.96 Hit 45.3% 1.22e-54
109 KP13_02426 Signal recognition particle protein ffh AlphaFold + ColabFold
3.6.5.4
GO:0016887Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient. GO:0003924Catalysis of the reaction: GTP + H2O = GDP + H+ + phosphate. GO:0048500A complex of protein and RNA which facilitates translocation of proteins across membranes. +36 total
0.728 Hit 34.4% 1.41e-54
110 KP13_03018 Imidazolonepropionase hutI AlphaFold + ColabFold
3.5.2.7
GO:0016787Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. GO:0016810Catalysis of the hydrolysis of any carbon-nitrogen bond, C-N, with the exception of peptide bonds. +69 total
0.465 Hit 34.1% 1.44e-54
111 KP13_01981 Chaperone protein dnaK dnaK AlphaFold + ColabFold –
GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. GO:0051082Binding to an unfolded protein. GO:0140662Binding to a protein or a protein-containing complex to assist the protein folding process, driven by ATP hydrolysis. +25 total
0.425 Hit 65.9% 4.46e-54
112 KP13_02408 chaperone protein clpB clpB AlphaFold + ColabFold –
GO:0016887Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient. GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. +36 total
0.698 Hit 42.3% 6.10e-54
113 KP13_05041 3-oxoadipate CoA-transferase subunit B pcaJ AlphaFold + ColabFold –
GO:0008410Catalysis of the transfer of a coenzyme A (CoA) group from one compound (donor) to another (acceptor).
0.362 Hit 44.7% 1.22e-53
114 KP13_05164 Tyrosyl-tRNA synthetase tyrS AlphaFold + ColabFold
6.1.1.1
GO:0004812Catalysis of the formation of aminoacyl-tRNA from ATP, amino acid, and tRNA with the release of diphosphate and AMP. GO:0004831Catalysis of the reaction: L-tyrosine + ATP + tRNA(Tyr) = L-tyrosyl-tRNA(Tyr) + AMP + diphosphate + 2 H+. GO:0006418The synthesis of aminoacyl tRNA by the formation of an ester bond between the 3'-hydroxyl group of the most 3' adenosine of the tRNA and the alpha carboxylic acid group of an amino acid, to be used in ribosome-mediated polypeptide synthesis. +69 total
0.419 Hit 42.0% 1.38e-53
115 KP13_05042 Beta-ketoadipyl-CoA thiolase catF AlphaFold + ColabFold
2.3.1.174
GO:0019619The chemical reactions and pathways resulting in the breakdown of 3,4-dihydroxybenzoate. GO:0016746Catalysis of the transfer of an acyl group from one compound (donor) to another (acceptor). GO:0016747Catalysis of the transfer of an acyl group, other than amino-acyl, from one compound (donor) to another (acceptor). +14 total
0.704 Hit 46.4% 1.08e-52
116 KP13_03169 FGGY carbohydrate kinase domain-containing protein AlphaFold + ColabFold –
GO:0016773Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to an alcohol group (acceptor). GO:0005975The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. GO:0016301Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule. +36 total
0.726 Hit 49.4% 5.24e-51
117 KP13_00958 Ribonucleoside-diphosphate reductase 1 subunit alpha nrdA AlphaFold + ColabFold
1.17.4.1
GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. GO:0006260The cellular metabolic process in which a cell duplicates one or more molecules of DNA. DNA replication begins when specific sequences, known as origins of replication, are recognized and bound by the origin recognition complex, and ends when the original DNA molecule has been completely duplicated and the copies topologically separated. The unit of replication usually corresponds to the genome of the cell, an organelle, or a virus. The template for replication can either be an existing DNA molecule or RNA. GO:0004748Catalysis of the reaction: 2'-deoxyribonucleoside diphosphate + thioredoxin disulfide + H2O = ribonucleoside diphosphate + thioredoxin. Thioredoxin disulfide is the oxidized form of thioredoxin. +25 total
0.354 Hit 27.6% 6.44e-51
118 KP13_31815 aldehyde dehydrogenase domain-containing protein AlphaFold + ColabFold –
GO:0016491Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. GO:0016620Catalysis of an oxidation-reduction (redox) reaction in which an aldehyde or ketone (oxo) group acts as a hydrogen or electron donor and reduces NAD or NADP. GO:0009447The chemical reactions and pathways resulting in the breakdown of putrescine, 1,4-diaminobutane; putrescine is the metabolic precursor of spermidine and spermine.
0.891 Hit 37.0% 7.04e-51
119 KP13_01706 Porphobilinogen deaminase hemC AlphaFold + ColabFold
2.5.1.61
GO:0004418Catalysis of the reaction: H2O + 4 porphobilinogen = hydroxymethylbilane + 4 NH4. GO:0033014The chemical reactions and pathways leading to the formation of tetrapyrroles, natural pigments containing four pyrrole rings joined by one-carbon units linking position 2 of one pyrrole ring to position 5 of the next. GO:0018160The covalent binding of a pyrromethane (dipyrrin) cofactor to protein via the sulfur atom of cysteine forming dipyrrolylmethanemethyl-L-cysteine. +25 total
0.52 Hit 47.3% 4.91e-50
120 KP13_04951 hypothetical protein AlphaFold + ColabFold
3.1.1.106
GO:0061463Catalysis of the reaction O-acetyl-ADP-ribose + H2O = ADP-ribose + acetate. Removes the acetyl group from either the 2'' or 3'' position of O-acetyl-ADP-ribose. GO:0001883Binding to a purine nucleoside, a compound consisting of a purine base linked either to ribose or deoxyribose. GO:0008428Binds to and stops, prevents or reduces the activity of ribonuclease. +14 total
0.404 Hit 50.9% 6.05e-50
121 KP13_02390 Enolase eno AlphaFold + ColabFold
4.2.1.11
GO:0000015A multimeric enzyme complex, usually a dimer or an octamer, that catalyzes the conversion of 2-phospho-D-glycerate to phosphoenolpyruvate and water. GO:0004634Catalysis of the reaction: 2-phospho-D-glycerate = phosphoenolpyruvate + H2O. GO:0000287Binding to a magnesium (Mg) ion. +36 total
0.651 Hit 61.6% 4.81e-49
122 KP13_01632 Copper homeostasis protein cutC cutC AlphaFold + ColabFold –
GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. GO:0005507Binding to a copper (Cu) ion.
0.329 Hit 50.9% 1.52e-48
123 KP13_31514 putative aldehyde/histidinol dehydrogenase AlphaFold + ColabFold –
GO:0016491Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. GO:0016620Catalysis of an oxidation-reduction (redox) reaction in which an aldehyde or ketone (oxo) group acts as a hydrogen or electron donor and reduces NAD or NADP.
0.947 Hit 42.5% 1.53e-48
124 KP13_03346 Lipoyl synthase lipA AlphaFold + ColabFold
2.8.1.8
GO:0051539Binding to a 4 iron, 4 sulfur (4Fe-4S) cluster; this cluster consists of four iron atoms, with the inorganic sulfur atoms found between the irons and acting as bridging ligands. GO:0016992Catalysis of the reaction: [[Fe-S] cluster scaffold protein carrying a second [4Fe-4S]2+ cluster] + N(6)-octanoyl-L-lysyl-[protein] + 2 oxidized [2Fe-2S]-[ferredoxin] + 2 S-adenosyl-L-methionine + 4 H+ = [[Fe-S] cluster scaffold protein] + N(6)-[(R)-dihydrolipoyl]-L-lysyl-[protein] + 4 Fe3+ + 2 hydrogen sulfide + 2 5'-deoxyadenosine + 2 L-methionine + 2 reduced [2Fe-2S]-[ferredoxin]. GO:0003824Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. +58 total
0.819 Hit 45.1% 4.07e-48
125 KP13_00023 ATP synthase subunit alpha atpA AlphaFold + ColabFold
7.1.2.2
GO:0046034The chemical reactions and pathways involving ATP, adenosine triphosphate, a universally important coenzyme and enzyme regulator. GO:1902600The directed movement of a proton across a membrane. GO:0032559Binding to an adenyl ribonucleotide, any compound consisting of adenosine esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose moiety. +710 total
0.735 Hit 56.6% 5.55e-48
Page of 234 · 5842 total proteins