Proteins

Genome: KpKP13

Description: Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence

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5192 proteins Structure: AlphaFold

Scoring formula None

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Structure: AlphaFold ×
# Protein Description Gene Structure EC GO Druggability FPocket druggability score for the preferred structure (0–1): experimental structure when available, otherwise predicted model. ≥ 0.7 highly druggable · ≥ 0.4 moderately druggable · < 0.4 low druggability. Human off-target BLASTP against the human proteome. Hit means at least one human match was detected at e-value <= 1e-5. Prefer No hit for pathogen-selective targets. Human identity (%) Best human BLAST identity percentage. Human E-value Best human BLAST E-value.
1351 KP13_06662 hypothetical protein AlphaFold + ColabFold – – 0.778 No Hit 0.0% —
1352 KP13_05539 putative exporter protein, LysE family protein AlphaFold + ColabFold –
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0006865The directed movement of amino acids, organic acids containing one or more amino substituents, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. +14 total
0.778 No Hit 0.0% —
1353 KP13_03353 Ribonuclease I rna AlphaFold + ColabFold –
GO:0003723Binding to an RNA molecule or a portion thereof. GO:0033897Catalysis of the reaction: a ribonucleotidyl-ribonucleotide-RNA + H2O = a 3'-end 3'-phospho-ribonucleotide-RNA + a 5'-end dephospho-ribonucleoside-RNA + H+. This reaction is a two-stage endonucleolytic cleavage to nucleoside 3'-phosphates and 3'-phosphooligonucleotides with 2',3'-cyclic phosphate intermediates. GO:0006401The chemical reactions and pathways resulting in the breakdown of RNA, ribonucleic acid, one of the two main type of nucleic acid, consisting of a long, unbranched macromolecule formed from ribonucleotides joined in 3',5'-phosphodiester linkage.
0.778 No Hit 0.0% —
1354 KP13_02527 Phenolic acid decarboxylase subunit C AlphaFold + ColabFold
4.1.1.-
GO:0016831Catalysis of the nonhydrolytic addition or removal of a carboxyl group to or from a compound. GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. GO:0008694Catalysis of the reaction: a 4-hydroxy-3-(all-trans-polyprenyl)benzoate + H+ = a 2-(all-trans-polyprenyl)phenol + CO2. +36 total
0.778 No Hit 0.0% —
1355 KP13_00617 D-tyrosyl-tRNA(Tyr) deacylase dtd AlphaFold + ColabFold
3.1.1.96 3.1.1.-
GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. GO:0051499Catalysis of the reaction: a D-aminoacyl-tRNA + H2O = a D-alpha-amino acid + a tRNA + H+. Removal of a D-amino acid from a charged tRNA. GO:0002161The hydrolysis of an incorrectly aminoacylated tRNA. +58 total
0.778 Hit 37.4% 3.65e-24
1356 KP13_04278 Raffinose permease AlphaFold + ColabFold –
GO:0008643The directed movement of carbohydrate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Carbohydrates are a group of organic compounds based of the general formula Cx(H2O)y. GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0005351Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: carbohydrate(out) + H+(out) = carbohydrate(in) + H+(in). +36 total
0.777 No Hit 0.0% —
1357 KP13_02710 putative deoxythimodone diphosphates-4-dehydrorhamnose 3,5-epimerase AlphaFold + ColabFold – – 0.777 No Hit 0.0% —
1358 KP13_02072 Branched-chain amino acid transport system 2 carrier protein brnQ AlphaFold + ColabFold –
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0015658Enables the transfer of branched-chain amino acids from one side of a membrane to the other. Branched-chain amino acids are amino acids with a branched carbon skeleton without rings. GO:0015803The directed movement of branched-chain amino acids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Branched-chain amino acids are amino acids with a branched carbon skeleton without rings. +69 total
0.777 No Hit 0.0% —
1359 KP13_01882 hypothetical protein AlphaFold + ColabFold – – 0.777 No Hit 0.0% —
1360 KP13_05284 putative high-affinity branched-chain amino acid ABC transporter membrane protein AlphaFold + ColabFold –
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0022857Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other. GO:0055085The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other. +25 total
0.776 No Hit 0.0% —
1361 KP13_04735 hypothetical protein AlphaFold + ColabFold – – 0.776 No Hit 0.0% —
1362 KP13_04557 hypothetical protein AlphaFold + ColabFold – – 0.776 No Hit 0.0% —
1363 KP13_01405 hypothetical protein AlphaFold + ColabFold – – 0.776 No Hit 0.0% —
1364 KP13_03900 HTH-type transcriptional regulator puuR puuR AlphaFold + ColabFold –
GO:0003677Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. GO:0003700A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons.
0.775 No Hit 0.0% —
1365 KP13_03397 Isochorismatase entB AlphaFold + ColabFold
3.3.2.1 6.3.2.14
GO:0008908Catalysis of the reaction: H2O + isochorismate = 2,3-dihydroxy-2,3-dihydrobenzoate + pyruvate. GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. GO:0047527Catalysis of the reaction: ATP + 2,3-dihydroxybenzoate + L-serine = products of ATP breakdown + N-(2,3-dihydroxybenzoyl)-L-serine. +25 total
0.775 No Hit 0.0% —
1366 KP13_01644 hypothetical protein AlphaFold + ColabFold – – 0.775 No Hit 0.0% —
1367 KP13_01458 Calcium/proton antiporter chaA AlphaFold + ColabFold –
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0055085The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other. GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. +25 total
0.775 No Hit 0.0% —
1368 KP13_00084 Sensor protein uhpB uhpB AlphaFold + ColabFold –
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0000155Catalysis of the phosphorylation of a histidine residue in response to detection of an extracellular signal such as a chemical ligand or change in environment, to initiate a change in cell state or activity. The two-component sensor is a histidine kinase that autophosphorylates a histidine residue in its active site. The phosphate is then transferred to an aspartate residue in a downstream response regulator, to trigger a response. GO:0000160A conserved series of molecular signals found in prokaryotes and eukaryotes; involves autophosphorylation of a histidine kinase and the transfer of the phosphate group to an aspartate that then acts as a phospho-donor to response regulator proteins. +25 total
0.775 No Hit 0.0% —
1369 KP13_06630 hypothetical protein AlphaFold + ColabFold – – 0.774 No Hit 0.0% —
1370 KP13_05139 HTH-type transcriptional repressor purR AlphaFold + ColabFold –
GO:0006355Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. GO:0003677Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). GO:0003700A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons. +36 total
0.774 No Hit 0.0% —
1371 KP13_02996 putative molybdenum transport ATP-binding protein modF modF AlphaFold + ColabFold
3.6.3.17
GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. GO:0016887Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient.
0.774 Hit 29.0% 1.08e-07
1372 KP13_00348 putative N-acetyltransferase AlphaFold + ColabFold –
GO:0016747Catalysis of the transfer of an acyl group, other than amino-acyl, from one compound (donor) to another (acceptor).
0.774 No Hit 0.0% —
1373 KP13_11079 Phosphate acetyltransferase pta AlphaFold + ColabFold
2.3.1.8
GO:0008959Catalysis of the reaction: acetyl-CoA + phosphate = CoA + acetyl phosphate. GO:0016407Catalysis of the transfer of an acetyl group to an acceptor molecule. GO:0016746Catalysis of the transfer of an acyl group from one compound (donor) to another (acceptor). +25 total
0.773 No Hit 0.0% —
1374 KP13_04561 putative glycosidase AlphaFold + ColabFold –
GO:0005975The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. GO:0016798Catalysis of the hydrolysis of any glycosyl bond.
0.773 Hit 43.5% 1.36e-11
1375 KP13_06631 phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase AlphaFold + ColabFold –
GO:0003824Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic.
0.772 No Hit 0.0% —
Page of 208 · 5192 total proteins