Proteins

Genome: KpKP13

Description: Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence

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5842 / 5842 proteins

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# Protein Description Gene Structure EC GO Druggability FPocket druggability score for the preferred structure (0–1): experimental structure when available, otherwise predicted model. ≥ 0.7 highly druggable · ≥ 0.4 moderately druggable · < 0.4 low druggability. Human off-target BLASTP against the human proteome. Hit means at least one human match was detected at e-value <= 1e-5. Prefer No hit for pathogen-selective targets. Human identity (%) Best human BLAST identity percentage. Human E-value Best human BLAST E-value.
1476 KP13_00312 Universal stress protein B uspB AlphaFold + ColabFold – – 0.747 No Hit 0.0% —
1477 KP13_00314 FAD-dependent oxidoreductase AlphaFold + ColabFold – – 0.999 No Hit 0.0% —
1478 KP13_00315 Magnesium transporter mgtE mgtE AlphaFold + ColabFold –
GO:0006812The directed movement of a monoatomic cation, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Monatomic cations (also called simple cations) are positively charged ions consisting of exactly one atom. GO:0008324Enables the transfer of cation from one side of a membrane to the other.
0.276 No Hit 0.0% —
1479 KP13_00316 Nickel-responsive regulator nikR AlphaFold + ColabFold –
GO:0016151Binding to a nickel (Ni) cation. GO:0006355Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. GO:0010045Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a nickel cation stimulus. +36 total
0.272 No Hit 0.0% —
1480 KP13_00319 Nickel transport system permease protein nikC nikC AlphaFold + ColabFold –
GO:0015099Enables the transfer of nickel (Ni) cations from one side of a membrane to the other. GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0055085The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other. +25 total
0.827 No Hit 0.0% —
1481 KP13_00320 Nickel transport system permease protein nikB nikB AlphaFold + ColabFold –
GO:0015099Enables the transfer of nickel (Ni) cations from one side of a membrane to the other. GO:0035444The directed movement of nickel (Ni) cations across a membrane by means of some agent such as a transporter or pore. GO:0055085The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other. +14 total
0.566 No Hit 0.0% —
1482 KP13_00321 Nickel-binding periplasmic protein nikA AlphaFold + ColabFold –
GO:0016151Binding to a nickel (Ni) cation. GO:0015675The directed movement of nickel (Ni) cations into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. GO:0043190A complex for the transport of metabolites into and out of the cell, typically comprised of four domains; two membrane-associated domains and two ATP-binding domains at the intracellular face of the membrane, that form a central pore through the plasma membrane. Each of the four core domains may be encoded as a separate polypeptide or the domains can be fused in any one of a number of ways into multidomain polypeptides. In Bacteria and Archaebacteria, ABC transporters also include substrate binding proteins to bind substrate external to the cytoplasm and deliver it to the transporter. +58 total
0.193 No Hit 0.0% —
1483 KP13_00322 LysR family transcriptional regulator AlphaFold + ColabFold –
GO:0006355Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. GO:0003700A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons. GO:0000976Binding to a specific sequence of DNA that is part of a regulatory region that controls transcription of that section of the DNA. The transcribed region might be described as a gene, cistron, or operon.
0.753 No Hit 0.0% —
1484 KP13_00323 putative phenolic acid decarboxylase padC AlphaFold + ColabFold –
GO:0016831Catalysis of the nonhydrolytic addition or removal of a carboxyl group to or from a compound.
0.834 No Hit 0.0% —
1485 KP13_00327 putative 4-deoxy-4-formamido-L-arabinose-phosphoundecaprenol deformylase ArnD arnD AlphaFold + ColabFold
3.5.1.n3
GO:0016811Catalysis of the hydrolysis of any non-peptide carbon-nitrogen bond in a linear amide. GO:0005975The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. GO:0016810Catalysis of the hydrolysis of any carbon-nitrogen bond, C-N, with the exception of peptide bonds. +58 total
0.709 No Hit 0.0% —
1486 KP13_00328 Undecaprenyl phosphate-alpha-4-amino-4-deoxy-L-arabinose arabinosyl transferase arnT AlphaFold + ColabFold
2.4.2.43
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0006493A glycoprotein biosynthetic process starting with the covalent linkage of carbohydrate or carbohydrate derivative unit via a glycosidic bond to the oxygen atom of a serine, threonine, hydroxylysine, hydroxyproline or tyrosine side chain in a protein, which can be further elongated with the sequential addition of sugar units resulting in the formation of a protein O-linked glycan. GO:0016763Catalysis of the transfer of a pentosyl group from one compound (donor) to another (acceptor). +69 total
0.915 No Hit 0.0% —
1487 KP13_00330 Undecaprenyl phosphate-aminoarabinose flippase subunit ArnF arnF AlphaFold + ColabFold –
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0009103The chemical reactions and pathways resulting in the formation of lipopolysaccharides, any of a group of related, structurally complex components of the outer membrane of Gram-negative bacteria. GO:1901505Enables the transfer of carbohydrate derivative from one side of a membrane to the other. +14 total
0.665 No Hit 0.0% —
1488 KP13_00331 PerM family protein AlphaFold + ColabFold –
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0055085The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other.
0.817 No Hit 0.0% —
1489 KP13_00332 Major facilitator superfamily MFS-1 protein AlphaFold + ColabFold –
GO:0022857Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other. GO:0055085The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other. GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
0.933 No Hit 0.0% —
1490 KP13_00334 putative integral membrane protein AlphaFold + ColabFold –
GO:1990397OBSOLETE. Any process which produces queuosine from derivatives of it, without de novo synthesis.
0.987 No Hit 0.0% —
1491 KP13_00335 Sulfurtransferase tusA tusA AlphaFold + ColabFold –
GO:0097163Covalently binding to sulfur and delivering it to an acceptor molecule. GO:0002143The process in which a uridine residue at position 34 in the anticodon of a tRNA is post-transcriptionally thiolated at the C2 position. This process involves transfer of a sulfur from cysteine to position C2 by several steps. GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
0.25 No Hit 0.0% —
1492 KP13_00337 TMEM86 family protein AlphaFold + ColabFold –
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0016787Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc.
0.988 No Hit 0.0% —
1493 KP13_00338 hypothetical protein AlphaFold + ColabFold – – 0.323 No Hit 0.0% —
1494 KP13_00339 hypothetical protein AlphaFold + ColabFold – – 0.472 No Hit 0.0% —
1495 KP13_00340 Ribosomal RNA small subunit methyltransferase D rsmD AlphaFold + ColabFold
2.1.1.171
GO:0003676Binding to a nucleic acid. GO:0032259The process in which a methyl group is covalently attached to a molecule. GO:0008168Catalysis of the transfer of a methyl group to an acceptor molecule. +25 total
0.395 No Hit 0.0% —
1496 KP13_00343 Cell division protein ftsX ftsX AlphaFold + ColabFold –
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0051301The process resulting in division and partitioning of components of a cell to form more cells; may or may not be accompanied by the physical separation of a cell into distinct, individually membrane-bounded daughter cells. GO:0032153The eventual plane of cell division (also known as cell cleavage or cytokinesis) in a dividing cell. In Eukaryotes, the cleavage apparatus, composed of septin structures and the actomyosin contractile ring, forms along this plane, and the mitotic, or meiotic, spindle is aligned perpendicular to the division plane. In bacteria, the cell division site is generally located at mid-cell and is the site at which the cytoskeletal structure, the Z-ring, assembles. +14 total
0.641 No Hit 0.0% —
1497 KP13_00348 putative N-acetyltransferase AlphaFold + ColabFold –
GO:0016747Catalysis of the transfer of an acyl group, other than amino-acyl, from one compound (donor) to another (acceptor).
0.774 No Hit 0.0% —
1498 KP13_00350 Malate synthase A aceB AlphaFold + ColabFold –
GO:0004474Catalysis of the reaction: acetyl-CoA + glyoxylate + H2O = (S)-malate + CoA + H+. GO:0003824Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. GO:0006097A modification of the TCA cycle occurring in some plants and microorganisms, in which isocitrate is cleaved to glyoxylate and succinate. Glyoxylate can then react with acetyl-CoA to form malate.
0.522 No Hit 0.0% —
1499 KP13_00351 Isocitrate lyase aceA AlphaFold + ColabFold
4.1.3.1
GO:0019752The chemical reactions and pathways involving carboxylic acids, any organic acid containing one or more carboxyl (COOH) groups or anions (COO-). GO:0003824Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. GO:0004451Catalysis of the reaction: isocitrate = glyoxylate + succinate. +36 total
0.795 No Hit 0.0% —
1500 KP13_00352 Isocitrate dehydrogenase kinase/phosphatase aceK AlphaFold + ColabFold
2.7.11.5 3.1.3.-
GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. GO:0016791Catalysis of the hydrolysis of a phosphoric monoester, releasing a phosphate. GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. +710 total
0.95 No Hit 0.0% —
Page of 234 · 5842 total proteins