Proteins

Genome: KpKP13

Description: Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence

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5840 proteins Structure: ColabFold

Scoring formula None

Sorted by Druggability (descending)

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Structure: ColabFold ×
# Protein Description Gene Structure EC GO Druggability FPocket druggability score for the preferred structure (0–1): experimental structure when available, otherwise predicted model. ≥ 0.7 highly druggable · ≥ 0.4 moderately druggable · < 0.4 low druggability. Human off-target BLASTP against the human proteome. Hit means at least one human match was detected at e-value <= 1e-5. Prefer No hit for pathogen-selective targets. Human identity (%) Best human BLAST identity percentage. Human E-value Best human BLAST E-value.
151 KP13_03188 Putative osmoprotectant uptake system permease protein AlphaFold + ColabFold –
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0055085The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other. GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. +14 total
0.985 No Hit 0.0% —
152 KP13_02954 Ribosomal protein L11 methyltransferase prmA AlphaFold + ColabFold
2.1.1.-
GO:0008276Catalysis of the transfer of a methyl group (CH3-) to a protein. GO:0006479The addition of a methyl group to a protein amino acid. A methyl group is derived from methane by the removal of a hydrogen atom. GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. +36 total
0.985 No Hit 0.0% —
153 KP13_02871 Inner membrane protein AlphaFold + ColabFold – – 0.985 No Hit 0.0% —
154 KP13_02711 putative MFS general substrate transporter AlphaFold + ColabFold –
GO:0022857Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other. GO:0055085The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other. GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it.
0.985 Hit 23.8% 4.48e-06
155 KP13_01133 putative HTH-type transcriptional regulator AlphaFold + ColabFold –
GO:0043565Binding to DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. GO:0006355Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. GO:0003700A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons.
0.985 No Hit 0.0% —
156 KP13_00582 Cation-efflux pump fieF fieF AlphaFold + ColabFold –
GO:0006812The directed movement of a monoatomic cation, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Monatomic cations (also called simple cations) are positively charged ions consisting of exactly one atom. GO:0008324Enables the transfer of cation from one side of a membrane to the other. GO:0006826The directed movement of iron (Fe) ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. +1013 total
0.985 Hit 23.5% 2.86e-09
157 KP13_00388 Quinone oxidoreductase qor AlphaFold + ColabFold
1.6.5.5
GO:0016491Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. GO:0008270Binding to a zinc ion (Zn). GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. +36 total
0.985 Hit 45.9% 7.21e-08
158 KP13_00019 ATP synthase subunit a atpB AlphaFold + ColabFold –
GO:0015078Enables the transfer of a proton from one side of a membrane to the other. GO:0015986The chemical reactions and pathways resulting in the formation of ATP driven by transport of protons across a membrane to generate an electrochemical gradient (proton-motive force). GO:0045263OBSOLETE. All non-F1 subunits of a hydrogen-transporting ATP synthase, including integral and peripheral membrane proteins. +47 total
0.985 No Hit 0.0% —
159 KP13_31970 cation transport regulator chaC AlphaFold + ColabFold
4.3.2.7
GO:0006751The chemical reactions and pathways resulting in the breakdown of glutathione, the tripeptide glutamylcysteinylglycine, which acts as a coenzyme for some enzymes and as an antioxidant in the protection of sulfhydryl groups in enzymes and other proteins. GO:0061928Catalysis of the reaction: glutathione = 5-oxoproline + L-cysteinylglycine. GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
0.984 Hit 33.9% 1.05e-17
160 KP13_31749 putative esterase AlphaFold + ColabFold –
GO:0047372Catalysis of the reaction: a monoacylglycerol + H2O = a fatty acid + glycerol + H+. GO:0034338Catalysis of the reaction: a carboxylic ester + H2O = an alcohol + a carboxylic anion, where the carboxylic chain has 8 or fewer carbon atoms.
0.984 Hit 32.4% 9.98e-15
161 KP13_13083 Tyrosine-specific transport protein tyrP AlphaFold + ColabFold –
GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0015801The directed movement of aromatic amino acids, amino acids with aromatic ring, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. GO:0003333The process in which an amino acid is transported across a membrane. +25 total
0.984 No Hit 0.0% —
162 KP13_04987 Transcriptional regulator slyA AlphaFold + ColabFold –
GO:0006355Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. GO:0003700A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons. GO:0003677Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
0.984 No Hit 0.0% —
163 KP13_03597 putative ABC transporter permease AlphaFold + ColabFold –
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
0.984 No Hit 0.0% —
164 KP13_03455 Acriflavin resistance family protein AlphaFold + ColabFold –
GO:0022857Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other. GO:0015562Enables the transfer of a specific substance or related group of substances from the inside of the cell to the outside of the cell across a membrane. GO:0042908The directed movement of a xenobiotic into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. A xenobiotic is a compound foreign to the organism exposed to it. It may be synthesized by another organism (like ampicilin) or it can be a synthetic chemical. +25 total
0.984 No Hit 0.0% —
165 KP13_02940 Methyltransferase type 11 family protein AlphaFold + ColabFold –
GO:0008168Catalysis of the transfer of a methyl group to an acceptor molecule. GO:0008757Catalysis of the transfer of a methyl group from S-adenosyl-L-methionine to a substrate. GO:0032259The process in which a methyl group is covalently attached to a molecule.
0.984 Hit 31.1% 1.52e-07
166 KP13_02807 SH3-like domain-containing protein AlphaFold + ColabFold –
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it.
0.984 No Hit 0.0% —
167 KP13_02582 6-phospho-beta-glucosidase ascB ascB AlphaFold + ColabFold –
GO:0005975The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. GO:0004553Catalysis of the hydrolysis of any O-glycosyl bond. GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. +25 total
0.984 Hit 39.6% 1.80e-14
168 KP13_01676 hypothetical protein AlphaFold + ColabFold – – 0.984 No Hit 0.0% —
169 KP13_01124 putative phospholipid-binding protein mlaC mlaC AlphaFold + ColabFold – – 0.984 No Hit 0.0% —
170 KP13_00703 Shikimate kinase 1 aroK AlphaFold + ColabFold
2.7.1.71
GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. GO:0000287Binding to a magnesium (Mg) ion. +47 total
0.984 Hit 29.5% 1.81e-07
171 KP13_00676 Maltodextrin phosphorylase malP Experimental + ColabFold
2.4.1.1
GO:0030170Binding to pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6. GO:0005975The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. GO:0008184Catalysis of the reaction: glycogen + phosphate = maltodextrin + alpha-D-glucose 1-phosphate. +47 total
0.984 Hit 49.6% 5.13e-69
172 KP13_04712 Respiratory nitrate reductase 1 alpha chain narG AlphaFold + ColabFold
1.7.5.1
GO:0009325An enzyme complex that catalyzes the formation of nitrate from nitrite with the concomitant reduction of an acceptor. GO:0051539Binding to a 4 iron, 4 sulfur (4Fe-4S) cluster; this cluster consists of four iron atoms, with the inorganic sulfur atoms found between the irons and acting as bridging ligands. GO:0016491Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. +811 total
0.983 No Hit 0.0% —
173 KP13_04449 Tellurite resistance protein tehA tehA AlphaFold + ColabFold –
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0055085The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other. GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. +47 total
0.983 No Hit 0.0% —
174 KP13_03821 Putative permease perM perM AlphaFold + ColabFold – – 0.983 No Hit 0.0% —
175 KP13_03559 hypothetical protein AlphaFold + ColabFold –
GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
0.983 Hit 27.5% 9.99e-30
Page of 234 · 5840 total proteins