Proteins

Genome: KpKP13

Description: Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence

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5192 / 5842 proteins Structure: AlphaFold

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Structure: AlphaFold ×
# Protein Description Gene Structure EC GO Druggability FPocket druggability score for the preferred structure (0–1): experimental structure when available, otherwise predicted model. ≥ 0.7 highly druggable · ≥ 0.4 moderately druggable · < 0.4 low druggability. Human off-target BLASTP against the human proteome. Hit means at least one human match was detected at e-value <= 1e-5. Prefer No hit for pathogen-selective targets. Human identity (%) Best human BLAST identity percentage. Human E-value Best human BLAST E-value.
1926 KP13_01184 GckR family protein AlphaFold + ColabFold –
GO:1901135The chemical reactions and pathways involving carbohydrate derivative. GO:0016835Catalysis of the breakage of a carbon-oxygen bond. GO:0046348The chemical reactions and pathways resulting in the breakdown of any amino sugar, sugars containing an amino group in place of a hydroxyl group. +36 total
0.671 No Hit 0.0% —
1927 KP13_00886 hypothetical protein AlphaFold + ColabFold – – 0.671 No Hit 0.0% —
1928 KP13_04112 Protein nrdI nrdI AlphaFold + ColabFold –
GO:0010181Binding to flavin mono nucleotide. Flavin mono nucleotide (FMN) is the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes. GO:0036211The covalent alteration of one or more amino acids occurring in proteins, peptides and nascent polypeptides (co-translational, post-translational modifications). Includes the modification of charged tRNAs that are destined to occur in a protein (pre-translation modification).
0.67 No Hit 0.0% —
1929 KP13_02119 branched-chain amino acid transport ATP-binding protein AlphaFold + ColabFold –
GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. GO:0016887Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient. GO:0015658Enables the transfer of branched-chain amino acids from one side of a membrane to the other. Branched-chain amino acids are amino acids with a branched carbon skeleton without rings. +14 total
0.67 Hit 29.4% 7.56e-08
1930 KP13_01718 Phospholipase A1 bifunctional protein pldA AlphaFold + ColabFold
3.1.1.32 3.1.1.4
GO:0004620Catalysis of the hydrolysis of a glycerophospholipid. GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0006629The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids. +58 total
0.67 No Hit 0.0% —
1931 KP13_04272 D-alanyl-D-alanine carboxypeptidase dacC dacC AlphaFold + ColabFold
3.4.16.4
GO:0006508The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds. GO:0009002Catalysis of the reaction: (Ac)2-L-Lys-D-alanyl-D-alanine + H2O = (Ac)2-L-Lys-D-alanine + D-alanine. GO:0004180Catalysis of the hydrolysis of a single C-terminal amino acid residue from a polypeptide chain. +710 total
0.669 No Hit 0.0% —
1932 KP13_03441 putative binding-protein-dependent transport system protein AlphaFold + ColabFold –
GO:0022857Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other. GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0043190A complex for the transport of metabolites into and out of the cell, typically comprised of four domains; two membrane-associated domains and two ATP-binding domains at the intracellular face of the membrane, that form a central pore through the plasma membrane. Each of the four core domains may be encoded as a separate polypeptide or the domains can be fused in any one of a number of ways into multidomain polypeptides. In Bacteria and Archaebacteria, ABC transporters also include substrate binding proteins to bind substrate external to the cytoplasm and deliver it to the transporter. +25 total
0.669 No Hit 0.0% —
1933 KP13_02737 hypothetical protein AlphaFold + ColabFold –
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it.
0.669 No Hit 0.0% —
1934 KP13_02416 Phospho-2-dehydro-3-deoxyheptonate aldolase, Tyr-sensitive aroF AlphaFold + ColabFold
2.5.1.54
GO:0003849Catalysis of the reaction: D-erythrose 4-phosphate + H2O + phosphoenolpyruvate = 7-phospho-2-dehydro-3-deoxy-D-arabino-heptonate + phosphate. GO:0009058A cellular process consisting of the biochemical pathways by which a living organism synthesizes chemical substances. This typically represents the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones. GO:0009073The chemical reactions and pathways resulting in the formation of aromatic amino acid family, amino acids with aromatic ring (phenylalanine, tyrosine, tryptophan). +47 total
0.669 No Hit 0.0% —
1935 KP13_02135 Phosphonate transport system permease protein AlphaFold + ColabFold –
GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0015416Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + phosphonate(out) = ADP + phosphate + phosphonate(in). A phosphonate is any salt, anion, or ester of phosphonic acid (HPO(OH)2). GO:0015716The directed movement of phosphonates into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. A phosphonate is any salt, anion, or ester of phosphonic acid (HPO(OH)2). +25 total
0.669 No Hit 0.0% —
1936 KP13_01675 hypothetical protein AlphaFold + ColabFold – – 0.669 No Hit 0.0% —
1937 KP13_01034 hypothetical protein AlphaFold + ColabFold – – 0.669 No Hit 0.0% —
1938 KP13_00698 hypothetical protein AlphaFold + ColabFold – – 0.669 No Hit 0.0% —
1939 KP13_13347 Uridine phosphorylase udp AlphaFold + ColabFold
2.4.2.3
GO:0009166The chemical reactions and pathways resulting in the breakdown of nucleotides, any nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the glycose moiety; may be mono-, di- or triphosphate; this definition includes cyclic-nucleotides (nucleoside cyclic phosphates). GO:0009116The chemical reactions and pathways involving a nucleoside, a nucleobase linked to either beta-D-ribofuranose (a ribonucleoside) or 2-deoxy-beta-D-ribofuranose, (a deoxyribonucleoside), e.g. adenosine, guanosine, inosine, cytidine, uridine and deoxyadenosine, deoxyguanosine, deoxycytidine and thymidine (= deoxythymidine). GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. +69 total
0.668 Hit 30.4% 3.22e-09
1940 KP13_05473 hypothetical protein AlphaFold + ColabFold – – 0.668 No Hit 0.0% —
1941 KP13_04993 N-succinylglutamate 5-semialdehyde dehydrogenase astD AlphaFold + ColabFold
1.2.1.71
GO:0016491Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. GO:0006527The chemical reactions and pathways resulting in the breakdown of L-arginine. GO:0016620Catalysis of an oxidation-reduction (redox) reaction in which an aldehyde or ketone (oxo) group acts as a hydrogen or electron donor and reduces NAD or NADP. +36 total
0.668 Hit 34.6% 4.95e-06
1942 KP13_04897 Peptidoglycan-binding lysin domain-containing protein AlphaFold + ColabFold
2.-.-.-
GO:0016740Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2. GO:0005576The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite. GO:0042597The region between the inner (cytoplasmic) and outer membrane (Gram-negative Bacteria) or cytoplasmic membrane and cell wall (Fungi and Gram-positive Bacteria). +58 total
0.668 No Hit 0.0% —
1943 KP13_04869 Virulence transcriptional regulatory protein phoP phoP AlphaFold + ColabFold –
GO:0006355Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. GO:0000160A conserved series of molecular signals found in prokaryotes and eukaryotes; involves autophosphorylation of a histidine kinase and the transfer of the phosphate group to an aspartate that then acts as a phospho-donor to response regulator proteins. GO:0003677Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
0.668 No Hit 0.0% —
1944 KP13_04321 ATP-dependent RNA helicase rhlE rhlE AlphaFold + ColabFold
3.6.4.13
GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. GO:0003676Binding to a nucleic acid. GO:0042255The aggregation, arrangement and bonding together of the mature ribosome and of its subunits. +47 total
0.668 Hit 52.5% 1.77e-12
1945 KP13_03402 Enterobactin exporter entS entS AlphaFold + ColabFold –
GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0042931Enables the directed movement of the siderochrome enterochelin, a cyclic trimer of 2, 3 dihydroxybenzoylserine from one side of a membrane to the other. GO:0022857Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other. +14 total
0.668 No Hit 0.0% —
1946 KP13_03360 hypothetical protein AlphaFold + ColabFold –
GO:0003824Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. GO:0071453Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus reflecting the presence, absence, or concentration of oxygen.
0.668 No Hit 0.0% —
1947 KP13_01403 hypothetical protein AlphaFold + ColabFold – – 0.668 No Hit 0.0% —
1948 KP13_00455 Protein phnH phnH AlphaFold + ColabFold –
GO:0019634The chemical reactions and pathways involving phosphonates, any organic compounds containing one or more C-PO(OH)2 or C-PO(OR)2 (with R=alkyl, aryl) groups. Metabolism of phosphonic acid itself, an inorganic compound without the biochemically relevant C-P bond, is not included. GO:0016829Catalysis of the cleavage of C-C, C-O, C-N and other bonds by other means than by hydrolysis or oxidation, or conversely adding a group to a double bond. They differ from other enzymes in that two substrates are involved in one reaction direction, but only one in the other direction. When acting on the single substrate, a molecule is eliminated and this generates either a new double bond or a new ring.
0.668 No Hit 0.0% —
1949 KP13_06711 hypothetical protein AlphaFold + ColabFold – – 0.667 No Hit 0.0% —
1950 KP13_05543 putative lactonase AlphaFold + ColabFold –
GO:0016787Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. GO:0046872Binding to a metal ion.
0.667 No Hit 0.0% —
Page of 208 · 5192 total proteins