Proteins

Genome: NC_002516.2

Description: Pseudomonas aeruginosa PAO1, complete genome

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5572 / 5572 proteins

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# Protein Description Gene Structure EC GO Druggability FPocket druggability score for the preferred structure (0–1): experimental structure when available, otherwise predicted model. ≥ 0.7 highly druggable · ≥ 0.4 moderately druggable · < 0.4 low druggability. Human off-target BLASTP against the human proteome. Hit means at least one human match was detected at e-value <= 1e-5. Prefer No hit for pathogen-selective targets. Human identity (%) Best human BLAST identity percentage. Human E-value Best human BLAST E-value.
3701 PA3081 hypothetical protein PA3081 AlphaFold – – 0.646 No Hit N/A —
3702 PA3077 two-component response regulator PA3077 AlphaFold –
GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. GO:0032993A macromolecular complex containing both protein and DNA molecules. GO:0000156Responds to a phosphorelay sensor to initiate a change in cell state or activity. The activity of the response regulator is regulated by transfer of a phosphate from a histidine residue in the sensor, to an aspartate residue in the response regulator. Many but not all response regulators act as transcriptional regulators to elicit a response. +58 total
0.646 No Hit N/A —
3703 PA2800 hypothetical protein PA2800 AlphaFold –
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0120010The transport of phospholipids between membranes in which a phospholipid molecule is transported through an aqueous phase from the outer leaflet of a donor membrane to the outer leaflet of an acceptor membrane.
0.646 No Hit N/A —
3704 PA1779 assimilatory nitrate reductase PA1779 AlphaFold
1.9.6.1
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:1990204Any protein complex that possesses oxidoreductase activity. GO:0051539Binding to a 4 iron, 4 sulfur (4Fe-4S) cluster; this cluster consists of four iron atoms, with the inorganic sulfur atoms found between the irons and acting as bridging ligands. +69 total
0.646 No Hit N/A —
3705 PA0827 hypothetical protein PA0827 AlphaFold – – 0.646 No Hit N/A —
3706 PA4941 protease subunit HflC hflC, PA4941 AlphaFold –
GO:0098797Any protein complex that is part of the plasma membrane. GO:0008233Catalysis of the hydrolysis of a peptide bond. A peptide bond is a covalent bond formed when the carbon atom from the carboxyl group of one amino acid shares electrons with the nitrogen atom from the amino group of a second amino acid. GO:0006508The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds. +25 total
0.645 Hit 28.9% 1.73e-14
3707 PA4388 hypothetical protein PA4388 Experimental + AlphaFold –
GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
0.645 No Hit N/A —
3708 PA4214 phenazine biosynthesis protein PhzE PA4214, PA1903, phzE2, phzE1 AlphaFold
4.1.3.27
GO:0004049Catalysis of the reaction: chorismate + L-glutamine = anthranilate + pyruvate + L-glutamate. GO:0000162The chemical reactions and pathways resulting in the formation of L-tryptophan, the chiral amino acid 2-amino-3-(1H-indol-3-yl)propanoic acid; L-tryptophan is synthesized from chorismate via anthranilate. GO:0002047The chemical reactions and pathways resulting in the formation of a phenazine antibiotic, a polycyclic pyrazine with two nitrogen atoms in the ring. +14 total
0.645 No Hit N/A —
3709 PA2823 hypothetical protein PA2823 AlphaFold – – 0.645 No Hit N/A —
3710 PA2577 transcriptional regulator PA2577 AlphaFold –
GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. GO:0043565Binding to DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. GO:0043200Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an amino acid stimulus. An amino acid is a carboxylic acids containing one or more amino groups.
0.645 No Hit N/A —
3711 PA1903 phenazine biosynthesis protein PhzE PA4214, PA1903, phzE2, phzE1 AlphaFold –
GO:0009058A cellular process consisting of the biochemical pathways by which a living organism synthesizes chemical substances. This typically represents the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones.
0.645 No Hit N/A —
3712 PA1216 hypothetical protein PA1216 AlphaFold –
GO:0008168Catalysis of the transfer of a methyl group to an acceptor molecule. GO:0032259The process in which a methyl group is covalently attached to a molecule.
0.645 No Hit N/A —
3713 PA2755a hypothetical protein ColabFold – – 0.644 No Hit N/A —
3714 PA0957 hypothetical protein PA0957 AlphaFold –
GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. GO:0061522Catalysis of the reaction 1,4-dihydroxy-2-naphthoyl-CoA + H2O = 1,4-dihydroxy-2-naphthoate + CoA + H+.
0.644 No Hit N/A —
3715 PA0718 hypothetical protein PA0718 AlphaFold – – 0.644 No Hit N/A —
3716 PA5425 5-(carboxyamino)imidazole ribonucleotide synthase purK, PA5425 AlphaFold
6.3.4.18
GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. GO:0034028Catalysis of the reaction: 5-amino-1-(5-phospho-D-ribosyl)imidazole + ATP + bicarbonate = 5-carboxyamino-1-(5-phospho-D-ribosyl)imidazole + ADP + 3 H+ + phosphate. GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. +36 total
0.643 No Hit N/A —
3717 PA5006 hypothetical protein PA5006 AlphaFold – – 0.643 No Hit N/A —
3718 PA4403 preprotein translocase subunit SecA PA4403, secA AlphaFold
7.4.2.8
GO:0031522A transmembrane protein complex involved in the translocation of proteins across the cytoplasmic membrane. In Gram-negative bacteria, Sec-translocated proteins are subsequently secreted via the type II, IV, or V secretion systems. Sec complex components include SecA, D, E, F, G, Y and YajC. GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. +912 total
0.643 No Hit N/A —
3719 PA4175 endopeptidase IV piv ColabFold – – 0.643 No Hit N/A —
3720 PA3878 two-component sensor NarX narX, PA3878 AlphaFold
2.7.13.3
GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. GO:0000155Catalysis of the phosphorylation of a histidine residue in response to detection of an extracellular signal such as a chemical ligand or change in environment, to initiate a change in cell state or activity. The two-component sensor is a histidine kinase that autophosphorylates a histidine residue in its active site. The phosphate is then transferred to an aspartate residue in a downstream response regulator, to trigger a response. +58 total
0.643 No Hit N/A —
3721 PA3236 glycine betaine-binding protein PA3236 AlphaFold –
GO:0043190A complex for the transport of metabolites into and out of the cell, typically comprised of four domains; two membrane-associated domains and two ATP-binding domains at the intracellular face of the membrane, that form a central pore through the plasma membrane. Each of the four core domains may be encoded as a separate polypeptide or the domains can be fused in any one of a number of ways into multidomain polypeptides. In Bacteria and Archaebacteria, ABC transporters also include substrate binding proteins to bind substrate external to the cytoplasm and deliver it to the transporter. GO:0042597The region between the inner (cytoplasmic) and outer membrane (Gram-negative Bacteria) or cytoplasmic membrane and cell wall (Fungi and Gram-positive Bacteria). GO:0015418Catalysis of the reaction: ATP + H2O + quaternary ammonium(out) = ADP + H+ + phosphate + quaternary ammonium(in). +58 total
0.643 No Hit N/A —
3722 PA2807 hypothetical protein copI, PA2807 AlphaFold –
GO:0042597The region between the inner (cytoplasmic) and outer membrane (Gram-negative Bacteria) or cytoplasmic membrane and cell wall (Fungi and Gram-positive Bacteria). GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0005507Binding to a copper (Cu) ion. +14 total
0.643 No Hit N/A —
3723 PA2009 homogentisate 1,2-dioxygenase PA2009, hmgA AlphaFold
1.13.11.5
GO:0004411Catalysis of the reaction: homogentisate + O2 = 4-maleylacetoacetate + H+. GO:0005506Binding to an iron (Fe) ion. GO:0006559The chemical reactions and pathways resulting in the breakdown of L-phenylalanine. +25 total
0.643 Hit 60.6% 4.45e-56
3724 PA5154 ABC transporter permease PA5154 AlphaFold –
GO:0043190A complex for the transport of metabolites into and out of the cell, typically comprised of four domains; two membrane-associated domains and two ATP-binding domains at the intracellular face of the membrane, that form a central pore through the plasma membrane. Each of the four core domains may be encoded as a separate polypeptide or the domains can be fused in any one of a number of ways into multidomain polypeptides. In Bacteria and Archaebacteria, ABC transporters also include substrate binding proteins to bind substrate external to the cytoplasm and deliver it to the transporter. GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0022857Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other. +47 total
0.642 No Hit N/A —
3725 PA5090 hypothetical protein PA5090, vgrG5 AlphaFold –
GO:0005576The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite. GO:0033104A complex of proteins that permits the transfer of proteins into the extracellular milieu or directly into host cells via the type VI secretion system. Proteins secreted by this complex do not require an N-terminal signal sequence. GO:0033103The process in which proteins are transferred into the extracellular milieu or directly into host cells by the type VI secretion system. Proteins secreted by this system do not require an N-terminal signal sequence.
0.642 No Hit N/A —
Page of 223 · 5572 total proteins