Proteins

Genome: NC_002516.2

Description: Pseudomonas aeruginosa PAO1, complete genome

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5572 proteins

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# Protein Description Gene Structure EC GO Druggability FPocket druggability score for the preferred structure (0–1): experimental structure when available, otherwise predicted model. ≥ 0.7 highly druggable · ≥ 0.4 moderately druggable · < 0.4 low druggability. Human off-target BLASTP against the human proteome. Hit means at least one human match was detected at e-value <= 1e-5. Prefer No hit for pathogen-selective targets. Human identity (%) Best human BLAST identity percentage. Human E-value Best human BLAST E-value.
1 PA0001 chromosome replication initiator DnaA PA0001, dnaA AlphaFold –
GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. +811 total
0.557 No Hit N/A —
2 PA0002 DNA polymerase III subunit beta PA0002, dnaN Experimental + AlphaFold –
GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. GO:0009360The DNA polymerase III holoenzyme is a complex that contains 10 different types of subunits. These subunits are organized into 3 functionally essential sub-assemblies: the pol III core, the beta sliding clamp processivity factor and the clamp-loading complex. The pol III core carries out the polymerase and the 3'-5' exonuclease proofreading activities. The polymerase is tethered to the template via the sliding clamp processivity factor. The clamp-loading complex assembles the beta processivity factor onto the primer template and plays a central role in the organization and communication at the replication fork. GO:0008408Catalysis of the hydrolysis of ester linkages within nucleic acids by removing nucleotide residues from the 3' end. +58 total
0.936 No Hit N/A —
3 PA0003 DNA replication and repair protein RecF PA0003, recF AlphaFold –
GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. GO:0003697Binding to single-stranded DNA. +58 total
0.702 No Hit N/A —
4 PA0004 DNA gyrase subunit B PA0004, gyrB Experimental + AlphaFold
5.6.2.2
GO:0005694A structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information. GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. +58 total
0.61 Hit 24.0% 2.97e-31
5 PA0005 lysophosphatidic acid acyltransferase PA0005, lptA AlphaFold
2.3.1.51
GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0003841Catalysis of the reaction: acyl-CoA + 1-acyl-sn-glycerol-3-phosphate = CoA + 1,2-diacyl-sn-glycerol-3-phosphate. GO:0042171Catalysis of the transfer of acyl groups from an acyl-CoA to lysophosphatidic acid to form phosphatidic acid. +47 total
0.903 Hit 32.0% 2.02e-18
6 PA0006 D-glycero-beta-D-manno-heptose-1,7-bisphosphate 7-phosphatase PA0006, gmhB AlphaFold
3.1.3.82
GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. GO:0034200Catalysis of the reaction: D-glycero-beta-D-manno-heptose 1,7-bisphosphate + H2O = D-glycero-beta-D-manno-heptose 1-phosphate + phosphate. GO:0000287Binding to a magnesium (Mg) ion. +69 total
0.57 No Hit N/A —
7 PA0007 hypothetical protein PA0007 AlphaFold –
GO:0004130Catalysis of the reaction: 2 ferrocytochrome c + H2O2 = 2 ferricytochrome c + 2 H2O. GO:0009055A molecular function representing the directed movement of electrons from one molecular entity to another, typically mediated by electron carriers or acceptors, resulting in the transfer of energy and/or the reduction-oxidation (redox) transformation of chemical species. This activity is fundamental to various biological processes, including cellular respiration and photosynthesis, as well as numerous enzymatic reactions involved in metabolic pathways. GO:0020037Binding to a heme, a compound composed of iron complexed in a porphyrin (tetrapyrrole) ring. +14 total
0.792 No Hit N/A —
8 PA0008 glycine--tRNA ligase subunit beta PA0008, glyS AlphaFold
6.1.1.14
GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. GO:0004814Catalysis of the reaction: ATP + L-arginine + tRNA(Arg) = AMP + diphosphate + L-arginyl-tRNA(Arg). GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. +58 total
0.812 No Hit N/A —
9 PA0009 glycine--tRNA ligase subunit alpha PA0009, glyQ AlphaFold
6.1.1.14
GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. GO:0004820Catalysis of the reaction: ATP + glycine + tRNA(Gly) = AMP + diphosphate + glycyl-tRNA(Gly). +25 total
0.469 No Hit N/A —
10 PA0010 DNA-3-methyladenine glycosidase I tag, PA0010 AlphaFold
3.2.2.20
GO:0008725Catalysis of the reaction: DNA containing 3-methyladenine + H2O = DNA with abasic site + 3-methyladenine. This reaction is the hydrolysis of DNA by cleavage of the N-C1' glycosidic bond between the damaged DNA 3-methyladenine and the deoxyribose sugar to remove the 3-methyladenine, leaving an abasic site. GO:0046872Binding to a metal ion. GO:0006284In base excision repair, an altered base is removed by a DNA glycosylase enzyme, followed by excision of the resulting sugar phosphate. The small gap left in the DNA helix is filled in by the sequential action of DNA polymerase and DNA ligase. +36 total
0.893 No Hit N/A —
11 PA0011 lipid A biosynthesis lauroyl acyltransferase PA0011 AlphaFold –
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0016746Catalysis of the transfer of an acyl group from one compound (donor) to another (acceptor). +710 total
0.347 No Hit N/A —
12 PA0012 hypothetical protein PA0012 Experimental + AlphaFold –
GO:0035438Binding to cyclic-di-GMP, cyclic dimeric guanosine monophosphate.
0.951 No Hit N/A —
13 PA0013 hypothetical protein PA0013 AlphaFold –
GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0022857Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other. GO:0072531The process in which a pyrimidine-containing compound is transported across a membrane. A pyrimidine-containing compound is any compound that contains pyrimidine or a formal derivative thereof. +14 total
0.82 No Hit N/A —
14 PA0014 hypothetical protein PA0014 AlphaFold – – 0.933 No Hit N/A —
15 PA0015 hypothetical protein PA0015 AlphaFold –
GO:0005515Binding to a protein.
0.787 No Hit N/A —
16 PA0016 potassium transporter inner membrane associated protein PA0016, trkA AlphaFold –
GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0005267Enables the energy-independent facilitated diffusion of a potassium ion through a transmembrane aqueous pore or channel. GO:0071805A process in which a potassium ion is transported from one side of a membrane to the other. +36 total
0.558 No Hit N/A —
17 PA0017 Ribosomal RNA small subunit methyltransferase B rsmB, rrmB, PA0017 AlphaFold
2.1.1.176
GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. GO:0003723Binding to an RNA molecule or a portion thereof. GO:0009383Catalysis of the transfer of a methyl group from S-adenosyl-L-methionine to cytosine to form 5-methylcytosine in small subunit ribosomal RNA. +69 total
0.815 Hit 34.0% 1.32e-15
18 PA0018 methionyl-tRNA formyltransferase fmt, PA0018 Experimental + AlphaFold
2.1.2.9
GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. GO:0004479Catalysis of the reaction: 10-formyltetrahydrofolate + L-methionyl-tRNA + H2O = tetrahydrofolate + N-formylmethionyl-tRNA. GO:0071951The modification process that results in the conversion of methionine charged on a tRNA(fMet) to N-formyl-methionine-tRNA(fMet). +25 total
0.778 Hit 32.3% 3.08e-14
19 PA0019 peptide deformylase def, PA0019 Experimental + AlphaFold
3.5.1.88
GO:0046872Binding to a metal ion. GO:0042586Catalysis of the reaction: formyl-L-methionyl peptide + H2O = formate + methionyl peptide. GO:0006412The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA or circRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA or circRNA. Translation ends with the release of a polypeptide chain from the ribosome.
0.804 Hit 32.7% 5.87e-20
20 PA0020 hypothetical protein PA0020 AlphaFold – – 0.894 No Hit N/A —
21 PA0021 hypothetical protein PA0021 AlphaFold –
GO:1990814An activity that facilitates the formation of a complementary double-stranded DNA molecule. GO:0009294The direct uptake and incorporation of exogenous genetic material (DNA or RNA) into a cell from its surroundings through the cell envelope.
0.647 No Hit N/A —
22 PA0022 threonylcarbamoyl-AMP synthase PA0022, rimN, tsaC AlphaFold
2.7.7.87
GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. GO:0003725Binding to double-stranded RNA. +58 total
No pocket Hit 30.3% 2.70e-06
23 PA0023 oxygen-dependent quinone oxidoreductase qor, PA0023 AlphaFold
1.6.5.5
GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. GO:0035925Binding to a region containing frequent adenine and uridine bases within the 3' untranslated region of a mRNA molecule or in pre-mRNA intron. The ARE-binding element consensus is UUAUUUAUU. ARE-binding proteins control the stability and/or translation of mRNAs. GO:0070402Binding to the reduced form, NADPH, of nicotinamide-adenine dinucleotide phosphate, a coenzyme involved in many redox and biosynthetic reactions. +36 total
0.755 Hit 52.6% 1.10e-06
24 PA0024 coproporphyrinogen III oxidase hemF, PA0024 AlphaFold
1.3.3.3
GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. GO:0004109Catalysis of the reaction: coproporphyrinogen III + 2 H+ + O2 = 2 CO2 + 2 H2O + protoporphyrinogen IX. GO:0046872Binding to a metal ion. +36 total
0.658 Hit 60.0% 1.34e-11
25 PA0025 shikimate dehydrogenase aroE, PA0025 AlphaFold
1.1.1.25
GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. GO:0050661Binding to nicotinamide-adenine dinucleotide phosphate, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NADP+, or the reduced form, NADPH. GO:0004764Catalysis of the reaction: shikimate + NADP+ = 3-dehydroshikimate + NADPH + H+. +47 total
0.795 No Hit N/A —
Page of 223 · 5572 total proteins