Proteins

Genome: NC_002516.2

Description: Pseudomonas aeruginosa PAO1, complete genome

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5572 proteins

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# Protein Description Gene Structure EC GO Druggability FPocket druggability score for the preferred structure (0–1): experimental structure when available, otherwise predicted model. ≥ 0.7 highly druggable · ≥ 0.4 moderately druggable · < 0.4 low druggability. Human off-target BLASTP against the human proteome. Hit means at least one human match was detected at e-value <= 1e-5. Prefer No hit for pathogen-selective targets. Human identity (%) Best human BLAST identity percentage. Human E-value Best human BLAST E-value.
1 PA0004 DNA gyrase subunit B gyrB, PA0004 Experimental + AlphaFold
5.6.2.2
GO:0005694A structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information. GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. +58 total
0.61 Hit 24.0% 2.97e-31
2 PA0005 lysophosphatidic acid acyltransferase lptA, PA0005 AlphaFold
2.3.1.51
GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0003841Catalysis of the reaction: acyl-CoA + 1-acyl-sn-glycerol-3-phosphate = CoA + 1,2-diacyl-sn-glycerol-3-phosphate. GO:0042171Catalysis of the transfer of acyl groups from an acyl-CoA to lysophosphatidic acid to form phosphatidic acid. +47 total
0.903 Hit 32.0% 2.02e-18
3 PA0017 Ribosomal RNA small subunit methyltransferase B rrmB, rsmB, PA0017 AlphaFold
2.1.1.176
GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. GO:0003723Binding to an RNA molecule or a portion thereof. GO:0009383Catalysis of the transfer of a methyl group from S-adenosyl-L-methionine to cytosine to form 5-methylcytosine in small subunit ribosomal RNA. +69 total
0.815 Hit 34.0% 1.32e-15
4 PA0018 methionyl-tRNA formyltransferase fmt, PA0018 Experimental + AlphaFold
2.1.2.9
GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. GO:0004479Catalysis of the reaction: 10-formyltetrahydrofolate + L-methionyl-tRNA + H2O = tetrahydrofolate + N-formylmethionyl-tRNA. GO:0071951The modification process that results in the conversion of methionine charged on a tRNA(fMet) to N-formyl-methionine-tRNA(fMet). +25 total
0.778 Hit 32.3% 3.08e-14
5 PA0019 peptide deformylase PA0019, def Experimental + AlphaFold
3.5.1.88
GO:0046872Binding to a metal ion. GO:0042586Catalysis of the reaction: formyl-L-methionyl peptide + H2O = formate + methionyl peptide. GO:0006412The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA or circRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA or circRNA. Translation ends with the release of a polypeptide chain from the ribosome.
0.804 Hit 32.7% 5.87e-20
6 PA0022 threonylcarbamoyl-AMP synthase PA0022, rimN, tsaC AlphaFold
2.7.7.87
GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. GO:0003725Binding to double-stranded RNA. +58 total
No pocket Hit 30.3% 2.70e-06
7 PA0023 oxygen-dependent quinone oxidoreductase PA0023, qor AlphaFold
1.6.5.5
GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. GO:0035925Binding to a region containing frequent adenine and uridine bases within the 3' untranslated region of a mRNA molecule or in pre-mRNA intron. The ARE-binding element consensus is UUAUUUAUU. ARE-binding proteins control the stability and/or translation of mRNAs. GO:0070402Binding to the reduced form, NADPH, of nicotinamide-adenine dinucleotide phosphate, a coenzyme involved in many redox and biosynthetic reactions. +36 total
0.755 Hit 52.6% 1.10e-06
8 PA0024 coproporphyrinogen III oxidase hemF, PA0024 AlphaFold
1.3.3.3
GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. GO:0004109Catalysis of the reaction: coproporphyrinogen III + 2 H+ + O2 = 2 CO2 + 2 H2O + protoporphyrinogen IX. GO:0046872Binding to a metal ion. +36 total
0.658 Hit 60.0% 1.34e-11
9 PA0029 sulfate transporter PA0029 AlphaFold –
GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0022857Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other. GO:0055085The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other. +14 total
0.922 Hit 48.5% 9.35e-07
10 PA0031 choline sulfatase PA0031, betC AlphaFold –
GO:0046872Binding to a metal ion. GO:0008484Catalysis of the reaction: RSO-R' + H2O = RSOOH + R'H. This reaction is the hydrolysis of a sulfuric ester bond, an ester formed from sulfuric acid, O=SO(OH)2.
0.576 Hit 34.5% 5.31e-10
11 PA0051 phenazine-modifying protein PA0051, phzH AlphaFold
6.3.5.4
GO:0004066Catalysis of the reaction: ATP + L-aspartate + L-glutamine = AMP + diphosphate + L-asparagine + L-glutamate. GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. GO:0006529OBSOLETE. The chemical reactions and pathways resulting in the formation of asparagine, 2-amino-3-carbamoylpropanoic acid.
0.826 Hit 35.9% 9.82e-10
12 PA0054 RNA 2'-phosphotransferase-like protein PA0054, kptA AlphaFold
2.7.1.-
GO:0003950Catalysis of the reaction: NAD+ + (ADP-D-ribosyl)(n)-acceptor = nicotinamide + (ADP-D-ribosyl)(n+1)-acceptor. GO:0000215Catalysis of the reaction: 2'-phospho-[ligated tRNA] + NAD+ = mature tRNA + ADP ribose 1'',2''-phosphate + nicotinamide + H2O. This reaction is the transfer of the splice junction 2-phosphate from ligated tRNA to NAD+ to produce ADP-ribose 1'-2' cyclic phosphate. GO:0008033The process in which a pre-tRNA molecule is converted to a mature tRNA, ready for addition of an aminoacyl group. +25 total
0.782 Hit 40.0% 7.43e-06
13 PA0066 hypothetical protein PA0066 AlphaFold – – No pocket Hit 27.3% 5.53e-06
14 PA0067 oligopeptidase A PA0067, prlC AlphaFold
3.4.24.70
GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. GO:0046872Binding to a metal ion. GO:0004222Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions. +47 total
0.766 Hit 44.3% 1.61e-36
15 PA0073 ABC transporter ATP-binding protein PA0073 AlphaFold –
GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. GO:0016887Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient. +47 total
0.484 Hit 35.2% 2.32e-16
16 PA0074 serine/threonine protein kinase PpkA PA0074, ppkA AlphaFold
2.7.11.1
GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. GO:0004674Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate. GO:0050714Any process that activates or increases the frequency, rate or extent of the controlled release of a protein from a cell. +25 total
0.778 Hit 39.4% 1.02e-20
17 PA0090 secretion protein ClpV1 clpV1, PA0090 Experimental + AlphaFold –
GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. GO:0016887Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient. +14 total
0.757 Hit 42.8% 2.00e-37
18 PA0103 sulfate transporter PA0103 AlphaFold –
GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0022857Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other. GO:0055085The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other. +14 total
0.884 Hit 32.8% 4.34e-06
19 PA0105 cytochrome C oxidase subunit II PA0105, coxB AlphaFold
7.1.1.9
GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0098803Any protein complex that is part of a respiratory chain. GO:0005507Binding to a copper (Cu) ion. +710 total
0.709 Hit 37.3% 5.29e-38
20 PA0106 cytochrome C oxidase subunit I PA0106, coxA AlphaFold
7.1.1.9
GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0045277A part of the respiratory chain, containing the 13 polypeptide subunits of cytochrome c oxidase, including cytochrome a and cytochrome a3. Catalyzes the oxidation of reduced cytochrome c by dioxygen (O2). GO:0004129Catalysis of the reaction: 4 Fe(II)-[cytochrome c] + O2 + 8 H+(in) = 4 Fe(III)-[cytochrome c] + 2 H2O + 4 H+(out). +710 total
0.704 Hit 48.8% 4.03e-154
21 PA0107 cytochrome C oxidase assembly protein PA0107 AlphaFold –
GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0005507Binding to a copper (Cu) ion.
0.793 Hit 34.5% 3.43e-28
22 PA0108 cytochrome C oxidase subunit III coIII, PA0108 AlphaFold
7.1.1.9
GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0045277A part of the respiratory chain, containing the 13 polypeptide subunits of cytochrome c oxidase, including cytochrome a and cytochrome a3. Catalyzes the oxidation of reduced cytochrome c by dioxygen (O2). GO:0004129Catalysis of the reaction: 4 Fe(II)-[cytochrome c] + O2 + 8 H+(in) = 4 Fe(III)-[cytochrome c] + 2 H2O + 4 H+(out). +58 total
0.73 Hit 38.5% 1.15e-47
23 PA0110 hypothetical protein PA0110 AlphaFold –
GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it.
0.681 Hit 37.3% 2.84e-08
24 PA0113 protoheme IX farnesyltransferase cyoE1, PA0113 AlphaFold
2.5.1.141
GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0008495Catalysis of the reaction: protoheme IX + (2E,6E)-farnesyl diphosphate + H2O = heme O + diphosphate. GO:0006783The chemical reactions and pathways resulting in the formation of heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring, from less complex precursors. +36 total
0.758 Hit 38.2% 2.70e-23
25 PA0114 cytochrome c oxidase assembly protein SenC senC, PA0114 AlphaFold –
GO:0046872Binding to a metal ion.
0.855 Hit 41.0% 2.42e-12
Page of 223 · 5572 total proteins