Proteins

Genome: KpATCC43816

Description: Klebsiella pneumoniae subsp. pneumoniae strain ATCC 43816 KPPR1, complete genome

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5081 proteins

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# Protein Description Gene Structure EC GO Druggability FPocket druggability score for the preferred structure (0–1): experimental structure when available, otherwise predicted model. ≥ 0.7 highly druggable · ≥ 0.4 moderately druggable · < 0.4 low druggability. Human off-target BLASTP against the human proteome. Hit means at least one human match was detected at e-value <= 1e-5. Prefer No hit for pathogen-selective targets. Human identity (%) Best human BLAST identity percentage. Human E-value Best human BLAST E-value.
3276 VK055_1528 aspC aspC AlphaFold + ColabFold
2.6.1.-
GO:0003824Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. GO:0009058A cellular process consisting of the biochemical pathways by which a living organism synthesizes chemical substances. This typically represents the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones. GO:0008483Catalysis of the transfer of an amino group to an acceptor, usually a 2-oxo acid. +710 total
0.431 Hit 42.7% 6.22e-101
3277 VK055_0046 hypothetical protein AlphaFold + ColabFold – – 0.431 No Hit 0.0% —
3278 VK055_5162 phage antitermination Q family protein AlphaFold + ColabFold – – 0.43 No Hit 0.0% —
3279 VK055_4861 hypothetical protein AlphaFold + ColabFold – – 0.43 Hit 28.1% 6.65e-09
3280 VK055_4222 putative membrane fusion protein of efflux pump AlphaFold + ColabFold – – 0.43 No Hit 0.0% —
3281 VK055_1986 hypothetical protein AlphaFold + ColabFold – – 0.43 No Hit 0.0% —
3282 VK055_1404 periplasmic glucan biosynthesis, MdoG family protein AlphaFold + ColabFold –
GO:0003824Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. GO:0030246Binding to a carbohydrate, which includes monosaccharides, oligosaccharides and polysaccharides as well as substances derived from monosaccharides by reduction of the carbonyl group (alditols), by oxidation of one or more hydroxy groups to afford the corresponding aldehydes, ketones, or carboxylic acids, or by replacement of one or more hydroxy group(s) by a hydrogen atom. Cyclitols are generally not regarded as carbohydrates. GO:0005975The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. +47 total
0.43 No Hit 0.0% —
3283 VK055_0655 bacterial extracellular solute-binding, 3 familyprotein AlphaFold + ColabFold – – 0.43 No Hit 0.0% —
3284 VK055_4458 hydrogenase 3 and formate hydrogenlyase complex,HycG subunit AlphaFold + ColabFold –
GO:0051536Binding to an iron-sulfur cluster, a combination of iron and sulfur atoms. GO:0051539Binding to a 4 iron, 4 sulfur (4Fe-4S) cluster; this cluster consists of four iron atoms, with the inorganic sulfur atoms found between the irons and acting as bridging ligands. GO:0048038Binding to a quinone, any member of a class of diketones derivable from aromatic compounds by conversion of two CH groups into CO groups with any necessary rearrangement of double bonds. +25 total
0.429 Hit 37.1% 9.65e-28
3285 VK055_0704 bacterial regulatory helix-turn-helix, AraC family protein AlphaFold + ColabFold –
GO:0043565Binding to DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. GO:0003700A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons. GO:0006355Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.
0.429 No Hit 0.0% —
3286 VK055_5176 hypothetical protein ColabFold – – 0.428 No Hit 0.0% —
3287 VK055_4287 phosphoenolpyruvate-protein phosphotransferase ptsP AlphaFold + ColabFold
2.7.3.9
GO:0016772Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to another (acceptor). GO:0003824Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. GO:0005515Binding to a protein. +69 total
0.428 No Hit 0.0% —
3288 VK055_2557 nhaR transcriptional activator nhaR AlphaFold + ColabFold –
GO:0003700A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons. GO:0006355Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. +25 total
0.428 No Hit 0.0% —
3289 VK055_1769 ybgS-like family protein AlphaFold + ColabFold –
GO:0003677Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
0.428 No Hit 0.0% —
3290 VK055_3554 glyoxylate/hydroxypyruvate reductase B ghrB AlphaFold + ColabFold
1.1.1.79 1.1.1.81
GO:0051287Binding to nicotinamide adenine dinucleotide, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NAD+, or the reduced form, NADH. GO:0016618Catalysis of the reaction: (R)-glycerate + NAD(P)+ = 3-hydroxypyruvate + NAD(P)H + H+. GO:0016616Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group acts as a hydrogen or electron donor and reduces NAD+ or NADP. +58 total
0.427 Hit 40.2% 3.45e-58
3291 VK055_2892 hflK protein hflK AlphaFold + ColabFold –
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0008233Catalysis of the hydrolysis of a peptide bond. A peptide bond is a covalent bond formed when the carbon atom from the carboxyl group of one amino acid shares electrons with the nitrogen atom from the amino group of a second amino acid. GO:0006508The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds.
0.427 Hit 25.0% 6.71e-06
3292 VK055_0931 hypothetical protein AlphaFold + ColabFold – – 0.427 No Hit 0.0% —
3293 VK055_4185 ABC transporter family protein AlphaFold + ColabFold
3.6.3.-
GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0016787Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc.
0.426 Hit 36.2% 3.36e-06
3294 VK055_3918 putative uPF0306 protein yhbP AlphaFold + ColabFold – – 0.426 No Hit 0.0% —
3295 VK055_1942 thiamine pyrophosphate enzyme, C-terminal TPP binding domain protein AlphaFold + ColabFold
2.2.1.1
GO:0004802Catalysis of the reversible transfer of a 2-carbon ketol group (CH2OH-CO-) from a ketose phosphate donor to an aldose phosphate acceptor.
0.426 Hit 39.4% 4.17e-15
3296 VK055_1532 hypothetical protein ColabFold – – 0.426 No Hit 0.0% —
3297 VK055_1105 type VI secretion system protein impC2 ColabFold – – 0.426 No Hit 0.0% —
3298 VK055_0123 hypothetical protein AlphaFold + ColabFold – – 0.426 No Hit 0.0% —
3299 VK055_5100 hypothetical protein AlphaFold + ColabFold – – 0.425 No Hit 0.0% —
3300 VK055_4932 GTP cyclohydrolase I folE AlphaFold + ColabFold
3.5.4.16
GO:0046654The chemical reactions and pathways resulting in the formation of tetrahydrofolate, 5,6,7,8-tetrahydrofolic acid, a folate derivative bearing additional hydrogens on the pterin group. GO:0003934Catalysis of the reaction: GTP + H2O = 7,8-dihydroneopterin 3'-triphosphate + formate + H+. GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. +47 total
0.425 Hit 36.0% 2.62e-34
Page of 204 · 5081 total proteins