Proteins

Genome: KpATCC43816

Description: Klebsiella pneumoniae subsp. pneumoniae strain ATCC 43816 KPPR1, complete genome

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5081 proteins

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# Protein Description Gene Structure EC GO Druggability FPocket druggability score for the preferred structure (0–1): experimental structure when available, otherwise predicted model. ≥ 0.7 highly druggable · ≥ 0.4 moderately druggable · < 0.4 low druggability. Human off-target BLASTP against the human proteome. Hit means at least one human match was detected at e-value <= 1e-5. Prefer No hit for pathogen-selective targets. Human identity (%) Best human BLAST identity percentage. Human E-value Best human BLAST E-value.
3476 VK055_3007 bacterial regulatory helix-turn-helix, AraC family protein soxS AlphaFold + ColabFold –
GO:0043565Binding to DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. GO:0003700A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons. GO:0006355Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.
0.395 No Hit 0.0% —
3477 VK055_2408 type II secretion system protein D gspD Experimental + AlphaFold + ColabFold –
GO:0009306The controlled release of proteins from a cell. GO:0019867The external membrane of Gram-negative bacteria or certain organelles such as mitochondria and chloroplasts; freely permeable to most ions and metabolites. GO:0015627A large protein complex, containing 12-15 subunits, that spans the cell envelope of Gram-negative bacteria and mediates the movement of proteins into the extracellular environment. The complex includes a component in the cytoplasm, an inner membrane subcomplex that reaches into the periplasmic compartment and a secretion pore in the outer membrane. Proteins using the Type II pathway are transported across the cytoplasmic membrane by the Sec or Tat complex. +36 total
0.395 No Hit 0.0% —
3478 VK055_1765 galactokinase galK AlphaFold + ColabFold
2.7.1.6
GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. GO:0006012The chemical reactions and pathways involving galactose, the aldohexose galacto-hexose. D-galactose is widely distributed in combined form in plants, animals and microorganisms as a constituent of oligo- and polysaccharides; it also occurs in galactolipids and as its glucoside in lactose and melibiose. GO:0016773Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to an alcohol group (acceptor). +69 total
0.395 Hit 43.8% 9.51e-92
3479 VK055_1310 protein yciE2 yciE2 AlphaFold + ColabFold – – 0.395 No Hit 0.0% —
3480 VK055_4762 glutamate--tRNA ligase gltX AlphaFold + ColabFold
6.1.1.17
GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. GO:0043039The chemical reactions and pathways by which the various amino acids become bonded to their corresponding tRNAs. The most common route for synthesis of aminoacyl tRNA is by the formation of an ester bond between the 3'-hydroxyl group of the most 3' adenosine of the tRNA and the alpha carboxylic acid group of an amino acid, usually catalyzed by the cognate aminoacyl-tRNA ligase. A given aminoacyl-tRNA ligase aminoacylates all species of an isoaccepting group of tRNA molecules. GO:0006424The process of coupling glutamate to glutamyl-tRNA, catalyzed by glutamyl-tRNA synthetase. The glutamyl-tRNA synthetase is a class-I synthetase. The activated amino acid is transferred to the 2'-OH group of a glutamic acid-accetping tRNA. The 2'-O-aminoacyl-tRNA will ultimately migrate to the 3' position via transesterification. +710 total
0.394 Hit 36.4% 3.48e-65
3481 VK055_2604 16S rRNA m2G1207 methyltransferase AlphaFold + ColabFold
2.1.1.172
GO:0008757Catalysis of the transfer of a methyl group from S-adenosyl-L-methionine to a substrate. GO:0008649Catalysis of the transfer of a methyl group from S-adenosyl-L-methionine to a nucleoside residue in an rRNA molecule. The methyl group can be transfered to the nucleobase or to the ribose group of the nucleoside. GO:0006364Any process involved in the conversion of a primary ribosomal RNA (rRNA) transcript into one or more mature rRNA molecules. +69 total
0.394 No Hit 0.0% —
3482 VK055_2518 holo-ACP synthase CitX citX AlphaFold + ColabFold
2.7.7.61
GO:0051191The chemical reactions and pathways resulting in the formation of a prosthetic group, the non-amino acid portion of certain protein molecules. Prosthetic groups may be inorganic or organic and are usually required for the biological activity of the protein. GO:0050519Catalysis of the reaction: apo-citrate lyase + 2'-(5''-triphosphoribosyl)-3'-dephospho-CoA = diphosphate + holo-citrate lyase.
0.394 No Hit 0.0% —
3483 VK055_2180 exodeoxyribonuclease VII, small subunit xseB AlphaFold + ColabFold
3.1.11.6
GO:0009318An enzyme complex that catalyzes exonucleolytic cleavage in either 5' to 3' or 3' to 5' direction to yield nucleoside 5'-phosphates; it prefers single-stranded DNA. GO:0006308The cellular DNA metabolic process resulting in the breakdown of DNA, deoxyribonucleic acid, one of the two main types of nucleic acid, consisting of a long unbranched macromolecule formed from one or two strands of linked deoxyribonucleotides, the 3'-phosphate group of each constituent deoxyribonucleotide being joined in 3',5'-phosphodiester linkage to the 5'-hydroxyl group of the deoxyribose moiety of the next one. GO:0008855Catalysis of the exonucleolytic cleavage in either 5' to 3' or 3' to 5' direction to yield 5'-phosphomononucleotides. +14 total
0.394 No Hit 0.0% —
3484 VK055_1632 phage small terminase subunit AlphaFold + ColabFold –
GO:0004519Catalysis of the cleavage of ester linkages within nucleic acids by creating internal breaks. GO:0003677Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). GO:0019069The assembly of a virus capsid from its protein subunits.
0.394 No Hit 0.0% —
3485 VK055_1158 binding-protein-dependent transport system innermembrane component family protein AlphaFold + ColabFold –
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0055085The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other. GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. +14 total
0.394 No Hit 0.0% —
3486 VK055_1100 type VI secretion ATPase, ClpV1 family clpV AlphaFold + ColabFold –
GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. GO:0016887Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient. GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. +36 total
0.394 Hit 35.3% 4.68e-39
3487 VK055_0049 ferritin-like domain protein AlphaFold + ColabFold –
GO:0008199Binding to a ferric iron ion, Fe(III).
0.394 No Hit 0.0% —
3488 VK055_3524 hypothetical protein AlphaFold + ColabFold – – 0.393 No Hit 0.0% —
3489 VK055_3281 molybdopterin oxidoreductase family protein AlphaFold + ColabFold –
GO:0051539Binding to a 4 iron, 4 sulfur (4Fe-4S) cluster; this cluster consists of four iron atoms, with the inorganic sulfur atoms found between the irons and acting as bridging ligands. GO:0016491Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced.
0.393 No Hit 0.0% —
3490 VK055_2819 anaerobic ribonucleoside-triphosphate reductase activating protein nrdG AlphaFold + ColabFold
1.97.1.-
GO:0003824Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. GO:0043365Catalysis of the reaction: S-adenosyl-L-methionine + dihydroflavodoxin + [formate C-acetyltransferase]-glycine = 5'-deoxyadenosine + L-methionine + flavodoxin semiquinone + [formate C-acetyltransferase]-glycin-2-yl radical. GO:0016491Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. +58 total
0.393 No Hit 0.0% —
3491 VK055_1026 ATP-dependent helicase HrpA hrpA AlphaFold + ColabFold
3.6.4.13
GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. GO:0003676Binding to a nucleic acid. GO:0003724Unwinding of an RNA helix, driven by ATP hydrolysis. +47 total
0.393 Hit 51.2% 1.18e-07
3492 VK055_0080 putative formate-tetrahydrofolate ligase AlphaFold + ColabFold – – 0.393 No Hit 0.0% —
3493 VK055_4959 putative uPF0387 membrane protein yohO AlphaFold + ColabFold –
GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
0.392 No Hit 0.0% —
3494 VK055_4811 amidophosphoribosyltransferase purF AlphaFold + ColabFold
2.4.2.14
GO:0004044Catalysis of the reaction: 5-phospho-beta-D-ribosylamine + L-glutamate + diphosphate = 5-phospho-alpha-D-ribose 1-diphosphate + L-glutamine + H2O. GO:0009113The chemical reactions and pathways resulting in the formation of purine nucleobases, one of the two classes of nitrogen-containing ring compounds found in DNA and RNA, which include adenine and guanine. GO:0000287Binding to a magnesium (Mg) ion. +14 total
0.392 Hit 40.3% 5.36e-20
3495 VK055_3092 DNA-binding protein HU-&alpha hupA AlphaFold + ColabFold –
GO:0030527The action of a molecule that contributes to the structural integrity of chromatin. GO:0003677Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
0.392 No Hit 0.0% —
3496 VK055_3091 hypothetical protein AlphaFold + ColabFold – – 0.392 No Hit 0.0% —
3497 VK055_2740 pglZ domain protein AlphaFold + ColabFold – – 0.392 No Hit 0.0% —
3498 VK055_1635 ATPase subunit of terminase family protein AlphaFold + ColabFold –
GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. GO:0019069The assembly of a virus capsid from its protein subunits.
0.392 No Hit 0.0% —
3499 VK055_0653 peroxiredoxin, OsmC subfamily protein AlphaFold + ColabFold –
GO:0006979Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals. GO:0004601Catalysis of the reaction: a reduced substrate + ROOH = an oxidized substrate + ROH + H2O.
0.392 No Hit 0.0% —
3500 VK055_4879 acetyl-CoA:acetoacetyl-CoA transferase, beta subunit atoA AlphaFold + ColabFold
2.8.3.8
GO:0008410Catalysis of the transfer of a coenzyme A (CoA) group from one compound (donor) to another (acceptor). GO:0008775Catalysis of the reaction: acyl-CoA + acetate = a fatty acid anion + acetyl-CoA.
0.391 Hit 46.5% 1.07e-61
Page of 204 · 5081 total proteins