Proteins

Genome: KpATCC43816

Description: Klebsiella pneumoniae subsp. pneumoniae strain ATCC 43816 KPPR1, complete genome

Search, filter, and prioritize proteins.

Export view
5081 / 5081 proteins
No filters or custom sorting applied — click to see defaults

Scoring formula None

Sorted by Druggability (P2Rank preferred) (descending)

Applied filters No active filters

Search query No active search

Rows per page 25

Rows
# Protein Description Gene Structure EC GO Metabolism Druggability (P2Rank) P2RANK ligandability score for the best pocket in the experimental structure (0–1). Higher values indicate higher predicted ligandability. Available only for genomes analyzed with the curated pipeline. Druggability (FPocket) FPocket druggability score for the preferred structure (0–1): experimental structure when available, otherwise predicted model. ≥ 0.7 highly druggable · ≥ 0.4 moderately druggable · < 0.4 low druggability. Human off-target BLASTP against the human proteome. Hit means at least one human match was detected at e-value <= 1e-5. Prefer No hit for pathogen-selective targets. Human identity (%) Best human BLAST identity percentage. Human E-value Best human BLAST E-value.
3901 VK055_3516 glutaredoxin 3 grxC AlphaFold DB model + ColabFold model –
GO:0045454Any process that maintains the redox environment of a cell or compartment within a cell. GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. GO:0015038Catalysis of the reaction: 2 glutathione + electron acceptor = glutathione disulfide + electron donor. +25 total
No map N/A 0.195 Hit 34.1% 3.47e-10
3902 VK055_3398 helix-turn-helix family protein AlphaFold DB model + ColabFold model –
GO:0003677Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
No map N/A 0.195 No Hit 0.0% —
3903 VK055_1134 hypothetical protein AlphaFold DB model + ColabFold model – – No map N/A 0.195 No Hit 0.0% —
3904 VK055_4486 recX family protein AlphaFold DB model + ColabFold model –
GO:0006282Any process that modulates the frequency, rate or extent of DNA repair. GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
No map N/A 0.194 No Hit 0.0% —
3905 VK055_3755 50S ribosomal protein L3 rplC AlphaFold DB model + ColabFold model –
GO:0003735The action of a molecule that contributes to the structural integrity of the ribosome. GO:0006412The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA or circRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA or circRNA. Translation ends with the release of a polypeptide chain from the ribosome. GO:0005840An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins.
No map N/A 0.194 Hit 31.5% 2.22e-27
3906 VK055_2113 ribosomal protein L36 rpmJ AlphaFold DB model + ColabFold model –
GO:0003735The action of a molecule that contributes to the structural integrity of the ribosome. GO:0006412The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA or circRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA or circRNA. Translation ends with the release of a polypeptide chain from the ribosome. GO:0005840An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins. +14 total
No map N/A 0.194 No Hit 0.0% —
3907 VK055_1643 phage regulatory CII family protein ColabFold model –
GO:0003677Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
No map 0.193 0.209 No Hit 0.0% —
3908 VK055_1576 AAA domain protein AlphaFold DB model + ColabFold model –
GO:0004519Catalysis of the cleavage of ester linkages within nucleic acids by creating internal breaks. GO:0000731Synthesis of DNA that proceeds from the broken 3' single-strand DNA end and uses the homologous intact duplex as the template. GO:0006302The repair of double-strand breaks in DNA via homologous and nonhomologous mechanisms to reform a continuous DNA helix.
No map 0.192 0.565 No Hit 0.0% —
3909 VK055_1284 hypothetical protein AlphaFold DB model + ColabFold model –
GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
No map 0.192 0.571 No Hit 0.0% —
3910 VK055_0880 periplasmic binding domain protein AlphaFold DB model + ColabFold model –
GO:0006865The directed movement of amino acids, organic acids containing one or more amino substituents, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
No map 0.192 0.341 No Hit 0.0% —
3911 VK055_4459 formate hydrogenlyase maturation HycH family protein AlphaFold DB model + ColabFold model – – No map N/A 0.191 No Hit 0.0% —
3912 VK055_2433 yadG yadG AlphaFold DB model + ColabFold model –
GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. GO:0016887Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient.
No map 0.191 0.231 Hit 39.2% 6.48e-34
3913 VK055_1310 protein yciE2 yciE2 AlphaFold DB model + ColabFold model – – No map 0.191 0.395 No Hit 0.0% —
3914 VK055_4986 HAD hydrolase, IA, variant 1 family protein AlphaFold DB model + ColabFold model –
GO:0016787Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. GO:0046872Binding to a metal ion.
No map 0.190 0.356 No Hit 0.0% —
3915 VK055_3662 hypothetical protein AlphaFold DB model + ColabFold model – – No map N/A 0.19 No Hit 0.0% —
3916 VK055_3547 glycyl-tRNA synthetase, &beta subunit glyS AlphaFold DB model + ColabFold model
6.1.1.14
GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. GO:0004820Catalysis of the reaction: ATP + glycine + tRNA(Gly) = AMP + diphosphate + glycyl-tRNA(Gly). GO:0006426The process of coupling glycine to glycyl-tRNA, catalyzed by glycyl-tRNA synthetase. The glycyll-tRNA synthetase is a class-II synthetase. The activated amino acid is transferred to the 3'-OH group of a glycine-accepting tRNA. +58 total
Mapped 1 0.190 0.918 No Hit 0.0% —
3917 VK055_3436 cupin domain protein AlphaFold DB model + ColabFold model –
GO:0043565Binding to DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. GO:0003700A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons. GO:0006355Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.
No map 0.190 0.336 No Hit 0.0% —
3918 VK055_2387 hypothetical protein AlphaFold DB model + ColabFold model – – No map N/A 0.19 No Hit 0.0% —
3919 VK055_0054 trehalose-phosphatase otsB AlphaFold DB model + ColabFold model
3.1.3.12
GO:0005992The chemical reactions and pathways resulting in the formation of trehalose, a disaccharide that consists of two molecules of glucose and is isomeric with sucrose. GO:0003824Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. GO:0004805Catalysis of the reaction: alpha,alpha-trehalose 6-phosphate + H2O = alpha,alpha-trehalose + phosphate. +14 total
Mapped 6 0.190 0.613 No Hit 0.0% —
3920 VK055_3646 tryptophan/tyrosine permease family protein AlphaFold DB model + ColabFold model –
GO:0003333The process in which an amino acid is transported across a membrane. GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
No map 0.189 0.602 No Hit 0.0% —
3921 VK055_3112 50S ribosomal subunit protein L10 rplJ AlphaFold DB model + ColabFold model –
GO:0015934The larger of the two subunits of a ribosome. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). GO:0006412The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA or circRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA or circRNA. Translation ends with the release of a polypeptide chain from the ribosome. GO:0003735The action of a molecule that contributes to the structural integrity of the ribosome. +14 total
No map 0.189 0.559 No Hit 0.0% —
3922 VK055_2758 putative conserved DNA-binding protein ColabFold model –
GO:0003677Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
No map 0.189 0.849 No Hit 0.0% —
3923 VK055_1490 phosphatidylethanolamine-binding family protein AlphaFold DB model + ColabFold model – – No map 0.189 0.482 No Hit 0.0% —
3924 VK055_0307 ABC transporter family protein AlphaFold DB model + ColabFold model –
GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. GO:0016887Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient.
No map 0.189 0.329 Hit 36.2% 6.53e-07
3925 VK055_5041 imidazole glycerol phosphate synthase, glutamineamidotransferase subunit hisH AlphaFold DB model + ColabFold model
4.3.2.10 3.5.1.2
GO:0016763Catalysis of the transfer of a pentosyl group from one compound (donor) to another (acceptor). GO:0000105The chemical reactions and pathways resulting in the formation of L-histidine, 2-amino-3-(1H-imidazol-4-yl)propanoic acid. GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. +36 total
Mapped 3 0.188 0.516 No Hit 0.0% —
Page of 204 · 5081 total proteins