Proteins

Genome: KpATCC43816

Description: Klebsiella pneumoniae subsp. pneumoniae strain ATCC 43816 KPPR1, complete genome

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5081 proteins

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# Protein Description Gene Structure EC GO Druggability FPocket druggability score for the preferred structure (0–1): experimental structure when available, otherwise predicted model. ≥ 0.7 highly druggable · ≥ 0.4 moderately druggable · < 0.4 low druggability. Human off-target BLASTP against the human proteome. Hit means at least one human match was detected at e-value <= 1e-5. Prefer No hit for pathogen-selective targets. Human identity (%) Best human BLAST identity percentage. Human E-value Best human BLAST E-value.
3901 VK055_2517 23S rRNA and tRNA pseudouridine synthase yabO AlphaFold + ColabFold
5.4.99.-
GO:0009451The covalent alteration of one or more nucleotides within an RNA molecule to produce an RNA molecule with a sequence that differs from that coded genetically. GO:0001522The intramolecular conversion of uridine to pseudouridine within an RNA molecule. GO:0003723Binding to an RNA molecule or a portion thereof. +58 total
0.318 Hit 48.1% 6.54e-12
3902 VK055_2329 L,D-transpeptidase catalytic domain protein AlphaFold + ColabFold –
GO:0016740Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2. GO:0004180Catalysis of the hydrolysis of a single C-terminal amino acid residue from a polypeptide chain. GO:0071555A process that results in the assembly, arrangement of constituent parts, or disassembly of the cell wall, the rigid or semi-rigid envelope lying outside the cell membrane of plant, fungal and most prokaryotic cells, maintaining their shape and protecting them from osmotic lysis. +25 total
0.318 No Hit 0.0% —
3903 VK055_1234 succinylarginine dihydrolase astB2 AlphaFold + ColabFold
3.5.3.23
GO:0006525The chemical reactions and pathways involving arginine, 2-amino-5-(carbamimidamido)pentanoic acid. GO:0009015Catalysis of the reaction: N(2)-succinyl-L-arginine + 2 H2O + 2 H+ = N(2)-succinyl-L-ornithine + CO2 + 2 NH4. GO:0019544OBSOLETE. The chemical reactions and pathways resulting in the breakdown of L-arginine into other compounds, including L-glutamate. +14 total
0.318 No Hit 0.0% —
3904 VK055_0622 polyphosphate kinase 2 ppk2 AlphaFold + ColabFold
2.7.4.-
GO:0008976Catalysis of the reaction: ATP + phosphate(n) = ADP + phosphate(n+1). GO:0006793The chemical reactions and pathways involving the nonmetallic element phosphorus or compounds that contain phosphorus.
0.318 No Hit 0.0% —
3905 VK055_0243 asnC family protein AlphaFold + ColabFold –
GO:0043565Binding to DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. GO:0043200Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an amino acid stimulus. An amino acid is a carboxylic acids containing one or more amino groups.
0.318 No Hit 0.0% —
3906 VK055_4683 ppx ppx Experimental + ColabFold
3.6.1.11
GO:0006793The chemical reactions and pathways involving the nonmetallic element phosphorus or compounds that contain phosphorus. GO:0004309Catalysis of the reaction: polyphosphate(n) + H2O = polyphosphate(n-1) + phosphate. GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. +25 total
0.317 No Hit 0.0% —
3907 VK055_4266 ABC transporter family protein AlphaFold + ColabFold –
GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. GO:0140359Primary active transporter characterized by two nucleotide-binding domains and two transmembrane domains. Uses the energy generated from ATP hydrolysis to drive the transport of a substance across a membrane. GO:0008643The directed movement of carbohydrate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Carbohydrates are a group of organic compounds based of the general formula Cx(H2O)y. +47 total
0.317 Hit 32.6% 1.10e-16
3908 VK055_3900 ribosome maturation protein rimP AlphaFold + ColabFold –
GO:0042274A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a small ribosomal subunit; includes transport to the sites of protein synthesis.
0.317 No Hit 0.0% —
3909 VK055_3293 GTP-binding protein TypA/BipA typA AlphaFold + ColabFold
3.6.5.-
GO:0005525Binding to GTP, guanosine triphosphate. GO:0003924Catalysis of the reaction: GTP + H2O = GDP + H+ + phosphate. GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. +811 total
0.317 Hit 58.3% 9.89e-12
3910 VK055_2906 oligoribonuclease monomer yjeR AlphaFold + ColabFold
3.1.-.-
GO:0000175Catalysis of the sequential cleavage of mononucleotides from a free 3' terminus of an RNA molecule. GO:0003676Binding to a nucleic acid. GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. +14 total
0.317 Hit 60.0% 4.57e-12
3911 VK055_2543 oxaloacetate decarboxylase gamma chain oadG AlphaFold + ColabFold
7.2.4.2
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0015081Enables the transfer of sodium ions (Na+) from one side of a membrane to the other. GO:0036376The directed movement of sodium ions from inside of a cell, across the plasma membrane and into the extracellular region. +36 total
0.317 No Hit 0.0% —
3912 VK055_5006 hsp70 family protein AlphaFold + ColabFold –
GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. GO:0140662Binding to a protein or a protein-containing complex to assist the protein folding process, driven by ATP hydrolysis.
0.316 Hit 25.3% 9.63e-06
3913 VK055_4120 homoserine dehydrogenase, NAD binding domain protein AlphaFold + ColabFold
1.4.1.21
GO:0050661Binding to nicotinamide-adenine dinucleotide phosphate, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NADP+, or the reduced form, NADPH. GO:0033735Catalysis of the reaction: Catalysis of the reaction: L-aspartate + NAD(P)+ + H2O = oxaloacetate + NH4+ + NADPH + H+. GO:0009435The chemical reactions and pathways resulting in the formation of nicotinamide adenine dinucleotide (NAD+), a coenzyme that interconverts with its reduced form, NADH, in many redox and catabolic reactions. NAD+ is derived from various sources including vitamin B3. +36 total
0.316 No Hit 0.0% —
3914 VK055_3727 stationary-phase protein with possible role in p-aminobenzoate/folate biosynthesis fic AlphaFold + ColabFold
2.7.7.108
GO:0070733Catalysis of the reaction: ATP + protein = diphosphate + adenylyl-protein; mediates the addition of an adenylyl (adenosine 5'-monophosphate; AMP group) to L-serine, L-threonine, and L-tyrosine residues in target proteins. GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. GO:0051302Any process that modulates the frequency, rate or extent of the physical partitioning and separation of a cell into daughter cells.
0.316 No Hit 0.0% —
3915 VK055_3264 rhamnulokinase rhaB AlphaFold + ColabFold
2.7.1.5
GO:0016301Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule. GO:0019301The chemical reactions and pathways resulting in the breakdown of rhamnose, the hexose 6-deoxy-L-mannose. GO:0005975The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. +58 total
0.316 No Hit 0.0% —
3916 VK055_2055 lipid A biosynthesis lauroyl (or palmitoleoyl) acyltransferase family protein lpxL3 AlphaFold + ColabFold
2.3.1.241
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0009245The chemical reactions and pathways resulting in the formation of lipid A, the glycolipid group of bacterial lipopolysaccharides, consisting of four to six fatty acyl chains linked to two glucosamine residues. Further modifications of the backbone are common. GO:0016740Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2. +47 total
0.316 No Hit 0.0% —
3917 VK055_1305 helix-turn-helix domain protein AlphaFold + ColabFold – – 0.316 No Hit 0.0% —
3918 VK055_0548 hypothetical protein AlphaFold + ColabFold – – 0.316 No Hit 0.0% —
3919 VK055_4451 hydrogenase nickel insertion protein HypA hypA AlphaFold + ColabFold –
GO:0016151Binding to a nickel (Ni) cation. GO:0051604Any process leading to the attainment of the full functional capacity of a protein. GO:0016530Binding to and delivering metal ions to a target protein. +14 total
0.315 No Hit 0.0% —
3920 VK055_3464 hypothetical protein AlphaFold + ColabFold – – 0.315 No Hit 0.0% —
3921 VK055_1865 penicillin-binding protein 2 mrdA2 AlphaFold + ColabFold
3.4.16.4
GO:0008658Binding to penicillin, an antibiotic that contains the condensed beta-lactamthiazolidine ring system. GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0009002Catalysis of the reaction: (Ac)2-L-Lys-D-alanyl-D-alanine + H2O = (Ac)2-L-Lys-D-alanine + D-alanine. +69 total
0.315 No Hit 0.0% —
3922 VK055_1822 esterase ybfF ybfF AlphaFold + ColabFold –
GO:0016787Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc.
0.315 Hit 45.1% 6.01e-15
3923 VK055_0812 methionine aminopeptidase, type I map AlphaFold + ColabFold
3.4.11.18
GO:0006508The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds. GO:0070006Catalysis of the hydrolysis of a single N-terminal amino acid residue from a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions. GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. +25 total
0.315 Hit 41.8% 6.42e-61
3924 VK055_0680 dipeptidase AC. Metallo peptidase AlphaFold + ColabFold –
GO:0006508The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds. GO:0070573Catalysis of the hydrolysis of a dipeptide by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions.
0.315 Hit 28.3% 9.92e-08
3925 VK055_0595 flavin reductase domain protein, FMN-binding protein AlphaFold + ColabFold –
GO:0010181Binding to flavin mono nucleotide. Flavin mono nucleotide (FMN) is the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes. GO:0016646Catalysis of an oxidation-reduction (redox) reaction in which a CH-NH group acts as a hydrogen or electron donor and reduces NAD or NADP.
0.315 No Hit 0.0% —
Page of 204 · 5081 total proteins