Proteins

Genome: KpATCC43816

Description: Klebsiella pneumoniae subsp. pneumoniae strain ATCC 43816 KPPR1, complete genome

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# Protein Description Gene Structure EC GO Metabolism Druggability (P2Rank) P2RANK ligandability score for the best pocket in the experimental structure (0–1). Higher values indicate higher predicted ligandability. Available only for genomes analyzed with the curated pipeline. Druggability (FPocket) FPocket druggability score for the preferred structure (0–1): experimental structure when available, otherwise predicted model. ≥ 0.7 highly druggable · ≥ 0.4 moderately druggable · < 0.4 low druggability. Human off-target BLASTP against the human proteome. Hit means at least one human match was detected at e-value <= 1e-5. Prefer No hit for pathogen-selective targets. Human identity (%) Best human BLAST identity percentage. Human E-value Best human BLAST E-value.
4126 VK055_1575 macA AlphaFold DB model + ColabFold model –
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:1990961A process that reduces or removes the toxicity of a xenobiotic by exporting it outside the cell. GO:1990195A bacterial transmembrane transporter complex that spans the entire cell membrane system and possesses ATP-dependent xenobiotic transport activity pumping drugs (typically antibiotics) and other toxins directly from the cytosol out of the bacterial cell. Typically, it is trimeric consisting of a inner membrane ATPase (IMP), a periplasmic membrane fusion protein (MFP) and an outer membrane factor (OMF). In E. coli, macrolide transporter complexes may consists of MacB (IMP), MacA (MFP) and TolC (OMF) or AcrB (IMP), AcrA (MFP) and TolC (OMF). Trimeric TolC is a common OMF found in many macrolide transporter complexes. +69 total
No map N/A 0.144 No Hit 0.0% —
4127 VK055_1172 glycine zipper 2TM domain protein AlphaFold DB model + ColabFold model –
GO:0019867The external membrane of Gram-negative bacteria or certain organelles such as mitochondria and chloroplasts; freely permeable to most ions and metabolites.
No map N/A 0.144 No Hit 0.0% —
4128 VK055_3830 hypothetical protein AlphaFold DB model + ColabFold model – – No map N/A 0.143 No Hit 0.0% —
4129 VK055_2487 mraZ family protein AlphaFold DB model + ColabFold model –
GO:0003700A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons. GO:0003677Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). GO:0006355Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.
No map 0.143 0.272 No Hit 0.0% —
4130 VK055_2162 cytochrome o ubiquinol oxidase, subunit III cyoC AlphaFold DB model + ColabFold model –
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0019646A process in which a series of electron carriers operate together to transfer electrons from donors such as NADH and FADH2 to oxygen to generate a transmembrane electrochemical gradient. GO:0022904A process in which a series of electron carriers operate together to transfer electrons from donors such as NADH and FADH2 to any of several different terminal electron acceptors to generate a transmembrane electrochemical gradient. +47 total
No map 0.143 0.541 Hit 27.9% 1.77e-09
4131 VK055_1642 hypothetical protein ColabFold model – – No map 0.143 0.937 No Hit 0.0% —
4132 VK055_0850 altronate oxidoreductase uxaB AlphaFold DB model + ColabFold model
1.1.1.58
GO:0009026Catalysis of the reaction: D-altronate + NAD+ = D-tagaturonate + H+ + NADH. GO:0016491Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. +36 total
Chokepoint 1 0.143 0.328 No Hit 0.0% —
4133 VK055_0501 pyridoxamine 5'-phosphate oxidase pdxH AlphaFold DB model + ColabFold model
1.4.3.5
GO:0004733Catalysis of the reaction: pyridoxamine 5'-phosphate + H2O + O2 = pyridoxal 5'-phosphate + NH4+ + H2O2. This activity can also oxidize pyridoxine 5'-phosphate to pyridoxal 5'-phosphate + H2O2. GO:0016638Catalysis of an oxidation-reduction (redox) reaction in which a CH-NH2 group acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor. GO:0010181Binding to flavin mono nucleotide. Flavin mono nucleotide (FMN) is the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes. +14 total
Chokepoint 2 0.143 0.553 Hit 47.4% 2.38e-42
4134 VK055_0269 YCII-related domain protein AlphaFold DB model + ColabFold model – – No map 0.143 0.388 No Hit 0.0% —
4135 VK055_4944 PRD domain protein AlphaFold DB model + ColabFold model –
GO:0045893Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription. GO:0003723Binding to an RNA molecule or a portion thereof. GO:0006355Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.
No map 0.142 0.229 No Hit 0.0% —
4136 VK055_4124 putative peptidase AlphaFold DB model + ColabFold model –
GO:0004222Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions. GO:0006508The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds. GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. +25 total
No map 0.142 0.359 No Hit 0.0% —
4137 VK055_2616 bacterial regulatory helix-turn-helix, AraC family protein AlphaFold DB model + ColabFold model –
GO:0043565Binding to DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. GO:0003700A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons. GO:0006355Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.
No map 0.142 0.738 No Hit 0.0% —
4138 VK055_0740 hypothetical protein AlphaFold DB model + ColabFold model – – No map 0.142 0.497 No Hit 0.0% —
4139 VK055_1563 essential cell division protein FtsK AlphaFold DB model + ColabFold model –
GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. GO:0000166Binding to a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose. GO:0003677Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). +47 total
No map 0.141 0.849 No Hit 0.0% —
4140 VK055_1391 hypothetical protein ColabFold model – – No map 0.141 0.184 No Hit 0.0% —
4141 VK055_1073 ABC transporter family protein AlphaFold DB model + ColabFold model –
GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. GO:0016887Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient. GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. +14 total
No map 0.141 0.657 Hit 46.2% 5.40e-07
4142 VK055_0151 A predicted alpha-helical domain with a conserved ER motif family protein AlphaFold DB model + ColabFold model – – No map 0.141 0.719 No Hit 0.0% —
4143 VK055_2881 hypothetical protein AlphaFold DB model + ColabFold model – – No map N/A 0.14 No Hit 0.0% —
4144 VK055_0659 bacterial regulatory helix-turn-helix, lysR family protein AlphaFold DB model + ColabFold model –
GO:0003700A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons. GO:0006355Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. GO:0003677Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). +14 total
No map 0.140 0.907 No Hit 0.0% —
4145 VK055_0408 alpha-acetolactate decarboxylase budA AlphaFold DB model + ColabFold model
4.1.1.5
GO:0045151The chemical reactions and pathways resulting in the formation of acetoin, 3-hydroxy-2-butanone. GO:0047605Catalysis of the reaction: (S)-2-hydroxy-2-methyl-3-oxobutanoate = (R)-2-acetoin + CO2.
Mapped 1 0.140 0.298 No Hit 0.0% —
4146 VK055_4613 holo-[acyl-carrier-protein] synthase acpS AlphaFold DB model + ColabFold model
2.7.8.7
GO:0008897Catalysis of the reaction: CoA + substrate-serine = adenosine 3',5'-bisphosphate + substrate-serine-4'-phosphopantetheine. The transfer of the 4'-phosphopantetheine (Ppant) co-factor from coenzyme A to the hydroxyl side chain of the serine residue of acyl- or peptidyl-carrier protein (ACP or PCP) to convert them from the apo to the holo form. GO:0000287Binding to a magnesium (Mg) ion. GO:0006633The chemical reactions and pathways resulting in the formation of a fatty acid, any of the aliphatic monocarboxylic acids that can be liberated by hydrolysis from naturally occurring fats and oils. Fatty acids are predominantly straight-chain acids of 4 to 24 carbon atoms, which may be saturated or unsaturated; branched fatty acids and hydroxy fatty acids also occur, and very long chain acids of over 30 carbons are found in waxes. +14 total
Mapped 2 0.139 0.047 No Hit 0.0% —
4147 VK055_4019 membrane fusogenic activity family protein AlphaFold DB model + ColabFold model –
GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. GO:0006744The chemical reactions and pathways resulting in the formation of ubiquinone, a lipid-soluble electron-transporting coenzyme.
No map N/A 0.139 No Hit 0.0% —
4148 VK055_2633 altronate oxidoreductase uxaB2 AlphaFold DB model + ColabFold model –
GO:0016491Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. GO:0008926Catalysis of the reaction: D-mannitol 1-phosphate + NAD+ = D-fructose 6-phosphate + NADH + H+. +36 total
Chokepoint 1 0.139 0.524 No Hit 0.0% —
4149 VK055_1475 diguanylate cyclase domain protein AlphaFold DB model + ColabFold model
2.7.7.65
GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0052621Catalysis of the reaction: 2 GTP = cyclic di-3',5'-guanylate + 2 diphosphate + 2 H+. GO:0005525Binding to GTP, guanosine triphosphate. +25 total
Chokepoint 1 0.139 0.379 No Hit 0.0% —
4150 VK055_3699 molecular chaperone Hsp33 hslO AlphaFold DB model + ColabFold model –
GO:0006457The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure. GO:0051082Binding to an unfolded protein. GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. +25 total
No map 0.138 0.294 No Hit 0.0% —
Page of 204 · 5081 total proteins