Proteins

Genome: KpATCC43816

Description: Klebsiella pneumoniae subsp. pneumoniae strain ATCC 43816 KPPR1, complete genome

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# Protein Description Gene Structure EC GO Metabolism Druggability (P2Rank) P2RANK ligandability score for the best pocket in the experimental structure (0–1). Higher values indicate higher predicted ligandability. Available only for genomes analyzed with the curated pipeline. Druggability (FPocket) FPocket druggability score for the preferred structure (0–1): experimental structure when available, otherwise predicted model. ≥ 0.7 highly druggable · ≥ 0.4 moderately druggable · < 0.4 low druggability. Human off-target BLASTP against the human proteome. Hit means at least one human match was detected at e-value <= 1e-5. Prefer No hit for pathogen-selective targets. Human identity (%) Best human BLAST identity percentage. Human E-value Best human BLAST E-value.
4151 VK055_3529 glutathione transferase-like protein possibly involved in selenium metabolism yibF AlphaFold DB model + ColabFold model –
GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
No map 0.138 0.673 Hit 30.3% 3.09e-08
4152 VK055_3250 ATP-dependent protease HslVU, peptidase subunit hslV AlphaFold DB model + ColabFold model
3.4.25.2
GO:0006508The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds. GO:0009376A protein complex that possesses ATP-dependent protease activity; consists of an ATPase large subunit with homology to other ClpX family ATPases and a peptidase small subunit related to the proteasomal beta-subunits of eukaryotes. In the E. coli complex, a double ring-shaped homohexamer of HslV is capped on each side by a ring-shaped HslU homohexamer. GO:0051603OBSOLETE. The hydrolysis of a peptide bond or bonds within a protein as part of the chemical reactions and pathways resulting in the breakdown of a protein by individual cells. +36 total
No map 0.138 0.059 No Hit 0.0% —
4153 VK055_2828 hypothetical protein AlphaFold DB model + ColabFold model – – No map 0.138 0.799 No Hit 0.0% —
4154 VK055_2568 hypothetical protein AlphaFold DB model + ColabFold model –
GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. GO:0003677Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). GO:0033194Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hydroperoxide stimulus. Hydroperoxides are monosubstitution products of hydrogen peroxide, HOOH.
No map 0.138 0.55 No Hit 0.0% —
4155 VK055_1370 yceG-like family protein AlphaFold DB model + ColabFold model
4.2.2.29
GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0016301Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule. GO:0008932Catalysis of the endolytic cleavage of the (1->4)-beta-glycosidic linkage between N-acetylmuramic acid (MurNAc) and N-acetylglucosamine (GlcNAc) residues in peptidoglycan with concomitant formation of a 1,6-anhydrobond in the MurNAc residue. +25 total
No map 0.138 0.631 No Hit 0.0% —
4156 VK055_1093 intracellular multiplication and human macrophage-killing family protein AlphaFold DB model + ColabFold model – – No map 0.138 0.923 No Hit 0.0% —
4157 VK055_4948 efflux transporter, outer membrane factor (OMF) lipo, NodT family protein AlphaFold DB model + ColabFold model –
GO:0022857Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other. GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0015562Enables the transfer of a specific substance or related group of substances from the inside of the cell to the outside of the cell across a membrane. +25 total
No map 0.137 0.197 No Hit 0.0% —
4158 VK055_2983 hypothetical protein ColabFold model – – No map 0.137 0.53 No Hit 0.0% —
4159 VK055_1818 putative arginine/ornithine antiporter AlphaFold DB model + ColabFold model – – No map 0.137 0.792 No Hit 0.0% —
4160 VK055_4316 diol dehydratase-reactivating factor small subunit ddrB AlphaFold DB model + ColabFold model – – No map N/A 0.136 No Hit 0.0% —
4161 VK055_4087 ABC transporter family protein AlphaFold DB model + ColabFold model
3.6.3.17
GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. GO:0016887Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient.
No map 0.136 0.285 Hit 35.0% 3.27e-23
4162 VK055_1977 hypothetical protein AlphaFold DB model + ColabFold model – – No map 0.136 0.691 No Hit 0.0% —
4163 VK055_1948 bacterial regulatory helix-turn-helix, lysR family protein AlphaFold DB model + ColabFold model –
GO:0003700A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons. GO:0006355Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. GO:0043565Binding to DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. +14 total
No map 0.136 0.627 No Hit 0.0% —
4164 VK055_0916 hypothetical protein AlphaFold DB model + ColabFold model – – No map N/A 0.136 No Hit 0.0% —
4165 VK055_4109 rieske [2Fe-2S] domain protein AlphaFold DB model + ColabFold model –
GO:0051537Binding to a 2 iron, 2 sulfur (2Fe-2S) cluster; this cluster consists of two iron atoms, with two inorganic sulfur atoms found between the irons and acting as bridging ligands. GO:0046872Binding to a metal ion.
No map N/A 0.135 Hit 34.3% 2.22e-09
4166 VK055_1501 outer membrane protein A ompA Experimental + AlphaFold DB model + ColabFold model –
GO:0015288Enables the transfer of substances, sized less than 1000 Da, from one side of a membrane to the other. The transmembrane portions of porins consist exclusively of beta-strands which form a beta-barrel. They are found in the outer membranes of Gram-negative bacteria, mitochondria, plastids and possibly acid-fast Gram-positive bacteria. GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0009279A lipid bilayer that forms the outermost membrane of the cell envelope; enriched in polysaccharide and protein; the outer leaflet of the membrane contains specific lipopolysaccharide structures. +36 total
No map 0.135 0.496 No Hit 0.0% —
4167 VK055_0184 ompA family protein AlphaFold DB model + ColabFold model –
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it.
No map 0.135 0.75 No Hit 0.0% —
4168 VK055_3303 DSBA-like thioredoxin domain protein AlphaFold DB model + ColabFold model –
GO:0016491Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. GO:0042597The region between the inner (cytoplasmic) and outer membrane (Gram-negative Bacteria) or cytoplasmic membrane and cell wall (Fungi and Gram-positive Bacteria). GO:0015036Catalysis of the reaction: substrate with reduced sulfide groups = substrate with oxidized disulfide bonds. +14 total
No map 0.134 0.38 No Hit 0.0% —
4169 VK055_0570 hypothetical protein ColabFold model – – No map N/A 0.134 No Hit 0.0% —
4170 VK055_4817 amino ABC transporter, permease, 3-TM region, His/Glu/Gln/Arg/opine family domain protein AlphaFold DB model + ColabFold model –
GO:0043190A complex for the transport of metabolites into and out of the cell, typically comprised of four domains; two membrane-associated domains and two ATP-binding domains at the intracellular face of the membrane, that form a central pore through the plasma membrane. Each of the four core domains may be encoded as a separate polypeptide or the domains can be fused in any one of a number of ways into multidomain polypeptides. In Bacteria and Archaebacteria, ABC transporters also include substrate binding proteins to bind substrate external to the cytoplasm and deliver it to the transporter. GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0055085The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other. +36 total
No map 0.133 0.704 No Hit 0.0% —
4171 VK055_1918 hypothetical protein AlphaFold DB model + ColabFold model – – No map N/A 0.133 No Hit 0.0% —
4172 VK055_2552 FKBP-type peptidyl-prolyl cis-trans isomerase family protein AlphaFold DB model + ColabFold model
5.2.1.8
GO:0003755Catalysis of the reaction: peptidyl-proline (omega=180) = peptidyl-proline (omega=0).
No map 0.132 0.567 Hit 35.0% 1.38e-06
4173 VK055_1899 methylthioribulose-1-phosphate dehydratase mtnB AlphaFold DB model + ColabFold model
4.2.1.109
GO:0019509OBSOLETE. The generation of L-methionine (2-amino-4-(methylthio)butanoic acid) from methylthioadenosine. GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. GO:0046872Binding to a metal ion. +58 total
No map 0.132 0.583 Hit 24.7% 2.37e-10
4174 VK055_0289 putative glutathione peroxidase AlphaFold DB model + ColabFold model
1.11.1.24 1.11.1.9
GO:0006979Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals. GO:0004602Catalysis of the reaction: 2 glutathione + H2O2 = oxidized glutathione + 2 H2O. GO:0140824Catalysis of the reaction: [thioredoxin]-dithiol + a hydroperoxide = [thioredoxin]-disulfide + an alcohol + H2O. +14 total
Mapped 1 0.132 0.284 Hit 56.5% 3.37e-17
4175 VK055_4160 tyrosine recombinase XerD xerD AlphaFold DB model + ColabFold model –
GO:0009009Catalysis of the formation of new phosphodiester bonds between a pair of short, unique target DNA sequences. GO:0015074The process in which a DNA segment is incorporated into another, usually larger, DNA molecule such as a chromosome. GO:0003677Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). +69 total
No map 0.131 0.135 No Hit 0.0% —
Page of 204 · 5081 total proteins