Proteins

Genome: KpATCC43816

Description: Klebsiella pneumoniae subsp. pneumoniae strain ATCC 43816 KPPR1, complete genome

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# Protein Description Gene Structure EC GO Metabolism Druggability (P2Rank) P2RANK ligandability score for the best pocket in the experimental structure (0–1). Higher values indicate higher predicted ligandability. Available only for genomes analyzed with the curated pipeline. Druggability (FPocket) FPocket druggability score for the preferred structure (0–1): experimental structure when available, otherwise predicted model. ≥ 0.7 highly druggable · ≥ 0.4 moderately druggable · < 0.4 low druggability. Human off-target BLASTP against the human proteome. Hit means at least one human match was detected at e-value <= 1e-5. Prefer No hit for pathogen-selective targets. Human identity (%) Best human BLAST identity percentage. Human E-value Best human BLAST E-value.
4176 VK055_1784 protein TolR tolR AlphaFold DB model + ColabFold model –
GO:0022857Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other. GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0015031The directed movement of proteins into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. +36 total
No map N/A 0.131 No Hit 0.0% —
4177 VK055_5042 hisB AlphaFold DB model + ColabFold model –
GO:0000105The chemical reactions and pathways resulting in the formation of L-histidine, 2-amino-3-(1H-imidazol-4-yl)propanoic acid. GO:0016791Catalysis of the hydrolysis of a phosphoric monoester, releasing a phosphate. GO:0004401Catalysis of the reaction: L-histidinol phosphate + H2O = L-histidinol + phosphate. +36 total
No map 0.130 0.318 No Hit 0.0% —
4178 VK055_3804 putative transcriptional regulator AlphaFold DB model + ColabFold model –
GO:0003677Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). GO:0003700A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons. GO:0045892Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription. +14 total
No map 0.130 0.595 No Hit 0.0% —
4179 VK055_2261 amino ABC transporter, permease, 3-TM region, His/Glu/Gln/Arg/opine family domain protein AlphaFold DB model + ColabFold model –
GO:0043190A complex for the transport of metabolites into and out of the cell, typically comprised of four domains; two membrane-associated domains and two ATP-binding domains at the intracellular face of the membrane, that form a central pore through the plasma membrane. Each of the four core domains may be encoded as a separate polypeptide or the domains can be fused in any one of a number of ways into multidomain polypeptides. In Bacteria and Archaebacteria, ABC transporters also include substrate binding proteins to bind substrate external to the cytoplasm and deliver it to the transporter. GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0055085The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other. +36 total
No map 0.130 0.759 No Hit 0.0% —
4180 VK055_1647 hypothetical protein ColabFold model – – No map 0.130 0.204 No Hit 0.0% —
4181 VK055_0824 bacterial regulatory helix-turn-helix, lysR family protein AlphaFold DB model + ColabFold model –
GO:0003700A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons. GO:0006355Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. GO:0000976Binding to a specific sequence of DNA that is part of a regulatory region that controls transcription of that section of the DNA. The transcribed region might be described as a gene, cistron, or operon.
No map 0.130 0.409 No Hit 0.0% —
4182 VK055_0539 hypothetical protein ColabFold model – – No map N/A 0.13 No Hit 0.0% —
4183 VK055_0283 endoribonuclease L-PSP family protein AlphaFold DB model + ColabFold model – – No map N/A 0.13 No Hit 0.0% —
4184 VK055_0216 peptide chain release factor 1 prfA AlphaFold DB model + ColabFold model –
GO:0006415The process resulting in the release of a polypeptide chain from the ribosome, usually in response to a termination codon (UAA, UAG, or UGA in the universal genetic code). GO:0003747Involved in catalyzing the release of a nascent polypeptide chain from a ribosome. GO:0016149A translation release factor that is specific for one or more particular termination codons; acts at the ribosomal A-site and require polypeptidyl-tRNA at the P-site. +14 total
No map 0.130 0.771 Hit 61.5% 3.41e-45
4185 VK055_3640 signal recognition particle-docking protein FtsY ftsY AlphaFold DB model + ColabFold model
3.6.5.4
GO:0005525Binding to GTP, guanosine triphosphate. GO:0016887Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient. GO:0006614The targeting of proteins to a membrane that occurs during translation and is dependent upon two key components, the signal-recognition particle (SRP) and the SRP receptor. SRP is a cytosolic particle that transiently binds to the endoplasmic reticulum (ER) signal sequence in a nascent protein, to the large ribosomal unit, and to the SRP receptor in the ER membrane. +58 total
No map 0.129 0.076 Hit 35.0% 1.41e-31
4186 VK055_2956 merR HTH regulatory family protein AlphaFold DB model + ColabFold model – – No map N/A 0.129 No Hit 0.0% —
4187 VK055_2100 primosomal replication priB and priC family protein AlphaFold DB model + ColabFold model – – No map 0.129 0.79 No Hit 0.0% —
4188 VK055_1595 artI artI2 AlphaFold DB model + ColabFold model –
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0030288The region between the inner (cytoplasmic or plasma) membrane and outer membrane of organisms with two membranes such as Gram negative bacteria. These periplasmic spaces are relatively thick and contain a thin peptidoglycan layer (PGL), also referred to as a thin cell wall. GO:0071705The directed movement of nitrogen-containing compounds into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. +14 total
No map 0.129 0.607 No Hit 0.0% —
4189 VK055_4481 ABC transporter family protein AlphaFold DB model + ColabFold model –
GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. GO:0016887Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient.
No map 0.128 0.363 Hit 34.6% 3.65e-13
4190 VK055_3372 hypothetical protein AlphaFold DB model + ColabFold model – – No map 0.128 0.286 No Hit 0.0% —
4191 VK055_1636 phage portal protein, PBSX family AlphaFold DB model + ColabFold model – – No map 0.128 0.881 No Hit 0.0% —
4192 VK055_1210 flagellin N-methylase family protein AlphaFold DB model + ColabFold model – – No map 0.128 0.175 No Hit 0.0% —
4193 VK055_0748 PTS system, Lactose/Cellobiose specific IIB subunit AlphaFold DB model + ColabFold model –
GO:0009401The uptake and phosphorylation of specific carbohydrates from the extracellular environment; uptake and phosphorylation are coupled, making the PTS a link between the uptake and metabolism of sugars; phosphoenolpyruvate is the original phosphate donor; phosphoenolpyruvate passes the phosphate via a signal transduction pathway, to enzyme 1 (E1), which in turn passes it on to the histidine protein, HPr; the next step in the system involves sugar-specific membrane-bound complex, enzyme 2 (EII), which transports the sugar into the cell; it includes the sugar permease, which catalyzes the transport reactions; EII is usually divided into three different domains, EIIA, EIIB, and EIIC. GO:0008982Catalysis of the PEP-dependent, phosphoryl transfer-driven transport of substances across a membrane. The transport happens by catalysis of the reaction: protein N-phosphohistidine + sugar(out) = protein histidine + sugar phosphate(in). This differs from primary and secondary active transport in that the solute is modified during transport.
No map N/A 0.128 No Hit 0.0% —
4194 VK055_0657 bestrophin, RFP-TM, chloride channel family protein Experimental + ColabFold model –
GO:0005254Enables the energy-independent facilitated diffusion of a chloride ion through a transmembrane aqueous pore or channel. GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0046872Binding to a metal ion.
No map 0.128 0.975 No Hit 0.0% —
4195 VK055_3406 2-aminoethylphosphonate ABC transporter, permease protein phnU AlphaFold DB model + ColabFold model –
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0055085The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other. GO:0033223The directed movement of 2-aminoethylphosphonate, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. +14 total
No map 0.127 0.736 No Hit 0.0% —
4196 VK055_2998 hypothetical protein AlphaFold DB model + ColabFold model – – No map N/A 0.127 No Hit 0.0% —
4197 VK055_2075 ABC transporter family protein AlphaFold DB model + ColabFold model –
GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. GO:0016887Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient.
No map 0.127 0.614 Hit 34.4% 1.56e-12
4198 VK055_1469 frwB frwB2 AlphaFold DB model + ColabFold model
2.7.1.202
GO:0009401The uptake and phosphorylation of specific carbohydrates from the extracellular environment; uptake and phosphorylation are coupled, making the PTS a link between the uptake and metabolism of sugars; phosphoenolpyruvate is the original phosphate donor; phosphoenolpyruvate passes the phosphate via a signal transduction pathway, to enzyme 1 (E1), which in turn passes it on to the histidine protein, HPr; the next step in the system involves sugar-specific membrane-bound complex, enzyme 2 (EII), which transports the sugar into the cell; it includes the sugar permease, which catalyzes the transport reactions; EII is usually divided into three different domains, EIIA, EIIB, and EIIC. GO:0022877Catalysis of the PEP-dependent, phosphoryl transfer-driven transport of substances across a membrane. The transport happens by catalysis of the reaction: protein N-phosphohistidine + fructose(out) = protein histidine + fructose phosphate(in). This differs from primary and secondary active transport in that the solute is modified during transport. GO:0008982Catalysis of the PEP-dependent, phosphoryl transfer-driven transport of substances across a membrane. The transport happens by catalysis of the reaction: protein N-phosphohistidine + sugar(out) = protein histidine + sugar phosphate(in). This differs from primary and secondary active transport in that the solute is modified during transport. +36 total
No map N/A 0.127 No Hit 0.0% —
4199 VK055_1173 translation initiation factor SUI1 family protein AlphaFold DB model + ColabFold model –
GO:0003743Functions in the initiation of ribosome-mediated translation of mRNA into a polypeptide. GO:0006413The process preceding formation of the peptide bond between the first two amino acids of a protein. This includes the formation of a complex of the ribosome, mRNA or circRNA, and an initiation complex that contains the first aminoacyl-tRNA. GO:0003729Binding to messenger RNA (mRNA), an intermediate molecule between DNA and protein. mRNA includes UTR and coding sequences, but does not contain introns. +36 total
No map N/A 0.127 No Hit 0.0% —
4200 VK055_5153 hypothetical protein AlphaFold DB model + ColabFold model –
GO:0005694A structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information. GO:0007059The process in which genetic material, in the form of chromosomes, is organized into specific structures and then physically separated and apportioned to two or more sets. In eukaryotes, chromosome segregation begins with the condensation of chromosomes, includes chromosome separation, and ends when chromosomes have completed movement to the spindle poles.
No map 0.126 0.165 No Hit 0.0% —
Page of 204 · 5081 total proteins