Proteins

Genome: KpATCC43816

Description: Klebsiella pneumoniae subsp. pneumoniae strain ATCC 43816 KPPR1, complete genome

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# Protein Description Gene Structure EC GO Metabolism Druggability (P2Rank) P2RANK ligandability score for the best pocket in the experimental structure (0–1). Higher values indicate higher predicted ligandability. Available only for genomes analyzed with the curated pipeline. Druggability (FPocket) FPocket druggability score for the preferred structure (0–1): experimental structure when available, otherwise predicted model. ≥ 0.7 highly druggable · ≥ 0.4 moderately druggable · < 0.4 low druggability. Human off-target BLASTP against the human proteome. Hit means at least one human match was detected at e-value <= 1e-5. Prefer No hit for pathogen-selective targets. Human identity (%) Best human BLAST identity percentage. Human E-value Best human BLAST E-value.
4201 VK055_5054 fusaric acid resistance protein-like family protein AlphaFold DB model + ColabFold model –
GO:0022857Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other. GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0055085The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other.
No map 0.126 0.571 No Hit 0.0% —
4202 VK055_4838 nuoB nuoB AlphaFold DB model + ColabFold model
7.1.1.-
GO:0051536Binding to an iron-sulfur cluster, a combination of iron and sulfur atoms. GO:0051539Binding to a 4 iron, 4 sulfur (4Fe-4S) cluster; this cluster consists of four iron atoms, with the inorganic sulfur atoms found between the irons and acting as bridging ligands. GO:0048038Binding to a quinone, any member of a class of diketones derivable from aromatic compounds by conversion of two CH groups into CO groups with any necessary rearrangement of double bonds. +710 total
Mapped 3 0.126 0.79 Hit 57.3% 5.01e-44
4203 VK055_3496 glycosyl transferase 2 family protein AlphaFold DB model + ColabFold model –
GO:0016740Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2.
No map 0.126 0.687 No Hit 0.0% —
4204 VK055_3489 dut dut AlphaFold DB model + ColabFold model
3.6.1.23
GO:0046081The chemical reactions and pathways resulting in the breakdown of dUTP, deoxyuridine (5'-)triphosphate. GO:0006226The chemical reactions and pathways resulting in the formation of dUMP, deoxyuridine monophosphate (2'-deoxyuridine 5'-phosphate). GO:0000287Binding to a magnesium (Mg) ion. +14 total
Chokepoint 1 0.126 0.387 Hit 37.8% 1.63e-10
4205 VK055_2040 branched-chain amino acid transport system / permease component family protein AlphaFold DB model + ColabFold model –
GO:0022857Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other. GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0055085The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other. +14 total
No map 0.126 0.812 No Hit 0.0% —
4206 VK055_1749 bacterial regulatory, luxR family protein AlphaFold DB model + ColabFold model –
GO:0003677Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). GO:0006355Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.
No map 0.126 0.579 No Hit 0.0% —
4207 VK055_4545 bacterial extracellular solute-binding, 3 familyprotein AlphaFold DB model + ColabFold model – – No map 0.125 0.352 No Hit 0.0% —
4208 VK055_4423 hemin import ATP-binding protein HmuV hmuV AlphaFold DB model + ColabFold model –
GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. GO:0016887Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient.
No map 0.125 0.3 Hit 33.3% 2.38e-08
4209 VK055_4234 hypothetical protein AlphaFold DB model + ColabFold model – – No map N/A 0.124 No Hit 0.0% —
4210 VK055_3551 helix-turn-helix family protein AlphaFold DB model + ColabFold model –
GO:0003677Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
No map N/A 0.124 No Hit 0.0% —
4211 VK055_3342 phosphate ABC transporter, phosphate-binding protein PstS pstS AlphaFold DB model + ColabFold model –
GO:0035435The process in which a phosphate is transported across a membrane. GO:0043190A complex for the transport of metabolites into and out of the cell, typically comprised of four domains; two membrane-associated domains and two ATP-binding domains at the intracellular face of the membrane, that form a central pore through the plasma membrane. Each of the four core domains may be encoded as a separate polypeptide or the domains can be fused in any one of a number of ways into multidomain polypeptides. In Bacteria and Archaebacteria, ABC transporters also include substrate binding proteins to bind substrate external to the cytoplasm and deliver it to the transporter. GO:0042301Binding to a phosphate ion.
No map 0.124 0.693 No Hit 0.0% —
4212 VK055_2365 glyoxalase/Bleomycin resistance /Dioxygenase superfamily protein AlphaFold DB model + ColabFold model –
GO:0046872Binding to a metal ion.
No map 0.124 0.238 No Hit 0.0% —
4213 VK055_0988 fumarate hydratase, class II fumC AlphaFold DB model + ColabFold model
4.2.1.2
GO:0003824Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. GO:0006106The chemical reactions and pathways involving fumarate, the anion of trans-1,2-ethenedicarboxylic acid, the diastereoisomer of maleate. It is a key intermediate in metabolism and is formed in the TCA cycle from succinate and converted into malate. GO:0045239Any of the heteromeric enzymes that act in the TCA cycle. +69 total
Mapped 1 0.124 0.806 Hit 61.9% 2.48e-175
4214 VK055_0387 hypothetical protein AlphaFold DB model + ColabFold model – – No map 0.124 0.044 No Hit 0.0% —
4215 VK055_4712 hypothetical protein AlphaFold DB model + ColabFold model – – No map 0.123 0.798 No Hit 0.0% —
4216 VK055_2937 copper binding protein CutA cutA AlphaFold DB model + ColabFold model –
GO:0005507Binding to a copper (Cu) ion. GO:0010038Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a metal ion stimulus. GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
No map 0.123 0.035 Hit 40.5% 7.82e-16
4217 VK055_2661 putative ascBF operon repressor AlphaFold DB model + ColabFold model – – No map 0.123 0.653 No Hit 0.0% —
4218 VK055_2527 protein ApaG apaG AlphaFold DB model + ColabFold model –
GO:0070987The conversion of DNA-damage induced single-stranded gaps into large molecular weight DNA after replication by using a specialized DNA polymerase or replication complex to insert a defined nucleotide across the lesion. This process does not remove the replication-blocking lesions but does not causes an increase in the endogenous mutation level. For S. cerevisiae, RAD30 encodes DNA polymerase eta, which incorporates two adenines. When incorporated across a thymine-thymine dimer, it does not increase the endogenous mutation level.
No map 0.123 0.271 Hit 43.2% 2.50e-12
4219 VK055_2020 lysine-arginine-ornithine-binding periplasmic family protein AlphaFold DB model + ColabFold model –
GO:0030288The region between the inner (cytoplasmic or plasma) membrane and outer membrane of organisms with two membranes such as Gram negative bacteria. These periplasmic spaces are relatively thick and contain a thin peptidoglycan layer (PGL), also referred to as a thin cell wall. GO:0071705The directed movement of nitrogen-containing compounds into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
No map 0.123 0.295 No Hit 0.0% —
4220 VK055_1305 helix-turn-helix domain protein AlphaFold DB model + ColabFold model – – No map 0.123 0.316 No Hit 0.0% —
4221 VK055_4461 hydrogenase maturation peptidase HycI hycI AlphaFold DB model + ColabFold model –
GO:0008233Catalysis of the hydrolysis of a peptide bond. A peptide bond is a covalent bond formed when the carbon atom from the carboxyl group of one amino acid shares electrons with the nitrogen atom from the amino group of a second amino acid. GO:0008047A molecular function regulator that increases a catalytic activity. GO:0004175Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain. +14 total
No map 0.122 0.193 No Hit 0.0% —
4222 VK055_4433 ABC 3 transport family protein AlphaFold DB model + ColabFold model –
GO:0043190A complex for the transport of metabolites into and out of the cell, typically comprised of four domains; two membrane-associated domains and two ATP-binding domains at the intracellular face of the membrane, that form a central pore through the plasma membrane. Each of the four core domains may be encoded as a separate polypeptide or the domains can be fused in any one of a number of ways into multidomain polypeptides. In Bacteria and Archaebacteria, ABC transporters also include substrate binding proteins to bind substrate external to the cytoplasm and deliver it to the transporter. GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0055085The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other. +47 total
No map 0.122 0.628 No Hit 0.0% —
4223 VK055_2373 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase lpxD AlphaFold DB model + ColabFold model
2.3.1.191
GO:0016747Catalysis of the transfer of an acyl group, other than amino-acyl, from one compound (donor) to another (acceptor). GO:0016410Catalysis of the transfer of an acyl group to a nitrogen atom on the acceptor molecule. GO:0009245The chemical reactions and pathways resulting in the formation of lipid A, the glycolipid group of bacterial lipopolysaccharides, consisting of four to six fatty acyl chains linked to two glucosamine residues. Further modifications of the backbone are common. +36 total
Chokepoint 1 0.122 0.707 No Hit 0.0% —
4224 VK055_1102 ompA family protein Experimental + AlphaFold DB model + ColabFold model –
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0009279A lipid bilayer that forms the outermost membrane of the cell envelope; enriched in polysaccharide and protein; the outer leaflet of the membrane contains specific lipopolysaccharide structures.
No map 0.122 0.656 No Hit 0.0% —
4225 VK055_0022 dextransucrase DSRB family protein AlphaFold DB model + ColabFold model – – No map N/A 0.122 No Hit 0.0% —
Page of 204 · 5081 total proteins