Proteins

Genome: KpATCC43816

Description: Klebsiella pneumoniae subsp. pneumoniae strain ATCC 43816 KPPR1, complete genome

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# Protein Description Gene Structure EC GO Metabolism Druggability (P2Rank) P2RANK ligandability score for the best pocket in the experimental structure (0–1). Higher values indicate higher predicted ligandability. Available only for genomes analyzed with the curated pipeline. Druggability (FPocket) FPocket druggability score for the preferred structure (0–1): experimental structure when available, otherwise predicted model. ≥ 0.7 highly druggable · ≥ 0.4 moderately druggable · < 0.4 low druggability. Human off-target BLASTP against the human proteome. Hit means at least one human match was detected at e-value <= 1e-5. Prefer No hit for pathogen-selective targets. Human identity (%) Best human BLAST identity percentage. Human E-value Best human BLAST E-value.
4501 VK055_1666 iaaA AlphaFold DB model + ColabFold model –
GO:0016787Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc.
No map 0.065 0.344 Hit 41.2% 4.93e-21
4502 VK055_1641 hypothetical protein ColabFold model – – No map 0.065 0.78 No Hit 0.0% —
4503 VK055_1426 DSBA-like thioredoxin domain protein Experimental + ColabFold model –
GO:0016491Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. GO:0042597The region between the inner (cytoplasmic) and outer membrane (Gram-negative Bacteria) or cytoplasmic membrane and cell wall (Fungi and Gram-positive Bacteria).
No map 0.065 0.536 No Hit 0.0% —
4504 VK055_0836 binding-protein-dependent transport system innermembrane component family protein AlphaFold DB model + ColabFold model –
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0055085The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other. GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. +14 total
No map 0.065 0.871 No Hit 0.0% —
4505 VK055_0106 kdgR transcriptional repressor kdgR AlphaFold DB model + ColabFold model –
GO:0003677Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). GO:0006355Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. +25 total
No map 0.065 0.971 No Hit 0.0% —
4506 VK055_4153 helix-turn-helix domain, rpiR family protein AlphaFold DB model + ColabFold model –
GO:0097367Binding to a carbohydrate derivative. GO:1901135The chemical reactions and pathways involving carbohydrate derivative. GO:0003700A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons. +25 total
No map 0.064 0.233 No Hit 0.0% —
4507 VK055_3585 yhjQ family protein ColabFold model – – No map 0.064 0.704 No Hit 0.0% —
4508 VK055_3479 hypothetical protein AlphaFold DB model + ColabFold model – – No map 0.064 0.956 No Hit 0.0% —
4509 VK055_2957 plasmid stability family protein AlphaFold DB model + ColabFold model – – No map 0.064 0.284 No Hit 0.0% —
4510 VK055_2305 glutathione S-transferase, C-terminal domain protein ColabFold model – – No map 0.064 0.559 Hit 34.6% 1.46e-11
4511 VK055_1322 lysogenization regulator hflD AlphaFold DB model + ColabFold model –
GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
No map 0.064 0.561 No Hit 0.0% —
4512 VK055_3765 ribosomal protein L14 rplN AlphaFold DB model + ColabFold model –
GO:0003735The action of a molecule that contributes to the structural integrity of the ribosome. GO:0006412The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA or circRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA or circRNA. Translation ends with the release of a polypeptide chain from the ribosome. GO:0005840An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins. +36 total
No map 0.063 0.742 Hit 45.0% 1.56e-07
4513 VK055_2547 dpiA-phosphorylated DNA binding transcriptional dual regulator dpiA2 AlphaFold DB model + ColabFold model –
GO:0003700A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons. GO:0000160A conserved series of molecular signals found in prokaryotes and eukaryotes; involves autophosphorylation of a histidine kinase and the transfer of the phosphate group to an aspartate that then acts as a phospho-donor to response regulator proteins. GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. +25 total
No map 0.063 0.186 No Hit 0.0% —
4514 VK055_2217 exonuclease SbcCD, D subunit sbcD AlphaFold DB model + ColabFold model –
GO:0008408Catalysis of the hydrolysis of ester linkages within nucleic acids by removing nucleotide residues from the 3' end. GO:0004519Catalysis of the cleavage of ester linkages within nucleic acids by creating internal breaks. GO:0006259Any cellular metabolic process involving deoxyribonucleic acid. This is one of the two main types of nucleic acid, consisting of a long, unbranched macromolecule formed from one, or more commonly, two, strands of linked deoxyribonucleotides. +36 total
No map 0.063 0.691 No Hit 0.0% —
4515 VK055_0460 lysE type translocator family protein AlphaFold DB model + ColabFold model –
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0006865The directed movement of amino acids, organic acids containing one or more amino substituents, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. +14 total
No map 0.063 0.734 No Hit 0.0% —
4516 VK055_0228 NMT1-like family protein AlphaFold DB model + ColabFold model –
GO:0012505A collection of membranous structures involved in transport within the cell. The main components of the endomembrane system are endoplasmic reticulum, Golgi bodies, vesicles, cell membrane and nuclear envelope. Members of the endomembrane system pass materials through each other or though the use of vesicles.
No map 0.063 0.532 No Hit 0.0% —
4517 VK055_3543 yiaA/B two helix domain protein AlphaFold DB model + ColabFold model –
GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0006974Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating damage to its DNA from environmental insults or errors during metabolism.
No map 0.062 0.594 No Hit 0.0% —
4518 VK055_1504 beta-hydroxyacyl-(acyl-carrier-protein) dehydratase FabA fabA AlphaFold DB model + ColabFold model
4.2.1.59 5.3.3.14
GO:0006633The chemical reactions and pathways resulting in the formation of a fatty acid, any of the aliphatic monocarboxylic acids that can be liberated by hydrolysis from naturally occurring fats and oils. Fatty acids are predominantly straight-chain acids of 4 to 24 carbon atoms, which may be saturated or unsaturated; branched fatty acids and hydroxy fatty acids also occur, and very long chain acids of over 30 carbons are found in waxes. GO:0008693OBSOLETE. Catalysis of the reaction: (3R)-3-hydroxydecanoyl-[acyl-carrier protein] = 2,3-decenoyl-[acyl-carrier protein] or 3,4-decenoyl-[acyl-carrier protein] + H2O. GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. +36 total
Chokepoint 10 0.062 0.288 No Hit 0.0% —
4519 VK055_4518 putative inner membrane protein AlphaFold DB model + ColabFold model –
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0034639Enables the transfer of an L-amino acid from the inside of the cell to the outside of the cell across a membrane. GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. +14 total
No map 0.061 0.995 No Hit 0.0% —
4520 VK055_3917 general stress protein 18 yfkM AlphaFold DB model + ColabFold model – – No map 0.061 0.627 Hit 27.8% 2.99e-06
4521 VK055_3574 hypothetical protein AlphaFold DB model + ColabFold model – – No map N/A 0.061 No Hit 0.0% —
4522 VK055_3519 serine O-acetyltransferase cysE Experimental + ColabFold model –
GO:0009001Catalysis of the reaction: L-serine + acetyl-CoA = O-acetyl-L-serine + CoA. GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. GO:0006535OBSOLETE. The chemical reactions and pathways resulting in the formation of cysteine from L- serine. +14 total
Mapped 1 0.061 0.415 No Hit 0.0% —
4523 VK055_3392 ilvN ilvN2 AlphaFold DB model + ColabFold model
2.2.1.6
GO:1990610Binds to and modulates the activity of acetolactate synthase. GO:0009082The chemical reactions and pathways resulting in the formation of amino acids containing a branched carbon skeleton, comprising isoleucine, leucine and valine. GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. +36 total
No map 0.061 0.222 No Hit 0.0% —
4524 VK055_3000 lrgA family protein AlphaFold DB model + ColabFold model –
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
No map 0.061 0.78 No Hit 0.0% —
4525 VK055_2735 hypothetical protein ColabFold model – – No map 0.061 0.163 No Hit 0.0% —
Page of 204 · 5081 total proteins