Proteins

Genome: KpATCC43816

Description: Klebsiella pneumoniae subsp. pneumoniae strain ATCC 43816 KPPR1, complete genome

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# Protein Description Gene Structure EC GO Metabolism Druggability (P2Rank) P2RANK ligandability score for the best pocket in the experimental structure (0–1). Higher values indicate higher predicted ligandability. Available only for genomes analyzed with the curated pipeline. Druggability (FPocket) FPocket druggability score for the preferred structure (0–1): experimental structure when available, otherwise predicted model. ≥ 0.7 highly druggable · ≥ 0.4 moderately druggable · < 0.4 low druggability. Human off-target BLASTP against the human proteome. Hit means at least one human match was detected at e-value <= 1e-5. Prefer No hit for pathogen-selective targets. Human identity (%) Best human BLAST identity percentage. Human E-value Best human BLAST E-value.
4876 VK055_4024 hypothetical protein AlphaFold DB model + ColabFold model – – No map 0.015 0.727 No Hit 0.0% —
4877 VK055_3708 protein involved in utilization of DNA as a carbon source hofQ AlphaFold DB model + ColabFold model –
GO:0009306The controlled release of proteins from a cell. GO:0009279A lipid bilayer that forms the outermost membrane of the cell envelope; enriched in polysaccharide and protein; the outer leaflet of the membrane contains specific lipopolysaccharide structures.
No map 0.015 0.811 No Hit 0.0% —
4878 VK055_3092 DNA-binding protein HU-&alpha hupA AlphaFold DB model + ColabFold model –
GO:0030527The action of a molecule that contributes to the structural integrity of chromatin. GO:0003677Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
No map 0.015 0.392 No Hit 0.0% —
4879 VK055_2441 FKBP-type peptidyl-prolyl cis-trans isomerase family protein AlphaFold DB model + ColabFold model
5.2.1.8
GO:0006457The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure. GO:0003755Catalysis of the reaction: peptidyl-proline (omega=180) = peptidyl-proline (omega=0). GO:0000775The region of a chromosome that includes the centromeric DNA and associated proteins. In monocentric chromosomes, this region corresponds to a single area of the chromosome, whereas in holocentric chromosomes, it is evenly distributed along the chromosome. +36 total
No map 0.015 0.72 No Hit 0.0% —
4880 VK055_0649 hypothetical protein AlphaFold DB model + ColabFold model –
GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
No map 0.015 0.48 No Hit 0.0% —
4881 VK055_0644 putative auxin efflux carrier AlphaFold DB model + ColabFold model – – No map 0.015 0.8 No Hit 0.0% —
4882 VK055_4903 50S ribosomal subunit protein L25 rplY AlphaFold DB model + ColabFold model –
GO:0003735The action of a molecule that contributes to the structural integrity of the ribosome. GO:0006412The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA or circRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA or circRNA. Translation ends with the release of a polypeptide chain from the ribosome. GO:0005840An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins. +25 total
No map 0.014 0.105 No Hit 0.0% —
4883 VK055_4728 ethanolamine ammonia-lyase light chain family protein AlphaFold DB model + ColabFold model
4.3.1.7
GO:0006520The chemical reactions and pathways involving amino acids, carboxylic acids containing one or more amino groups. GO:0008851Catalysis of the reaction: ethanolamine = acetaldehyde + NH4+. GO:0009350An enzyme complex that catalyzes the breakdown of ethanolamine to form acetaldehyde and ammonia. +36 total
No map 0.014 0.491 No Hit 0.0% —
4884 VK055_4163 peptide chain release factor 2 prfB AlphaFold DB model + ColabFold model –
GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. GO:0006415The process resulting in the release of a polypeptide chain from the ribosome, usually in response to a termination codon (UAA, UAG, or UGA in the universal genetic code). GO:0003747Involved in catalyzing the release of a nascent polypeptide chain from a ribosome. +14 total
No map 0.014 0.048 Hit 49.2% 3.63e-36
4885 VK055_3097 regulator of RNA polymerase sigma(70) subunit, Rsd/AlgQ family protein AlphaFold DB model + ColabFold model –
GO:0006355Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.
No map 0.014 0.581 No Hit 0.0% —
4886 VK055_2436 hypothetical protein AlphaFold DB model + ColabFold model – – No map 0.014 0.213 No Hit 0.0% —
4887 VK055_1921 proofreading thioesterase in enterobactin biosynthesis ybdB2 AlphaFold DB model + ColabFold model
3.1.2.-
GO:0009239The chemical reactions and pathways resulting in the formation of enterobactin, a catechol-derived siderochrome of Enterobacteria; enterobactin (N',N',N''-(2,6,10-trioxo-1,5,9-triacyclodecane-3,7,11-triyl)tris(2,3-dihydroxy)benzamide) is a self-triester of 2,3-dihydroxy-N-benzoyl-L-serine and a product of the shikimate pathway. GO:0016790Catalysis of the reaction: RCO-SR' + H2O = RCOOH + HSR'. This reaction is the hydrolysis of a thiolester bond, an ester formed from a carboxylic acid and a thiol (i.e., RCO-SR'), such as that found in acetyl-coenzyme A. GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. +14 total
Mapped 1 0.014 0.631 No Hit 0.0% —
4888 VK055_1525 asnC family protein AlphaFold DB model + ColabFold model –
GO:0043565Binding to DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. GO:0003677Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). GO:0006355Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. +25 total
No map 0.014 0.264 No Hit 0.0% —
4889 VK055_0941 malonate decarboxylase acyl carrier protein mdcC AlphaFold DB model + ColabFold model – – No map 0.014 0.699 No Hit 0.0% —
4890 VK055_0809 hypothetical protein AlphaFold DB model + ColabFold model – – No map 0.014 0.009 No Hit 0.0% —
4891 VK055_0715 hxlR-like helix-turn-helix family protein AlphaFold DB model + ColabFold model –
GO:0003677Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
No map 0.014 0.752 No Hit 0.0% —
4892 VK055_0616 molybdopterin oxidoreductase family protein AlphaFold DB model + ColabFold model –
GO:0051539Binding to a 4 iron, 4 sulfur (4Fe-4S) cluster; this cluster consists of four iron atoms, with the inorganic sulfur atoms found between the irons and acting as bridging ligands. GO:0016491Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. GO:0030313An envelope that surrounds a bacterial cell and includes the cytoplasmic membrane and everything external, encompassing the periplasmic space, cell wall, and outer membrane if present. +36 total
No map 0.014 0.433 No Hit 0.0% —
4893 VK055_0381 CRISPR type I-E/ECOLI-associated protein CasB/Cse2 casB AlphaFold DB model + ColabFold model – – No map 0.014 0.017 No Hit 0.0% —
4894 VK055_0064 MAPEG family protein AlphaFold DB model + ColabFold model –
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it.
No map 0.014 0.554 No Hit 0.0% —
4895 VK055_4822 dihydroneopterin triphosphate 2'-epimerase folX AlphaFold DB model + ColabFold model
5.1.99.7
GO:0004150Catalysis of the reaction: 2-amino-4-hydroxy-6-(D-erythro-1,2,3-trihydroxypropyl)-7,8-dihydropteridine = 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine + glycolaldehyde. GO:0006760The chemical reactions and pathways involving a folic acid-containing compound, i.e. any of a group of heterocyclic compounds based on the pteroic acid skeleton conjugated with one or more L-glutamic acid or L-glutamate units. GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. +25 total
Chokepoint 1 0.013 0.36 No Hit 0.0% —
4896 VK055_4770 hypothetical protein AlphaFold DB model + ColabFold model – – No map 0.013 0.466 No Hit 0.0% —
4897 VK055_4071 gram-negative pili assembly chaperone, C-terminal domain protein ColabFold model – – No map 0.013 0.289 No Hit 0.0% —
4898 VK055_2845 hypothetical protein AlphaFold DB model + ColabFold model – – No map 0.013 0.278 No Hit 0.0% —
4899 VK055_2817 helix-turn-helix domain, rpiR family protein AlphaFold DB model + ColabFold model –
GO:0003700A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons. GO:1901135The chemical reactions and pathways involving carbohydrate derivative. GO:0097367Binding to a carbohydrate derivative. +25 total
No map 0.013 0.434 No Hit 0.0% —
4900 VK055_2707 membrane fusion protein of the CusCFBA copper efflux system AlphaFold DB model + ColabFold model –
GO:0022857Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other. GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0055085The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other. +58 total
No map 0.013 0.318 No Hit 0.0% —
Page of 204 · 5081 total proteins