Proteins

Genome: KpATCC43816

Description: Klebsiella pneumoniae subsp. pneumoniae strain ATCC 43816 KPPR1, complete genome

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# Protein Description Gene Structure EC GO Metabolism Druggability (P2Rank) P2RANK ligandability score for the best pocket in the experimental structure (0–1). Higher values indicate higher predicted ligandability. Available only for genomes analyzed with the curated pipeline. Druggability (FPocket) FPocket druggability score for the preferred structure (0–1): experimental structure when available, otherwise predicted model. ≥ 0.7 highly druggable · ≥ 0.4 moderately druggable · < 0.4 low druggability. Human off-target BLASTP against the human proteome. Hit means at least one human match was detected at e-value <= 1e-5. Prefer No hit for pathogen-selective targets. Human identity (%) Best human BLAST identity percentage. Human E-value Best human BLAST E-value.
4901 VK055_2010 helix-turn-helix family protein AlphaFold DB model + ColabFold model –
GO:0003677Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). GO:0006355Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. GO:0001046Binding to a sequence of DNA that is part of a core promoter region. The core promoter is composed of the transcription start site and binding sites for the RNA polymerase and the basal transcription machinery. The transcribed region might be described as a gene, cistron, or operon.
No map 0.013 0.581 No Hit 0.0% —
4902 VK055_0965 3-oxoadipate CoA-transferase subunit A pcaI AlphaFold DB model + ColabFold model –
GO:0008410Catalysis of the transfer of a coenzyme A (CoA) group from one compound (donor) to another (acceptor).
Chokepoint 2 0.013 0.178 Hit 48.2% 4.34e-21
4903 VK055_0907 hypothetical protein AlphaFold DB model + ColabFold model –
GO:0003697Binding to single-stranded DNA. GO:0018142OBSOLETE. The formation of a covalent cross-link between DNA and a protein. GO:0006974Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating damage to its DNA from environmental insults or errors during metabolism.
No map 0.013 0.096 Hit 33.3% 5.13e-07
4904 VK055_5183 hypothetical protein ColabFold model – – No map 0.012 0.295 No Hit 0.0% —
4905 VK055_4809 cell division protein DedD AlphaFold DB model + ColabFold model –
GO:0032506A cellular process that is involved in cytokinesis (the division of the cytoplasm of a cell and its separation into two daughter cells). GO:0030428A structure composed of peptidoglycan and often chitin in addition to other materials. It usually forms perpendicular to the long axis of a cell or hypha and grows centripetally from the cell wall to the center of the cell and often functions in the compartmentalization of a cell into two daughter cells. GO:0042834Interacting selectively and non-covalently, in a non-covalent manner, with peptidoglycan, any of a class of glycoconjugates found in bacterial cell walls. +25 total
Mapped 1 N/A 0.012 No Hit 0.0% —
4906 VK055_4730 putative structural protein, ethanolamine utilization microcompartment AlphaFold DB model + ColabFold model –
GO:0031469An organelle found in bacteria consisting of a proteinaceous coat containing metabolic enzymes whose purpose is the sequestration or concentration of metabolites and which has the appearance of a polygonal granule by electron microscopy.
No map 0.012 0.329 No Hit 0.0% —
4907 VK055_4298 hypothetical protein AlphaFold DB model + ColabFold model – – No map 0.012 0.768 No Hit 0.0% —
4908 VK055_4238 marR family protein AlphaFold DB model + ColabFold model –
GO:0003700A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons. GO:0006355Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. GO:0003677Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
No map 0.012 0.903 No Hit 0.0% —
4909 VK055_3374 small heat shock protein ibpB ibpB AlphaFold DB model + ColabFold model –
GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. GO:0050821Any process involved in maintaining the structure and integrity of a protein and preventing it from degradation or aggregation.
No map 0.012 0.409 No Hit 0.0% —
4910 VK055_1132 hypothetical protein AlphaFold DB model + ColabFold model – – No map 0.012 0.025 No Hit 0.0% —
4911 VK055_0966 smr domain protein AlphaFold DB model + ColabFold model –
GO:0004520Catalysis of the cleavage of ester linkages within deoxyribonucleic acid by creating internal breaks.
No map 0.012 0.378 No Hit 0.0% —
4912 VK055_4675 hypothetical protein ColabFold model – – No map N/A 0.011 No Hit 0.0% —
4913 VK055_3745 sulfur relay protein TusC/DsrF tusC AlphaFold DB model + ColabFold model –
GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. GO:0008033The process in which a pre-tRNA molecule is converted to a mature tRNA, ready for addition of an aminoacyl group.
No map 0.011 0.461 No Hit 0.0% —
4914 VK055_3695 transcription elongation factor GreB greB AlphaFold DB model + ColabFold model –
GO:0070063Binding to an RNA polymerase molecule or complex. GO:0032784Any process that modulates the frequency, rate or extent of transcription elongation, the extension of an RNA molecule after transcription initiation and promoter clearance by the addition of ribonucleotides catalyzed by a DNA-dependent RNA polymerase. GO:0003677Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). +25 total
No map 0.011 0.419 No Hit 0.0% —
4915 VK055_3281 molybdopterin oxidoreductase family protein AlphaFold DB model + ColabFold model –
GO:0051539Binding to a 4 iron, 4 sulfur (4Fe-4S) cluster; this cluster consists of four iron atoms, with the inorganic sulfur atoms found between the irons and acting as bridging ligands. GO:0016491Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced.
No map 0.011 0.393 No Hit 0.0% —
4916 VK055_1697 hypothetical protein AlphaFold DB model + ColabFold model –
GO:0042597The region between the inner (cytoplasmic) and outer membrane (Gram-negative Bacteria) or cytoplasmic membrane and cell wall (Fungi and Gram-positive Bacteria).
No map N/A 0.011 No Hit 0.0% —
4917 VK055_3819 rod shape-determining protein MreC mreC AlphaFold DB model + ColabFold model –
GO:0008360Any process that modulates the surface configuration of a cell. GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
No map 0.010 0.32 No Hit 0.0% —
4918 VK055_2621 dnaT dnaT AlphaFold DB model + ColabFold model –
GO:1990077Any of a family of protein complexes that form at the origin of replication or stalled replication forks and function in replication primer synthesis in all organisms. Early complexes initiate double-stranded DNA unwinding. The core unit consists of a replicative helicase and a primase. The helicase further unwinds the DNA and recruits the polymerase machinery. The primase synthesizes RNA primers that act as templates for complementary stand replication by the polymerase machinery. The primosome contains a number of associated proteins and protein complexes and contributes to the processes of replication initiation, lagging strand elongation, and replication restart. GO:0006260The cellular metabolic process in which a cell duplicates one or more molecules of DNA. DNA replication begins when specific sequences, known as origins of replication, are recognized and bound by the origin recognition complex, and ends when the original DNA molecule has been completely duplicated and the copies topologically separated. The unit of replication usually corresponds to the genome of the cell, an organelle, or a virus. The template for replication can either be an existing DNA molecule or RNA. GO:0003697Binding to single-stranded DNA. +14 total
No map 0.010 0.412 No Hit 0.0% —
4919 VK055_2559 chaperone protein DnaJ dnaJ AlphaFold DB model + ColabFold model –
GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. GO:0051082Binding to an unfolded protein. GO:0006457The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure. +69 total
No map 0.010 0.492 Hit 61.3% 4.18e-07
4920 VK055_2165 hypothetical protein AlphaFold DB model + ColabFold model – – No map 0.010 0.515 No Hit 0.0% —
4921 VK055_1917 plasmid stabilization system family protein AlphaFold DB model + ColabFold model – – No map 0.010 0.515 No Hit 0.0% —
4922 VK055_1293 hypothetical protein AlphaFold DB model + ColabFold model – – No map 0.010 0.658 No Hit 0.0% —
4923 VK055_1279 dinI-like family protein AlphaFold DB model + ColabFold model – – No map 0.010 0.498 No Hit 0.0% —
4924 VK055_5076 prokaryotic E2 E family protein AlphaFold DB model + ColabFold model – – No map 0.009 0.745 No Hit 0.0% —
4925 VK055_4638 iscR transcriptional regulator IscR transcriptional dual regulator iscR AlphaFold DB model + ColabFold model –
GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. GO:0051537Binding to a 2 iron, 2 sulfur (2Fe-2S) cluster; this cluster consists of two iron atoms, with two inorganic sulfur atoms found between the irons and acting as bridging ligands. GO:0003700A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons. +25 total
No map 0.009 0.096 No Hit 0.0% —
Page of 204 · 5081 total proteins