Proteins

Genome: KpATCC43816

Description: Klebsiella pneumoniae subsp. pneumoniae strain ATCC 43816 KPPR1, complete genome

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5081 proteins

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# Protein Description Gene Structure EC GO Druggability FPocket druggability score for the preferred structure (0–1): experimental structure when available, otherwise predicted model. ≥ 0.7 highly druggable · ≥ 0.4 moderately druggable · < 0.4 low druggability. Human off-target BLASTP against the human proteome. Hit means at least one human match was detected at e-value <= 1e-5. Prefer No hit for pathogen-selective targets. Human identity (%) Best human BLAST identity percentage. Human E-value Best human BLAST E-value.
4901 VK055_3096 NUDIX domain protein AlphaFold + ColabFold
3.6.1.- 3.6.1.22
GO:0016787Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. GO:0000210Catalysis of the reaction: NAD+ + H2O = AMP + NMN. GO:0046872Binding to a metal ion. +811 total
0.07 Hit 40.7% 1.43e-19
4902 VK055_1592 artI artI AlphaFold + ColabFold –
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0030288The region between the inner (cytoplasmic or plasma) membrane and outer membrane of organisms with two membranes such as Gram negative bacteria. These periplasmic spaces are relatively thick and contain a thin peptidoglycan layer (PGL), also referred to as a thin cell wall. GO:0071705The directed movement of nitrogen-containing compounds into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. +25 total
0.07 No Hit 0.0% —
4903 VK055_2762 prophage CP4-57 regulatory family protein AlphaFold + ColabFold – – 0.069 No Hit 0.0% —
4904 VK055_0973 methylated-DNA-[]-cysteine S-methyltransferase family protein AlphaFold + ColabFold
2.1.1.63
GO:0003908Catalysis of the reaction: DNA (containing 6-O-methylguanine) + (protein)-L-cysteine = DNA (without 6-O-methylguanine) + protein S-methyl-L-cysteine. GO:0003824Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. GO:0006281The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway. +36 total
0.069 Hit 52.4% 1.31e-21
4905 VK055_4590 hypothetical protein AlphaFold + ColabFold – – 0.068 No Hit 0.0% —
4906 VK055_4488 global regulator family protein ColabFold –
GO:0006109Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving carbohydrates. GO:0003723Binding to an RNA molecule or a portion thereof. GO:0006402The chemical reactions and pathways resulting in the breakdown of mRNA, messenger RNA, which is responsible for carrying the coded genetic 'message', transcribed from DNA, to sites of protein assembly at the ribosomes.
0.068 No Hit 0.0% —
4907 VK055_4439 PTS system, Lactose/Cellobiose specific IIA subunit AlphaFold + ColabFold –
GO:0009401The uptake and phosphorylation of specific carbohydrates from the extracellular environment; uptake and phosphorylation are coupled, making the PTS a link between the uptake and metabolism of sugars; phosphoenolpyruvate is the original phosphate donor; phosphoenolpyruvate passes the phosphate via a signal transduction pathway, to enzyme 1 (E1), which in turn passes it on to the histidine protein, HPr; the next step in the system involves sugar-specific membrane-bound complex, enzyme 2 (EII), which transports the sugar into the cell; it includes the sugar permease, which catalyzes the transport reactions; EII is usually divided into three different domains, EIIA, EIIB, and EIIC. GO:0046872Binding to a metal ion. GO:0016740Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2.
0.067 No Hit 0.0% —
4908 VK055_4282 putative lipoprotein AlphaFold + ColabFold – – 0.067 No Hit 0.0% —
4909 VK055_4162 single-stranded-DNA-specific exonuclease RecJ recJ AlphaFold + ColabFold –
GO:0008409Catalysis of the hydrolysis of ester linkages within nucleic acids by removing nucleotide residues from the 5' end. GO:0006281The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway. GO:0006310Any process in which a new genotype is formed by reassortment of genes resulting in gene combinations different from those that were present in the parents. In eukaryotes genetic recombination can occur by chromosome assortment, intrachromosomal recombination, or nonreciprocal interchromosomal recombination. Interchromosomal recombination occurs by crossing over. In bacteria it may occur by genetic transformation, conjugation, transduction, or F-duction. +14 total
0.067 No Hit 0.0% —
4910 VK055_2660 4-hydroxyphenylacetate 3-monooxygenase, reductase component hpaC AlphaFold + ColabFold
1.5.1.36
GO:0051287Binding to nicotinamide adenine dinucleotide, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NAD+, or the reduced form, NADH. GO:0042537The chemical reactions and pathways involving benzene, C6H6, a volatile, very inflammable liquid, contained in the naphtha produced by the destructive distillation of coal, from which it is separated by fractional distillation, or any of its derivatives. GO:0010181Binding to flavin mono nucleotide. Flavin mono nucleotide (FMN) is the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes. +47 total
0.067 No Hit 0.0% —
4911 VK055_2614 bglJ transcriptional regulator domain protein bglJ AlphaFold + ColabFold –
GO:0003677Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). GO:0006355Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.
0.067 No Hit 0.0% —
4912 VK055_3683 bacterial regulatory, luxR family protein ColabFold –
GO:0005515Binding to a protein. GO:0003677Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). GO:0006355Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.
0.066 No Hit 0.0% —
4913 VK055_3254 6-phosphofructokinase pfkA AlphaFold + ColabFold
2.7.1.11
GO:0006002The chemical reactions and pathways involving fructose 6-phosphate, also known as F6P. The D-enantiomer is an important intermediate in glycolysis, gluconeogenesis, and fructose metabolism. GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. GO:0003872Catalysis of the reaction: ATP + D-fructose-6-phosphate = ADP + D-fructose 1,6-bisphosphate. +1013 total
0.066 Hit 57.8% 6.10e-09
4914 VK055_3068 PTS system, mannose/fructose/sorbose family, IIAcomponent domain protein AlphaFold + ColabFold –
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0016773Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to an alcohol group (acceptor). GO:0008643The directed movement of carbohydrate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Carbohydrates are a group of organic compounds based of the general formula Cx(H2O)y. +36 total
0.066 No Hit 0.0% —
4915 VK055_3793 hypothetical protein AlphaFold + ColabFold – – 0.065 No Hit 0.0% —
4916 VK055_0029 ABC transporter family protein AlphaFold + ColabFold –
GO:0015424Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + amino acid(out/in) = ADP + phosphate + amino acid(in/out). GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. GO:0016887Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient. +25 total
0.062 Hit 37.1% 5.41e-27
4917 VK055_4232 fimbrial family protein AlphaFold + ColabFold –
GO:0007155The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules. GO:0009289A proteinaceous hair-like appendage on the surface of bacteria ranging from 2-8 nm in diameter. GO:0043709The attachment of a cell to a solid substrate, via cell adhesion molecules, during the formation of a biofilm composed of microorganisms of the same species.
0.061 No Hit 0.0% —
4918 VK055_3733 phosphoribulokinase / Uridine kinase family protein AlphaFold + ColabFold
2.7.1.19
GO:0008974Catalysis of the reaction: D-ribulose 5-phosphate + ATP = D-ribulose 1,5-bisphosphate + ADP + 2 H+. GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. GO:0016301Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule. +14 total
0.061 No Hit 0.0% —
4919 VK055_3574 hypothetical protein AlphaFold + ColabFold – – 0.061 No Hit 0.0% —
4920 VK055_0303 hypothetical protein AlphaFold + ColabFold – – 0.061 No Hit 0.0% —
4921 VK055_3250 ATP-dependent protease HslVU, peptidase subunit hslV AlphaFold + ColabFold
3.4.25.2
GO:0006508The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds. GO:0009376A protein complex that possesses ATP-dependent protease activity; consists of an ATPase large subunit with homology to other ClpX family ATPases and a peptidase small subunit related to the proteasomal beta-subunits of eukaryotes. In the E. coli complex, a double ring-shaped homohexamer of HslV is capped on each side by a ring-shaped HslU homohexamer. GO:0051603OBSOLETE. The hydrolysis of a peptide bond or bonds within a protein as part of the chemical reactions and pathways resulting in the breakdown of a protein by individual cells. +36 total
0.059 No Hit 0.0% —
4922 VK055_2407 type II secretion system protein C gspC Experimental + AlphaFold + ColabFold –
GO:0015627A large protein complex, containing 12-15 subunits, that spans the cell envelope of Gram-negative bacteria and mediates the movement of proteins into the extracellular environment. The complex includes a component in the cytoplasm, an inner membrane subcomplex that reaches into the periplasmic compartment and a secretion pore in the outer membrane. Proteins using the Type II pathway are transported across the cytoplasmic membrane by the Sec or Tat complex. GO:0005515Binding to a protein. GO:0015628The process in which proteins are secreted across the outer membrane of Gram-negative bacteria by the type II secretion system. Proteins using this pathway are first translocated across the cytoplasmic membrane via the Sec or Tat pathways. +14 total
0.059 No Hit 0.0% —
4923 VK055_3923 hypothetical protein AlphaFold + ColabFold –
GO:0003676Binding to a nucleic acid.
0.058 No Hit 0.0% —
4924 VK055_2634 putative L-galactonate oxidoreductase AlphaFold + ColabFold –
GO:0008270Binding to a zinc ion (Zn). GO:0016491Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced.
0.058 Hit 39.8% 2.53e-11
4925 VK055_2126 hypothetical protein ColabFold – – 0.058 No Hit 0.0% —
Page of 204 · 5081 total proteins