Proteins

Genome: KpATCC43816

Description: Klebsiella pneumoniae subsp. pneumoniae strain ATCC 43816 KPPR1, complete genome

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# Protein Description Gene Structure EC GO Metabolism Druggability (P2Rank) P2RANK ligandability score for the best pocket in the experimental structure (0–1). Higher values indicate higher predicted ligandability. Available only for genomes analyzed with the curated pipeline. Druggability (FPocket) FPocket druggability score for the preferred structure (0–1): experimental structure when available, otherwise predicted model. ≥ 0.7 highly druggable · ≥ 0.4 moderately druggable · < 0.4 low druggability. Human off-target BLASTP against the human proteome. Hit means at least one human match was detected at e-value <= 1e-5. Prefer No hit for pathogen-selective targets. Human identity (%) Best human BLAST identity percentage. Human E-value Best human BLAST E-value.
4851 VK055_5151 hypothetical protein ColabFold model – – No map 0.018 0.378 No Hit 0.0% —
4852 VK055_4199 hypothetical protein AlphaFold DB model + ColabFold model –
GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
No map 0.018 0.726 No Hit 0.0% —
4853 VK055_3019 hypothetical protein AlphaFold DB model + ColabFold model – – No map N/A 0.018 No Hit 0.0% —
4854 VK055_2082 cu(I)-responsive transcriptional regulator cueR AlphaFold DB model + ColabFold model –
GO:0005507Binding to a copper (Cu) ion. GO:0006355Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. GO:0003700A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons. +36 total
No map 0.018 0.362 No Hit 0.0% —
4855 VK055_1609 glutaredoxin, GrxA family grxA AlphaFold DB model + ColabFold model –
GO:0015035Catalysis of the reaction: a protein with reduced sulfide groups = a protein with oxidized disulfide bonds. GO:0009055A molecular function representing the directed movement of electrons from one molecular entity to another, typically mediated by electron carriers or acceptors, resulting in the transfer of energy and/or the reduction-oxidation (redox) transformation of chemical species. This activity is fundamental to various biological processes, including cellular respiration and photosynthesis, as well as numerous enzymatic reactions involved in metabolic pathways. GO:0045454Any process that maintains the redox environment of a cell or compartment within a cell. +47 total
No map 0.018 0.391 Hit 32.1% 1.21e-07
4856 VK055_1590 putative lipoprotein AlphaFold DB model + ColabFold model – – No map 0.018 0.173 No Hit 0.0% —
4857 VK055_1338 ribose 5-phosphate isomerase B rpiB AlphaFold DB model + ColabFold model
5.3.1.6 5.3.1.-
GO:0005975The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. GO:0016853Catalysis of the geometric or structural changes within one molecule. Isomerase is the systematic name for any enzyme of EC class 5. GO:0004751Catalysis of the reaction: aldehydo-D-ribose 5-phosphate = D-ribulose 5-phosphate.
Mapped 4 0.018 0.385 No Hit 0.0% —
4858 VK055_0012 hypothetical protein ColabFold model – – No map 0.018 0.48 No Hit 0.0% —
4859 VK055_5140 cbl transcriptional activator AlphaFold DB model + ColabFold model –
GO:0003700A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons. GO:0006355Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. GO:0000976Binding to a specific sequence of DNA that is part of a regulatory region that controls transcription of that section of the DNA. The transcribed region might be described as a gene, cistron, or operon. +14 total
No map 0.017 0.929 No Hit 0.0% —
4860 VK055_4824 glutathione S-transferase, N-terminal domain protein Experimental + ColabFold model – – No map 0.017 0.534 Hit 36.6% 2.76e-14
4861 VK055_3325 asnC transcriptional repressor AsnC transcriptional dual regulator asnC AlphaFold DB model + ColabFold model –
GO:0043565Binding to DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. GO:0006355Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. +14 total
No map 0.017 0.038 No Hit 0.0% —
4862 VK055_3111 ribosomal protein L7/L12 rplL AlphaFold DB model + ColabFold model –
GO:0003735The action of a molecule that contributes to the structural integrity of the ribosome. GO:0006412The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA or circRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA or circRNA. Translation ends with the release of a polypeptide chain from the ribosome. GO:0005840An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins. +25 total
No map N/A 0.017 Hit 38.7% 7.16e-06
4863 VK055_2009 hypothetical protein AlphaFold DB model + ColabFold model – – No map 0.017 0.305 No Hit 0.0% —
4864 VK055_1607 NADPH-flavin oxidoreductase frp AlphaFold DB model + ColabFold model –
GO:0016491Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced.
Mapped 2 0.017 0.858 No Hit 0.0% —
4865 VK055_1008 hypothetical protein AlphaFold DB model + ColabFold model – – No map 0.017 0.434 No Hit 0.0% —
4866 VK055_0233 narL transcriptional dual regulator narL AlphaFold DB model + ColabFold model –
GO:0006355Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. GO:0003677Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). GO:0000160A conserved series of molecular signals found in prokaryotes and eukaryotes; involves autophosphorylation of a histidine kinase and the transfer of the phosphate group to an aspartate that then acts as a phospho-donor to response regulator proteins. +25 total
No map 0.017 0.349 No Hit 0.0% —
4867 VK055_4193 ureE urease accessory, N-terminal domain protein AlphaFold DB model + ColabFold model –
GO:0019627The chemical reactions and pathways involving urea, the water soluble compound O=C-(NH2)2. GO:0006457The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure. GO:0065003The aggregation, arrangement and bonding together of a set of macromolecules to form a protein-containing complex. +36 total
No map 0.016 0.241 No Hit 0.0% —
4868 VK055_3054 phosphate-starvation-inducible E family protein AlphaFold DB model + ColabFold model –
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0016036Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of deprivation of phosphate. GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
No map 0.016 0.897 No Hit 0.0% —
4869 VK055_2916 small Multidrug Resistance family protein AlphaFold DB model + ColabFold model –
GO:0022857Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other. GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. +14 total
No map 0.016 0.906 No Hit 0.0% —
4870 VK055_1610 inner membrane of Enterobacteriaceae family protein AlphaFold DB model + ColabFold model –
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it.
No map 0.016 0.819 No Hit 0.0% —
4871 VK055_0282 integration host factor, alpha subunit ihfA AlphaFold DB model + ColabFold model –
GO:0030527The action of a molecule that contributes to the structural integrity of chromatin. GO:0006310Any process in which a new genotype is formed by reassortment of genes resulting in gene combinations different from those that were present in the parents. In eukaryotes genetic recombination can occur by chromosome assortment, intrachromosomal recombination, or nonreciprocal interchromosomal recombination. Interchromosomal recombination occurs by crossing over. In bacteria it may occur by genetic transformation, conjugation, transduction, or F-duction. GO:0003677Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). +14 total
No map 0.016 0.673 No Hit 0.0% —
4872 VK055_0023 positive DNA-binding transcriptional regulator of capsular polysaccharide synthesis, activates its own expression rcsA AlphaFold DB model + ColabFold model –
GO:0003677Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). GO:0006355Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.
No map 0.016 0.263 No Hit 0.0% —
4873 VK055_5095 putative sAM-dependent methyltransferase ColabFold model – – No map 0.015 0.593 No Hit 0.0% —
4874 VK055_5089 type IV secretion system family protein AlphaFold DB model + ColabFold model – – No map 0.015 0.038 No Hit 0.0% —
4875 VK055_4449 hydrogenase assembly chaperone HypC/HupF hypC AlphaFold DB model + ColabFold model –
GO:1902670Binding to carbon dioxide. GO:0005506Binding to an iron (Fe) ion. GO:0051604Any process leading to the attainment of the full functional capacity of a protein.
No map 0.015 0.401 No Hit 0.0% —
Page of 204 · 5081 total proteins