Proteins

Genome: KpATCC43816

Description: Klebsiella pneumoniae subsp. pneumoniae strain ATCC 43816 KPPR1, complete genome

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5081 proteins

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# Protein Description Gene Structure EC GO Druggability FPocket druggability score for the preferred structure (0–1): experimental structure when available, otherwise predicted model. ≥ 0.7 highly druggable · ≥ 0.4 moderately druggable · < 0.4 low druggability. Human off-target BLASTP against the human proteome. Hit means at least one human match was detected at e-value <= 1e-5. Prefer No hit for pathogen-selective targets. Human identity (%) Best human BLAST identity percentage. Human E-value Best human BLAST E-value.
4851 VK055_0093 hypothetical protein AlphaFold + ColabFold – – 0.09 No Hit 0.0% —
4852 VK055_4704 phospholipase/Carboxylesterase family protein AlphaFold + ColabFold –
GO:0016787Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc.
0.089 No Hit 0.0% —
4853 VK055_1143 6-phospho-beta-glucosidase AlphaFold + ColabFold –
GO:0003824Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. GO:0016616Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group acts as a hydrogen or electron donor and reduces NAD+ or NADP. GO:0005975The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. +25 total
0.089 No Hit 0.0% —
4854 VK055_0831 cupin domain protein AlphaFold + ColabFold – – 0.089 No Hit 0.0% —
4855 VK055_0652 hypothetical protein AlphaFold + ColabFold – – 0.089 No Hit 0.0% —
4856 VK055_5190 resolvase, N terminal domain protein AlphaFold + ColabFold –
GO:0006310Any process in which a new genotype is formed by reassortment of genes resulting in gene combinations different from those that were present in the parents. In eukaryotes genetic recombination can occur by chromosome assortment, intrachromosomal recombination, or nonreciprocal interchromosomal recombination. Interchromosomal recombination occurs by crossing over. In bacteria it may occur by genetic transformation, conjugation, transduction, or F-duction. GO:0000150Catalysis of the identification and base-pairing of homologous sequences between single-stranded DNA and double-stranded DNA. GO:0003677Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). +14 total
0.088 No Hit 0.0% —
4857 VK055_4380 tRNA pseudouridine 65 synthase yqcB AlphaFold + ColabFold
5.4.99.26
GO:0009451The covalent alteration of one or more nucleotides within an RNA molecule to produce an RNA molecule with a sequence that differs from that coded genetically. GO:0001522The intramolecular conversion of uridine to pseudouridine within an RNA molecule. GO:0003723Binding to an RNA molecule or a portion thereof. +47 total
0.088 Hit 30.4% 4.91e-15
4858 VK055_1639 DNA adenine methylase family protein dam ColabFold –
GO:0003676Binding to a nucleic acid. GO:0008168Catalysis of the transfer of a methyl group to an acceptor molecule. GO:0009007Catalysis of the reaction: S-adenosyl-L-methionine + DNA adenine = S-adenosyl-L-homocysteine + DNA 6-methylaminopurine. +25 total
0.088 No Hit 0.0% —
4859 VK055_1634 phage capsid scaffolding (GPO) serine peptidase family protein AlphaFold + ColabFold –
GO:0019069The assembly of a virus capsid from its protein subunits.
0.088 No Hit 0.0% —
4860 VK055_0009 resolvase, N terminal domain protein AlphaFold + ColabFold –
GO:0006310Any process in which a new genotype is formed by reassortment of genes resulting in gene combinations different from those that were present in the parents. In eukaryotes genetic recombination can occur by chromosome assortment, intrachromosomal recombination, or nonreciprocal interchromosomal recombination. Interchromosomal recombination occurs by crossing over. In bacteria it may occur by genetic transformation, conjugation, transduction, or F-duction. GO:0000150Catalysis of the identification and base-pairing of homologous sequences between single-stranded DNA and double-stranded DNA. GO:0003677Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
0.088 No Hit 0.0% —
4861 VK055_1752 hypothetical protein AlphaFold + ColabFold – – 0.087 No Hit 0.0% —
4862 VK055_3827 aaeAB Hydroxylated, Aromatic Carboxylic Acid Efflux Transport System Protein A aaeA AlphaFold + ColabFold –
GO:0022857Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other. GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0055085The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other.
0.086 No Hit 0.0% —
4863 VK055_1320 NUDIX domain protein AlphaFold + ColabFold
3.6.1.-
GO:0004787Catalysis of the reaction: thiamine diphosphate + H2O = thiamine monophosphate + phosphate. GO:0017111Catalysis of the reaction: a ribonucleoside triphosphate + H2O = a ribonucleoside diphosphate + H+ + phosphate. GO:0017110Catalysis of the reaction: a nucleoside diphosphate + H2O = a nucleoside monophosphate + phosphate. +14 total
0.086 Hit 28.4% 3.26e-06
4864 VK055_0441 transposase family protein AlphaFold + ColabFold –
GO:0006313A type of transposition in which a transposable element (transposon) is moved to another part of a genome, either by a cut-and-paste mechanism or a replicative mechanism. GO:0004803Catalysis of the transposition of transposable elements or transposons. Transposases are involved in recombination required for transposition and are site-specific for the transposon/transposable element. GO:0003677Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
0.086 No Hit 0.0% —
4865 VK055_4908 nickel import ATP-binding protein NikE nikE4 AlphaFold + ColabFold –
GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. GO:0015833The directed movement of peptides, compounds of two or more amino acids where the alpha carboxyl group of one is bound to the alpha amino group of another, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. GO:0000166Binding to a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose. +25 total
0.085 Hit 40.3% 1.11e-06
4866 VK055_4502 emrA Membrane Fusion Protein AlphaFold + ColabFold –
GO:0042910Enables the directed movement of a xenobiotic from one side of a membrane to the other. A xenobiotic is a compound foreign to the organism exposed to it. It may be synthesized by another organism (like ampicilin) or it can be a synthetic chemical. GO:1990961A process that reduces or removes the toxicity of a xenobiotic by exporting it outside the cell. GO:0055085The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other. +36 total
0.085 No Hit 0.0% —
4867 VK055_2238 isochorismatase family protein AlphaFold + ColabFold –
GO:0016787Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc.
0.085 No Hit 0.0% —
4868 VK055_1792 hypothetical protein AlphaFold + ColabFold – – 0.085 No Hit 0.0% —
4869 VK055_3664 acetyltransferase family protein AlphaFold + ColabFold
2.3.1.-
GO:0016747Catalysis of the transfer of an acyl group, other than amino-acyl, from one compound (donor) to another (acceptor).
0.083 No Hit 0.0% —
4870 VK055_3375 hypothetical protein ColabFold – – 0.083 No Hit 0.0% —
4871 VK055_2729 integrase core domain protein AlphaFold + ColabFold –
GO:0015074The process in which a DNA segment is incorporated into another, usually larger, DNA molecule such as a chromosome. GO:0003676Binding to a nucleic acid.
0.083 No Hit 0.0% —
4872 VK055_0679 coenzyme PQQ biosynthesis protein B pqqB AlphaFold + ColabFold –
GO:0018189The chemical reactions and pathways resulting in the formation of the cofactor pyrroloquinoline quinone (PQQ); it is synthesized from a small peptide containing tyrosine and glutamic acid; these amino acids in the peptide are multiply cross-linked and the rest of the peptide is removed.
0.083 No Hit 0.0% —
4873 VK055_0553 bacterial extracellular solute-binding family protein AlphaFold + ColabFold –
GO:0015846The directed movement of polyamines, organic compounds containing two or more amino groups, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. GO:0019808Binding to a polyamine, an organic compound containing two or more amino groups. GO:0042597The region between the inner (cytoplasmic) and outer membrane (Gram-negative Bacteria) or cytoplasmic membrane and cell wall (Fungi and Gram-positive Bacteria). +14 total
0.083 No Hit 0.0% —
4874 VK055_4821 hypothetical protein AlphaFold + ColabFold – – 0.079 No Hit 0.0% —
4875 VK055_4599 stress-induced alternate pyruvate formate-lyase subunit yfiD AlphaFold + ColabFold –
GO:0003824Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. GO:0008861Catalysis of the reaction: acetyl-CoA + formate = CoA + pyruvate.
0.079 No Hit 0.0% —
Page of 204 · 5081 total proteins